中医药治疗放射性肺损伤研究进展
|
摘要
放射性肺损伤是胸部肿瘤放疗后常见的严重并发症之一。早期主要表现为放射性肺炎,后期可表现为肺纤维化,目前仍无有效方法来预防或治疗放射性肺损伤,成为胸部肿瘤放疗剂量的限制性因素。临床治疗主要是吸氧,卧床休息,应用支气管扩张剂、抗生素及糖皮质激素对症处理,但总体效果欠佳,中医药在治疗放射性肺损伤上做了大量研究,效果显著。文章从单味中药、中药复方及中成药制剂等方面系统总结中医药治疗放射性肺损伤研究进展。
Radioactive lung injury is one of the most common complication for chest radiotherapy. Early major realization is radiation pneumonitis, while later main realization is radiation pulmonary fibrosis. There is still no effective method to prevent or treat radioactive lung injury, which becomes a limiting factor of chest radiotherapy dose. Clinical treatment is giving oxygen, staying in bed, using bronchodilators, antibiotics, glucocorticoid, but overall effect is poor. Traditional Chinese medicine(TCM) made a lot of research on radioactive lung injury, and the effect is remarkable. This paper will systematic summary the research progress of radioactive lung injury with traditional Chinese medicine from single TCM, TCM compound and Chinese patent medicine preparation.
Radioactive lung injury is one of the most common complication for chest radiotherapy. Early major realization is radiation pneumonitis, while later main realization is radiation pulmonary fibrosis. There is still no effective method to prevent or treat radioactive lung injury, which becomes a limiting factor of chest radiotherapy dose. Clinical treatment is giving oxygen, staying in bed, using bronchodilators, antibiotics, glucocorticoid, but overall effect is poor. Traditional Chinese medicine(TCM) made a lot of research on radioactive lung injury, and the effect is remarkable. This paper will systematic summary the research progress of radioactive lung injury with traditional Chinese medicine from single TCM, TCM compound and Chinese patent medicine preparation.
引文
[1]程文芳,钱飞宇,李云英.肺癌放疗与放射性肺炎的研究.实用肿瘤学杂志,2000,14(4):274-275
[2]Benvebuste M F,Welsh J,Godoy M C,et al.New era of radiotherapy:An update inradiation-induced lung disease.Clin Radiol,2013,68(6):e275-e290
[3]Tabata C,Kadokawa Y,Tabata R,et al.All-trans-retinoic acidprevents radiation-or bleomycin-induced pulmonary fibrosis.American Journal of Respiratory and Critical Care Medicine,2006,174(12):1352-1360
[4]Wang J Y,Chen K Y,Wang J T,et al.Outcome and prognostic factorsfor patients with non-small-cell lung cancer and severe radiationpneumonitis.Int J Radiat Oncol Biol Phys,2002,54(3):735-741
[5]冯勤付,VUJASKOVIC Z,BRIZEL D M,等.阿米福汀对单次肺照射的保护作用及TGF-β1活性的影响.中华放射肿瘤学杂志,2004,13(3):222-225
[6]蓝柳,杨春旭.放射性肺损伤的监测与防治进展.实用医学杂志,2011,27(17):3251-3252
[7]Sirichanchuen B,Pengsuparp T,Chanvorachotep P.Long-term cispl-atin exporure impairs autophagy and causes cisplatin resistanceinhuman lung cancer cells.Mol Cell Biochem,2012,364(1/2):11-18
[8]Liu Y,Xia T,Zhang W,et al.Variations of circulating endothelialprogenitor cells and transforming growth factor-beta-1(TGF-beta1)during thoracic radiotherapy are predictive for radiationpneumonitis.Radiat Oncol,2013,25(8):189
[9]王蕊,贾波,严然,等.基于伏气温病理论探讨放射性肺损伤的中医病机与治法.中华中医药杂志,2018,33(3):972-974
[10]余维巍,刘晓晴,黄芪对内毒素性急性肺损伤大鼠肝细胞生长因子表达的影响.中国中西医结合杂志,2005,12(5):309-311
[11]解珂,陶富盛,房晓云,等.黄芪对急性肺损伤鼠中性粒细胞粘附功能的影响.临床麻醉学杂志,2006,22(5):375-377
[12]夏德洪,奚蕾,沈伟生,等.黄芪对放射性肺损伤干预作用及对TGF-β1,IL-1表达影响的研究.中国中药杂志,2010,35(8):1079-1081
[13]姚岚,盛丽,王莉,等.沙参对肺纤维化大鼠FN、LN的影响.中国工业医学杂志,2007,20(2)118-119
[14]姚岚,盛丽,李东书,等.中药沙参对肺纤维化大鼠肺组织TGF-β1及TNF-α蛋白表达的影响.中医研究,2007,20(4):24-26
[15]俞静,刘莲,张玥,等.延胡索乙素对大鼠急性放射性肺损伤的保护作用.临床与病理杂志,2017,37(1):62-68
[16]徐婷贞,杨起初,安娇娇.虎杖对放射性肺损伤大鼠血浆TGF-β、IL-6、ACE含量的影响.中国中医药科技,2016,23(1):32-36
[17]谢丛华,周云峰,彭纲,等.当归调控放射性肺损伤TGF-β1表达水平的研究.中华放射医学与防护杂志,2005,25(2):143-146
[18]王珏,李永强,张卫平,等.加味麻杏石甘汤防治放射性肺损伤的临床研究.天津中医药,2011,28(5):377-378
[19]陆金华,林胜友.麻杏石甘汤对放射性肺炎TGF-β1、SMAD7调控的实验研究.2012年浙江省中医药学会博士学术研究分会学术年会论文集,2012:76-79
[20]林胜友,周罗瑜,许远.加味麻杏石甘汤对放射性肺损伤TGF-β/Smad信号通路调控的研究.浙江中医药大学学报,2015,39(12):843-848
[21]林胜友,谢磊,钟亚珍.加味麻杏石甘汤对急性放射性肺损伤TGF-β/Smad信号通路的影响.中华中医药杂志,2015,30(11):4117-4119
[22]张燕,张爱琴,马胜林,等.中肺合剂对放射性肺损伤大鼠血液中TGF-β1、IL-6及IL-1的影响.中华中医药学刊,2010,28(3):571-573
[23]刘珺,吴晨雯,熊绍军.经方麦门冬汤预防放射性肺损伤及其对血浆TGF-β1的影响.实用癌症杂志,2016,31(12):1947-1950
[24]潘纯国,刘智华,朱根华,等.益气活血养阴解毒方对大鼠放射性肺损伤的治疗作用.实用癌症杂志,2017,32(10):1584-1587
[25]王静,高桂新,万云焱,等.益气活血养阴解毒方对放射性肺损伤中TGF-β1、TNF-α表达的影响.山东大学学报,2015,53(7):13-18
[26]郑海红,甘梅,富翁寿,等.扶正活血中药治疗放射性肺损伤的实验研究.浙江医学,2015,37(2):104-106
[27]衷敬华,王祥财,许明君,等.百令胶囊对放射性肺损伤大鼠血浆IL-6、TNF-α、TGF-β1影响的实验研究.亚太传统医药,2015,11(24):17-18
[28]孙芳初,刘春秋,吴琼,等.血府逐瘀胶囊对肺癌患者放射性肺损伤血TGF-β1影响的临床研究.现代中西医结合杂志,2017,26(12):1317-1319
[29]张洪峰,赵永军,相霞,等.血府逐瘀胶囊对放射性肺损伤中TGF-β1、TNF-α表达的影响.湖南师范大学学报,2017,14(1):162-164
[30]曾洁,沈伟生,盛华明,等.丹参川芎嗪注射液治疗放射性肺损伤的疗效及其机制研究,湖北中医药大学学报,2014,16(1):35-37
[2]Benvebuste M F,Welsh J,Godoy M C,et al.New era of radiotherapy:An update inradiation-induced lung disease.Clin Radiol,2013,68(6):e275-e290
[3]Tabata C,Kadokawa Y,Tabata R,et al.All-trans-retinoic acidprevents radiation-or bleomycin-induced pulmonary fibrosis.American Journal of Respiratory and Critical Care Medicine,2006,174(12):1352-1360
[4]Wang J Y,Chen K Y,Wang J T,et al.Outcome and prognostic factorsfor patients with non-small-cell lung cancer and severe radiationpneumonitis.Int J Radiat Oncol Biol Phys,2002,54(3):735-741
[5]冯勤付,VUJASKOVIC Z,BRIZEL D M,等.阿米福汀对单次肺照射的保护作用及TGF-β1活性的影响.中华放射肿瘤学杂志,2004,13(3):222-225
[6]蓝柳,杨春旭.放射性肺损伤的监测与防治进展.实用医学杂志,2011,27(17):3251-3252
[7]Sirichanchuen B,Pengsuparp T,Chanvorachotep P.Long-term cispl-atin exporure impairs autophagy and causes cisplatin resistanceinhuman lung cancer cells.Mol Cell Biochem,2012,364(1/2):11-18
[8]Liu Y,Xia T,Zhang W,et al.Variations of circulating endothelialprogenitor cells and transforming growth factor-beta-1(TGF-beta1)during thoracic radiotherapy are predictive for radiationpneumonitis.Radiat Oncol,2013,25(8):189
[9]王蕊,贾波,严然,等.基于伏气温病理论探讨放射性肺损伤的中医病机与治法.中华中医药杂志,2018,33(3):972-974
[10]余维巍,刘晓晴,黄芪对内毒素性急性肺损伤大鼠肝细胞生长因子表达的影响.中国中西医结合杂志,2005,12(5):309-311
[11]解珂,陶富盛,房晓云,等.黄芪对急性肺损伤鼠中性粒细胞粘附功能的影响.临床麻醉学杂志,2006,22(5):375-377
[12]夏德洪,奚蕾,沈伟生,等.黄芪对放射性肺损伤干预作用及对TGF-β1,IL-1表达影响的研究.中国中药杂志,2010,35(8):1079-1081
[13]姚岚,盛丽,王莉,等.沙参对肺纤维化大鼠FN、LN的影响.中国工业医学杂志,2007,20(2)118-119
[14]姚岚,盛丽,李东书,等.中药沙参对肺纤维化大鼠肺组织TGF-β1及TNF-α蛋白表达的影响.中医研究,2007,20(4):24-26
[15]俞静,刘莲,张玥,等.延胡索乙素对大鼠急性放射性肺损伤的保护作用.临床与病理杂志,2017,37(1):62-68
[16]徐婷贞,杨起初,安娇娇.虎杖对放射性肺损伤大鼠血浆TGF-β、IL-6、ACE含量的影响.中国中医药科技,2016,23(1):32-36
[17]谢丛华,周云峰,彭纲,等.当归调控放射性肺损伤TGF-β1表达水平的研究.中华放射医学与防护杂志,2005,25(2):143-146
[18]王珏,李永强,张卫平,等.加味麻杏石甘汤防治放射性肺损伤的临床研究.天津中医药,2011,28(5):377-378
[19]陆金华,林胜友.麻杏石甘汤对放射性肺炎TGF-β1、SMAD7调控的实验研究.2012年浙江省中医药学会博士学术研究分会学术年会论文集,2012:76-79
[20]林胜友,周罗瑜,许远.加味麻杏石甘汤对放射性肺损伤TGF-β/Smad信号通路调控的研究.浙江中医药大学学报,2015,39(12):843-848
[21]林胜友,谢磊,钟亚珍.加味麻杏石甘汤对急性放射性肺损伤TGF-β/Smad信号通路的影响.中华中医药杂志,2015,30(11):4117-4119
[22]张燕,张爱琴,马胜林,等.中肺合剂对放射性肺损伤大鼠血液中TGF-β1、IL-6及IL-1的影响.中华中医药学刊,2010,28(3):571-573
[23]刘珺,吴晨雯,熊绍军.经方麦门冬汤预防放射性肺损伤及其对血浆TGF-β1的影响.实用癌症杂志,2016,31(12):1947-1950
[24]潘纯国,刘智华,朱根华,等.益气活血养阴解毒方对大鼠放射性肺损伤的治疗作用.实用癌症杂志,2017,32(10):1584-1587
[25]王静,高桂新,万云焱,等.益气活血养阴解毒方对放射性肺损伤中TGF-β1、TNF-α表达的影响.山东大学学报,2015,53(7):13-18
[26]郑海红,甘梅,富翁寿,等.扶正活血中药治疗放射性肺损伤的实验研究.浙江医学,2015,37(2):104-106
[27]衷敬华,王祥财,许明君,等.百令胶囊对放射性肺损伤大鼠血浆IL-6、TNF-α、TGF-β1影响的实验研究.亚太传统医药,2015,11(24):17-18
[28]孙芳初,刘春秋,吴琼,等.血府逐瘀胶囊对肺癌患者放射性肺损伤血TGF-β1影响的临床研究.现代中西医结合杂志,2017,26(12):1317-1319
[29]张洪峰,赵永军,相霞,等.血府逐瘀胶囊对放射性肺损伤中TGF-β1、TNF-α表达的影响.湖南师范大学学报,2017,14(1):162-164
[30]曾洁,沈伟生,盛华明,等.丹参川芎嗪注射液治疗放射性肺损伤的疗效及其机制研究,湖北中医药大学学报,2014,16(1):35-37