心脏交感神经功能检测方法的评价
摘要
心脏神经系统对心脏电、生理活动具有重要的调节作用,心脏神经系统功能异常与心律失常、心肌梗死等心血管疾病密切相关。心脏交感神经是心脏自主神经系统的重要组成部分,交感神经功能测定对于研究心血管病发病机制、指导相关心脏疾病治疗具有重要意义。本文从心率变异性、心脏交感神经成像、免疫组织化学神经纤维染色、心脏局部血浆去甲肾上腺素含量测定、QT间期及复极离散度等方面介绍目前心脏交感神经功能评价的常用方法。
引文
[1]Parati G,Esler M.The human sympathetic nervous system:its relevance in hypertension and heart failure.Eur Heart J,2012,33:1058-1066.
[2]Hazari MA,Khan RT,Reddy BR,et al.Cardiovascular autonomic dysfunction in type 2 diabetes mellitus and essential hypertension in a South Indian population.Neurosciences(Riyadh),2012,17:173-175.
[3]Vaseghi M,Shivkumar K.The role of the autonomic nervous system in sudden cardiac death.Prog Cardiovasc Dis,2008,50:404-419.
[4]Palma JA,Benarroch EE.Neural control of the heart recent concepts and clinical correlations.Neurology,2014,83:261-271.
[5]Chen PS,Chen LS,Fishbein MC,et al.Role of the autonomic nervous system in atrial fibrillation pathophysiology and therapy.Circ Res,2014,114:1500-1515.
[6]Janse MJ,Schwartz PJ,Wilms-Schopman F,et al.Effects of unilateral stellate ganglion stimulation and ablation on electrophysiologic changes induced by acute myocardial ischemia in dogs.Circulation,1985,72:585-595.
[7]Brandys JC,Hopkins DA,Armour JA.Cardiac responses to stimulation of discrete loci within canine sympathetic ganglia following hexamethonium.J Auton Nerv Syst,1984,11:243-255.
[8]Cardinal R,Scherlag BJ,Vermeulen M,et al.Distinct activation patterns of idioventricular rhythms and sympathetically induced ventricular tachycardias in dogs with atrioventricular block.Pacing Clin Electrophysiol,1992,15:1300-1316.
[9]Kiviniemi AM,Hautala AJ,M?kikallio TH,et al.Cardiac vagal outflow after aerobic training by analysis of high-frequency oscillation of the R-R interval.Eur J Appl Physiol,2006,96:686-692.
[10]Nieminen T,K?h?nen M,K??bi T,et al.Heart rate variability is dependent on the level of heart rate.Am Heart J,2007,154:e13.
[11]Chen J,Yang SB,Liu J,et al.Diagnostic performance analysis for diabetic cardiovascular autonomic neuropathy based on short-term heart rate variability using bayesian methods:preliminary analysis.Diabetol Metab Syndr,2015,7:74.
[12]Ieda M,Kanazawa H,Ieda Y,et al.Nerve growth factor is critical for cardiac sensory innervation and rescues neuropathy in diabetic hearts.Circulation,2006,114:2351-2363.
[13]Wong KK,Raffel DM,Koeppe RA,et al.Pattern of cardiac sympathetic denervation in idiopathic parkinson disease studied with11C hydroxyephedrine PET.Radiology,2012,265:240-247.
[14]杨团峰,王丽,程敏,等.帕金森病,多系统萎缩和特发性震颤患者(131)碘-间碘苄胍心肌显像研究.中风与神经疾病杂志,2016,33:215-218.
[15]Garcia-González P,Fabregat-Andrésó,Cozar-Santiago P,et al.Cardiac sympathetic innervation assessed with(123)I-MIBG retains prognostic utility in diabetic patients with severe left ventricular dysfunction evaluated for primary prevention implantable cardioverterdefibrillator.Rev Esp Med Nucl Imagen Mol,2016,35:74-80.
[16]Freeman K,Tao W,Sun H,et al.In situ three-dimensional reconstruction of mouse heart sympathetic innervation by two-photon excitation fluorescence imaging.J Neurosci Methods,2014,221:48-61.
[17]靳文英,乔正国,郑春华,等.阿霉素诱导的心力衰竭小鼠心脏去甲肾上腺素转运蛋白的表达变化.中国循环杂志,2013,28:458-462.
[18]吴晓羽,张京慧,谷宏越,等.心室流出道室性心动过速模型的构建.中国心脏起搏与电生理杂志,2010,24:527-529.
[19]Xuan YL,Wang Y,Xue M,et al.In rats the duration of diabetes influences its impact on cardiac autonomic innervations and electrophysiology.Auton Neurosci,2015,189:31-36.
[20]薛梅.糖尿病自主神经病变对心脏电生理的影响及其干预研究.山东大学,2013.
[21]李世军,付治卿,郭园园,等.高血压心肌肥厚患者心脏交感神经分布与勿动蛋白A表达变化的关系.中华老年心脑血管病杂志,2012,14:162-165.
[22]Brunner-La Rocca HP,Esler MD,Jennings GL,et al.Effect of cardiac sympathetic nervous activity on mode of death in congestive heart failure.Eur Heart J,2001,22:1136-1143.
[23]Fukumoto T,Tawa M,Kitada K,et al.Different effects of AT1 receptor antagonist and ET(A)receptor antagonist on ischemia-induced norepinephrine release in rat hearts.J Cardiovasc Pharmacol,2012,60:55-60.
[24]Boehm S,Kubista H.Fine tuning of sympathetic transmitter release via ionotropic and metabotropic presynaptic receptors.Pharmacol Rev,2002,54:43-99.
[25]Rubart M,Zipes DP.Mechanisms of sudden cardiac death.J Clin Invest,2005,115:2305-2315.
[26]Liu YB,Wu CC,Lu LS,et al.Sympathetic nerve sprouting,electrical remodeling,and increased vulnerability to ventricular fibrillation in hypercholesterolemic rabbits.Circ Res,2003,92:1145-1152.
[27]Baumert M,Schlaich MP,Nalivaiko E,et al.relation between QTinterval variability and cardiac sympathetic activity in hypertension.Am J Physiol Heart Circ Physiol,2011,300:H1412-H1417.
[28]Palma JA,Benarroch EE.Neural control of the heart Recent concepts and clinical correlations.Neurology,2014,83:261-271.
[29]Jiang H,Lu Z,Yu Y,et al.Relationship between sympathetic nerve sprouting and repolarization dispersion at peri-infarct zone after myocardial infarction.Auton Neurosci,2007,134:18-25.
[30]周惠云,兰曦,梁一鸣.交感神经对急性心肌梗塞后QT间期离散度的影响.中国循环杂志,2001,16:147-149.
[31]Ramchandra R,Hood SG,Frithiof R,et al.Discharge properties of cardiac and renal sympathetic nerves and their impaired responses to changes in blood volume in heart failure.Am J Physiol Regul Integr Comp Physio,2009,297:R665-R674.
[2]Hazari MA,Khan RT,Reddy BR,et al.Cardiovascular autonomic dysfunction in type 2 diabetes mellitus and essential hypertension in a South Indian population.Neurosciences(Riyadh),2012,17:173-175.
[3]Vaseghi M,Shivkumar K.The role of the autonomic nervous system in sudden cardiac death.Prog Cardiovasc Dis,2008,50:404-419.
[4]Palma JA,Benarroch EE.Neural control of the heart recent concepts and clinical correlations.Neurology,2014,83:261-271.
[5]Chen PS,Chen LS,Fishbein MC,et al.Role of the autonomic nervous system in atrial fibrillation pathophysiology and therapy.Circ Res,2014,114:1500-1515.
[6]Janse MJ,Schwartz PJ,Wilms-Schopman F,et al.Effects of unilateral stellate ganglion stimulation and ablation on electrophysiologic changes induced by acute myocardial ischemia in dogs.Circulation,1985,72:585-595.
[7]Brandys JC,Hopkins DA,Armour JA.Cardiac responses to stimulation of discrete loci within canine sympathetic ganglia following hexamethonium.J Auton Nerv Syst,1984,11:243-255.
[8]Cardinal R,Scherlag BJ,Vermeulen M,et al.Distinct activation patterns of idioventricular rhythms and sympathetically induced ventricular tachycardias in dogs with atrioventricular block.Pacing Clin Electrophysiol,1992,15:1300-1316.
[9]Kiviniemi AM,Hautala AJ,M?kikallio TH,et al.Cardiac vagal outflow after aerobic training by analysis of high-frequency oscillation of the R-R interval.Eur J Appl Physiol,2006,96:686-692.
[10]Nieminen T,K?h?nen M,K??bi T,et al.Heart rate variability is dependent on the level of heart rate.Am Heart J,2007,154:e13.
[11]Chen J,Yang SB,Liu J,et al.Diagnostic performance analysis for diabetic cardiovascular autonomic neuropathy based on short-term heart rate variability using bayesian methods:preliminary analysis.Diabetol Metab Syndr,2015,7:74.
[12]Ieda M,Kanazawa H,Ieda Y,et al.Nerve growth factor is critical for cardiac sensory innervation and rescues neuropathy in diabetic hearts.Circulation,2006,114:2351-2363.
[13]Wong KK,Raffel DM,Koeppe RA,et al.Pattern of cardiac sympathetic denervation in idiopathic parkinson disease studied with11C hydroxyephedrine PET.Radiology,2012,265:240-247.
[14]杨团峰,王丽,程敏,等.帕金森病,多系统萎缩和特发性震颤患者(131)碘-间碘苄胍心肌显像研究.中风与神经疾病杂志,2016,33:215-218.
[15]Garcia-González P,Fabregat-Andrésó,Cozar-Santiago P,et al.Cardiac sympathetic innervation assessed with(123)I-MIBG retains prognostic utility in diabetic patients with severe left ventricular dysfunction evaluated for primary prevention implantable cardioverterdefibrillator.Rev Esp Med Nucl Imagen Mol,2016,35:74-80.
[16]Freeman K,Tao W,Sun H,et al.In situ three-dimensional reconstruction of mouse heart sympathetic innervation by two-photon excitation fluorescence imaging.J Neurosci Methods,2014,221:48-61.
[17]靳文英,乔正国,郑春华,等.阿霉素诱导的心力衰竭小鼠心脏去甲肾上腺素转运蛋白的表达变化.中国循环杂志,2013,28:458-462.
[18]吴晓羽,张京慧,谷宏越,等.心室流出道室性心动过速模型的构建.中国心脏起搏与电生理杂志,2010,24:527-529.
[19]Xuan YL,Wang Y,Xue M,et al.In rats the duration of diabetes influences its impact on cardiac autonomic innervations and electrophysiology.Auton Neurosci,2015,189:31-36.
[20]薛梅.糖尿病自主神经病变对心脏电生理的影响及其干预研究.山东大学,2013.
[21]李世军,付治卿,郭园园,等.高血压心肌肥厚患者心脏交感神经分布与勿动蛋白A表达变化的关系.中华老年心脑血管病杂志,2012,14:162-165.
[22]Brunner-La Rocca HP,Esler MD,Jennings GL,et al.Effect of cardiac sympathetic nervous activity on mode of death in congestive heart failure.Eur Heart J,2001,22:1136-1143.
[23]Fukumoto T,Tawa M,Kitada K,et al.Different effects of AT1 receptor antagonist and ET(A)receptor antagonist on ischemia-induced norepinephrine release in rat hearts.J Cardiovasc Pharmacol,2012,60:55-60.
[24]Boehm S,Kubista H.Fine tuning of sympathetic transmitter release via ionotropic and metabotropic presynaptic receptors.Pharmacol Rev,2002,54:43-99.
[25]Rubart M,Zipes DP.Mechanisms of sudden cardiac death.J Clin Invest,2005,115:2305-2315.
[26]Liu YB,Wu CC,Lu LS,et al.Sympathetic nerve sprouting,electrical remodeling,and increased vulnerability to ventricular fibrillation in hypercholesterolemic rabbits.Circ Res,2003,92:1145-1152.
[27]Baumert M,Schlaich MP,Nalivaiko E,et al.relation between QTinterval variability and cardiac sympathetic activity in hypertension.Am J Physiol Heart Circ Physiol,2011,300:H1412-H1417.
[28]Palma JA,Benarroch EE.Neural control of the heart Recent concepts and clinical correlations.Neurology,2014,83:261-271.
[29]Jiang H,Lu Z,Yu Y,et al.Relationship between sympathetic nerve sprouting and repolarization dispersion at peri-infarct zone after myocardial infarction.Auton Neurosci,2007,134:18-25.
[30]周惠云,兰曦,梁一鸣.交感神经对急性心肌梗塞后QT间期离散度的影响.中国循环杂志,2001,16:147-149.
[31]Ramchandra R,Hood SG,Frithiof R,et al.Discharge properties of cardiac and renal sympathetic nerves and their impaired responses to changes in blood volume in heart failure.Am J Physiol Regul Integr Comp Physio,2009,297:R665-R674.