医用同位素生产现状及技术展望
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摘要
本文概述同位素生产技术,介绍医用同位素生产现状,分析供求关系和面临的问题,提出医用同位素的发展趋势和技术展望。随着核医学迅速发展,医用同位素在疾病诊断和临床治疗中发挥越来越重要的作用。我国人口基数庞大,国内医用同位素主要依赖进口。建立产能高、安全性好的医用同位素生产堆有望突破核医学的发展瓶颈。传统反应堆同位素生产技术仍有优化空间,新型反应堆同位素生产技术亟待研究和推广,不依赖反应堆的同位素生产技术仍具有一定的市场前景。
The isotope production technology was overviewed,including traditional and newest technology.The current situation of medical isotope production was introduced.The problems faced by isotope supply and demand were analyzed.The future development trend of medical isotopes and technology prospect were put forward.As the most populous country,nuclear medicine develops rapidly,however,domestic isotope mainly relies on imports.The highly productive and relatively safe MIPR is expected to be an effective way to breakthrough the bottleneck of the development of nuclear medicine.Traditional isotope production technologies with reactor can be improved.It's urgent to research and promote new isotope production technologies with reactor.Those technologies which do not depend on reactor will have a bright market prospects.
The isotope production technology was overviewed,including traditional and newest technology.The current situation of medical isotope production was introduced.The problems faced by isotope supply and demand were analyzed.The future development trend of medical isotopes and technology prospect were put forward.As the most populous country,nuclear medicine develops rapidly,however,domestic isotope mainly relies on imports.The highly productive and relatively safe MIPR is expected to be an effective way to breakthrough the bottleneck of the development of nuclear medicine.Traditional isotope production technologies with reactor can be improved.It's urgent to research and promote new isotope production technologies with reactor.Those technologies which do not depend on reactor will have a bright market prospects.
引文
[1]Glenn D,Heger A S,Hladik W B.Comparison of characteristics of solution and conventional reactors for 99 Mo production[J].Nuclear Technology,1997,118:142-150.
[2]Sciuto R,Festa A,Pasqualonir R,et al.Metastatic bone pain palliation with 89-Sr and 186-ReHEDP in breast cancer patients[J].Br Cancer Res Treat,2001,66(2):101-109.
[3]Lane J A,Macpherson H G,Maslan F.Fluid Fuel Reactors[M].Massachusetts:AddisonWesley Publishing Co Inc,1958.
[4]Method of 89Sr medical radioisotope production:US,538333[P].2002-01-22.
[5]Souta F J,Kimpland R H.Analysis of the effects of radiolytic-gas bubbles on the operation of solution reactors for the production of medical isotopes[J].Nuclear Science and Engineer,2005,150:322-335.
[6]Chuvilin D Y,Khvostionov V E,Markovskij D V,et al.Production of 89Sr in solution reactor[J].Applied Radiation and Isotopes,2007,65:1 087-1 094.
[7]Ball R M.Characteristic of nuclear reactors used for the production 99 Mo[R].USA:Ball Systems Company,1997.
[8]Maria L.Alternative production methods to face global molybdenum-99supply shortage[J].Hellenic Journal of Nuclear Medicine,2011,14(1):49-55.
[9]李明起,邓启民.医用放射性同位素生产现状和主要问题[J].同位素,2013,26(3):186-191.Li Mingqi,Deng Qimin.Production and application of medical radionuclide:status and urgent problems to be resolved in China[J].Journal of Isotopes,2013,26(3):186-191(in Chinese).
[10]王刚,向学琴,傅红宇,等.应用溶液堆生产裂变99 Mo[J].同位素,2004,17(4):247-249.Wang Gang,Xiang Xueqin,Fu Hongyu,et al.The production of fission 99 Mo using a solution reactor[J].Journal of Isotopes,2004,17(4):247-249(in Chinese).
[11]Sameh A A,Ache H J.Production techniques of fission 99 Mo[M]∥IAEA.IAEA-TECDOC-515.Karlsruhe:[s.n.],1987:13-16.
[12]Khvostionov V Y E,Pavshook V A,Talyzin V M.Studies of the opportunity to convert the ARGUS-90research reactor with 90%fuel enrichment in U-235to low enriched fuel(20%):RERTR Conference[C].Wyoming:Argonne National Lab,1997:5-10.
[13]邓启民,李茂良,程作用.利用医用同位素生产堆生产89Sr[J].同位素,2007,20(3):185-188.Deng Qimin,Li Maoliang,Cheng Zuoyong.Strontium-99production through medical isotope production reactor(MIPR)[J].Journal of Isotopes,2007,20(3):185-188(in Chinese).
[2]Sciuto R,Festa A,Pasqualonir R,et al.Metastatic bone pain palliation with 89-Sr and 186-ReHEDP in breast cancer patients[J].Br Cancer Res Treat,2001,66(2):101-109.
[3]Lane J A,Macpherson H G,Maslan F.Fluid Fuel Reactors[M].Massachusetts:AddisonWesley Publishing Co Inc,1958.
[4]Method of 89Sr medical radioisotope production:US,538333[P].2002-01-22.
[5]Souta F J,Kimpland R H.Analysis of the effects of radiolytic-gas bubbles on the operation of solution reactors for the production of medical isotopes[J].Nuclear Science and Engineer,2005,150:322-335.
[6]Chuvilin D Y,Khvostionov V E,Markovskij D V,et al.Production of 89Sr in solution reactor[J].Applied Radiation and Isotopes,2007,65:1 087-1 094.
[7]Ball R M.Characteristic of nuclear reactors used for the production 99 Mo[R].USA:Ball Systems Company,1997.
[8]Maria L.Alternative production methods to face global molybdenum-99supply shortage[J].Hellenic Journal of Nuclear Medicine,2011,14(1):49-55.
[9]李明起,邓启民.医用放射性同位素生产现状和主要问题[J].同位素,2013,26(3):186-191.Li Mingqi,Deng Qimin.Production and application of medical radionuclide:status and urgent problems to be resolved in China[J].Journal of Isotopes,2013,26(3):186-191(in Chinese).
[10]王刚,向学琴,傅红宇,等.应用溶液堆生产裂变99 Mo[J].同位素,2004,17(4):247-249.Wang Gang,Xiang Xueqin,Fu Hongyu,et al.The production of fission 99 Mo using a solution reactor[J].Journal of Isotopes,2004,17(4):247-249(in Chinese).
[11]Sameh A A,Ache H J.Production techniques of fission 99 Mo[M]∥IAEA.IAEA-TECDOC-515.Karlsruhe:[s.n.],1987:13-16.
[12]Khvostionov V Y E,Pavshook V A,Talyzin V M.Studies of the opportunity to convert the ARGUS-90research reactor with 90%fuel enrichment in U-235to low enriched fuel(20%):RERTR Conference[C].Wyoming:Argonne National Lab,1997:5-10.
[13]邓启民,李茂良,程作用.利用医用同位素生产堆生产89Sr[J].同位素,2007,20(3):185-188.Deng Qimin,Li Maoliang,Cheng Zuoyong.Strontium-99production through medical isotope production reactor(MIPR)[J].Journal of Isotopes,2007,20(3):185-188(in Chinese).