阿魏属药用植物的物质基础
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摘要
阿魏属在植物分类学上归类为伞形科,全球约150余种,其中13个物种在我国药用。本文评述其化学成分和生物学活性以及临床应用。阿魏属药用植物中单萜、倍半萜和香豆素类化合物无论是在含量上还是在化学结构多样性上,占绝对优势地位,它们可能是阿魏属药用植物的重要生物活性物质基础之一。最具特色的是该属的大部分单萜或倍半萜类化合物在化学结构类型上杂合香豆素的结构单元。该属药用植物的许多活性诸如细胞毒、抗菌、抗病毒、P-糖蛋白抑制和抗炎等皆与单萜杂合香豆素或倍半萜杂合香豆素化合物有关。这些研究结果能够用于阿魏属药用植物的药用亲缘学研究。
Genus Ferula is taxonomically classified as a member of Umbelliferae and a genus of well over 150 species in global,13 of which are medicinal in China. In this article,studies on their chemical constituents and biological activities as well as clinical uses were reviewed. The monoterpenoid,sesquiterpenoid and coumarin compounds are predominantly dominant type not only in amount but also in structural varieties,which should be one of important bioactive material basis of medicinal plants in the genus Ferula. The most characteristic feature of many monoterpenoid or sesquiterpenoid compounds in genus Ferula is embellished having the structural unit of coumarins. Many biological features of medicinal plants in this genus such as cytotoxicity,antibacterial,antiviral,P-glycoprotein inhibitory and antiinflammatory activities have been attributed to monoterpene-coumarin or sesquiterpene-coumarin. These results could be used for pharmaphylogenic research of the medicinal herbs in genus Ferula.
Genus Ferula is taxonomically classified as a member of Umbelliferae and a genus of well over 150 species in global,13 of which are medicinal in China. In this article,studies on their chemical constituents and biological activities as well as clinical uses were reviewed. The monoterpenoid,sesquiterpenoid and coumarin compounds are predominantly dominant type not only in amount but also in structural varieties,which should be one of important bioactive material basis of medicinal plants in the genus Ferula. The most characteristic feature of many monoterpenoid or sesquiterpenoid compounds in genus Ferula is embellished having the structural unit of coumarins. Many biological features of medicinal plants in this genus such as cytotoxicity,antibacterial,antiviral,P-glycoprotein inhibitory and antiinflammatory activities have been attributed to monoterpene-coumarin or sesquiterpene-coumarin. These results could be used for pharmaphylogenic research of the medicinal herbs in genus Ferula.
引文
[1]Kuliev Z A,Khasanov T Kh,Malikov V M.Ferula conocaula coumarins[J].Khim Prir Soedin,1982,18(1):120-121.
[2]Kuliev Z A,Khasanov T Kh.Structure of kauferin and kauferidin[J].Khim Prir Soedin,1978,14(3):327-331.
[3]Kuliev Z A,Khasanov T Kh,Malikov V M.Terpenoid glycocoumarins of Ferula conocaula[J].Khim Prir Soedin,1979,15(4):477-480.
[4]Vandy shev V V,Perel’son M E,Sklyar Yu E,et al.Conferin,a new coumarin from Ferula conocaula roots[J].Khim Prir Soedin,1974,10(5):660-661
[5]Vandyshev V V,Sklyar Yu E,Perel’son M E,et al.Conferol,a new coumarin from Ferula conocaula and F.moschata roots[J].Khim Prir Soedin,1972,8(5):670-671.
[6]Kuliev Z A,Khasanov T Kh,Malikov V M.Structure and configuration of cauferinin[J].Khim Prir Soedin,1979,15(2):151-154.
[7]Perel’son M E,Vandyshev V V,Sklyar Yu E.Structure and stereochemistry of conferin[J].Khim Prir Soedin,1975,11(2):248-249.
[8]Vandyshev V V,Sklyar Yu E,Perel’son M E,et al.Conferdion,a new coumarin from Ferula conocaula[J].Khim Prir Soedin,1974,10(5):658-659.
[9]Kuliev Z A,Khasanov T Kh.Structure of ferocolin,ferocolinin,ferocolidin,and ferocolicin[J].Khim Prir Soedin,1978,14(3):322-327.
[10]Vandyshev V V,Sklyar Yu E,Perel’son M E,et al.Conferone,a new terpenoid coumarin from Ferule conocaula fruits[J].Khim Prir Soedin,1972,8(5):669-670.
[11]Chen X Y,Liu Q X.Luteolin glycosides as taxonomic markers in Ferula and related genera[J].Biochem System Ecol,1989,17(4):309-310.
[12]Ryu S Y,Lee C O,Choi S U,et al.Anticancer composition comprising sesquiterpenes isolated from Resina Ferulae:US20040043083[P].2004-03-04.
[13]泽仁班鸠.一种治疗流行性传染病的药物组合物及其制备方法:200410021998X[P].2005-09-14.
[14]Sriraman M C,Nagasampagi B A,Pandey R C,et al.Sesquiterpenes.XLIX.Sesquiterpenes from Ferula jaeschkeana.1.Jaeschkeanadiol,structure and stereochemistry[J].Tetrahedron,1973,29(7):985-991.
[15]Garg S N,Misra L N,Agarwal S K,et al.Carotane derivatives from Ferula jaeschkeana[J].Phytochemistry,1987,26(2):449-450.
[16]Garg S N,Agarwal S K,Mahajan V P,et al.Feruginidin and ferugin,two new sesquiterpenoids based on the carotane skeleton from Ferula jaeschkeana[J].J Nat Prod,1987,50(2):253-255.
[17]Garg S N,Agarwal S K.New sesquiterpenes from Ferula jaeschkeana[J].Planta Med,1987,53(4):341-342.
[18]Garg S N,Agarwal S K.Further new sesquiterpenes from Ferula jaeschkeana[J].J Nat Prod,1988,51(4):771-774.
[19]Razdan T K,Qadri B,Qurishi M A,et al.Sesquiterpene esters and sesquiterpene-coumarin ethers from Ferula jaeskeana[J].Phytochemistry,1989,28(12):3389-3393.
[20]Garg S N,Vishwapaul,Rastogi S N.Isocarotane and carotane derivatives from Ferula jaeschkeana[J].Phytochemistry,1990,29(2):531-533.
[21]Garg S N,Agarwal S K,Fidelis K,et al.New jaeschkeanadiol derivatives from Ferula jaeschkeana[J].J Nat Prod,1993,56(4):539-544.
[22]Garg S N,Agarwal S.New carotane sesquiterpenes from Ferula jaeschkeana[J].J Med Arom Plant Sci,1996,18(1):7-9.
[23]Garg S N,Gupta M M,Kumar S.Isocarotane esters from Ferula jaeschkeana[J].J Indian Chem Soc,1998,75(9):536-537.
[24]Bizhanova K B,Saidkhodzhaev A I,Malikov V M.Structure of jaeschferin[J].Khim Prir Soedin,1980,16(1):127-128.
[25]Singh M M,Gupta D N,Wadhwa V,et al.Contraceptive efficacy and hormonal profile of ferujol:a new coumarin from Ferula jaeschkeana[J].Planta Med,1985,(3):268-270.
[26]Garg S N,Agarwal S K.New monoterpene diols from essential oil of Ferula jaeschkeana[J].Phytochemistry,1988,27(3):936-937.
[27]Garg S N,Misra L N,Agarwal S K.Essential oil from rhizomes of Ferula jaeschkeana[J].Phytochemistry,1989,28(2):634-636.
[28]Goryaev M I,Tikhonova L K,Dembitskii A D,et al.Essential oil composition.XXIII.Essential oil hydrocarbons from Ferula jaeschkeana stems[J].Izvest Akad Nauk Kazakh SSR,Ser Khim,1967,17(3):80-84.
[29]Bersutskii V P.Chemical investigation of the fruits of Ferula jaeschkeana Vatke[J].Bull Univ Asie centrale,1938,22:119-124.
[30]Khalilova E K,Saidkhodzhaev A I.Sesquiterpenoid esters of Ferula jaeschkeana[J].Chem Nat Compd,1998,34(4):516.
[31]Tiwana S J,Saleem M,Ahmad M,et al.Lipid composition of Ferula jaeschkeana-presence of an odd fatty acid[J].Pakistan J Sci Ind Res,1988,31(9):626-628.
[32]Ahmad M,Maqbool J R,Sabir A W,et al.Studies on the essential oils of the Pakistani species of the family Umbelliferae.Part LIV.Ferula jaeschkeana seeds and stalk oil[J].Pakistan J Sci Ind Res,1987,30(9):667-668.
[33]Prakash A O,Pathak S,Mathur R.Postcoital contraceptive action in rats of a hexane extract of the aerial parts of Ferula jaeschkeana[J].J Ethnopharmacol,1991,34(2/3):221-234.
[34]Prakash A O,Jonathan S.Effect of hexane extract of Ferula jaeschkeana on the reproductive organs in cyclic female rats[J].Philippine J Sci,1996,125(2):129-146.
[35]Pathak S,Prakash A O.Effect of hexane extract of ferula jaeschkeana on the uterus of adult ovariectomised rats[J].Ancient Sci life,1992,12(1-2):231-241.
[36]Pathak S,Jonathan S,Prakash A O.Timely administration of extract of Ferula jaeschkeana causes luteolysis in the ovary of cyclic guineapig[J].Indian J Physiol Pharmacol,1995,39(4):395-399.
[37]Singh M M,Agnihotri A,Garg S N,et al.Antifertility and hormonal properties of certain carotane sesquiterpenes of Ferula jaeschkeana[J].Planta Med,1988,54(6):492-494.
[38]Yang J R,An Z,Li Z H,et al.Sesquiterpene coumarins from the roots of Ferula sinkiangensis and Ferula teterrima[J].Chem Pharm Bull,2006,54(11):1595-1598.
[39]杨俊荣,敬松,李志宏,等.新疆阿魏化学成分研究[J],中国中药杂志,2007,32(22):2382-2384.
[40]Xing Y C,Li N,Zhou D,et al.Sesquiterpene coumarins from Ferula sinkiangensis act as neuroinflammation inhibitors[J].Planta Med,2017,83(1/2):135-142.
[41]Teng L,Ma G Z,Li L,et al.Karatavicinol a,a new anti-ulcer sesquiterpene coumarin from Ferula sinkiangensis[J].Chem Nat Compd,2013,49(4):606-609.
[42]邢亚超,汤迎湛,潘英,等.新疆阿魏树脂的化学成分研究[J].现代药物与临床,2013,28(1):11-13.
[43]邓卫萍,解成喜,符继红,等.新疆阿魏挥发油成分气相色谱-质谱分析[J].质谱学报,2007,28(2):114-116.
[44]郭亭亭,姜林,卢军,等.新疆阿魏及其不同炮制品挥发油成分GC-MS分析[J].中成药,2014,36(7):1551-1553.
[45]戴斌,丘翠嫦.中国传统药物阿魏挥发油成分的气相色谱-质谱分析比较[J].药物分析杂志,1992,12(5):285-288.
[46]Min Z D,Mai Q F,Mizuno M,et al.Polysulfanes in the volatile oils of Ferula species[J].Planta Med,1987,53(3):300-302.
[47]Ye B G,Wang S,Zhang L.Studies on the detoxification effects and acute toxicity of a mixture of cis-sec-butyl-1-propoenyl disulphide and trans-sec-butyl-1-propoenyl disulphide isolated from crude essential oil of Ferula sinkiangensis K.M.Shen,a Chinese traditional herbal medicine[J].Nat Prod Res,2011,25(12):1161-1170.
[48]Zhang L J,Si J Y,Li G Z,et al.Umbelliprenin and lariciresinol isolated from a long-term-used herb medicine Ferula sinkiangensis induce apoptosis and G0/G1arresting in gastric cancer cells[J].RSC Advances,2015,5(110):91006-91017.
[49]Li G Z,Li X J,Cao L,et al.Sesquiterpene coumarins from seeds of Ferula sinkiangensis[J].Fitoterapia,2015,103:222-226.
[50]Li G Z,Wang J C,Cao L,et al.An unusual sesquiterpene coumarin from the seeds of Ferula sinkiangensis[J].J Asian Nat Prod Res,2016,18(9):891-896.
[51]Li G Z,Wang J C,Li X J,et al.Two new sesquiterpene coumarins from the seeds of Ferula sinkiangensis[J].Phytochem Lett,2015,13:123-126.
[52]王月娥,斯建勇,李晓瑾,等.新疆阿魏种子化学成分的研究(I)[J].中国现代中药,2011,13(1):26-28.
[53]Li G Z,Li X J,Cao L,et al.Steroidal esters from Ferula sinkiangensis[J].Fitoterapia,2014,97:247-252.
[54]李广志,李晓瑾,曹丽,等.新疆阿魏种子化学成分的研究[J].中草药,2015,46(12):1730-1736.
[55]高源,邢亚超,郭俐含,等.新疆阿魏树脂不同极性部位对人肺癌细胞的体外抑制作用研究[J].现代药物与临床,2015,30(4):366-369.
[56]Zhang H Y,Lu J,Jiang L,et al.Antioxidant and antitumor effects of ferula sinkiangensis K.M.Shen[J].Int J Clin Exp Med,2015,8(11):20845-20852.
[57]Motai T,Daikonya A,Kitanaka S.Sesquiterpene coumarins from Ferula fukanensis and nitric oxide production inhibitory effects[J].J Nat Prod,2004,67(3):432-436.
[58]Motai T,Kitanaka S.Sesquiterpene coumarins from Ferula fukanensis and nitric oxide production inhibitory effects[J].Chem Pharm Bull,2004,52(10):1215-1218.
[59]Motai T,Daikonya A,Kitanaka S.Sesquiterpene coumarins from Ferula fukanensis and their proinflammatory cytokine gene expression inhibitory effects[J].Chem Pharm Bull,2013,61(6):618-623.
[60]Motai T,Kitanaka S.Sesquiterpenoids from Ferula fukanensis and their inhibitory effects on nitric oxide production[J].J Nat Med,2006,60(1):54-57.
[61]许琼明,李国强,刘艳丽,等.阜康阿魏中倍半萜香豆素类化学成分研究[J].中国药学杂志,2009,44(4):255-257.
[62]Motai T,Kitanaka S.Sesquiterpene phenylpropanoids from Ferula fukanensis and their nitric oxide production inhibitory effects[J].J Nat Prod,2005,68(3):365-368.
[63]Motai T,Kitanaka S.Sesquiterpene chromones from Ferula fukanensis and their nitric oxide production inhibitory effects[J].J Nat Prod,2005,68(12):1732-1735.
[64]王东东,刘宏炳,宋海龙.HPLC法测定阜康阿魏根和叶中阿魏酸的含量[J].新疆医科大学学报,2012,35(9):1139-1142.
[65]Min Z D,Mai Q F,Mizuno M,et al.Polysulfanes in the volatile oils of Ferula species[J].Planta Med,1987,53(3):300-302.
[66]李肖宇,李国玉,王航宇.大果阿魏化学成分的研究[J].中国现代中药,2010,12(8):17-20.
[67]顾新宇,张涵庆,薛怡琛,等.大果阿魏酮化学结构的研究[J].植物资源与环境,1995,4(2):13-16.
[68]Sagitdinova G V,Saidkhodzhaev A I,Malikov V M.Structure and stereochemistry of Ferula lehmanni coumarins[J].Khim Prir Soedin,1983,19(6):709-712.
[69]赵文彬,谭勇,相颖,等.新疆大果阿魏中氨基酸和矿物元素含量测定[J].现代中药研究与实践,2009,23(3):67-68.
[70]赵文彬,朱芸,相颖,等.气相色谱-质谱法分析新疆阿魏挥发油化学成分[J].时珍国医国药,2007,18(5):1063-1064.
[71]Perel’son M E,Sokolova A I,Sklyar Yu E.Structure of feterin-a new terpenoid coumarin from Ferula teterrima[J].Khim Prir Soedin,1978,14(3):318-22.
[72]杨俊荣,李国强,李志宏,等.臭阿魏化学成分研究[J].天然产物研究与开发,2006,18(2):246-248.
[73]Yang J R,An Z,Li Z H,et al.Sesquiterpene coumarins from the roots of Ferula sinkiangensis and Ferula teterrima[J].Chem Pharm Bull,2006,54(11):1595-1598.
[74]Sokolova A I,Sklyar Yu E,Pimenov M G.Terpenoid coumarins from Ferula teterrima[J].Khim Prir Soedin,1978,14(1):134-135.
[75]罗茜,马桂芝,单萌,等.两种阿魏挥发油急性毒性及其化学成分的比较研究[J].中成药,2015,37(5):1130-1135.
[76]Veselovskaya N V,Sklyar Yu E,Savina A A.Fekrynol and its acetate from Ferula krylovii[J].Khim Prir Soedin,1981,17(6):798-799.
[77]Veselovskaya N V,Sklyar Yu E,Perel’son M E,et al.Terpenoid coumarins from Ferula krylovii[J].Khim Prir Soedin,1979,15(2):227-228.
[78]Perel’son M E,Sklyar Yu E,Veselovskaya N V,et al.Ferukrin-a new terpenoid coumarin from Ferula krylovii[J].Khim-Farm Zh,1977,11(3):78-80.
[79]Veselovskaya N V,Sklyar Yu E,Fesenko D A,et al.Fekrol-a terpenoid coumarin from Ferula krylovii[J].Khim Prir Soedin,1979,15(6):851.
[80]胡跃,李晓东,李国玉,等.阿魏的化学成分研究[J].中国现代中药,2009,11(7):18-19.
[81]堵年生,曲淑惠,支玲.新疆托里阿魏根中精油成分的研究[J].中国药科大学学报,1989,20(3):164-166.
[82]Suleimenov Ye M,Machmudah S,Ishmuratova M Yu,et al.Investigation of kazakhstani flora.II.GC/MS analysis of Ferula soongarica pall.ex schult.essential oil obtained by supercritical CO2extraction[J].Khim Rastit Syr’ya,2010(4):183-184.
[83]Zhou P,Takaishi Y,Duan H Q,et al.Coumarins and bicoumarin from Ferula sumbul:anti-HIV activity and inhibition of cytokine release[J].Phytochemistry,2000,53(6):689-697.
[84]Vandyshev V V,Sklyar Yu E,Perel’son M E,et al.Conferol,a new coumarin from Ferula conocaula and F.moschata roots[J].Khim Prir Soedin,1972,8(5):670-671.
[85]Khalilova E Kh,Saidkhodzhaev A I.Terpenoid coumarins of Ferula sumbul[J].Chem Nat Compd,1999,34(4):506-507.
[86]Sklyar Yu S,Perel’son M E,Pimenov M G.Moschatol,a new coumarin from Ferula moschata roots[J].Khim Prir Soedin,1973,9(3):428.
[87]Eshbakova K A,Saidkhodzhaev A I,Vdovin A D,et al.Terpenoid coumarins from Ferula feruloides[J].Chem Nat Compd,2009,45(5):708-709.
[88]Meng H,Li G Y,Huang J,et al.Sesquiterpene coumarin and sesquiterpene chromone derivatives from Ferula ferulaeoides(Steud.)Korov.[J].Fitoterapia,2013,86:70-77.
[89]Liu T,Wang S Y,Xu L L,et al.Sesquiterpenoids with anti-MDR Staphylococcus aureus activities from Ferula ferulioides[J].Chem Biodivers,2015,12(4):599-614.
[90]Isaka K,Nagatsu A,Purev O.Sesquiterpenoid derivatives from Ferula ferulioides V[J].Chem Pharm Bull,2001,49(9):1072-1076.
[91]Kojima K,Isaka K,Purev O.Sesquiterpenoid derivatives from Ferula ferulioides IV[J].Chem Pharm Bull,2000,48(3):353-356.
[92]Nagatsu A,Isaka K,Kojima K,et al.New sesquiterpenes from Ferula ferulaeoides(STEUD.)KOROVIN.VI.Isolation and identification of three new dihydrofuro[2,3-b]chromones[J].Chem Pharm Bull,2002,50(5):675-677.
[93]Kojima K,Isaka K,Purev O,et al.Sesquiterpenoid derivatives from Ferula ferulioides[J].Chem Pharm Bull,1998,46(11):1781-1784.
[94]Liu T,Osman K,Kaatz G W,et al.Antibacterial sesquiterpenoid derivatives from Ferula ferulaeoides[J].Planta Med,2013,79(8):701-706.
[95]Kojima K,Isaka K,Ondognii P,et al.Sesquiterpenoid derivatives from Ferula ferulioides.III[J].Chem Pharm Bull,1999,47(8):1145-1147.
[96]Kojima K,Isaka K,Purev O,et al.Sesquiterpenoid derivatives from Ferula ferulioides.II.[J].Chem Pharm Bull,1999,47(5):690-691.
[97]Meng H,Li G Y,Huang J,et al.Sesquiterpenoid derivatives from Ferula ferulaeoides(Steud.)Korov.[J].Phytochemistry,2013,86:151-158.
[98]Hu Y,Li X D,Li G Y,et al.Two novel sesquiterpenoids from the roots of Ferula ferulaeoides(Steud.)Korov.[J].Helv Chim Acta,2010,93(5):1019-1024.
[99]Liu T,Wang C J,Xie H Q,et al.Guaiol-a naturally occurring insecticidal sesquiterpene[J].Nat Prod Commun,2013,8(10):1353-1354.
[100]Borisov V N,Ban’kovskii A I,Sheichenko V I,et al.Guaiol and hydroxy-aromatic acids from Ferula ferulaeoides[J].Khim Prir Soedin,1976,12(5):666-667.
[101]王飒,盛萍,姚蓝,等.维药多伞阿魏体外抗胃癌活性部位GC-MS指纹图谱的研究[J].中草药,2015,46(19):2874-2879.
[102]宋东伟,赵文军,吴雪萍,等.新疆多伞阿魏化学成分研究[J].中草药,2006,37(11):1627-1629.
[103]倪慧,姜传义,陈茂齐.新疆多伞阿魏根中挥发油成分研究[J].中成药,2001,23(1):54-57.
[104]盛萍,王飒,苗莉娟,等.不同方法提取的多伞阿魏挥发油化学成分及其体外抗胃癌活性比较[J].中成药,2013,35(11):2442-2448.
[105]倪慧,姜传义,刘淑兰,等.新疆多伞阿魏中挥发油成分报道[J].中药材,1997,20(1):34-35.
[106]Eshbakova K A,Saidkhodzhaev A I,Vdovin A D,et al.Terpenoid coumarins from Ferula feruloides[J].Chem Nat Compd,2009,45(5):708-709.
[107]Zhang L,Tong X P,Zhang J,et al.DAW22,a natural sesquiterpene coumarin isolated from Ferula ferulaeoides(Steud.)Korov.that induces C6 glioma cell apoptosis and endoplasmic reticulum(ER)stress[J].Fitoterapia,2015,103:46-54.
[108]熊元君,刘发,叶尔波,等.新疆三种阿魏对胃肠道作用的比较[J].新疆医学院报.1993,16(4):300-302.
[109]Wang X,Ren Z Z,He Y,et al.A combination of pharmacophore modeling,molecular docking and virtual screening for i NOS inhibitors from Chinese herbs[J].Bio-Med Mater Eng,2014,24(1):1315-1322.
[110]Zhukov G O.Extraction and investigation of coumarins from Ferula caspica[J].Farm Zh(Kiev),1963,18(6):20-22.
[111]Zhukov G A,Prokopenko A P,Kolesnikov D G.Coumarins of roots of Ferula caspica[J].Med Promy-st'SSSR,1965,19(5):32-34.
[112]Zhukov G A,Prokopenko A P.Coumarins of Ferula caspica[J].Khim Prir Soedin,1967,3(3):214-215.
[113]Yelkenci S,Altundag H,Sagiroglu M,et al.Quantitative ICP-OES determination of trace and essential elements in the plant species of genus ferula[J].At Spectrosc,2016,37(3):102-107.
[114]Dzhumazhanov O D.Pharmacodynamics of preparations of Ferula caspica[J].Izvest Akad Nauk Kazakh SSR,Ser Med i Fiziol,1957,(1):111-121.
[115]Iranshahi M,Noroozi S,Behravan J,et al.Persicasulphide C,a new sulphur-containing derivative from Ferula persica[J].Nat Prod Res,2009,23(17):1584-1588.
[116]Abd El-Razek M H,Ohta S,Hirata T.Terpenoid coumarins of the genus Ferula[J].Heterocycles,2003,60(3):689-716.
[117]Alam M,Khan A,Wadood A,et al.Bioassay-guided isolation of sesquiterpene coumarins from Ferula narthex bioss:a new anticancer agent[J].Front Pharmacol,2016,7:26/1-26/6.
[118]Iranshahi M,Amanolahi F,Schneider B.New sesquiterpene coumarin from the roots of Ferula latisecta[J].Avicenna J Phytomed,2012,2(3):133-138.
[119]Abourashed E A,Galal A M,El-Feraly F S,et al.Separation and quantification of the major daucane esters of Ferula hermonis by HPLC[J].Planta Med,2001,67(7):681-682.
[120]Cha M R,Choi Y H,Choi C W,et al.Galbanic acid,a cytotoxic sesquiterpene from the gum resin of Ferula asafoetida,blocks protein farnesyltransferase[J].Planta Med,2011,77(1):52-54.
[121]Khasanov T Kh,Saidkhodzhaev A I,Nikonov G K.Structure of mogoltacin[J].Khim Prir Soedin,1976,12(1):95-96.
[122]Nazari Z E,Iranshahi M.Biologically active sesquiterpene coumarins from Ferula species[J].Phytother Res,2011,25(3):315-323.
[123]Iranshahi M,Kalategi F,Sahebkar A,et al.New sesquiterpene coumarins from the roots of Ferula flabelliloba[J].Pharm Biol,2010,48(2):217-220.
[124]Iranshahi M,Kalategi F,Rezaee R,et al.Cancer chemopreventive activity of terpenoid coumarins from Ferula species[J].Planta Med,2008,74(2):147-150.
[125]杨秀伟.中药新药有效成分研究及其标准制定的科学依据[J].中草药,2009,40(增刊):8-13,18.
[126]杨秀伟.中药物质基础研究是中药继承、发展、创新的关键科学问题[J].中国中药杂志,2015,40(17):3429-3434.
[2]Kuliev Z A,Khasanov T Kh.Structure of kauferin and kauferidin[J].Khim Prir Soedin,1978,14(3):327-331.
[3]Kuliev Z A,Khasanov T Kh,Malikov V M.Terpenoid glycocoumarins of Ferula conocaula[J].Khim Prir Soedin,1979,15(4):477-480.
[4]Vandy shev V V,Perel’son M E,Sklyar Yu E,et al.Conferin,a new coumarin from Ferula conocaula roots[J].Khim Prir Soedin,1974,10(5):660-661
[5]Vandyshev V V,Sklyar Yu E,Perel’son M E,et al.Conferol,a new coumarin from Ferula conocaula and F.moschata roots[J].Khim Prir Soedin,1972,8(5):670-671.
[6]Kuliev Z A,Khasanov T Kh,Malikov V M.Structure and configuration of cauferinin[J].Khim Prir Soedin,1979,15(2):151-154.
[7]Perel’son M E,Vandyshev V V,Sklyar Yu E.Structure and stereochemistry of conferin[J].Khim Prir Soedin,1975,11(2):248-249.
[8]Vandyshev V V,Sklyar Yu E,Perel’son M E,et al.Conferdion,a new coumarin from Ferula conocaula[J].Khim Prir Soedin,1974,10(5):658-659.
[9]Kuliev Z A,Khasanov T Kh.Structure of ferocolin,ferocolinin,ferocolidin,and ferocolicin[J].Khim Prir Soedin,1978,14(3):322-327.
[10]Vandyshev V V,Sklyar Yu E,Perel’son M E,et al.Conferone,a new terpenoid coumarin from Ferule conocaula fruits[J].Khim Prir Soedin,1972,8(5):669-670.
[11]Chen X Y,Liu Q X.Luteolin glycosides as taxonomic markers in Ferula and related genera[J].Biochem System Ecol,1989,17(4):309-310.
[12]Ryu S Y,Lee C O,Choi S U,et al.Anticancer composition comprising sesquiterpenes isolated from Resina Ferulae:US20040043083[P].2004-03-04.
[13]泽仁班鸠.一种治疗流行性传染病的药物组合物及其制备方法:200410021998X[P].2005-09-14.
[14]Sriraman M C,Nagasampagi B A,Pandey R C,et al.Sesquiterpenes.XLIX.Sesquiterpenes from Ferula jaeschkeana.1.Jaeschkeanadiol,structure and stereochemistry[J].Tetrahedron,1973,29(7):985-991.
[15]Garg S N,Misra L N,Agarwal S K,et al.Carotane derivatives from Ferula jaeschkeana[J].Phytochemistry,1987,26(2):449-450.
[16]Garg S N,Agarwal S K,Mahajan V P,et al.Feruginidin and ferugin,two new sesquiterpenoids based on the carotane skeleton from Ferula jaeschkeana[J].J Nat Prod,1987,50(2):253-255.
[17]Garg S N,Agarwal S K.New sesquiterpenes from Ferula jaeschkeana[J].Planta Med,1987,53(4):341-342.
[18]Garg S N,Agarwal S K.Further new sesquiterpenes from Ferula jaeschkeana[J].J Nat Prod,1988,51(4):771-774.
[19]Razdan T K,Qadri B,Qurishi M A,et al.Sesquiterpene esters and sesquiterpene-coumarin ethers from Ferula jaeskeana[J].Phytochemistry,1989,28(12):3389-3393.
[20]Garg S N,Vishwapaul,Rastogi S N.Isocarotane and carotane derivatives from Ferula jaeschkeana[J].Phytochemistry,1990,29(2):531-533.
[21]Garg S N,Agarwal S K,Fidelis K,et al.New jaeschkeanadiol derivatives from Ferula jaeschkeana[J].J Nat Prod,1993,56(4):539-544.
[22]Garg S N,Agarwal S.New carotane sesquiterpenes from Ferula jaeschkeana[J].J Med Arom Plant Sci,1996,18(1):7-9.
[23]Garg S N,Gupta M M,Kumar S.Isocarotane esters from Ferula jaeschkeana[J].J Indian Chem Soc,1998,75(9):536-537.
[24]Bizhanova K B,Saidkhodzhaev A I,Malikov V M.Structure of jaeschferin[J].Khim Prir Soedin,1980,16(1):127-128.
[25]Singh M M,Gupta D N,Wadhwa V,et al.Contraceptive efficacy and hormonal profile of ferujol:a new coumarin from Ferula jaeschkeana[J].Planta Med,1985,(3):268-270.
[26]Garg S N,Agarwal S K.New monoterpene diols from essential oil of Ferula jaeschkeana[J].Phytochemistry,1988,27(3):936-937.
[27]Garg S N,Misra L N,Agarwal S K.Essential oil from rhizomes of Ferula jaeschkeana[J].Phytochemistry,1989,28(2):634-636.
[28]Goryaev M I,Tikhonova L K,Dembitskii A D,et al.Essential oil composition.XXIII.Essential oil hydrocarbons from Ferula jaeschkeana stems[J].Izvest Akad Nauk Kazakh SSR,Ser Khim,1967,17(3):80-84.
[29]Bersutskii V P.Chemical investigation of the fruits of Ferula jaeschkeana Vatke[J].Bull Univ Asie centrale,1938,22:119-124.
[30]Khalilova E K,Saidkhodzhaev A I.Sesquiterpenoid esters of Ferula jaeschkeana[J].Chem Nat Compd,1998,34(4):516.
[31]Tiwana S J,Saleem M,Ahmad M,et al.Lipid composition of Ferula jaeschkeana-presence of an odd fatty acid[J].Pakistan J Sci Ind Res,1988,31(9):626-628.
[32]Ahmad M,Maqbool J R,Sabir A W,et al.Studies on the essential oils of the Pakistani species of the family Umbelliferae.Part LIV.Ferula jaeschkeana seeds and stalk oil[J].Pakistan J Sci Ind Res,1987,30(9):667-668.
[33]Prakash A O,Pathak S,Mathur R.Postcoital contraceptive action in rats of a hexane extract of the aerial parts of Ferula jaeschkeana[J].J Ethnopharmacol,1991,34(2/3):221-234.
[34]Prakash A O,Jonathan S.Effect of hexane extract of Ferula jaeschkeana on the reproductive organs in cyclic female rats[J].Philippine J Sci,1996,125(2):129-146.
[35]Pathak S,Prakash A O.Effect of hexane extract of ferula jaeschkeana on the uterus of adult ovariectomised rats[J].Ancient Sci life,1992,12(1-2):231-241.
[36]Pathak S,Jonathan S,Prakash A O.Timely administration of extract of Ferula jaeschkeana causes luteolysis in the ovary of cyclic guineapig[J].Indian J Physiol Pharmacol,1995,39(4):395-399.
[37]Singh M M,Agnihotri A,Garg S N,et al.Antifertility and hormonal properties of certain carotane sesquiterpenes of Ferula jaeschkeana[J].Planta Med,1988,54(6):492-494.
[38]Yang J R,An Z,Li Z H,et al.Sesquiterpene coumarins from the roots of Ferula sinkiangensis and Ferula teterrima[J].Chem Pharm Bull,2006,54(11):1595-1598.
[39]杨俊荣,敬松,李志宏,等.新疆阿魏化学成分研究[J],中国中药杂志,2007,32(22):2382-2384.
[40]Xing Y C,Li N,Zhou D,et al.Sesquiterpene coumarins from Ferula sinkiangensis act as neuroinflammation inhibitors[J].Planta Med,2017,83(1/2):135-142.
[41]Teng L,Ma G Z,Li L,et al.Karatavicinol a,a new anti-ulcer sesquiterpene coumarin from Ferula sinkiangensis[J].Chem Nat Compd,2013,49(4):606-609.
[42]邢亚超,汤迎湛,潘英,等.新疆阿魏树脂的化学成分研究[J].现代药物与临床,2013,28(1):11-13.
[43]邓卫萍,解成喜,符继红,等.新疆阿魏挥发油成分气相色谱-质谱分析[J].质谱学报,2007,28(2):114-116.
[44]郭亭亭,姜林,卢军,等.新疆阿魏及其不同炮制品挥发油成分GC-MS分析[J].中成药,2014,36(7):1551-1553.
[45]戴斌,丘翠嫦.中国传统药物阿魏挥发油成分的气相色谱-质谱分析比较[J].药物分析杂志,1992,12(5):285-288.
[46]Min Z D,Mai Q F,Mizuno M,et al.Polysulfanes in the volatile oils of Ferula species[J].Planta Med,1987,53(3):300-302.
[47]Ye B G,Wang S,Zhang L.Studies on the detoxification effects and acute toxicity of a mixture of cis-sec-butyl-1-propoenyl disulphide and trans-sec-butyl-1-propoenyl disulphide isolated from crude essential oil of Ferula sinkiangensis K.M.Shen,a Chinese traditional herbal medicine[J].Nat Prod Res,2011,25(12):1161-1170.
[48]Zhang L J,Si J Y,Li G Z,et al.Umbelliprenin and lariciresinol isolated from a long-term-used herb medicine Ferula sinkiangensis induce apoptosis and G0/G1arresting in gastric cancer cells[J].RSC Advances,2015,5(110):91006-91017.
[49]Li G Z,Li X J,Cao L,et al.Sesquiterpene coumarins from seeds of Ferula sinkiangensis[J].Fitoterapia,2015,103:222-226.
[50]Li G Z,Wang J C,Cao L,et al.An unusual sesquiterpene coumarin from the seeds of Ferula sinkiangensis[J].J Asian Nat Prod Res,2016,18(9):891-896.
[51]Li G Z,Wang J C,Li X J,et al.Two new sesquiterpene coumarins from the seeds of Ferula sinkiangensis[J].Phytochem Lett,2015,13:123-126.
[52]王月娥,斯建勇,李晓瑾,等.新疆阿魏种子化学成分的研究(I)[J].中国现代中药,2011,13(1):26-28.
[53]Li G Z,Li X J,Cao L,et al.Steroidal esters from Ferula sinkiangensis[J].Fitoterapia,2014,97:247-252.
[54]李广志,李晓瑾,曹丽,等.新疆阿魏种子化学成分的研究[J].中草药,2015,46(12):1730-1736.
[55]高源,邢亚超,郭俐含,等.新疆阿魏树脂不同极性部位对人肺癌细胞的体外抑制作用研究[J].现代药物与临床,2015,30(4):366-369.
[56]Zhang H Y,Lu J,Jiang L,et al.Antioxidant and antitumor effects of ferula sinkiangensis K.M.Shen[J].Int J Clin Exp Med,2015,8(11):20845-20852.
[57]Motai T,Daikonya A,Kitanaka S.Sesquiterpene coumarins from Ferula fukanensis and nitric oxide production inhibitory effects[J].J Nat Prod,2004,67(3):432-436.
[58]Motai T,Kitanaka S.Sesquiterpene coumarins from Ferula fukanensis and nitric oxide production inhibitory effects[J].Chem Pharm Bull,2004,52(10):1215-1218.
[59]Motai T,Daikonya A,Kitanaka S.Sesquiterpene coumarins from Ferula fukanensis and their proinflammatory cytokine gene expression inhibitory effects[J].Chem Pharm Bull,2013,61(6):618-623.
[60]Motai T,Kitanaka S.Sesquiterpenoids from Ferula fukanensis and their inhibitory effects on nitric oxide production[J].J Nat Med,2006,60(1):54-57.
[61]许琼明,李国强,刘艳丽,等.阜康阿魏中倍半萜香豆素类化学成分研究[J].中国药学杂志,2009,44(4):255-257.
[62]Motai T,Kitanaka S.Sesquiterpene phenylpropanoids from Ferula fukanensis and their nitric oxide production inhibitory effects[J].J Nat Prod,2005,68(3):365-368.
[63]Motai T,Kitanaka S.Sesquiterpene chromones from Ferula fukanensis and their nitric oxide production inhibitory effects[J].J Nat Prod,2005,68(12):1732-1735.
[64]王东东,刘宏炳,宋海龙.HPLC法测定阜康阿魏根和叶中阿魏酸的含量[J].新疆医科大学学报,2012,35(9):1139-1142.
[65]Min Z D,Mai Q F,Mizuno M,et al.Polysulfanes in the volatile oils of Ferula species[J].Planta Med,1987,53(3):300-302.
[66]李肖宇,李国玉,王航宇.大果阿魏化学成分的研究[J].中国现代中药,2010,12(8):17-20.
[67]顾新宇,张涵庆,薛怡琛,等.大果阿魏酮化学结构的研究[J].植物资源与环境,1995,4(2):13-16.
[68]Sagitdinova G V,Saidkhodzhaev A I,Malikov V M.Structure and stereochemistry of Ferula lehmanni coumarins[J].Khim Prir Soedin,1983,19(6):709-712.
[69]赵文彬,谭勇,相颖,等.新疆大果阿魏中氨基酸和矿物元素含量测定[J].现代中药研究与实践,2009,23(3):67-68.
[70]赵文彬,朱芸,相颖,等.气相色谱-质谱法分析新疆阿魏挥发油化学成分[J].时珍国医国药,2007,18(5):1063-1064.
[71]Perel’son M E,Sokolova A I,Sklyar Yu E.Structure of feterin-a new terpenoid coumarin from Ferula teterrima[J].Khim Prir Soedin,1978,14(3):318-22.
[72]杨俊荣,李国强,李志宏,等.臭阿魏化学成分研究[J].天然产物研究与开发,2006,18(2):246-248.
[73]Yang J R,An Z,Li Z H,et al.Sesquiterpene coumarins from the roots of Ferula sinkiangensis and Ferula teterrima[J].Chem Pharm Bull,2006,54(11):1595-1598.
[74]Sokolova A I,Sklyar Yu E,Pimenov M G.Terpenoid coumarins from Ferula teterrima[J].Khim Prir Soedin,1978,14(1):134-135.
[75]罗茜,马桂芝,单萌,等.两种阿魏挥发油急性毒性及其化学成分的比较研究[J].中成药,2015,37(5):1130-1135.
[76]Veselovskaya N V,Sklyar Yu E,Savina A A.Fekrynol and its acetate from Ferula krylovii[J].Khim Prir Soedin,1981,17(6):798-799.
[77]Veselovskaya N V,Sklyar Yu E,Perel’son M E,et al.Terpenoid coumarins from Ferula krylovii[J].Khim Prir Soedin,1979,15(2):227-228.
[78]Perel’son M E,Sklyar Yu E,Veselovskaya N V,et al.Ferukrin-a new terpenoid coumarin from Ferula krylovii[J].Khim-Farm Zh,1977,11(3):78-80.
[79]Veselovskaya N V,Sklyar Yu E,Fesenko D A,et al.Fekrol-a terpenoid coumarin from Ferula krylovii[J].Khim Prir Soedin,1979,15(6):851.
[80]胡跃,李晓东,李国玉,等.阿魏的化学成分研究[J].中国现代中药,2009,11(7):18-19.
[81]堵年生,曲淑惠,支玲.新疆托里阿魏根中精油成分的研究[J].中国药科大学学报,1989,20(3):164-166.
[82]Suleimenov Ye M,Machmudah S,Ishmuratova M Yu,et al.Investigation of kazakhstani flora.II.GC/MS analysis of Ferula soongarica pall.ex schult.essential oil obtained by supercritical CO2extraction[J].Khim Rastit Syr’ya,2010(4):183-184.
[83]Zhou P,Takaishi Y,Duan H Q,et al.Coumarins and bicoumarin from Ferula sumbul:anti-HIV activity and inhibition of cytokine release[J].Phytochemistry,2000,53(6):689-697.
[84]Vandyshev V V,Sklyar Yu E,Perel’son M E,et al.Conferol,a new coumarin from Ferula conocaula and F.moschata roots[J].Khim Prir Soedin,1972,8(5):670-671.
[85]Khalilova E Kh,Saidkhodzhaev A I.Terpenoid coumarins of Ferula sumbul[J].Chem Nat Compd,1999,34(4):506-507.
[86]Sklyar Yu S,Perel’son M E,Pimenov M G.Moschatol,a new coumarin from Ferula moschata roots[J].Khim Prir Soedin,1973,9(3):428.
[87]Eshbakova K A,Saidkhodzhaev A I,Vdovin A D,et al.Terpenoid coumarins from Ferula feruloides[J].Chem Nat Compd,2009,45(5):708-709.
[88]Meng H,Li G Y,Huang J,et al.Sesquiterpene coumarin and sesquiterpene chromone derivatives from Ferula ferulaeoides(Steud.)Korov.[J].Fitoterapia,2013,86:70-77.
[89]Liu T,Wang S Y,Xu L L,et al.Sesquiterpenoids with anti-MDR Staphylococcus aureus activities from Ferula ferulioides[J].Chem Biodivers,2015,12(4):599-614.
[90]Isaka K,Nagatsu A,Purev O.Sesquiterpenoid derivatives from Ferula ferulioides V[J].Chem Pharm Bull,2001,49(9):1072-1076.
[91]Kojima K,Isaka K,Purev O.Sesquiterpenoid derivatives from Ferula ferulioides IV[J].Chem Pharm Bull,2000,48(3):353-356.
[92]Nagatsu A,Isaka K,Kojima K,et al.New sesquiterpenes from Ferula ferulaeoides(STEUD.)KOROVIN.VI.Isolation and identification of three new dihydrofuro[2,3-b]chromones[J].Chem Pharm Bull,2002,50(5):675-677.
[93]Kojima K,Isaka K,Purev O,et al.Sesquiterpenoid derivatives from Ferula ferulioides[J].Chem Pharm Bull,1998,46(11):1781-1784.
[94]Liu T,Osman K,Kaatz G W,et al.Antibacterial sesquiterpenoid derivatives from Ferula ferulaeoides[J].Planta Med,2013,79(8):701-706.
[95]Kojima K,Isaka K,Ondognii P,et al.Sesquiterpenoid derivatives from Ferula ferulioides.III[J].Chem Pharm Bull,1999,47(8):1145-1147.
[96]Kojima K,Isaka K,Purev O,et al.Sesquiterpenoid derivatives from Ferula ferulioides.II.[J].Chem Pharm Bull,1999,47(5):690-691.
[97]Meng H,Li G Y,Huang J,et al.Sesquiterpenoid derivatives from Ferula ferulaeoides(Steud.)Korov.[J].Phytochemistry,2013,86:151-158.
[98]Hu Y,Li X D,Li G Y,et al.Two novel sesquiterpenoids from the roots of Ferula ferulaeoides(Steud.)Korov.[J].Helv Chim Acta,2010,93(5):1019-1024.
[99]Liu T,Wang C J,Xie H Q,et al.Guaiol-a naturally occurring insecticidal sesquiterpene[J].Nat Prod Commun,2013,8(10):1353-1354.
[100]Borisov V N,Ban’kovskii A I,Sheichenko V I,et al.Guaiol and hydroxy-aromatic acids from Ferula ferulaeoides[J].Khim Prir Soedin,1976,12(5):666-667.
[101]王飒,盛萍,姚蓝,等.维药多伞阿魏体外抗胃癌活性部位GC-MS指纹图谱的研究[J].中草药,2015,46(19):2874-2879.
[102]宋东伟,赵文军,吴雪萍,等.新疆多伞阿魏化学成分研究[J].中草药,2006,37(11):1627-1629.
[103]倪慧,姜传义,陈茂齐.新疆多伞阿魏根中挥发油成分研究[J].中成药,2001,23(1):54-57.
[104]盛萍,王飒,苗莉娟,等.不同方法提取的多伞阿魏挥发油化学成分及其体外抗胃癌活性比较[J].中成药,2013,35(11):2442-2448.
[105]倪慧,姜传义,刘淑兰,等.新疆多伞阿魏中挥发油成分报道[J].中药材,1997,20(1):34-35.
[106]Eshbakova K A,Saidkhodzhaev A I,Vdovin A D,et al.Terpenoid coumarins from Ferula feruloides[J].Chem Nat Compd,2009,45(5):708-709.
[107]Zhang L,Tong X P,Zhang J,et al.DAW22,a natural sesquiterpene coumarin isolated from Ferula ferulaeoides(Steud.)Korov.that induces C6 glioma cell apoptosis and endoplasmic reticulum(ER)stress[J].Fitoterapia,2015,103:46-54.
[108]熊元君,刘发,叶尔波,等.新疆三种阿魏对胃肠道作用的比较[J].新疆医学院报.1993,16(4):300-302.
[109]Wang X,Ren Z Z,He Y,et al.A combination of pharmacophore modeling,molecular docking and virtual screening for i NOS inhibitors from Chinese herbs[J].Bio-Med Mater Eng,2014,24(1):1315-1322.
[110]Zhukov G O.Extraction and investigation of coumarins from Ferula caspica[J].Farm Zh(Kiev),1963,18(6):20-22.
[111]Zhukov G A,Prokopenko A P,Kolesnikov D G.Coumarins of roots of Ferula caspica[J].Med Promy-st'SSSR,1965,19(5):32-34.
[112]Zhukov G A,Prokopenko A P.Coumarins of Ferula caspica[J].Khim Prir Soedin,1967,3(3):214-215.
[113]Yelkenci S,Altundag H,Sagiroglu M,et al.Quantitative ICP-OES determination of trace and essential elements in the plant species of genus ferula[J].At Spectrosc,2016,37(3):102-107.
[114]Dzhumazhanov O D.Pharmacodynamics of preparations of Ferula caspica[J].Izvest Akad Nauk Kazakh SSR,Ser Med i Fiziol,1957,(1):111-121.
[115]Iranshahi M,Noroozi S,Behravan J,et al.Persicasulphide C,a new sulphur-containing derivative from Ferula persica[J].Nat Prod Res,2009,23(17):1584-1588.
[116]Abd El-Razek M H,Ohta S,Hirata T.Terpenoid coumarins of the genus Ferula[J].Heterocycles,2003,60(3):689-716.
[117]Alam M,Khan A,Wadood A,et al.Bioassay-guided isolation of sesquiterpene coumarins from Ferula narthex bioss:a new anticancer agent[J].Front Pharmacol,2016,7:26/1-26/6.
[118]Iranshahi M,Amanolahi F,Schneider B.New sesquiterpene coumarin from the roots of Ferula latisecta[J].Avicenna J Phytomed,2012,2(3):133-138.
[119]Abourashed E A,Galal A M,El-Feraly F S,et al.Separation and quantification of the major daucane esters of Ferula hermonis by HPLC[J].Planta Med,2001,67(7):681-682.
[120]Cha M R,Choi Y H,Choi C W,et al.Galbanic acid,a cytotoxic sesquiterpene from the gum resin of Ferula asafoetida,blocks protein farnesyltransferase[J].Planta Med,2011,77(1):52-54.
[121]Khasanov T Kh,Saidkhodzhaev A I,Nikonov G K.Structure of mogoltacin[J].Khim Prir Soedin,1976,12(1):95-96.
[122]Nazari Z E,Iranshahi M.Biologically active sesquiterpene coumarins from Ferula species[J].Phytother Res,2011,25(3):315-323.
[123]Iranshahi M,Kalategi F,Sahebkar A,et al.New sesquiterpene coumarins from the roots of Ferula flabelliloba[J].Pharm Biol,2010,48(2):217-220.
[124]Iranshahi M,Kalategi F,Rezaee R,et al.Cancer chemopreventive activity of terpenoid coumarins from Ferula species[J].Planta Med,2008,74(2):147-150.
[125]杨秀伟.中药新药有效成分研究及其标准制定的科学依据[J].中草药,2009,40(增刊):8-13,18.
[126]杨秀伟.中药物质基础研究是中药继承、发展、创新的关键科学问题[J].中国中药杂志,2015,40(17):3429-3434.