中药巴戟天对动物骨骼生长影响的研究进展
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摘要
骨骼的生长发育对动物非常重要,其正常的生长主要通过成骨细胞的骨形成和破骨细胞的骨吸收来共同维持骨的动态平衡。巴戟天作为一种中药,不仅在抗衰老、增强免疫方面作用显著,而且在补肾壮阳、强筋健骨方面尤为突出。就巴戟天通过细胞水平和动物水平如何影响骨骼的生长发育进行综述,旨在为中药巴戟天作为一种口服添加制剂在改善动物骨骼生长上的应用提供理论依据。
Bone growth and development is very important for animals. Its normal growth mainly maintains the dynamic balance of bone through the bone formation of osteoblasts and bone resorption of osteoclasts. Morinda officinalis, as a kind of traditional Chinese medicine, not only plays an important role in anti-aging and immunity enhancing, but also is particularly prominent in tonifying kidney and strengthening bones and muscles. This article reviews how Morinda officinalis influences the growth and development of bone at cell level and animal level, in hoping to provide theoretical basis for the application of Morinda officinalis as an oral additive in improving the growth of animal bone.
Bone growth and development is very important for animals. Its normal growth mainly maintains the dynamic balance of bone through the bone formation of osteoblasts and bone resorption of osteoclasts. Morinda officinalis, as a kind of traditional Chinese medicine, not only plays an important role in anti-aging and immunity enhancing, but also is particularly prominent in tonifying kidney and strengthening bones and muscles. This article reviews how Morinda officinalis influences the growth and development of bone at cell level and animal level, in hoping to provide theoretical basis for the application of Morinda officinalis as an oral additive in improving the growth of animal bone.
引文
[1]李运海,王亚非,尉志强,等.巴戟天对骨代谢相关作用的实验研究进展[J].中国医药科学,2013(22):27-29.
[2]赖满香,冯娟,阮志燕,等.巴戟天多糖含药血清对骨髓间充质干细胞成骨分化过程中Cbfa-1 mRNA表达的影响[J].中国医药科学,2017,7(15):27-30.
[3]郭梁.成骨细胞、破骨细胞及OPG/RANK/RANK轴与骨质疏松症[J].中医正骨,2010,22(7):41-47.
[4]MUNISSO M C,KANG J H,TSURUFUJI M,et al.Cilomilast enhances osteoblast differentiation of mesenchymal stem cells and bone formation induced by bone morphogenetic protein 2[J].Biochimie,2012,94(11):2360-2365.
[5]赖满香,冯娟,陈侠,等.巴戟天多糖对大鼠骨髓间充质干细胞增殖和骨向分化的影响[J].中国医药科学,2018,8(7):33-36.
[6]黄胜杰,李媚,王和鸣.温阳补肾药对骨髓间充质干细胞促增殖的实验研究[J].中国中医骨伤科杂志,2012(10):1-4.
[7]赵荣兰,彭效祥,楚海荣,等.IGF-I对破骨细胞骨吸收的促进作用依赖成骨细胞的协同[J].中华内分泌代谢杂志,2012,28(12):962-966.
[8]MANOLAGAS S C.Birth and death of bone cells:basic regulatory meachanisms and implications for the pathogenesis and treatment of osteoprosis[J].Endocorin Reviews,2000,21(2):115-137.
[9]吴国志,欧积壮,吴昌新,等.巴戟天及其糖提取物对于体外培养成骨细胞OPG/RANK基因系统表达的影响[J].现代生物医学进展,2016,16(20):3849-3852,3868.
[10]凌昆,赵诣,郭素华.巴戟天药物血清对成骨细胞生物学特性的影响[J].中华中医药杂志,2010,25(6):846-849.
[11]洪懿燚,陈健.巴戟天对成骨细胞影响的实验研究进展[J].世界中西医结合杂志,2015,10(11):1613-1616.
[12]李楠,王和鸣,郭素华,等.巴戟天多糖对体外培养成骨细胞核心结合因子α1 mRNA表达的影响[J].中华中医药杂志,2007(8):517-519.
[13]马丽英.锌与骨代谢的研究进展[J].环境卫生学杂志,1998(5):271-274.
[14]KNEISSEL M,HONG N,NGUYEN I,et al.Everolimus suppresses can-cellous bone loss,bone resorption,and cathepsin by osteociasts[J].Bone,2004,35(5):1144.
[15]KIM B J,LEE Y S,LEE S Y,et al.Osteoclast-secreted SLIT3 coordinates bone resorption and formation[J].The Journal of Clinical Investigation,2018,128(4):1429-1441.
[16]WU Y B,ZHENG C J,QIN L P,et al.Antiosteoporotic activity of anthraquinones from morinda officinalis on osteoblasts and osteoclasts[J].Molecules,2009,14(1):573-583.
[17]张智海,刘忠厚,李娜,等.中国人骨质疏松症诊断标准专家共识[J].中国骨质疏松杂志,2014(9):1007-1010.
[18]鲍蕾蕾,秦路平,卞俊,等.巴戟天甲基异茜草素对破骨细胞性骨吸收的影响[J].解放军药学学报,2009,25(6):505-509.
[19]何剑全,陈健,郑素玉,等.巴戟天含药血清对原代破骨细胞RANK和CAⅡmRNA表达的影响[J].中国骨质疏松杂志,2013,19(5):469-475.
[20]王筠,苗德胜,吕刚,等.巴戟天对骨质疏松破骨细胞表面Ⅰ型跨膜受体蛋白的影响[J].中国组织工程研究,2016,20(24):3516-3522.
[21]赖满香,陈侠,冯娟,等.梓醇对成骨细胞-破骨细胞共育体系中破骨细胞活性、凋亡的影响及其机制研究[J].中国药房,2016,27(10):1318-1321.
[22]黄慧,陈健,何剑全,等.巴戟天含药血清对成骨-破骨细胞共育体系OPG mRNA、RANKL mRNA表达的影响[J].中国骨质疏松杂志,2015(1):67-71.
[23]郑素玉,陈健,何建全,等.巴戟天含药血清对成骨-破骨细胞共育体系CAⅡ、NFAT2 m RNA表达的影响[J].中国骨质疏松杂志,2013,19(2):120-124,134.
[24]李艺敏,陈健,何建全,等.巴戟天含药血清对成骨-破骨细胞共育体系原癌基因、核心结合因子1 mRNA表达的影响[J].中老年学杂志,2015,35(9):2328-2331.
[25]YU N Y,LIM E,LEE N,et al.Screening of korean medicinal plants for possible osteoclastogenesis effects in vitro[J].Genes&Nutrition,2008,2(4):375-380.
[26]NEW S A,ROBINS S P,CAMPBELL M K,et al.Dietary influences on bone mass and bone metabolism:further evidence of a positive link between fruit and vegetable consumption and bone health[J].American Journal of Clinical Nutrition,2000,71(1):142-151.
[27]ZHU M Y,WANG C J,ZHANG H S,et al.Protective effect of polysaccharides from morinda officinalis on bone loss in ovariectomized rats[J].International Journal of Biological Macromolecules,2008,43(3):276-278.
[28]龙华,叶文明,麦卫,等.巴戟天治疗骨质疏松症的临床研究[J].中国医药科学,2013,7(3):80-81.
[29]王洪英,毛敏,齐小雪,等.巴戟天总蒽醌对去卵巢大鼠骨质疏松的影响[J].世界最新医学信息文摘,2018,18(A2):29-30,33.
[30]ZHANG Z,ZHANG Q,YANG H,et al.Monotropein isolated from the roots of Morinda officinalis increases osteoblastic bone formation and prevents bone loss in ovariectomized mice[J].Fitoterapia,2016,110:166-172.
[31]刘亦恒,张寿,朱振标,等.巴戟天多糖对去卵巢大鼠核因子-κB受体激活因子配体和骨保护素表达的影响[J].中国老年学杂志,2015,35(16):4456-4457.
[32]何渝煦,魏庆中,熊启良,等.骨质疏松性骨折与骨密度关系的研究进展[J].中国骨质疏松杂志,2014,20(2):219-224.
[33]朱梦勇,赫长胜,王彩娇.巴戟天多糖对骨质疏松大鼠骨密度及血清微量元素的影响[J].中草药,2010(9):1513-1515.
[34]LI N,QIN L P,HAN T,et al.Inhibitory effects of Morin da officinalis extract on bone loss in ovariectomized rats[J].Molecules,2009,14(6):2049-2061.
[35]XIA T,DONG X,LIN L,et al.Metabolomics profiling provides valuable insights into the underlying mechanisms of Morinda officinalis on protecting glucocorticoid-induced osteoporosis[J].Journal of Pharmaceutical and Biomedical Analysis,2019(16):336-346.
[36]刘汝银,岳宗进,包德明.巴戟天多糖对骨质疏松模型大鼠5-HT、VEGF与体内矿物质含量影响研究[J].中国生化药物杂志,2015,35(4):59-62.
[37]渠海波,张朝,吴刚.骨质疏松的研究进展[J].包头医学院学报,2013(3):119-121.
[38]王莹,王少君,潘静华,等.巴戟天对卵巢切除大鼠骨质疏松的治疗作用及机理探讨[J].中国中医基础医学杂志,2018,18(10):1080-1082.
[39]靳波,赵海忠.猪腿蹄病的研究进展及防治[J].湖北畜牧兽医,2006(2):24-26.
[40]HUANG S,ZHANG L,ZHANG J,et al.Role and regulation of growth plate vascularization during coupling with osteogenesis in tibial dyschondroplasia of chickens[J].Scientific Reports,2018,8(1):3680.
[41]KNOWLES T G,KESTIN S C,HASLAM S M,et al.Leg disorders in broiler chickens:prevalence,risk factors and prevention[J].PLoS One,2008,3(2):1545.
[42]ALMEIDA P I,GARCIA R G,BERNARDI R,et al.Selecting appropriate bedding to reduce locomotion problems in broilers[J].Revista Brasileira de Ciência Avícola,2010,12(3):189-195.
[2]赖满香,冯娟,阮志燕,等.巴戟天多糖含药血清对骨髓间充质干细胞成骨分化过程中Cbfa-1 mRNA表达的影响[J].中国医药科学,2017,7(15):27-30.
[3]郭梁.成骨细胞、破骨细胞及OPG/RANK/RANK轴与骨质疏松症[J].中医正骨,2010,22(7):41-47.
[4]MUNISSO M C,KANG J H,TSURUFUJI M,et al.Cilomilast enhances osteoblast differentiation of mesenchymal stem cells and bone formation induced by bone morphogenetic protein 2[J].Biochimie,2012,94(11):2360-2365.
[5]赖满香,冯娟,陈侠,等.巴戟天多糖对大鼠骨髓间充质干细胞增殖和骨向分化的影响[J].中国医药科学,2018,8(7):33-36.
[6]黄胜杰,李媚,王和鸣.温阳补肾药对骨髓间充质干细胞促增殖的实验研究[J].中国中医骨伤科杂志,2012(10):1-4.
[7]赵荣兰,彭效祥,楚海荣,等.IGF-I对破骨细胞骨吸收的促进作用依赖成骨细胞的协同[J].中华内分泌代谢杂志,2012,28(12):962-966.
[8]MANOLAGAS S C.Birth and death of bone cells:basic regulatory meachanisms and implications for the pathogenesis and treatment of osteoprosis[J].Endocorin Reviews,2000,21(2):115-137.
[9]吴国志,欧积壮,吴昌新,等.巴戟天及其糖提取物对于体外培养成骨细胞OPG/RANK基因系统表达的影响[J].现代生物医学进展,2016,16(20):3849-3852,3868.
[10]凌昆,赵诣,郭素华.巴戟天药物血清对成骨细胞生物学特性的影响[J].中华中医药杂志,2010,25(6):846-849.
[11]洪懿燚,陈健.巴戟天对成骨细胞影响的实验研究进展[J].世界中西医结合杂志,2015,10(11):1613-1616.
[12]李楠,王和鸣,郭素华,等.巴戟天多糖对体外培养成骨细胞核心结合因子α1 mRNA表达的影响[J].中华中医药杂志,2007(8):517-519.
[13]马丽英.锌与骨代谢的研究进展[J].环境卫生学杂志,1998(5):271-274.
[14]KNEISSEL M,HONG N,NGUYEN I,et al.Everolimus suppresses can-cellous bone loss,bone resorption,and cathepsin by osteociasts[J].Bone,2004,35(5):1144.
[15]KIM B J,LEE Y S,LEE S Y,et al.Osteoclast-secreted SLIT3 coordinates bone resorption and formation[J].The Journal of Clinical Investigation,2018,128(4):1429-1441.
[16]WU Y B,ZHENG C J,QIN L P,et al.Antiosteoporotic activity of anthraquinones from morinda officinalis on osteoblasts and osteoclasts[J].Molecules,2009,14(1):573-583.
[17]张智海,刘忠厚,李娜,等.中国人骨质疏松症诊断标准专家共识[J].中国骨质疏松杂志,2014(9):1007-1010.
[18]鲍蕾蕾,秦路平,卞俊,等.巴戟天甲基异茜草素对破骨细胞性骨吸收的影响[J].解放军药学学报,2009,25(6):505-509.
[19]何剑全,陈健,郑素玉,等.巴戟天含药血清对原代破骨细胞RANK和CAⅡmRNA表达的影响[J].中国骨质疏松杂志,2013,19(5):469-475.
[20]王筠,苗德胜,吕刚,等.巴戟天对骨质疏松破骨细胞表面Ⅰ型跨膜受体蛋白的影响[J].中国组织工程研究,2016,20(24):3516-3522.
[21]赖满香,陈侠,冯娟,等.梓醇对成骨细胞-破骨细胞共育体系中破骨细胞活性、凋亡的影响及其机制研究[J].中国药房,2016,27(10):1318-1321.
[22]黄慧,陈健,何剑全,等.巴戟天含药血清对成骨-破骨细胞共育体系OPG mRNA、RANKL mRNA表达的影响[J].中国骨质疏松杂志,2015(1):67-71.
[23]郑素玉,陈健,何建全,等.巴戟天含药血清对成骨-破骨细胞共育体系CAⅡ、NFAT2 m RNA表达的影响[J].中国骨质疏松杂志,2013,19(2):120-124,134.
[24]李艺敏,陈健,何建全,等.巴戟天含药血清对成骨-破骨细胞共育体系原癌基因、核心结合因子1 mRNA表达的影响[J].中老年学杂志,2015,35(9):2328-2331.
[25]YU N Y,LIM E,LEE N,et al.Screening of korean medicinal plants for possible osteoclastogenesis effects in vitro[J].Genes&Nutrition,2008,2(4):375-380.
[26]NEW S A,ROBINS S P,CAMPBELL M K,et al.Dietary influences on bone mass and bone metabolism:further evidence of a positive link between fruit and vegetable consumption and bone health[J].American Journal of Clinical Nutrition,2000,71(1):142-151.
[27]ZHU M Y,WANG C J,ZHANG H S,et al.Protective effect of polysaccharides from morinda officinalis on bone loss in ovariectomized rats[J].International Journal of Biological Macromolecules,2008,43(3):276-278.
[28]龙华,叶文明,麦卫,等.巴戟天治疗骨质疏松症的临床研究[J].中国医药科学,2013,7(3):80-81.
[29]王洪英,毛敏,齐小雪,等.巴戟天总蒽醌对去卵巢大鼠骨质疏松的影响[J].世界最新医学信息文摘,2018,18(A2):29-30,33.
[30]ZHANG Z,ZHANG Q,YANG H,et al.Monotropein isolated from the roots of Morinda officinalis increases osteoblastic bone formation and prevents bone loss in ovariectomized mice[J].Fitoterapia,2016,110:166-172.
[31]刘亦恒,张寿,朱振标,等.巴戟天多糖对去卵巢大鼠核因子-κB受体激活因子配体和骨保护素表达的影响[J].中国老年学杂志,2015,35(16):4456-4457.
[32]何渝煦,魏庆中,熊启良,等.骨质疏松性骨折与骨密度关系的研究进展[J].中国骨质疏松杂志,2014,20(2):219-224.
[33]朱梦勇,赫长胜,王彩娇.巴戟天多糖对骨质疏松大鼠骨密度及血清微量元素的影响[J].中草药,2010(9):1513-1515.
[34]LI N,QIN L P,HAN T,et al.Inhibitory effects of Morin da officinalis extract on bone loss in ovariectomized rats[J].Molecules,2009,14(6):2049-2061.
[35]XIA T,DONG X,LIN L,et al.Metabolomics profiling provides valuable insights into the underlying mechanisms of Morinda officinalis on protecting glucocorticoid-induced osteoporosis[J].Journal of Pharmaceutical and Biomedical Analysis,2019(16):336-346.
[36]刘汝银,岳宗进,包德明.巴戟天多糖对骨质疏松模型大鼠5-HT、VEGF与体内矿物质含量影响研究[J].中国生化药物杂志,2015,35(4):59-62.
[37]渠海波,张朝,吴刚.骨质疏松的研究进展[J].包头医学院学报,2013(3):119-121.
[38]王莹,王少君,潘静华,等.巴戟天对卵巢切除大鼠骨质疏松的治疗作用及机理探讨[J].中国中医基础医学杂志,2018,18(10):1080-1082.
[39]靳波,赵海忠.猪腿蹄病的研究进展及防治[J].湖北畜牧兽医,2006(2):24-26.
[40]HUANG S,ZHANG L,ZHANG J,et al.Role and regulation of growth plate vascularization during coupling with osteogenesis in tibial dyschondroplasia of chickens[J].Scientific Reports,2018,8(1):3680.
[41]KNOWLES T G,KESTIN S C,HASLAM S M,et al.Leg disorders in broiler chickens:prevalence,risk factors and prevention[J].PLoS One,2008,3(2):1545.
[42]ALMEIDA P I,GARCIA R G,BERNARDI R,et al.Selecting appropriate bedding to reduce locomotion problems in broilers[J].Revista Brasileira de Ciência Avícola,2010,12(3):189-195.