磁性药物载体在抗肿瘤方面的研究进展
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摘要
通过外加磁场的引导作用,使负载抗癌药物的磁性载体靶向定位于靶区,提高靶组织的药物浓度,有效降低药物对正常组织或细胞的毒副作用及其他不良反应。磁性药物载体还具有靶向性、缓释、控释等优点,已成了肿瘤靶向治疗常用的新型载体系统。本文综述了磁性药物载体磁性纳米颗粒、磁性脂质体、磁性微球在肿瘤治疗与诊断中的应用进展。
The magnetic carrier carrying anticancer drugs is targeted to the target area by the action of external magnetic field,which increases the drug concentration of the target tissue and effectively reduces the toxic side effects.Magnetic drug carrier has the advantages of targeting,slow release and controlled release,and has become a new carrier system commonly used in tumor targeted therapy.This paper reviewed the application of magnetic drug carrier magnetic nanoparticles,magnetic liposomes and magnetic microspheres in the treatment and diagnosis of tumors.
The magnetic carrier carrying anticancer drugs is targeted to the target area by the action of external magnetic field,which increases the drug concentration of the target tissue and effectively reduces the toxic side effects.Magnetic drug carrier has the advantages of targeting,slow release and controlled release,and has become a new carrier system commonly used in tumor targeted therapy.This paper reviewed the application of magnetic drug carrier magnetic nanoparticles,magnetic liposomes and magnetic microspheres in the treatment and diagnosis of tumors.
引文
[1] WANG Z,DUAN Y,DUAN Y.Application of polydopamine in tumor targeted drug delivery system and its drug release behavior[J].J Control Release,2018(290):56-74.
[2] BAROUTI G,JAFFREDO C G,GUILLAUME S M.Advances in drug delivery systems based on synthetic poly(hydroxybutyrate) (co)polymers[J].Prog Polym Sci,2017(73):1-31.
[3] GAO H,WANG J Y,SHEN X Z,et al.Preparation of magnetic polybutylcyanoacrylate nanospheres encapsulated with aclacinomycin A and its effect on gastric tumor[J].World J Gastroenterol,2004,10(14):2010-2013.
[4] TONG L Q,ZHAO M,ZHU S,et al.Synthesis and application of superparamagnetic iron oxide nanoparticles in targeted therapy and imaging of cancer[J].Front Med,2011,5(4):379-387.
[5] 崔亚丽.磁性微粒——一种有效的靶向给药系统[J].西北药学杂志,2003,18(1):37-39.
[6] MENG J,AGRAHARI V,YOUM I.Advances in Targeted Drug Delivery Approaches for the Central Nervous System Tumors:The Inspiration of Nanobiotechnology[J].J Neuroimmune Pharmacol,2016,12(1):84-98.
[7] 孙蕊,朱琰,刘玉琴.肿瘤靶向治疗药物载体的研究进展[J].药学研究,2014,33(5):249-252.
[8] 杨继晨,田建飞,王芹,等.多巴胺仿生修饰超顺磁性纳米颗粒作为基因载体的可行性研究[J].德州学院学报,2018,34(4):25-29.
[9] AVEDIAN N,ZAAERI F,DARYASARI M P,et al.pH-sensitive biocompatible mesoporous magnetic nanoparticles labeled with folic acid as an efficient carrier for controlled anticancer drug delivery[J].J Drug Deliv Sci Tec,2018(44):323-332.
[10] 史巍,陆莹,龚锐.长循环pH敏感顺铂脂质体的制备和研究进展[J].中国组织工程研究,2018,22(26):4229-4234.
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[12] GARCI A A R,LACKO C,SNYDER C,et al.Processing-size correlations in the preparation of magnetic alginate microspheres through emulsification and ionic crosslinking[J].Colloids Surf A Physicochem Eng Asp,2017(529):119-127.
[13] 沈启慧,蔡汝文,刘岩.单分散磁性高分子微球的制备与表征[J].吉林化工学院学报,2018,35(7):79-81.
[14] LI H,SUN X,LI Y,et al.Preparation and properties of carbon nanotube (Fe)/hydroxyapatite composite as magnetic targeted drug delivery carrier[J].Mater Sci Eng C Mater Biol Appl,2019(97):222-229.
[15] ELBIALY N S,FATHY M M,AL-WAFI R,et al.Multifunctional magnetic-gold nanoparticles for efficient combined targeted drug delivery and interstitial photothermal therapy[J].Int J Pharm,2019(554):256-263.
[16] ZHU L,MA J,JIA N,et al.Chitosan-coated magnetic nanoparticles as carriers of 5-Fluorouracil :Preparation,characterization and cytotoxicity studies[J].Colloids Surf B Biointerfaces,2009,68(1):1-6.
[17] WANG G,ZHAO D,LI N,et al.Drug-loaded poly(ε-caprolactone)/Fe3O4 composite microspheres for magnetic resonance imaging and controlled drug delivery[J].J Magn Magn Mater,2018(456):316-323.
[18] WEINSTEIN J N,MAGIN R L,YATVIN M B,et al.Liposomes and local hyperthermia:selective delivery of methotrexate to heated tumors[J].Science,1979,204(4389):188-191.
[19] ZHANG D J,ZHANG J P,LV P,et al.Biotin-functionalized targeting anti-tumor complex based on β-cyclodextrinand methotrexate[J].J Drug Deliv Sci Tec,2019(49):152-161.
[20] LIU E G,ZHANG M,CUI H,et al.Tat-functionalized Ag-Fe3O4nano-composites as tissue-penetrating vehicles for tumor magnetic targeting and drug delivery[J].Acta Pharmaceutica Sinica B,2018,8(6):956-968.
[21] RAVAR F,SAADAT E,GHOLAMI M,et al.Hyaluronic acid-coated liposomes for targeted delivery of paclitaxel,in-vitro characterization and in-vivo evaluation[J].J Control Release,2016(229):10-22.
[22] LI Z,ZHANG J Y,LI X,et al.Preparation and Evaluation of Multifunctional Autofluorescent Magnetic Nanoparticlee Based Drug Delivery Systems Against Mammary Cancer[J].JPharm Sci,2018,107(10):2694-2701.
[23] NAPOLITANO S,BRANCACCIO G,ARGENZIANO G,et al.It is finally time for adjuvant therapy in melanoma[J].Cancer Treat Rev,2018(69):101-111.
[24] NIGAM S,BAHADUR D.Doxorubicin-loaded dendritic-Fe3O4 supramolecular nanoparticles for magnetic drug targeting and tumor regression in spheroid murine melanoma model[J].Nanomedicine:NBM,2018,14(3):759-768.
[25] CHEN Z,WU C,ZHANG Z F,et al.Synthesis,functionalization,and nanomedical applications of functional magnetic nanoparticles[J].Chinese Chem Lett,2018,29(11):1601-1608.
[26] HORST M F,CORAL D F,FERNANDEZ VAN RAAP M B,et al.Hybrid nanomaterials based on gum Arabic and magnetite for hyperthermia treatments[J].Mater Sci Eng C Mater Biol Appl,2017(74):443-450.
[27] OLIVEIRA R R,CARRI?O M S,PACHECO M T,et al.Triggered release of paclitaxel from magnetic solid lipid nanoparticles by magnetic hyperthermia[J].Mater Sci Eng C Mater Biol Appl,2018(92):547-553.
[28] QIAO R R,YANG C H,GAO M Y.Superparamagnetic iron oxide nanoparticles:from preparations to in vivo MRI applications[J].J Mater Chem,2009,19(35):6274-6293.
[29] TANAKA K,NARITA A,KITAMURA N,et al.Preparation for highly sensitive MRI contrast agents using core/shell type nanoparticles consisting of multiple SPIO cores with thin silica coating[J].Langmuir,2010,26(14):11759-11762.
[30] ATASHI Z,DIVBAND B,KESHTKAR A,et al.Synthesis of cytocompatible Fe3O4@ZSM-5 nanocomposite as magnetic resonance imaging contrast agent[J].J Magn Magn Mater,2017(438):46-51.
[31] LI J,WU C,HOU P,et al.One-pot preparation of hydrophilic manganese oxide nanoparticles as T1 nano-contrast agent for molecular magnetic resonance imaging of renal carcinoma in vitro and in vivo[J].Biosens Bioelectron,2018(102):1-8.
[32] LEE H Y,LI Z,CHEN K,et al.PET/MRI dual-modality tumor imaging using arginine-glycine-aspartic(RGD)-conjugated radiolabeled iron oxide nanoparticles[J].J Nucl Med,2008,49(8):1371-1379
[33] KANIA G,STERNAK M,JASZTAL A,et al.Uptake and bioreactivity of charged chitosan-coated superpara-magnetic nanoparticles as promising contrast agents for magnetic resonance imaging[J].Nanomedicine,2018,14(1):131-140.
[34] FARAJI S,DINI G,ZAHRAEI M.Polyethyleneglycol-coated manganese-ferrite nanoparticles as contrast agents for magnetic resonance imaging[J].J Magn Magn Mater,2019(475):137-145.
[35] ARSALANI S,GUIDELLI E J,SILVEIRA M A,et al.Magnetic Fe3O4 Nanoparticles Coated by Natural Rubber Latex as MRIContrast Agent[J].J Magn Magn Mater,2019(475):458-464.
[2] BAROUTI G,JAFFREDO C G,GUILLAUME S M.Advances in drug delivery systems based on synthetic poly(hydroxybutyrate) (co)polymers[J].Prog Polym Sci,2017(73):1-31.
[3] GAO H,WANG J Y,SHEN X Z,et al.Preparation of magnetic polybutylcyanoacrylate nanospheres encapsulated with aclacinomycin A and its effect on gastric tumor[J].World J Gastroenterol,2004,10(14):2010-2013.
[4] TONG L Q,ZHAO M,ZHU S,et al.Synthesis and application of superparamagnetic iron oxide nanoparticles in targeted therapy and imaging of cancer[J].Front Med,2011,5(4):379-387.
[5] 崔亚丽.磁性微粒——一种有效的靶向给药系统[J].西北药学杂志,2003,18(1):37-39.
[6] MENG J,AGRAHARI V,YOUM I.Advances in Targeted Drug Delivery Approaches for the Central Nervous System Tumors:The Inspiration of Nanobiotechnology[J].J Neuroimmune Pharmacol,2016,12(1):84-98.
[7] 孙蕊,朱琰,刘玉琴.肿瘤靶向治疗药物载体的研究进展[J].药学研究,2014,33(5):249-252.
[8] 杨继晨,田建飞,王芹,等.多巴胺仿生修饰超顺磁性纳米颗粒作为基因载体的可行性研究[J].德州学院学报,2018,34(4):25-29.
[9] AVEDIAN N,ZAAERI F,DARYASARI M P,et al.pH-sensitive biocompatible mesoporous magnetic nanoparticles labeled with folic acid as an efficient carrier for controlled anticancer drug delivery[J].J Drug Deliv Sci Tec,2018(44):323-332.
[10] 史巍,陆莹,龚锐.长循环pH敏感顺铂脂质体的制备和研究进展[J].中国组织工程研究,2018,22(26):4229-4234.
[11] 伍旭明,许亚萍.苦参碱磁性脂质体的制备和表征的实验研究[J].中国中医药科技,2017,24(1):41-43.
[12] GARCI A A R,LACKO C,SNYDER C,et al.Processing-size correlations in the preparation of magnetic alginate microspheres through emulsification and ionic crosslinking[J].Colloids Surf A Physicochem Eng Asp,2017(529):119-127.
[13] 沈启慧,蔡汝文,刘岩.单分散磁性高分子微球的制备与表征[J].吉林化工学院学报,2018,35(7):79-81.
[14] LI H,SUN X,LI Y,et al.Preparation and properties of carbon nanotube (Fe)/hydroxyapatite composite as magnetic targeted drug delivery carrier[J].Mater Sci Eng C Mater Biol Appl,2019(97):222-229.
[15] ELBIALY N S,FATHY M M,AL-WAFI R,et al.Multifunctional magnetic-gold nanoparticles for efficient combined targeted drug delivery and interstitial photothermal therapy[J].Int J Pharm,2019(554):256-263.
[16] ZHU L,MA J,JIA N,et al.Chitosan-coated magnetic nanoparticles as carriers of 5-Fluorouracil :Preparation,characterization and cytotoxicity studies[J].Colloids Surf B Biointerfaces,2009,68(1):1-6.
[17] WANG G,ZHAO D,LI N,et al.Drug-loaded poly(ε-caprolactone)/Fe3O4 composite microspheres for magnetic resonance imaging and controlled drug delivery[J].J Magn Magn Mater,2018(456):316-323.
[18] WEINSTEIN J N,MAGIN R L,YATVIN M B,et al.Liposomes and local hyperthermia:selective delivery of methotrexate to heated tumors[J].Science,1979,204(4389):188-191.
[19] ZHANG D J,ZHANG J P,LV P,et al.Biotin-functionalized targeting anti-tumor complex based on β-cyclodextrinand methotrexate[J].J Drug Deliv Sci Tec,2019(49):152-161.
[20] LIU E G,ZHANG M,CUI H,et al.Tat-functionalized Ag-Fe3O4nano-composites as tissue-penetrating vehicles for tumor magnetic targeting and drug delivery[J].Acta Pharmaceutica Sinica B,2018,8(6):956-968.
[21] RAVAR F,SAADAT E,GHOLAMI M,et al.Hyaluronic acid-coated liposomes for targeted delivery of paclitaxel,in-vitro characterization and in-vivo evaluation[J].J Control Release,2016(229):10-22.
[22] LI Z,ZHANG J Y,LI X,et al.Preparation and Evaluation of Multifunctional Autofluorescent Magnetic Nanoparticlee Based Drug Delivery Systems Against Mammary Cancer[J].JPharm Sci,2018,107(10):2694-2701.
[23] NAPOLITANO S,BRANCACCIO G,ARGENZIANO G,et al.It is finally time for adjuvant therapy in melanoma[J].Cancer Treat Rev,2018(69):101-111.
[24] NIGAM S,BAHADUR D.Doxorubicin-loaded dendritic-Fe3O4 supramolecular nanoparticles for magnetic drug targeting and tumor regression in spheroid murine melanoma model[J].Nanomedicine:NBM,2018,14(3):759-768.
[25] CHEN Z,WU C,ZHANG Z F,et al.Synthesis,functionalization,and nanomedical applications of functional magnetic nanoparticles[J].Chinese Chem Lett,2018,29(11):1601-1608.
[26] HORST M F,CORAL D F,FERNANDEZ VAN RAAP M B,et al.Hybrid nanomaterials based on gum Arabic and magnetite for hyperthermia treatments[J].Mater Sci Eng C Mater Biol Appl,2017(74):443-450.
[27] OLIVEIRA R R,CARRI?O M S,PACHECO M T,et al.Triggered release of paclitaxel from magnetic solid lipid nanoparticles by magnetic hyperthermia[J].Mater Sci Eng C Mater Biol Appl,2018(92):547-553.
[28] QIAO R R,YANG C H,GAO M Y.Superparamagnetic iron oxide nanoparticles:from preparations to in vivo MRI applications[J].J Mater Chem,2009,19(35):6274-6293.
[29] TANAKA K,NARITA A,KITAMURA N,et al.Preparation for highly sensitive MRI contrast agents using core/shell type nanoparticles consisting of multiple SPIO cores with thin silica coating[J].Langmuir,2010,26(14):11759-11762.
[30] ATASHI Z,DIVBAND B,KESHTKAR A,et al.Synthesis of cytocompatible Fe3O4@ZSM-5 nanocomposite as magnetic resonance imaging contrast agent[J].J Magn Magn Mater,2017(438):46-51.
[31] LI J,WU C,HOU P,et al.One-pot preparation of hydrophilic manganese oxide nanoparticles as T1 nano-contrast agent for molecular magnetic resonance imaging of renal carcinoma in vitro and in vivo[J].Biosens Bioelectron,2018(102):1-8.
[32] LEE H Y,LI Z,CHEN K,et al.PET/MRI dual-modality tumor imaging using arginine-glycine-aspartic(RGD)-conjugated radiolabeled iron oxide nanoparticles[J].J Nucl Med,2008,49(8):1371-1379
[33] KANIA G,STERNAK M,JASZTAL A,et al.Uptake and bioreactivity of charged chitosan-coated superpara-magnetic nanoparticles as promising contrast agents for magnetic resonance imaging[J].Nanomedicine,2018,14(1):131-140.
[34] FARAJI S,DINI G,ZAHRAEI M.Polyethyleneglycol-coated manganese-ferrite nanoparticles as contrast agents for magnetic resonance imaging[J].J Magn Magn Mater,2019(475):137-145.
[35] ARSALANI S,GUIDELLI E J,SILVEIRA M A,et al.Magnetic Fe3O4 Nanoparticles Coated by Natural Rubber Latex as MRIContrast Agent[J].J Magn Magn Mater,2019(475):458-464.