基于中医整体系统平衡理论分析缺血性中风后病理层级损伤的演变
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摘要
文章以中医整体系统动态平衡分析模型为基础,以缺血性中风后病理损伤层级的演变为对象,分别对脑系统层级和细胞层级中的星形胶质细胞系统状态及转化,给出了缺血性中风脑系统状态表示、脑系统状态转化的描述。对脑系统结构逻辑划分和系统状态转化过程的描述,有利于对脑系统状态进行分析和诊疗;可用于脑系统结构状态的知识表达、数据存储和操作,可用来更好地阐明脑组织功能及其交互作用,为理解和分析脑系统的整合调节效应机制积累相关研究的大数据,为人工智能分析、建立智能专家系统创造条件。
Based on the dynamic balance analysis model of traditional Chinese medicine system, the evolution of pathological stage of ischemic stroke was analyzed in this paper. The status and the transformation of the astrocyte system in the brain system and the cell hierarchy were presented in the perspective of the ischemic mesencephalic system and the transformation of the brain system. The description of the logical division of brain system structure and the process of system state transformation is conducive to the analysis and diagnosis of the state of the brain system. Moreover, it can be used for the knowledge expression, data storage and operation of the state of the brain system, and can be used to better clarify the brain function and its interaction. It can accumulate large data related to the study in order to understand and analyze the mechanism of the integration of the brain system, and create the conditions for artificial intelligence analysis and the establishment of intelligent expert system.
Based on the dynamic balance analysis model of traditional Chinese medicine system, the evolution of pathological stage of ischemic stroke was analyzed in this paper. The status and the transformation of the astrocyte system in the brain system and the cell hierarchy were presented in the perspective of the ischemic mesencephalic system and the transformation of the brain system. The description of the logical division of brain system structure and the process of system state transformation is conducive to the analysis and diagnosis of the state of the brain system. Moreover, it can be used for the knowledge expression, data storage and operation of the state of the brain system, and can be used to better clarify the brain function and its interaction. It can accumulate large data related to the study in order to understand and analyze the mechanism of the integration of the brain system, and create the conditions for artificial intelligence analysis and the establishment of intelligent expert system.
引文
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[13]王琳,许能贵.针刺对脑缺血后大脑可塑性促进作用的研究进展.中华中医药杂志,2014,29(8):2548-2550
[2]邱鸿钟.中医理论的系统结构主义观.中华中医药杂志,2014,29(4):1010-1012
[3]李生强,谢冰颖.中医健康状态辨识与系统科学.中华中医药杂志,2015,30(9):3137-3139
[4]白永生.Fibulin-5对大鼠缺血再灌注脑损伤后脑水肿和轴突再生的影响及机制研究.重庆:重庆医科大学,2014:19-26
[5]Noda K,Dabovic B,Takagi K,et al.Latent TGF-βbinding protein 4 promotes elastic fiber assembly by interacting with fibulin-5.Proceedings of the National Academy of Sciences,2013,110(8):2852-2857
[6]Jens P M,Christian G,Jemal T,et al.A latent neurogenic program in astrocytes regulated by Notch signaling in the mouse.Science,2014,346(6206):237-241
[7]石巧娟.半胱氨酰白三烯受体-2选择性拮抗剂HAMI3379对脑缺血损伤的作用.杭州:浙江大学,2015:1-10
[8]张翔南,陈忠.缺血性脑损伤中的自噬——研究进展与挑战.中国科学:生命科学,2014,44(4):379-386
[9]Kitagawa K,Matsumoto M,Kuwabara K,et al.Protective effect of apolipoprotein E against ischemic neuronal injury is mediated through antioxidant action.J Neurosci Res,2002,68(2):226-232
[10]武明明,孙晓川,吴海涛,等.载脂蛋白E基因多态性与星形胶质细胞损伤后兴奋性氨基酸变化的关系.第三军医大学学报,2011,33(9):928-931
[11]Matute C,Domercq M,Sanchez-Gomez M V.Glutamatemediated glial injury:mechanisms and clinical importance.Glia,2006,53(2):212-224
[12]Yin C,Zhou S,Jiang L,et al.Mechanical injured neurons stimulate astrocytes to express apolipoprotein E through ERK pathway.Neurosci Lett,2012,515(1):77-81
[13]王琳,许能贵.针刺对脑缺血后大脑可塑性促进作用的研究进展.中华中医药杂志,2014,29(8):2548-2550