ArcCheck系统在TrueBeam加速器非均整模式下剂量验证中的应用
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摘要
目的:研究Arc Check验证系统在非均整模式(flattening filter free,FFF)下立体定向放射治疗(stereotactic radiotherapy,SRT)剂量验证中的应用。方法:将76例SRT治疗计划导入Arc Check模体重新计算,阈值标准分别选择(3%,3 mm,10%)和(2%,2 mm,10%)时,分别采用等值间距法(distance to agree,DTA)和Gamma分析法比较Arc Check模体中计算的剂量与Arc Check模体实测的剂量差异。结果:标准为(3%,3 mm,10%)时,SRT计划的两种分析法的相对通过率和绝对通过率的均值均大于95%;标准为(2%,2 mm,10%)时,SRT计划的两种分析法的相对通过率和绝对通过率的均值均约90%。Gamma分析法的剂量通过率高于DTA分析法剂量通过率(P<0.001)。结论:Arc Check验证系统是一种快捷准确的SRT剂量验证方法,采用不同的分析方法其验证结果有一定差异。
Objective: To study the feasibility of Arc Check verification system in dosimetric verification for stereotactic radiotherapy(SRT) the stereotactic radiotherapy(SRT) with f lat t ening filter free(FFF) model. Methods: A total of 76 cases under SRT treatment plans were introduced into Arc Check phantom and recalculated. Threshold criteria was set as(3%, 3 mm, 10%) or(2%, 2 mm, 10%). Th e calculated dose distribution and the measured dose distribution of Arc Check phantom were compared by means of distance to agree(DTA) and Gamma analysis method respectively.Results: Based on the threshold criteria(3%, 3 mm, 10%), the relative and absolute mean pass rates of SRT treatment plans by DTA and Gamma analysis were greater than 95%. Based on the threshold criteria(2%, 2 mm, 10%), the relative and absolute mean pass rates of SRT treatment plan by DTA and Gamma analysis were about 90%. The dose pass rate of Gamma analysis method was slightly higher than that of DTA analysis method(P<0.001). Conclusion: The Arc Check verification system is a rapid and accurate method for SRT dose verification, and discrepancies are found in different analysis methods.
Objective: To study the feasibility of Arc Check verification system in dosimetric verification for stereotactic radiotherapy(SRT) the stereotactic radiotherapy(SRT) with f lat t ening filter free(FFF) model. Methods: A total of 76 cases under SRT treatment plans were introduced into Arc Check phantom and recalculated. Threshold criteria was set as(3%, 3 mm, 10%) or(2%, 2 mm, 10%). Th e calculated dose distribution and the measured dose distribution of Arc Check phantom were compared by means of distance to agree(DTA) and Gamma analysis method respectively.Results: Based on the threshold criteria(3%, 3 mm, 10%), the relative and absolute mean pass rates of SRT treatment plans by DTA and Gamma analysis were greater than 95%. Based on the threshold criteria(2%, 2 mm, 10%), the relative and absolute mean pass rates of SRT treatment plan by DTA and Gamma analysis were about 90%. The dose pass rate of Gamma analysis method was slightly higher than that of DTA analysis method(P<0.001). Conclusion: The Arc Check verification system is a rapid and accurate method for SRT dose verification, and discrepancies are found in different analysis methods.
引文
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[8]董可,黄拔群,刘跃龙,等.头颈部肿瘤调强放疗计划的剂量验证研究[J].中国现代医学杂志,2014,24(12):42-46.DONG Ke,HUANG Baqun,LIU Yuelong,et al.Clinical study on dose verification of IMRT for head and neck cancer[J].China Journal of Modern Medicine,2014,24(12):42-46.
[9]Prendergast BM,Fiveash JB,Popple RA,et al.Flattening filter-free linac improves treatment delivery efficiency in stereotactic body radiation therapy[J].J Appl Clin Med Phys,2013,14(3):64-71.
[10]Benedict SH,Yenice KM,Followill D,et al.Stereotactic body radiation therapy:The report of AAPM Task Group 101[J].Med Phys,2010,37(8):4078-4101.
[11]Yan G,Lu B,Kozelka J,et al.Calibration of a novel four-dimensional diode array[J].Med Phys,2010,37(1):108-115.
[12]黎旦,宾石珍,程品晶,等.非晶硅电子射野影像系统与Arc CHECK在直肠癌容积旋转调强剂量验证中的应用[J].中国医学物理杂志,2016,33(7):674-677.LI Dan,BIN Shizhen,CHENG Pinjing,et al.A-Si EPID and Arc CHECK dosimetric verification for VMAT of rectum cancer[J].Chinese Journal of Medical Physics,2016,33(7):674-677.
[13]李成强,李光俊,冀传仙,等.Arc Check半导体探头特性及在容积调强弧形治疗剂量验证应用研究[J].中华放射肿瘤学杂志,2013,23(3):235-238.LI Chengqiang,LI Guangjun,JI Chuanxian,et al.The characteristies and clinical application of the Arc Check diode array for volumetric modulated arc therapy verification[J].Chinese Journal Radiation Oncology,2013,23(3):235-238.
[14]苗利,孙彦泽,李新民.放射治疗剂量验证中常用剂量分布比较方法及分析[J].辐射研究与辐射工艺学报,2012,30(4):247-251.MIAO Li,SUN Yanze,LI Xinmin.Analysis of the most commonly used dose distribution comparison methods in radiotherapy dosimetric verification[J].Journal of Radiation Research and Radiation Processing,2012,30(4):247-251.
[2]Kalantzis G,Qian J,Han B,et al.Fidelity of dose delivery at high dose rate of volumetric modulated arc therapy in a True Beam linac with flattening filter free beams[J].Med Phys,2012,37(4):193-199.
[3]张基永,张武哲,陆佳扬,等.True Beam加速器无均整滤过器6MV X射线SBRT疗计划的剂量验证评估[J].中国医学物理杂志,2015,34(4):510-513.ZHANG Jiyong,ZHANG Wuzhe,LU Jiayang,et al.Dose verification and assessment of stereotactic body radiation therapy plans based on True Beam accelerator with the 6 MV X-ray of flattening filter free[J].Chinese Journal of Medical Physics,2015,34(4):510-513.
[4]Tambe NS,Fryer A,Marsden JE,et al.Determination of clinically appropriate flattening filter free(FFF)energy for treating lung SABR using reatment plans and delivery measurements[J].Biomed Phys Eng Express,2016,2(6):1-8.
[5]Cozzolino M,Oliviero C,Califano G,et al.Clinically relevant quality assurance(QA)for prostate Rapid Arc plans:Gamma maps and DVH-based evaluation[J].Phys Med,2014,30:462-472.
[6]Chaswal V,Weldon M,Gupta N,et al.Commissioning and comprehensive evaluation of the Arc Clendheck cylindrical diode array for VMAT pretreatment delivery QA[J].J Appl Clin Med Phys,2014,15(4):212-225.
[7]李定杰,张有改,薛莹,等.早期NSCLC无均整器模式VMAT计划剂量比较研究[J].中华放射肿瘤学杂志,2017,26(1):53-57.LI Dingjie,ZHANG Yougai,XUE Ying,et al.The comparison of plan dose and dose verification involumetric modulated arc therapy for early stage non-small cell lung cancer with non-flattening filter[J].Chinese Journal Radiotion Oncology,2017,26(1):53-57.
[8]董可,黄拔群,刘跃龙,等.头颈部肿瘤调强放疗计划的剂量验证研究[J].中国现代医学杂志,2014,24(12):42-46.DONG Ke,HUANG Baqun,LIU Yuelong,et al.Clinical study on dose verification of IMRT for head and neck cancer[J].China Journal of Modern Medicine,2014,24(12):42-46.
[9]Prendergast BM,Fiveash JB,Popple RA,et al.Flattening filter-free linac improves treatment delivery efficiency in stereotactic body radiation therapy[J].J Appl Clin Med Phys,2013,14(3):64-71.
[10]Benedict SH,Yenice KM,Followill D,et al.Stereotactic body radiation therapy:The report of AAPM Task Group 101[J].Med Phys,2010,37(8):4078-4101.
[11]Yan G,Lu B,Kozelka J,et al.Calibration of a novel four-dimensional diode array[J].Med Phys,2010,37(1):108-115.
[12]黎旦,宾石珍,程品晶,等.非晶硅电子射野影像系统与Arc CHECK在直肠癌容积旋转调强剂量验证中的应用[J].中国医学物理杂志,2016,33(7):674-677.LI Dan,BIN Shizhen,CHENG Pinjing,et al.A-Si EPID and Arc CHECK dosimetric verification for VMAT of rectum cancer[J].Chinese Journal of Medical Physics,2016,33(7):674-677.
[13]李成强,李光俊,冀传仙,等.Arc Check半导体探头特性及在容积调强弧形治疗剂量验证应用研究[J].中华放射肿瘤学杂志,2013,23(3):235-238.LI Chengqiang,LI Guangjun,JI Chuanxian,et al.The characteristies and clinical application of the Arc Check diode array for volumetric modulated arc therapy verification[J].Chinese Journal Radiation Oncology,2013,23(3):235-238.
[14]苗利,孙彦泽,李新民.放射治疗剂量验证中常用剂量分布比较方法及分析[J].辐射研究与辐射工艺学报,2012,30(4):247-251.MIAO Li,SUN Yanze,LI Xinmin.Analysis of the most commonly used dose distribution comparison methods in radiotherapy dosimetric verification[J].Journal of Radiation Research and Radiation Processing,2012,30(4):247-251.