摘要
1例8岁患儿,诊断为"性早熟",第6次皮下注射重组人生长激素后10 min出现呕吐、腹痛,20 min后自行缓解;次日晨起诉恶心、双上肢酸痛,后自动缓解。停药后,患儿上述症状均未再出现。经分析,该患儿的呕吐和腹痛症状是由重组人生长激素药物本身或辅料苯酚的不良反应导致的。临床上如出现上述情况,应立即停药就医,及时缓解不良反应症状,并寻找治疗原疾病的替代药物。
An 8-year-old child was diagnosed as "precocious puberty". The 6 th subcutaneous injection of recombinant human growth hormone was followed by vomiting and abdominal pain for 10 min and spontaneous remission for 20 min.The next morning, the child complained of nausea and pain in both upper limbs. After withdraw of drugs, the above symptoms did not appear again. After analysis, the symptoms of vomiting and abdominal pain in the child were caused by adverse drug reactions of the recombinant human growth hormone itself or the excipient phenol. In clinical practice, in case of the above situation occurs, it is necessary to stop drugs and seek medical advice immediately, relieve the symptoms of adverse drug reaction in time, and look for alternative drugs for the original disease.
引文
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