抗中性粒细胞胞浆抗体相关性血管炎神经系统病变的研究进展
摘要
抗中性粒细胞胞浆抗体相关性血管炎是以产生ANCA和小血管炎为特征的全身多系统受累的自身免疫性疾病。神经系统病变作为抗中性粒细胞胞浆抗体相关性血管炎常见的临床表现之一在临床上容易被忽视,因此容易被误诊、漏诊而耽误其治疗时机。本文主要从抗中性粒细胞胞浆抗体相关性血管炎神经系统病变的病理基础、临床特点、诊断、治疗和预后情况进行综述,以帮助临床医生重视和及早诊断治疗该疾病。
引文
[1] Pagnoux C. Updates in ANCA-associated vasculitis[J]. Eur J Rheumatol,2016,3(3):122-133.
[2] Sada KE, Yamamura M, Harigai M, et al. Classification and characteristics of Japanese patients with antineutrophil cytoplasmic antibody-associated vasculitis in a nationwide, prospective, inception cohort study[J]. Arthritis Res Ther,2014,16(2):R101.
[3] Morinaga A, Ono K, Komai K, et al. Microscopic polyangitis presenting with temporal arteritis and multiple cranial neuropathies[J]. J Neurol Sci,2007,256(1/2):81-83.
[4] 张文,周国庆,刘晓萍,等. 抗中性粒细胞胞质抗体相关性小血管炎的神经系统损害[J]. 中华风湿病学杂志,2008,12(2):104-107.
[5] Camara-Lemarroy CR, Infante-Valenzuela A, Villareal-Montemayor HJ, et al. Eosinophilic Granulomatosis with Polyangiitis Presenting as Acute Polyneuropathy Mimicking Guillain-Barre Syndrome[J]. Case Rep Neurol Med,2015,2015:981439.
[6] Collins MP, Dyck PJ, Gronseth GS, et al. Peripheral Nerve Society Guideline on the classification, diagnosis, investigation, and immunosuppressive therapy of non-systemic vasculitic neuropathy: executive summary[J]. J Peripher Nerv Syst,2010,15(3):176-184.
[7] Koike H, Sobue G. Clinicopathological features of neuropathy in anti-neutrophil cytoplasmic antibody-associated vasculitis[J]. Clin Exp Nephrol,2013,17(5):683-685.
[8] 孟德涛,王守春,赵璐,等. 以神经系统损害为首发症状的抗中性粒细胞胞质抗体相关性血管炎1例报道[J]. 中风与神经疾病杂志,2015,32(1):76-77.
[9] 彭子娟,包正军,曾国华,等. 抗中性粒细胞胞质抗体相关性系统性血管炎周围神经损伤临床与神经传导检测[J]. 癫癎与神经电生理学杂志,2013,22(3):164-166.
[10] Go MH, Park JU, Kang JG, et al. Subarachnoid and intracerebral hemorrhage in patients with churg-strauss syndrome: two case reports[J]. J Cerebrovasc Endovasc Neurosurg,2012,14(3):255-261.
[11] Ozaki Y, Tanaka A, Shimamoto K, et al. Effective intravenous immunoglobulin therapy for Churg-Strauss syndrome (allergic granulomatous angiitis) complicated by neuropathy of the eighth cranial nerve: a case report[J]. J Med Case Rep,2012,6(1):310.
[12] Comarmond C, Pagnoux C, Khellaf M, et al. Eosinophilic granulomatosis with polyangiitis (Churg-Strauss): clinical characteristics and long-term followup of the 383 patients enrolled in the French Vasculitis Study Group cohort[J]. Arthritis Rheum,2013,65(1):270-281.
[13] 王立,丽晶,钱敏,等. 显微镜下多血管炎周围神经病变的特点[J]. 中华医学杂志,2015,95(27):2190-2193.
[14] Cattaneo L, Chierici E, Pavone L, et al. Peripheral neuropathy in Wegener′s granulomatosis, Churg-Strauss syndrome and microscopic polyangiitis[J]. J Neurol Neurosurg Psychiatry,2007,78(10):1119-1123.
[15] Sakellariou GT, Kefala N. Pachymeningitis in granulomatosis with polyangiitis: a case report and a review of the literature[J]. Case Rep Rheumatol,2013,2013:840984.
[16] Wludarczyk A, Szczeklik W. Neurological manifestations in ANCA-associated vasculitis-assessment and treatment[J]. Expert Rev Neurother,2016,16(8):861-863.
[17] Ghinoi A, Zuccoli G, Pipitone N, et al. Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis involving the central nervous system: case report and review of the literature[J]. Clin Exp Rheumatol,2010,28(5):759-766.
[18] Matsuda H, Harada T, Ando Y, et al.Case of microscopic polyangiitis accompanied by central nervous system symptoms and brain vasculitis observed histopathologically[J]. Nihon Jinzo Gakkai Shi,2011,53(4):648-653.
[19] Mujagic S, Sarihodzic S, Huseinagic H, et al. Wegener′s granulomatosis of the paranasal sinuses with orbital and central nervous system involvement-diagnostic imaging[J]. Acta Neurol Belg,2011,111(3):241-244.
[20] Decker ML, Emery DJ, Smyth PS, et al. Microscopic Polyangiitis with Spinal Cord Involvement: A Case Report and Review of the Literature[J]. J Stroke Cerebrovasc Dis,2016,25(7):1696-1704.
[21] Taraschenko OD, Amory CF, Waldman J, et al. Lateral medullary stroke in patient with granulomatous polyangiitis[J]. J Stroke Cerebrovasc Dis,2014,23(5):1259-1261.
[22] Tsuda R, Taki H, Shinoda K, et al. Hypertrophic pachymeningitis in an individual with microscopic polyangiitis[J]. J Am Geriatr Soc,2013,61(6):1043-1044.
[23] Kumamoto M, Tomoda K, Furuya Y, et al. Hypertrophic Pachymeningitis as a Delayed Complication of Granulomatosis with Polyangiitis[J]. Intern Med,2016,55(4):413-417.
[24] Wolf J, Bergner R, Mutallib S, et al. Neurologic complications of Churg-Strauss syndrome——a prospective monocentric study[J]. Eur J Neurol,2010,17(4):582-588.
[25] Cheng MJ, Huang PH, Liao PW, et al. Multiple cerebral and cerebellar infarcts as the first clinical manifestation in a patient with Churg-Strauss syndrome: case report and literature review[J]. Acta Neurol Taiwan,2012,21(4):169-175.
[26] Aly Z, Libman R, Seidman R, et al. Ischemic and Hemorrhagic Strokes due to Eosinophilic Granulomatosis with Polyangiitis[J]. J Stroke Cerebrovasc Dis,2015,24(9):e279-e282.
[27] Murthy SB, Khalaf N, Shah S, et al. Churg-Strauss syndrome: an uncommon cause of intracerebral hemorrhage[J]. JAMA Neurol,2013,70(12):1580-1581.
[28] Suganuma K, Hashimoto T, Sato H, et al. Oculomotor Nerve Palsy following Cardiac Tamponade with Churg-Strauss Syndrome: A Case Report[J]. Case Rep Neurol,2011,3(3):274-277.
[29] Ku BD, Shin HY. Multiple bilateral non-hemorrhagic cerebral infarctions associated with microscopic polyangiitis[J]. Clin Neurol Neurosurg,2009,111(10):904-906.
[30] Takaoka H, Hashimoto A, Nogi S, et al. Case of granulomatosis with polyangiitis (Wegener′s granulomatosis) manifested with asymptomatic intracerebral hemorrhage[J]. Nihon Rinsho Meneki Gakkai Kaishi,2013,36(1):58-61.
[31] 崔思玲,夏红强,冷晓梅,等. 53例显微镜下多血管炎临床特点及预后[J]. 中华临床免疫和变态反应杂志,2014,8(4):300-305.
[32] Lucic AT, Veselinovic M, Pantovic S, et al. Granulomatosis with polyangitis (Wegener′s) and central nervous system involvement: case report[J]. Srp Arh Celok Lek,2015,143(1/2):83-86.
[33] 袁晶,关鸿志,吴庆军,等. 韦格纳肉芽肿病神经系统损害33例临床特点分析[J]. 中华神经科杂志,2004,37(5):48-50.
[34] 林森,张文. 抗中性粒细胞胞浆抗体相关性血管炎神经损害的病理和临床特点[J]. 中华临床免疫和变态反应杂志,2013,7(3):282-286.
[35] 刘冬舟,谭艳红,肖学吕,等. 变应性肉芽肿性血管炎69例荟萃分析[J]. 临床和实验医学杂志,2008,7(7):59-60.
[36] Koike H, Akiyama K, Saito T, et al. Intravenous immunoglobulin for chronic residual peripheral neuropathy in eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome): a multicenter, double-blind trial[J]. J Neurol,2015,262(3):752-759.
[2] Sada KE, Yamamura M, Harigai M, et al. Classification and characteristics of Japanese patients with antineutrophil cytoplasmic antibody-associated vasculitis in a nationwide, prospective, inception cohort study[J]. Arthritis Res Ther,2014,16(2):R101.
[3] Morinaga A, Ono K, Komai K, et al. Microscopic polyangitis presenting with temporal arteritis and multiple cranial neuropathies[J]. J Neurol Sci,2007,256(1/2):81-83.
[4] 张文,周国庆,刘晓萍,等. 抗中性粒细胞胞质抗体相关性小血管炎的神经系统损害[J]. 中华风湿病学杂志,2008,12(2):104-107.
[5] Camara-Lemarroy CR, Infante-Valenzuela A, Villareal-Montemayor HJ, et al. Eosinophilic Granulomatosis with Polyangiitis Presenting as Acute Polyneuropathy Mimicking Guillain-Barre Syndrome[J]. Case Rep Neurol Med,2015,2015:981439.
[6] Collins MP, Dyck PJ, Gronseth GS, et al. Peripheral Nerve Society Guideline on the classification, diagnosis, investigation, and immunosuppressive therapy of non-systemic vasculitic neuropathy: executive summary[J]. J Peripher Nerv Syst,2010,15(3):176-184.
[7] Koike H, Sobue G. Clinicopathological features of neuropathy in anti-neutrophil cytoplasmic antibody-associated vasculitis[J]. Clin Exp Nephrol,2013,17(5):683-685.
[8] 孟德涛,王守春,赵璐,等. 以神经系统损害为首发症状的抗中性粒细胞胞质抗体相关性血管炎1例报道[J]. 中风与神经疾病杂志,2015,32(1):76-77.
[9] 彭子娟,包正军,曾国华,等. 抗中性粒细胞胞质抗体相关性系统性血管炎周围神经损伤临床与神经传导检测[J]. 癫癎与神经电生理学杂志,2013,22(3):164-166.
[10] Go MH, Park JU, Kang JG, et al. Subarachnoid and intracerebral hemorrhage in patients with churg-strauss syndrome: two case reports[J]. J Cerebrovasc Endovasc Neurosurg,2012,14(3):255-261.
[11] Ozaki Y, Tanaka A, Shimamoto K, et al. Effective intravenous immunoglobulin therapy for Churg-Strauss syndrome (allergic granulomatous angiitis) complicated by neuropathy of the eighth cranial nerve: a case report[J]. J Med Case Rep,2012,6(1):310.
[12] Comarmond C, Pagnoux C, Khellaf M, et al. Eosinophilic granulomatosis with polyangiitis (Churg-Strauss): clinical characteristics and long-term followup of the 383 patients enrolled in the French Vasculitis Study Group cohort[J]. Arthritis Rheum,2013,65(1):270-281.
[13] 王立,丽晶,钱敏,等. 显微镜下多血管炎周围神经病变的特点[J]. 中华医学杂志,2015,95(27):2190-2193.
[14] Cattaneo L, Chierici E, Pavone L, et al. Peripheral neuropathy in Wegener′s granulomatosis, Churg-Strauss syndrome and microscopic polyangiitis[J]. J Neurol Neurosurg Psychiatry,2007,78(10):1119-1123.
[15] Sakellariou GT, Kefala N. Pachymeningitis in granulomatosis with polyangiitis: a case report and a review of the literature[J]. Case Rep Rheumatol,2013,2013:840984.
[16] Wludarczyk A, Szczeklik W. Neurological manifestations in ANCA-associated vasculitis-assessment and treatment[J]. Expert Rev Neurother,2016,16(8):861-863.
[17] Ghinoi A, Zuccoli G, Pipitone N, et al. Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis involving the central nervous system: case report and review of the literature[J]. Clin Exp Rheumatol,2010,28(5):759-766.
[18] Matsuda H, Harada T, Ando Y, et al.Case of microscopic polyangiitis accompanied by central nervous system symptoms and brain vasculitis observed histopathologically[J]. Nihon Jinzo Gakkai Shi,2011,53(4):648-653.
[19] Mujagic S, Sarihodzic S, Huseinagic H, et al. Wegener′s granulomatosis of the paranasal sinuses with orbital and central nervous system involvement-diagnostic imaging[J]. Acta Neurol Belg,2011,111(3):241-244.
[20] Decker ML, Emery DJ, Smyth PS, et al. Microscopic Polyangiitis with Spinal Cord Involvement: A Case Report and Review of the Literature[J]. J Stroke Cerebrovasc Dis,2016,25(7):1696-1704.
[21] Taraschenko OD, Amory CF, Waldman J, et al. Lateral medullary stroke in patient with granulomatous polyangiitis[J]. J Stroke Cerebrovasc Dis,2014,23(5):1259-1261.
[22] Tsuda R, Taki H, Shinoda K, et al. Hypertrophic pachymeningitis in an individual with microscopic polyangiitis[J]. J Am Geriatr Soc,2013,61(6):1043-1044.
[23] Kumamoto M, Tomoda K, Furuya Y, et al. Hypertrophic Pachymeningitis as a Delayed Complication of Granulomatosis with Polyangiitis[J]. Intern Med,2016,55(4):413-417.
[24] Wolf J, Bergner R, Mutallib S, et al. Neurologic complications of Churg-Strauss syndrome——a prospective monocentric study[J]. Eur J Neurol,2010,17(4):582-588.
[25] Cheng MJ, Huang PH, Liao PW, et al. Multiple cerebral and cerebellar infarcts as the first clinical manifestation in a patient with Churg-Strauss syndrome: case report and literature review[J]. Acta Neurol Taiwan,2012,21(4):169-175.
[26] Aly Z, Libman R, Seidman R, et al. Ischemic and Hemorrhagic Strokes due to Eosinophilic Granulomatosis with Polyangiitis[J]. J Stroke Cerebrovasc Dis,2015,24(9):e279-e282.
[27] Murthy SB, Khalaf N, Shah S, et al. Churg-Strauss syndrome: an uncommon cause of intracerebral hemorrhage[J]. JAMA Neurol,2013,70(12):1580-1581.
[28] Suganuma K, Hashimoto T, Sato H, et al. Oculomotor Nerve Palsy following Cardiac Tamponade with Churg-Strauss Syndrome: A Case Report[J]. Case Rep Neurol,2011,3(3):274-277.
[29] Ku BD, Shin HY. Multiple bilateral non-hemorrhagic cerebral infarctions associated with microscopic polyangiitis[J]. Clin Neurol Neurosurg,2009,111(10):904-906.
[30] Takaoka H, Hashimoto A, Nogi S, et al. Case of granulomatosis with polyangiitis (Wegener′s granulomatosis) manifested with asymptomatic intracerebral hemorrhage[J]. Nihon Rinsho Meneki Gakkai Kaishi,2013,36(1):58-61.
[31] 崔思玲,夏红强,冷晓梅,等. 53例显微镜下多血管炎临床特点及预后[J]. 中华临床免疫和变态反应杂志,2014,8(4):300-305.
[32] Lucic AT, Veselinovic M, Pantovic S, et al. Granulomatosis with polyangitis (Wegener′s) and central nervous system involvement: case report[J]. Srp Arh Celok Lek,2015,143(1/2):83-86.
[33] 袁晶,关鸿志,吴庆军,等. 韦格纳肉芽肿病神经系统损害33例临床特点分析[J]. 中华神经科杂志,2004,37(5):48-50.
[34] 林森,张文. 抗中性粒细胞胞浆抗体相关性血管炎神经损害的病理和临床特点[J]. 中华临床免疫和变态反应杂志,2013,7(3):282-286.
[35] 刘冬舟,谭艳红,肖学吕,等. 变应性肉芽肿性血管炎69例荟萃分析[J]. 临床和实验医学杂志,2008,7(7):59-60.
[36] Koike H, Akiyama K, Saito T, et al. Intravenous immunoglobulin for chronic residual peripheral neuropathy in eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome): a multicenter, double-blind trial[J]. J Neurol,2015,262(3):752-759.