IgG、IgM表达在不稳定心绞痛诊断中的价值及临床意义分析
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摘要
目的探讨血IgG、IgM表达对不稳定心绞痛的诊断价值,及其与肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)、组织型纤溶酶原激活物(t PA)、组织型纤溶酶原激活物抑制物-1(PAI-1)水平的相关性。方法选取2016年2月~2017年4月于山东省莱芜市人民医院心内科接受治疗的不稳定心绞痛患者80例为研究对象,同时选取同期在我院接受体检的80名健康成年人作为对照。观察两组IgG、IgM阳性表达情况,比较两组血清TNF-α、CRP、t PA、PAI-1和心功能指标的差异,分析不稳定心绞痛患者IgG、IgM表达与TNF-α、CRP、t PA、PAI-1和心功能指标的相关性。结果不稳定心绞痛组患者的IgG阳性表达率高于对照组,两组的IgM阳性表达率无差别;不稳定心绞痛组患者血清TNF-α、CRP、PAI-1水平高于对照组,两组的t PA水平无明显差别;不稳定心绞痛组患者的左心房内径(LAD)、右心房内径(RAD)和脑钠肽(BNP)水平高于对照组,LVEF水平低于对照组;不稳定心绞痛组患者的IgG阳性表达率与TNF-α、CRP、PAI-1、LAD、RAD和BNP水平正相关,与LVEF水平负相关;而IgM阳性表达率与TNF-α、CRP、t PA、PAI-1和心功能指标等无明显相关关系。结论不稳定心绞痛患者的IgG阳性表达较高,且与TNF-α、CRP、PAI-1水平密切相关。
Objective To investigate the value of Ig G and Ig M in the diagnosis of unstable angina pectoris and its correlation with the levels of TNF-α, CRP, t PA and PAI-1. Methods The patients with unstable angina pectoris treated from February 2016 to April 2017 were selected as the subjects, and the healthy adults who underwent physical examination were selected as the control group. To observe the expression of two groups of Ig G and Ig M, the difference between the two groups of serum TNF-α, CRP, t PA, PAI-1 and heart function index, correlation analysis in patients with unstable angina Ig G, the expression of Ig M and TNF-α, CRP, t PA, alpha PAI-1 and cardiac function index. Results The positive rate of Ig G in the unstable angina pectoris group was higher than that in the control group, and there is no difference of the positive rate of Ig M between the two groups. The serum levels of TNF-α, CRP and PAI-1 in the patients with unstable angina pectoris were higher than those in the control group, and there was no significant difference in the levels of t PA between the two groups. The levels of LAD, RAD and BNP in the patients with unstable angina pectoris were higher than those in the control group, and the level of LVEF was lower than that of the control group. Unstable angina in patients with Ig G positive expression rate of TNF-α and CRP, PAI-1, alpha, LAD, RAD and BNP correlated inversely related to LVEF levels, while the positive expression rate of Ig M and TNF-α, CRP, t PA, alpha PAI-1 and heart function index has no significant correlation. Conclusion The positive expression of Ig G in patients with unstable angina pectoris is higher, and is closely related to the levels of TNF-α, CRP and PAI-1.
Objective To investigate the value of Ig G and Ig M in the diagnosis of unstable angina pectoris and its correlation with the levels of TNF-α, CRP, t PA and PAI-1. Methods The patients with unstable angina pectoris treated from February 2016 to April 2017 were selected as the subjects, and the healthy adults who underwent physical examination were selected as the control group. To observe the expression of two groups of Ig G and Ig M, the difference between the two groups of serum TNF-α, CRP, t PA, PAI-1 and heart function index, correlation analysis in patients with unstable angina Ig G, the expression of Ig M and TNF-α, CRP, t PA, alpha PAI-1 and cardiac function index. Results The positive rate of Ig G in the unstable angina pectoris group was higher than that in the control group, and there is no difference of the positive rate of Ig M between the two groups. The serum levels of TNF-α, CRP and PAI-1 in the patients with unstable angina pectoris were higher than those in the control group, and there was no significant difference in the levels of t PA between the two groups. The levels of LAD, RAD and BNP in the patients with unstable angina pectoris were higher than those in the control group, and the level of LVEF was lower than that of the control group. Unstable angina in patients with Ig G positive expression rate of TNF-α and CRP, PAI-1, alpha, LAD, RAD and BNP correlated inversely related to LVEF levels, while the positive expression rate of Ig M and TNF-α, CRP, t PA, alpha PAI-1 and heart function index has no significant correlation. Conclusion The positive expression of Ig G in patients with unstable angina pectoris is higher, and is closely related to the levels of TNF-α, CRP and PAI-1.
引文
[1]刘云宝,侯晋,李馨.抗血小板治疗药物氯吡格雷对不稳定型心绞痛患者炎症因子hs-CRP及sl CAM-1的影响[J].中西医结合心血管病杂志,2015,13(7):921-2.
[2]Murray LG,Colombo J.Ranolazine Therapy reduces non-ST-segment elevation myocardial infarction and unstable angina in coronary disease patients with angina[J].Int J Angiol,2016,25(3):159-64.
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[6]苏伟,龚少愚,高枫,等.莲子心对不稳定心绞痛患者生活质量及基质金属蛋白酶-9和基质金属蛋白酶抑制因子-1m RNA表达水平的影响[J].中华中医药杂志,2014,29(8):2640-4.
[7]Du FM,Yong CW,Ping J,et al.N-Terminal pro-B-type natriuretic peptide levels inversely correlated with heart rate variability in patients with unstable angina pectoris[J].Int Heart J,2016,57(3):292-8.
[8]刘波,程波,朱磊,等.不稳定心绞痛患者肺炎衣原体抗体Ig G和Ig M表达状况及感染相关性分析[J].中华医院感染学杂志,2017,27(6):1244-6.
[9]邓艳云.冠心病患者血清中抗肺炎衣原体抗体、细胞间黏附分子-1及C反应蛋白的水平及其临床意义探讨[J].中国医药导刊,2015,17(10):987-8.
[10]刘红,赵敏,刘一宁,等.肺炎衣原体感染和老年急性脑梗死患者血脂及C反应蛋白的关系研究[J].中华临床医师杂志(电子版),2015,9(5):740-3.
[11]周敏,胥学伟,杨兰菊,等.肺炎衣原体感染对老年冠心病患者疾病进展影响的研究[J].中华医院感染学杂志,2014,24(23):5794-6.
[12]程琳,王利宏,夏淑东,等.肺炎衣原体感染与不稳定心绞痛的关系研究[J].中华医院感染学杂志,2015,25(20):4639-41.
[13]Tok D,Turak O,Yayla C,et al.Monocyte to HDL ratio in prediction of BMS restenosis in subjects with stable and unstable angina pectoris[J].Biomark Med,2016,10(8):853-60.
[14]赵春明,赵岩峰,崔诗涵.2880例血清肺炎衣原体抗体Ig M分析[J].中国医学工程,2014,22(2):87.
[15]滕贤麟,翁巍,戚建锋.肺炎衣原体感染与老年冠心病的相关性研究[J].全科医学临床与教育,2015,13(3):278-9.本文编辑:李丹花,田国祥
[2]Murray LG,Colombo J.Ranolazine Therapy reduces non-ST-segment elevation myocardial infarction and unstable angina in coronary disease patients with angina[J].Int J Angiol,2016,25(3):159-64.
[3]宋丽薇,沈小梅.非杓型高血压患者尿酸、超敏C反应蛋白与动态动脉硬化指数的关系[J].解放军医学院学报,2015,36(2):112-4,154.
[4]刘冬梅,谢艳凤,马丽,等.中青年高血压合并不稳定心绞痛患者动态脉压、脉压指数与MMP-9、Hs-CRP的相关性[J].长春中医药大学学报,2016,32(3):607-9.
[5]韩全乐,刘晓堃,张琦,等.原发性高血压患者动态动脉僵硬度指数、动态脉压指数与hs-CRP、MMP-9的相关性[J].中国老年学杂志,2014,34(13):3577-9.
[6]苏伟,龚少愚,高枫,等.莲子心对不稳定心绞痛患者生活质量及基质金属蛋白酶-9和基质金属蛋白酶抑制因子-1m RNA表达水平的影响[J].中华中医药杂志,2014,29(8):2640-4.
[7]Du FM,Yong CW,Ping J,et al.N-Terminal pro-B-type natriuretic peptide levels inversely correlated with heart rate variability in patients with unstable angina pectoris[J].Int Heart J,2016,57(3):292-8.
[8]刘波,程波,朱磊,等.不稳定心绞痛患者肺炎衣原体抗体Ig G和Ig M表达状况及感染相关性分析[J].中华医院感染学杂志,2017,27(6):1244-6.
[9]邓艳云.冠心病患者血清中抗肺炎衣原体抗体、细胞间黏附分子-1及C反应蛋白的水平及其临床意义探讨[J].中国医药导刊,2015,17(10):987-8.
[10]刘红,赵敏,刘一宁,等.肺炎衣原体感染和老年急性脑梗死患者血脂及C反应蛋白的关系研究[J].中华临床医师杂志(电子版),2015,9(5):740-3.
[11]周敏,胥学伟,杨兰菊,等.肺炎衣原体感染对老年冠心病患者疾病进展影响的研究[J].中华医院感染学杂志,2014,24(23):5794-6.
[12]程琳,王利宏,夏淑东,等.肺炎衣原体感染与不稳定心绞痛的关系研究[J].中华医院感染学杂志,2015,25(20):4639-41.
[13]Tok D,Turak O,Yayla C,et al.Monocyte to HDL ratio in prediction of BMS restenosis in subjects with stable and unstable angina pectoris[J].Biomark Med,2016,10(8):853-60.
[14]赵春明,赵岩峰,崔诗涵.2880例血清肺炎衣原体抗体Ig M分析[J].中国医学工程,2014,22(2):87.
[15]滕贤麟,翁巍,戚建锋.肺炎衣原体感染与老年冠心病的相关性研究[J].全科医学临床与教育,2015,13(3):278-9.本文编辑:李丹花,田国祥