新型电磁搏动式血泵的实验研究
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摘要
目的探究一种新型电磁搏动式血泵的动力输出性能及血液相容性。方法首先通过建立理论模型对该血泵驱动力进行分析,并基于该模型计算出满足条件的实验驱动电压。设计体外模拟循环实验,对新型血泵的输出流量和输出压力特性及血泵的体外溶血性能进行初步实验研究。结果实验测得当血泵后负荷为73.5 mmHg(9.78 kPa, 1 mmHg=0.133 kPa)、驱动电压达到35 V、搏动频率为75/min时,实际输出的流量为3.18 L/min,可以提供高压132 mmHg(17.56 kPa)、低压66 mmHg(8.78 kPa)、平均压力98 mmHg(13.03 kPa),体外实验标准溶血指数(normalized index of haematolysis, NIH)为(0.049 15±0.003 75) mg/dL。结论该新型搏动式血泵能够满足离体器官灌注和体外循环短期辅助的临床要求,对体外循环血泵的发展具有重要意义。
Objective To explore the power output and blood compatibility of a novel electromagnetic pulsatile blood pump. Methods First, a theoretical model was established to analyze the driving force of the blood pump, and the experimental driving voltage satisfying the conditions was calculated based on this model. Then, the output flow rate, output pressure characteristics and hemolysis performance of the new blood pump in vitro were preliminarily analyzed by simulated circulation experiments. Results The experimental result showed that when the pump load was 73.5 mmHg(9.78 kPa, 1 mmHg=0.133 kPa), the driving voltage was 35 V and the pulsation frequency was 75 beats/min, the flow rate of the pump was 3.18 L/min, producing high, low and average pressure of 132, 66, 98 mmHg(17.56, 8.78, 13.03 kPa), and the normalized index of haematolysis(NIH) in vitro was(0.049 15+0.003 75) mg/dL. Conclusions The new pulsatile blood pump can satisfy the clinical requirements for perfusion of isolated organs and short-term assistance of cardiopulmonary bypass, which is of great significance to the development of cardiopulmonary bypass blood pump.
Objective To explore the power output and blood compatibility of a novel electromagnetic pulsatile blood pump. Methods First, a theoretical model was established to analyze the driving force of the blood pump, and the experimental driving voltage satisfying the conditions was calculated based on this model. Then, the output flow rate, output pressure characteristics and hemolysis performance of the new blood pump in vitro were preliminarily analyzed by simulated circulation experiments. Results The experimental result showed that when the pump load was 73.5 mmHg(9.78 kPa, 1 mmHg=0.133 kPa), the driving voltage was 35 V and the pulsation frequency was 75 beats/min, the flow rate of the pump was 3.18 L/min, producing high, low and average pressure of 132, 66, 98 mmHg(17.56, 8.78, 13.03 kPa), and the normalized index of haematolysis(NIH) in vitro was(0.049 15+0.003 75) mg/dL. Conclusions The new pulsatile blood pump can satisfy the clinical requirements for perfusion of isolated organs and short-term assistance of cardiopulmonary bypass, which is of great significance to the development of cardiopulmonary bypass blood pump.
引文
[1] 张岩,孙寒松,胡盛寿.左心室辅助血泵及其临床应用研究进展[J].中国胸心血管外科临床杂志,2017,24(2):152-155.
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[15] 路力军,胡兆燕,陈正龙,等.体外循环用血泵研究进展[J].北京生物医学工程,2012,31(4):433-439.
[16] 刘京京,葛斌,陆通,等.短期辅助用直流电磁驱动搏动式血泵设计与测试[J].中国生物医学工程学报,2018(1):49-56.
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[18] 李冰一,蔺嫦燕,姜以岭,等.三种叶片式血泵的体外溶血试验研究[J].北京生物医学工程,2001,20(3):212-214.
[19] TANSLEY GD,COOK MC,WOODARD JC.Axial flow blood pump:USA,US7798952 [P].2010.
[2] JAMIESON RW,FRIENG PJ.Organ reperfusion and preservation [J].Front Biosci,2008,13(13):221-229.
[3] VOIGT O,KAUFMANN F.Engineering and clinical considerations in pulsatile blood pump [M]//Mechanical Circulatory Support in End-Stage Heart Failure.Switzerland:Springer,2017.
[4] 韩元杰,杨明.搏动型血泵驱动系统的探讨[J].中国医疗器械杂志,2009,33(1):1-6.
[5] 胡卫,肖颖彬.微型体外循环应用的进展[J].重庆医学,2009,38(6):711-713.
[6] 吴广辉,蔺嫦燕,李冰一,等.自制轴流血泵溶血实验[J].中国生物医学工程学报,2007,26(5):793-795.
[7] 谭江浩,葛斌,方旭晨,等.磁耦合驱动搏动式血泵的可行性研究[J].医用生物力学,2015,30(5):458-462.TAN JH,GE B,FANG XC,et al.Feasibility study on magnetic coupling-driven pulsate blood pump [J].J Med Biomech,2015,30(5):458-462.
[8] 张磊,葛斌,张少伟,等.搏动式血泵的电磁驱动装置设计及可行性研究[J].生物医学工程研究,2018,37(4):470-475.
[9] BABIC S,SIROIS F,AKYEL C,et al.New formulas for mutual inductance and axial magnetic force between a thin wall solenoid and a thick circular coil of rectangular cross-section [J].IEEE T Magn,2011,47(8):2034-2044.
[10] ROBERTSON W,CAZZOLATO B,ZANDER A.Axial force between a thick coil and a cylindrical permanent magnet:Optimizing the geometry of an electromagnetic actuator [J].IEEE T Magn,2012,48(9):2479-2487.
[11] BABIC S,AKYEL C.Calculation of mutual inductance and magnetic force between two thick coaxial Bitter coils of rectangular cross section [J].IET Electr Power App,2017,11(3):441-446.
[12] RAVAUD R,LEMARQUAND G,BABIC S,et al.Cylindrical magnets and coils:Fields,forces,and inductances [J].IEEE T Magn,2010,46(9):3585-3590.
[13] 黄柊喻,党维国,陈琛,等.完全磁悬浮心室辅助装置的体外模拟循环系统实验研究[J].医用生物力学,2017,32(2):174-180.HUANG ZY,DANG WG,CHEN C,et al.In vitro simulation experimental study of a fully magnetically levitated ventricular assist device based on mock circulatory system [J].J Med Biomech,,2017,32(2):174-180.
[14] MIZUGUCHI K,DAMM G,BENKOWSKY R,et al.Development of an axial flow ventricular assist device:In vitro and in vivo evaluation [J].Artif Organs,2010,19(7):653-659.
[15] 路力军,胡兆燕,陈正龙,等.体外循环用血泵研究进展[J].北京生物医学工程,2012,31(4):433-439.
[16] 刘京京,葛斌,陆通,等.短期辅助用直流电磁驱动搏动式血泵设计与测试[J].中国生物医学工程学报,2018(1):49-56.
[17] BOCK E,ANTUNES P,LEAO T,et al.Implantable centrifugal blood pump with dual impeller and double pivot bearing system:Electromechanical actuator,prototyping,and anatomical studies [J].Artif Organs,2011,35(5):437-442.
[18] 李冰一,蔺嫦燕,姜以岭,等.三种叶片式血泵的体外溶血试验研究[J].北京生物医学工程,2001,20(3):212-214.
[19] TANSLEY GD,COOK MC,WOODARD JC.Axial flow blood pump:USA,US7798952 [P].2010.