新型四唑并[1,5-a]哌嗪类螺环化合物的合成研究
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摘要
以取代苄胺、1-叔丁氧羰基-4-哌啶酮、叠氮基三甲基硅烷(TMSN3)和异腈化合物为原料,经4组分"一锅煮"反应,得到新型四唑并[1,5-a]哌嗪类螺环化合物。研究了温度和溶剂对反应的影响,得到最佳反应条件:以甲醇为溶剂,65℃回流条件下反应48 h。所有产物结构经~1HNMR和MS进行表征。
An efficient one-pot synthesis of spirotetrazole[1,5-a] piperazine-piperidines by the four-component condensation of benzylamine,1-boc-4-piperidinone,TMSN_3 and isocyanides derivatives was reported.The effects of solvent and temperature on the reaction were elucidated and the optimal reaction conditions were obtained.The structures of products were confirmed by ~1HNMR and MS.
An efficient one-pot synthesis of spirotetrazole[1,5-a] piperazine-piperidines by the four-component condensation of benzylamine,1-boc-4-piperidinone,TMSN_3 and isocyanides derivatives was reported.The effects of solvent and temperature on the reaction were elucidated and the optimal reaction conditions were obtained.The structures of products were confirmed by ~1HNMR and MS.
引文
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