3种苯并咪唑类药物对大熊猫西氏贝蛔虫的驱虫效果初步观察
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摘要
西氏贝蛔虫Baylisascaris schroederi是圈养大熊猫Ailuropoda melanoleuca最常见、危害最严重的一种体内寄生虫,采用药物驱虫是目前控制圈养大熊猫蛔虫病的主要措施。为了筛选有效的驱虫药物,本研究观察了3种苯并咪唑类药物(阿苯达唑片剂、芬苯达唑膏剂和甲苯咪唑片剂)对大熊猫蛔虫的驱虫效果,统计了驱虫前后粪检蛔虫卵转阴率及排虫情况。结果表明,除芬苯达唑按5 mg·kg~(-1)体质量口服,每天1次,连续服用2 d,效果较差外,3种药物按10 mg·kg~(-1)体质量口服,每天1次,连续服用2 d,用药安全且有较好的驱虫效果。
Baylisascaris schroederi is one of the most common and harmful endoparasites in captive giant pandas. Drug repellent is the main measure to control this ascariasis in captive giant pandas. In order to screen effective anthelmintic drugs, the anthelmintic effects of 3 benzimidazoles(albendazole tablets, fenbendazole ointment and mebendazole tablets) on B.schroederi were studied using egg negative rate and excretion rate. The results showed that the effectiveness of fenbendazole taken orally at 5 mg·kg~(-1) body mass once a day for 2 days was poor. However, the 3 drugs had good anthelmintic effect on B.schroederi when they were orally administered at 10 mg·kg~(-1) body mass once a day for 2 days.
Baylisascaris schroederi is one of the most common and harmful endoparasites in captive giant pandas. Drug repellent is the main measure to control this ascariasis in captive giant pandas. In order to screen effective anthelmintic drugs, the anthelmintic effects of 3 benzimidazoles(albendazole tablets, fenbendazole ointment and mebendazole tablets) on B.schroederi were studied using egg negative rate and excretion rate. The results showed that the effectiveness of fenbendazole taken orally at 5 mg·kg~(-1) body mass once a day for 2 days was poor. However, the 3 drugs had good anthelmintic effect on B.schroederi when they were orally administered at 10 mg·kg~(-1) body mass once a day for 2 days.
引文
曹授俊,常建宇,侯晓林.2005.大环内酯类驱虫药物的耐药性[J].中国兽医杂志,41(7):41-43.
冯文和,张安居.1991.大熊猫繁殖与疾病研究[M].成都:四川科学技术出版社:244-248.
赖从龙,邱贤猛,罗秀芬,等.1993.野生大熊猫内寄生虫病调查[J].中国兽医杂志,19(5):10-11.
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刘维忠,杨光成.1994.大熊猫西氏蛔虫病病例诊疗[J].河南畜牧兽医,15(4):48.
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杨光友.1998.大熊猫寄生虫与寄生虫病研究进展[J].中国兽医学报,18(2):206-208.
杨美兰,肖啸,杨继生,等.2008.芬苯哒唑对猪蛔虫移行期幼虫的效果观察[J].黑龙江畜牧兽医,2:79-80.
叶志勇,张安居.1981.驱除熊猫蛔虫用药规律的探讨[J].动物学杂志,3(2):46-47.
叶志勇.1989.50例野外大熊猫疾病及防治[J].中国兽医杂志,15(2):30-31.
张华,王小慧,范文安,等.2010.大熊猫寄生虫病综述[J].甘肃畜牧兽医,3:40-43.
张均利,蔡蓉根.1987.疳病痊驱除大熊猫蛔虫[J].中国兽医杂志,(8):30.
张锐.1991.大熊猫蛔虫病治疗一例[J].中国兽医科技,21(4):37.
钟志军,黄祥明,杨洋,等.2014.大熊猫布鲁氏菌病、弓形虫病以及心丝虫病的血清学调查研究[J].四川动物,33(6):836-839.
周忠勇,朱雪勇,陈玉秀.1997.芬苯达唑驱除野生动物寄生蠕虫试验[J].中国兽医寄生虫病,(2):33-34.
Li B,Zhao B,Yang GY,et al.2012.Mebendazole in the treatment of Hymenolepis nana infections in the captive ring-tailed lemur (Lemur catta),China[J].Parasitology Research,111(2):935-937.
Peng ZW,Zhang CS,Shen MY,et al.2017.Baylisascaris schroederi infection in giant pandas (Ailuropoda melanoleuca) in Foping National Nature Reserve,China[J].Journal of Wildlife Diseases,53(4):854-858.
Slocombe JOD,de Gannes RVG,Lake MC.2007.Macrocyclic lactone-resistant Parascaris equorum on stud farms in Canada and effectiveness of fenbendazole and pyrantel pamoate[J].Veterinary Parasitology,145(3-4):371-376.
Wang T,Xie Y,Zheng YL,et al.2018.Parasites of the giant panda:a risk factor in the conservation of a species[J].Advances in Parasitology,99:1-33.
冯文和,张安居.1991.大熊猫繁殖与疾病研究[M].成都:四川科学技术出版社:244-248.
赖从龙,邱贤猛,罗秀芬,等.1993.野生大熊猫内寄生虫病调查[J].中国兽医杂志,19(5):10-11.
李德生,何燕,邓林华,等.2015.伊维菌素和双羟萘酸噻嘧啶对圈养大熊猫西氏贝蛔虫驱除试验[J].畜牧与兽医,47(6):87-89.
李德生,何燕,吴虹林,等.2014.圈养大熊猫蠕虫病感染情况调查[J].经济动物学报,18(4):214-216.
刘维忠,杨光成.1994.大熊猫西氏蛔虫病病例诊疗[J].河南畜牧兽医,15(4):48.
孙四平,关新,兰忠诚,等.2008.阿苯哒唑和复方甲苯咪唑驱除蛔虫的最佳剂量初探[J].中国病原生物学杂志,3(9):698,716.
唐耀,陈小丽.2018.福州动物园圈养灵长类动物肠道寄生虫感染情况调查及其驱虫效果[J].野生动物学报,39(1):127-132.
杨光友.1998.大熊猫寄生虫与寄生虫病研究进展[J].中国兽医学报,18(2):206-208.
杨美兰,肖啸,杨继生,等.2008.芬苯哒唑对猪蛔虫移行期幼虫的效果观察[J].黑龙江畜牧兽医,2:79-80.
叶志勇,张安居.1981.驱除熊猫蛔虫用药规律的探讨[J].动物学杂志,3(2):46-47.
叶志勇.1989.50例野外大熊猫疾病及防治[J].中国兽医杂志,15(2):30-31.
张华,王小慧,范文安,等.2010.大熊猫寄生虫病综述[J].甘肃畜牧兽医,3:40-43.
张均利,蔡蓉根.1987.疳病痊驱除大熊猫蛔虫[J].中国兽医杂志,(8):30.
张锐.1991.大熊猫蛔虫病治疗一例[J].中国兽医科技,21(4):37.
钟志军,黄祥明,杨洋,等.2014.大熊猫布鲁氏菌病、弓形虫病以及心丝虫病的血清学调查研究[J].四川动物,33(6):836-839.
周忠勇,朱雪勇,陈玉秀.1997.芬苯达唑驱除野生动物寄生蠕虫试验[J].中国兽医寄生虫病,(2):33-34.
Li B,Zhao B,Yang GY,et al.2012.Mebendazole in the treatment of Hymenolepis nana infections in the captive ring-tailed lemur (Lemur catta),China[J].Parasitology Research,111(2):935-937.
Peng ZW,Zhang CS,Shen MY,et al.2017.Baylisascaris schroederi infection in giant pandas (Ailuropoda melanoleuca) in Foping National Nature Reserve,China[J].Journal of Wildlife Diseases,53(4):854-858.
Slocombe JOD,de Gannes RVG,Lake MC.2007.Macrocyclic lactone-resistant Parascaris equorum on stud farms in Canada and effectiveness of fenbendazole and pyrantel pamoate[J].Veterinary Parasitology,145(3-4):371-376.
Wang T,Xie Y,Zheng YL,et al.2018.Parasites of the giant panda:a risk factor in the conservation of a species[J].Advances in Parasitology,99:1-33.