纹状体中等多棘神经元侧抑制效应与基底神经节运动功能调控
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摘要
中等多棘神经元(medium spiny neurons,MSNs)是纹状体的主要投射神经元,其细胞膜上表达的不同类型多巴胺(dopamine,DA)受体,分别参与基底神经节直接与间接两条运动神经通路功能的调节。近年来发现,纹状体相邻MSNs之间还存在突触连接,这种突触结构对直接或间接通路的电活动产生侧抑制效应(lateral inhibition),并通过其前馈作用进一步调节基底神经节信息输出核团的兴奋性。因此,纹状体MSNs的侧抑制效应对运动的精确调节具有重要意义。本文拟从纹状体神经元构筑与侧抑制突触效应、纹状体MSNs侧抑制突触效应参与基底神经节调控的生理学机制、MSNs侧抑制效应异常与帕金森病(Parkinson's disease,PD)等方面对纹状体MSNs侧抑制效应与基底神经节功能调控的机制进行综述。
引文
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17 Lalchandani RR,Vicini S.Inhibitory collaterals in genetically identified medium spiny neurons in mouse primary corticostriatal cultures.Physiol Rep,2013,1e00164.
18 Dobbs LK,Kaplan AR,Lemos JC,et al.Dopamine regulation of lateral inhibition between striatal neurons gates the stimulant actions of cocaine.Neuron,2016,901100~1113.
19 Klug JR,Engelhardt MD,Cadman CN,et al.Differential inputs to striatal cholinergic and parvalbumin interneurons imply functional distinctions.Elife,2018,1~25.
20 Kohnomi S,Ebihara K,Kobayashi M.Suppressive regulation of lateral inhibition between medium spiny neurons via dopamine D1 receptors in the rat nucleus accumbens shell.Neurosci.Lett,2017,63658~63.
21 Kravitz AV,Freeze BS,Parker PRL,et al.Regulation of parkinsonian motor behaviours by optogenetic control of basal ganglia circuitry.Nature,2010,466622~626.
22 Anzalone A,Lizardi-Ortiz JE,Ramos M,et al.Dual control of dopamine synthesis and release by presynaptic and postsynaptic dopamine D2 receptors.J Neurosci,2012,329023~9034.
23 Lalchandani RR,van der Goes MS,Partridge JG,et al.Dopamine D2 receptors regulate collateral inhibition between striatal medium spiny neurons.J Neurosci,2013,3314075~14086.
24 Kravitz AV,Freeze BS,Parker PR,et al.Regulation of parkinsonian motor behaviours by optogenetic control of basal ganglia circuitry.Nature,2010,466622~666.
25 Bian WJ,Miao WY,He SJ,et al.Coordinated spine pruning and maturation mediated by inter-spine competition for cadherin/catenin complexes.Cell,2015,162808~822.
26 Toy WA,Petzinger GM,Leyshon BJ,et al.Treadmill exercise reverses dendritic spine loss in direct and indirect striatal medium spiny neurons in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP)mouse model of Parkinson's disease.Neurobiol Dis,2014,63201~209.
27 Taverna S,Ilijic E,Surmeier DJ.Recurrent collateral connections of striatal medium spiny neurons are disrupted in models of Parkinson's disease.J Neurosci,2008,285504~5512.
28 Li L,Sagot B,Zhou FM.Similar L-dopa-stimulated motor activity in mice with adult-onset 6-hydroxydopamine-induced symmetric dopamine denervation and in transcription factor Pitx3 null mice with perinatal-onset symmetric dopamine denervation.Brain Res,2015,161512~21.
29 Wei W,Li L,Yu G,et al.Supersensitive presynaptic dopamine D2 receptor inhibition of the striatopallidal projection in nigrostriatal dopamine-deficient mice.J Neurophysiol,2013,1102203~2216.
30 Wei W,Ding S,Zhou FM.Dopaminergic treatment weakens medium spiny neuron collateral inhibition in the parkinsonian striatum.J Neurophysiol,2017,117987~999.
2 Redgrave P,Rodriguez M,Smith Y,et al.Goal-directed and habitual control in the basal ganglia:implications for Parkinson's disease.Nat Rev Neurosci,2010,11760~772.
3 Moyer JT,Halterman BL,Finkel LH,et al.Lateral and feedforward inhibition suppress asynchronous activity in a large,biophysically-detailed computational model of the striatal network.Front Comput Neurosci,2014,8:152.
4 Cazorla M,de Carvalho FD,Chohan MO,et al.Dopamine D2 receptors regulate the anatomical and functional balance of basal ganglia circuitry.Neuron,2014,81153~164.
5 Gagnon D,Petryszyn S,Sanchez MG,et al.Striatal neurons expressing D1 and D2 receptors are morphologically distinct and differently affected by dopamine denervation in mice.Nat Publ Gr,2017,129~17.
6 Straub C,Saulnier JL,Bègue A,et al.Principles of synaptic organization of GABAergic interneurons in the striatum.Neuron,2016,9284~92.
7 Tepper JM,Koós T.GABAergic interneurons of the striatum.Handbook of Behavioral Neuroscience.Elsevier,2017,24157~178.
8 Zhai S,Tanimura A,Graves SM,et al.Science direct striatal synapses,circuits,and Parkinson's disease.Curr Opin Neurobiol,2018,489~16.
9 Wang Y,Zhou F.Striatal but not extrastriatal dopamine receptors are critical to dopaminergic motor stimulation.Front Pharmacol,2017,81~13.
10 Sippy T,Lapray D,Crochet S,et al.Cell-type-specific sensorimotor processing in striatal projection neurons during goal-directed behavior.Neuron,2015,88298~305.
11 Rothwell PE,Fuccillo MV,Maxeiner S,et al.Autism-associated neuroligin-3 mutations common-ly impair striatal circuits to boost repetitive behaviors.Cell,2014,158198~212.
12 Burke DA,Rotstein HG,Alvarez VA.Striatal local circuitry:a new framework for lateral inhibition.Neuron,2017,96267~284.
13 Freeze BS,Kravitz AV,Hammack N,et al.Control of basal ganglia output by direct and indirect pathway projection neurons.J Neurosci,2013,3318531~18539.
14 Gulley JM,Kosobud AEK,Rebec GV.Behavior related modulation of substantia nigra pars reticulata neurons in rats performing a conditioned reinforcement task.Neuroscience,2002,111337~349.
15 Schmidt R,Leventhal DK,Mallet N,et al.Canceling actions involves a race between basal ganglia pathways.Nat Neurosci,2013,161118~1124.
16 Chen W,Qiao D,Liu X,et al.Treadmill exercise improves motor dysfunction and hyperactivity of the corticostriatal glutamatergic pathway in rats with 6-OHDA-induced Parkinson's disease.Neural Plast,2017,20171~11.
17 Lalchandani RR,Vicini S.Inhibitory collaterals in genetically identified medium spiny neurons in mouse primary corticostriatal cultures.Physiol Rep,2013,1e00164.
18 Dobbs LK,Kaplan AR,Lemos JC,et al.Dopamine regulation of lateral inhibition between striatal neurons gates the stimulant actions of cocaine.Neuron,2016,901100~1113.
19 Klug JR,Engelhardt MD,Cadman CN,et al.Differential inputs to striatal cholinergic and parvalbumin interneurons imply functional distinctions.Elife,2018,1~25.
20 Kohnomi S,Ebihara K,Kobayashi M.Suppressive regulation of lateral inhibition between medium spiny neurons via dopamine D1 receptors in the rat nucleus accumbens shell.Neurosci.Lett,2017,63658~63.
21 Kravitz AV,Freeze BS,Parker PRL,et al.Regulation of parkinsonian motor behaviours by optogenetic control of basal ganglia circuitry.Nature,2010,466622~626.
22 Anzalone A,Lizardi-Ortiz JE,Ramos M,et al.Dual control of dopamine synthesis and release by presynaptic and postsynaptic dopamine D2 receptors.J Neurosci,2012,329023~9034.
23 Lalchandani RR,van der Goes MS,Partridge JG,et al.Dopamine D2 receptors regulate collateral inhibition between striatal medium spiny neurons.J Neurosci,2013,3314075~14086.
24 Kravitz AV,Freeze BS,Parker PR,et al.Regulation of parkinsonian motor behaviours by optogenetic control of basal ganglia circuitry.Nature,2010,466622~666.
25 Bian WJ,Miao WY,He SJ,et al.Coordinated spine pruning and maturation mediated by inter-spine competition for cadherin/catenin complexes.Cell,2015,162808~822.
26 Toy WA,Petzinger GM,Leyshon BJ,et al.Treadmill exercise reverses dendritic spine loss in direct and indirect striatal medium spiny neurons in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP)mouse model of Parkinson's disease.Neurobiol Dis,2014,63201~209.
27 Taverna S,Ilijic E,Surmeier DJ.Recurrent collateral connections of striatal medium spiny neurons are disrupted in models of Parkinson's disease.J Neurosci,2008,285504~5512.
28 Li L,Sagot B,Zhou FM.Similar L-dopa-stimulated motor activity in mice with adult-onset 6-hydroxydopamine-induced symmetric dopamine denervation and in transcription factor Pitx3 null mice with perinatal-onset symmetric dopamine denervation.Brain Res,2015,161512~21.
29 Wei W,Li L,Yu G,et al.Supersensitive presynaptic dopamine D2 receptor inhibition of the striatopallidal projection in nigrostriatal dopamine-deficient mice.J Neurophysiol,2013,1102203~2216.
30 Wei W,Ding S,Zhou FM.Dopaminergic treatment weakens medium spiny neuron collateral inhibition in the parkinsonian striatum.J Neurophysiol,2017,117987~999.