精神科常用中草药的微量元素检测
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摘要
目的分析柴胡、姜半夏、淡竹叶、夏枯草、白术、玫瑰花、生地、丹参、甘草、百合、黄芪和黄连这12种精神科常用中草药中的铍、钠、镁、钾、钙、钒、铬、锰、铁、钴、镍、铜、锌、砷、硒、钼、镉、锑、钡、汞、铊、铅、钍和铀水平。方法选取精神科常用12种中草药作为研究对象,利用电感耦合等离子体质谱法测定微波消解法制备后样品中的24种微量元素水平,对测定结果进行分析、比较。结果各元素在参考范围内线性良好,相关系数均大于0.999,加标回收率为91.14%～113.01%,相对标准偏差(n=6)为2.9%～6.5%。结论微量元素的总量在12种不同中草药中的差异较大,不同中草药中不同微量元素的水平分布不同。
Objective To analyze the beryllium,sodium,magnesium,potassium,calcium,vanadium,chromium,manganese,iron,cobalt,nickel,copper,zinc,arsenic,selenium,molybdenum,cadmium,antimony,barium,mercury,thallium,lead and thorium and uranium 12 kinds of traditional Chinese medicine.Methods Inductively coupled plasma masss pectrometry(ICP-MS)was used to determine 24 kinds of trace elements levels in12 kinds of traditional Chinese medicine prepared by microwave digestion,the results were analyzed and compared.Results The standard curves of each element had good linear relation,the correlative coefficients for all elements were above 0.999,the standard recovery ranged from 91.14%to 113.01%,relative standard deviation(n=6)ranged from 2.9%to 6.5%.Conclusion The total amount of trace elements varied greatly among the 12 different traditional Chinese medicines,and the contents and the distribution of different trace elements in traditional Chinese medicine were different.
Objective To analyze the beryllium,sodium,magnesium,potassium,calcium,vanadium,chromium,manganese,iron,cobalt,nickel,copper,zinc,arsenic,selenium,molybdenum,cadmium,antimony,barium,mercury,thallium,lead and thorium and uranium 12 kinds of traditional Chinese medicine.Methods Inductively coupled plasma masss pectrometry(ICP-MS)was used to determine 24 kinds of trace elements levels in12 kinds of traditional Chinese medicine prepared by microwave digestion,the results were analyzed and compared.Results The standard curves of each element had good linear relation,the correlative coefficients for all elements were above 0.999,the standard recovery ranged from 91.14%to 113.01%,relative standard deviation(n=6)ranged from 2.9%to 6.5%.Conclusion The total amount of trace elements varied greatly among the 12 different traditional Chinese medicines,and the contents and the distribution of different trace elements in traditional Chinese medicine were different.
引文
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[2]田柱萍,何邦平,王小燕,等.中草药材的药效与其所含微量元素关系的研究进展[J].微量元素与健康研究,2005,22(4):54-56.
[3]章颖慧,王秀英,杨明,等.中草药有害残留物限量制定原则及其影响因素[J].药物分析杂志,2015,35(3):558-567.
[4]中华人民共和国对外贸易经济合作部发部.药用植物及制剂进出口绿色行业标准:WM2-2001[S].北京:中华人民共和国对外贸易经济合作部发部,2001.
[5]张伯礼,张俊华.中医药现代化研究20年回顾与展望[J].中国中草药杂志,2015,40(17):3331-3334.
[6]赵艳青,滕晶.基于中医传承辅助平台系统精神分裂症的组方用药规律分析[J].中国中医急症,2014,23(11):1980-1983.
[7]姜敏.浅谈王琦教授治疗失眠的经验与思路[J].北京中医药大学学报,2010,33(6):425-426.
[8]王永志,杜仪,韩玉,等.柴胡疏肝散对抑郁症大鼠海马神经递质含量的影响[J].北京中医药,2014,33(1):50-53.
[9]刘绛云,陈炯华.清心安神颗粒治疗失眠之痰热扰心证的临床观察[J].南京中医药大学学报,2014,30(3):217-220.
[10]金慧英,胡惠民,周雍,等.急性镉中毒的肝脏损伤机制及金属硫蛋白的保护作用[J].中华劳动卫生职业病杂志,1998,16(1):45-48.
[11]赵静,刘勇,张艾华,等.不同产地三七中重金属元素的含量测定及分析[J].中国中草药杂志,2014,39(20):4001-4006.
[12]卢丹,周凌,赵月然.ICP-MS法测定减肥类保健品中重金属的含量[J].中国药物评价,2016,33(5):414-416.