贵金属纳米材料用于生物成像研究进展
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摘要
贵金属纳米材料在光稳定性、光信号强度、生物兼容性等方面具有其他材料无法比拟的优势,已成功应用于各科学研究领域,尤其是在生命科学与生物医学研究等方面具有广阔的应用前景。本文简介贵金属纳米材料在荧光成像、拉曼成像、暗场成像的成像原理及优缺点,综述贵金属纳米材料在生物成像方面的最新研究进展。随着纳米合成技术的快速发展及检测手段的提高,贵金属纳米材料将会从基础的科学研究领域更全面地走向实际应用。而单分子光谱和光学显微成像技术取得了长足的进步,很有可能带给生物成像表征手段一次全新的革命。
Noble metal nanomaterials, with the unique characteristics including light stability, strong optical signal, good bio-compatibility and so on, have incomparable advantages over other materials. They have been successfully utilized in various scientific and living areas,with broad application prospects in the area of life science and biological medicine, attracting more and more attention all over the world.This article simply summarizes the advantages and disadvantages of fluorescence imaging, Raman imaging, and the imaging principle of dark field imaging. The dark field imaging detecting scattered light of nanomaterials can eliminate effectively the background interference of sample, which has a lot of incomparable advantages. We review the latest research progress and prospect in biological imaging of noble metal nanomaterials. With the rapid development of nanometer composite technology and the improvement of detection means, noble metal nanomaterials will be brought from fundamental scientific research into practical application. And single molecular spectroscopy and optical microscopic imaging technology has made great progress, which is likely to bring new revolution in biological imaging characterization.
Noble metal nanomaterials, with the unique characteristics including light stability, strong optical signal, good bio-compatibility and so on, have incomparable advantages over other materials. They have been successfully utilized in various scientific and living areas,with broad application prospects in the area of life science and biological medicine, attracting more and more attention all over the world.This article simply summarizes the advantages and disadvantages of fluorescence imaging, Raman imaging, and the imaging principle of dark field imaging. The dark field imaging detecting scattered light of nanomaterials can eliminate effectively the background interference of sample, which has a lot of incomparable advantages. We review the latest research progress and prospect in biological imaging of noble metal nanomaterials. With the rapid development of nanometer composite technology and the improvement of detection means, noble metal nanomaterials will be brought from fundamental scientific research into practical application. And single molecular spectroscopy and optical microscopic imaging technology has made great progress, which is likely to bring new revolution in biological imaging characterization.
引文
[1]Liu J W,Lu Y.A colorimetric lead biosensor using DNAzyme-directedassembly of gold nanoparticles[J].Journal of the American ChemicalSociety,2003,125(22):6642-6643.
[2]Lee J S,Han M S,Mirkin C A.Colorimetric detection of mercuric ion(Hg2+)in aqueous media using DNA-functionalized gold nanoparticles[J].Angewandte Chemie International Edition,2007,46(22):4093-4096.
[3]Ai K,Liu Y,Lu L.Hydrogen-bonding recognition-induced color changeof gold nanoparticles for visual detection of melamine in raw milk andinfant formula[J].Journal of the American Chemical Society,2009,131(27):9496-9497.
[4]Li W,Liang C,Zhou W,et al.Preparation and Characterization ofMultiwalled Carbon Nanotube-Supported Platinum for CathodeCatalysts of Direct Methanol Fuel Cells[J].The Journal of PhysicalChemistry B,2003,107(26):6292-6299.
[5]Bashyam R,Zelenay P.A class of non-precious metal compositecatalysts for fuel cells[J].Nature,2006,443(7107):63-66.
[6]Jain J,Arora S,Rajwade J M,et al.Silver nanoparticles in therapeutics:Development of an antimicrobial gel formulation for topical use[J].Molecular Pharmaceutics,2009,6(5):1388-1401.
[7]Kumar K,Duan H,Hegde R S,et al.Printing colour at the opticaldiffraction limit[J].Nature Nano,2012,7(9):557-561.
[8]Ko S H,Park I,Pan H,et al.Direct Nanoimprinting of metal nanoparticlesfor nanoscale electronics fabrication[J].Nano Letters,2007,7(7):1869-1877.
[9]Hadjipanayis C G,Machaidze R,Kaluzova M,et al.EGFRv IIIantibody-conjugated iron oxide nanoparticles for magnetic resonanceimaging-guided convection-enhanced delivery and targeted therapy ofglioblastoma[J].Cancer Research,2010,70(15):6303-6312.
[10]Zhu A,Qu Q,Shao X,et al.Carbon-dot-based dual-emissionnanohybrid produces a ratiometric fluorescent sensor for in vivoimaging of cellular copper ions[J].Angewandte Chemie,2012,124(29):7297-7301.
[11]Yu J H,Kwon S H,Petrasek Z,et al.High-resolution three-photonbiomedical imaging using doped Zn S nanocrystals[J].NatureMaterials,2013,12(4):359-366.
[12]Ma N,Yang J,Stewart K M,et al.DNA-Passivated Cd S Nanocrystals:Luminescence,bioimaging,and toxicity profiles[J].Langmuir,2007,23(26):12783-12787.
[13]Lim S F,Riehn R,Ryu W S,et al.In vivo and scanning electronmicroscopy imaging of upconverting nanophosphors in caenorhabditiselegans[J].Nano Letters,2006,6(2):169-174.
[14]Chatterjee D K,Rufaihah A J,Zhang Y.Upconversion fluorescenceimaging of cells and small animals using lanthanide dopednanocrystals[J].Biomaterials,2008,29(7):937-943.
[15]Bruchez M,Moronne M,Gin P,et al.Semiconductor nanocrystals asfluorescent biological labels[J].Science,1998,281(5385):2013-2016.
[16]Chan W C W,Nie S.Quantum dot bioconjugates for ultrasensitivenonisotopic detection[J].Science,1998,281(5385):2016-2018.
[17]Yezhelyev M V,Al-Hajj A,Morris C,et al.In situ molecular profilingof breast cancer biomarkers with multicolor quantum dots[J].Advanced Materials,2007,19(20):3146-3151.
[18]Metz S,Bonaterra G,Rudelius M,et al.Capacity of human monocytesto phagocytose approved iron oxide MR contrast agents in vitro[J].EurRadiol,2004,14(10):1851-1858.
[19]Shapiro E M,Skrtic S,Koretsky A P.Sizing it up:Cellular MRI usingmicron-sized iron oxide particles[J].Magnetic Resonance inMedicine,2005,53(2):329-338.
[20]Mei Q,Jiang C,Guan G,et al.Fluorescent graphene oxide logic gatesfor discrimination of iron(3+)and iron(2+)in living cells by imaging[J].Chemical Communications,2012,48(60):7468-7470.
[21]Sun X,Liu Z,Welsher K,et al.Nano-graphene oxide for cellularimaging and drug delivery[J].Nano Research,2008,1(3):203-212.
[22]He H,Xie C,Ren J.Nonbleaching fluorescence of gold nanoparticlesand its applications in cancer cell imaging[J].Analytical Chemistry,2008,80(15):5951-5957.
[23]Wang H,Huff T B,Zweifel D A,et al.In vitro and in vivo two-photonluminescence imaging of single gold nanorods[J].Proceedings of theNational Academy of Sciences of the United States of America,2005,102(44):15752-15756.
[24]Liu C L,Ho M L,Chen Y C,et al.Thiol-functionalized goldnanodots:Two-photon absorption property and imaging in vitro[J].The Journal of Physical Chemistry C,2009,113(50):21082-21089.
[25]Wang C,Li J,Amatore C,et al.Gold nanoclusters and graphenenanocomposites for drug delivery and imaging of cancer cells[J].Angewandte Chemie International Edition,2011,50(49):11644-11648.
[26]Wang J,Zhang G,Li Q,et al.In vivo self-bio-imaging of tumorsthrough in situ biosynthesized fluorescent gold nanoclusters[J].Scientific Reports,2013,1157(3):1-7.
[27]Choi S,Yu J,Patel S A,et al.Tailoring silver nanodots forintracellular staining[J].Photochemical&Photobiological Sciences,2011,10(1):109-115.
[28]Yu J,Patel S A,Dickson R M.In vitro and intracellular production ofpeptide-encapsulated fluorescent silver nanoclusters[J].AngewandteChemie,2007,119(12):2074-2076.
[29]Gao S,Chen D,Li Q,et al.Near-infrared fluorescence imaging ofcancer cells and tumors through specific biosynthesis of silvernanoclusters[J].Scientific Reports,2014,1038(4):1-6.
[30]Lee H,Lee K,Kim I K,et al.Fluorescent gold nanoprobe sensitive tointracellular reactive oxygen species[J].Advanced FunctionalMaterials,2009,19(12):1884-1890.
[31]Seferos D S,Giljohann D A,Hill H D,et al.Nano-flares:Probes fortransfection and m RNA detection in living cells[J].Journal of theAmerican Chemical Society,2007,129(50):15477-15479.
[32]Park H,Lee S,Chen L,et al.SERS imaging of HER2-overexpressedMCF7 cells using antibody-conjugated gold nanorods[J].PhysicalChemistry Chemical Physics,2009,11(34):7444-7449.
[33]Chon H,Lee S,Yoon S Y,et al.Simultaneous immunoassay for thedetection of two lung cancer markers using functionalized SERSnanoprobes[J].Chemical Communications,2011,47(46):12515-12517.
[34]Wang Z,Zong S,Yang J,et al.Dual-mode probe based onmesoporous silica coated gold nanorods for targeting cancer cells[J].Biosensors and Bioelectronics,2011,26(6):2883-2889.
[35]von Maltzahn G,Centrone A,Park J H,et al.SERS-coded goldnanorods as a multifunctional platform for densely multiplexed near-infrared imaging and photothermal heating[J].Advanced Materials,2009,21(31):3175-3180.
[36]Willets K A,Van Duyne R P.Localized surface plasmon resonancespectroscopy and sensing[J].Annual Review of Physical Chemistry,2007,58(1):267-297.
[37]Homola J.Surface plasmon resonance sensors for detection of chemicaland biological species[J].Chemical Reviews,2008,108(2):462-493.
[38]Mayer K M,Hafner J H.Localized surface plasmon resonance sensors[J].Chemical Reviews,2011,111(6):3828-3857.
[39]Burda C,Chen X,Narayanan R,et al.Chemistry and properties ofnanocrystals of different shapes[J].Chemical Reviews,2005,105(4):1025-1102.
[40]Lee K J,Browning L M,Nallathamby P D,et al.In vivo quantitativestudy of sized-dependent transport and toxicity of single silvernanoparticles using zebrafish embryos[J].Chemical Research inToxicology,2012,25(5):1029-1046.
[41]Lee K J,Nallathamby P D,Browning L M,et al.In vivo imaging oftransport and biocompatibility of single silver nanoparticles in earlydevelopment of zebrafish embryos[J].ACS Nano,2007,1(2):133-143.
[42]Nallathamby P D,Lee K J,Xu X H.Design of stable and uniformsingle nanoparticle photonics for in vivo dynamics imaging ofnanoenvironments of zebrafish embryonic fluids[J].ACS Nano,2008,2(7):1371-1380.
[43]Xu X H,Brownlow W J,Kyriacou S V,et al.Real-time probing ofmembrane transport in living microbial cells using single nanoparticleoptics and living cell imaging[J].Biochemistry,2004,43(32):10400-10413.
[44]Xu X H,Chen J,Jeffers R B,et al.Direct Measurement of sizes anddynamics of single living membrane transporters using nanooptics[J].Nano Letters,2002,2(3):175-182.
[45]Huang X,El-Sayed I H,Qian W,et al.Cancer cell imaging andphotothermal therapy in the near-infrared region by using goldnanorods[J].Journal of the American Chemical Society,2006,128(6):2115-2120.
[46]Nan X,Sims P A,Xie X S.Organelle tracking in a living cell withmicrosecond time resolution and nanometer spatial precision[J].Chem Phys Chem,2008,9(5):707-712.
[47]Jun Y W,Sheikholeslami S,Hostetter D R,et al.Continuous imagingof plasmon rulers in live cells reveals early-stage caspase-3activation at the single-molecule level[J].Proceedings of the NationalAcademy of Sciences,2009,106(42):17735-17740.
[48]Lee C W,Chen M J,Cheng J Y,et al.Morphological studies of livingcells using gold nanoparticles and dark-field optical section microscopy[J].Journal of Biomedical Optics,2009,14(3):034016-1-6.
[49]Wang S H,Lee C W,Chiou A,et al.Size-dependent endocytosis ofgold nanoparticles studied by three-dimensional mapping of plasmonicscattering images[J].Journal of Nanobiotechnology,2010,8:33.
[2]Lee J S,Han M S,Mirkin C A.Colorimetric detection of mercuric ion(Hg2+)in aqueous media using DNA-functionalized gold nanoparticles[J].Angewandte Chemie International Edition,2007,46(22):4093-4096.
[3]Ai K,Liu Y,Lu L.Hydrogen-bonding recognition-induced color changeof gold nanoparticles for visual detection of melamine in raw milk andinfant formula[J].Journal of the American Chemical Society,2009,131(27):9496-9497.
[4]Li W,Liang C,Zhou W,et al.Preparation and Characterization ofMultiwalled Carbon Nanotube-Supported Platinum for CathodeCatalysts of Direct Methanol Fuel Cells[J].The Journal of PhysicalChemistry B,2003,107(26):6292-6299.
[5]Bashyam R,Zelenay P.A class of non-precious metal compositecatalysts for fuel cells[J].Nature,2006,443(7107):63-66.
[6]Jain J,Arora S,Rajwade J M,et al.Silver nanoparticles in therapeutics:Development of an antimicrobial gel formulation for topical use[J].Molecular Pharmaceutics,2009,6(5):1388-1401.
[7]Kumar K,Duan H,Hegde R S,et al.Printing colour at the opticaldiffraction limit[J].Nature Nano,2012,7(9):557-561.
[8]Ko S H,Park I,Pan H,et al.Direct Nanoimprinting of metal nanoparticlesfor nanoscale electronics fabrication[J].Nano Letters,2007,7(7):1869-1877.
[9]Hadjipanayis C G,Machaidze R,Kaluzova M,et al.EGFRv IIIantibody-conjugated iron oxide nanoparticles for magnetic resonanceimaging-guided convection-enhanced delivery and targeted therapy ofglioblastoma[J].Cancer Research,2010,70(15):6303-6312.
[10]Zhu A,Qu Q,Shao X,et al.Carbon-dot-based dual-emissionnanohybrid produces a ratiometric fluorescent sensor for in vivoimaging of cellular copper ions[J].Angewandte Chemie,2012,124(29):7297-7301.
[11]Yu J H,Kwon S H,Petrasek Z,et al.High-resolution three-photonbiomedical imaging using doped Zn S nanocrystals[J].NatureMaterials,2013,12(4):359-366.
[12]Ma N,Yang J,Stewart K M,et al.DNA-Passivated Cd S Nanocrystals:Luminescence,bioimaging,and toxicity profiles[J].Langmuir,2007,23(26):12783-12787.
[13]Lim S F,Riehn R,Ryu W S,et al.In vivo and scanning electronmicroscopy imaging of upconverting nanophosphors in caenorhabditiselegans[J].Nano Letters,2006,6(2):169-174.
[14]Chatterjee D K,Rufaihah A J,Zhang Y.Upconversion fluorescenceimaging of cells and small animals using lanthanide dopednanocrystals[J].Biomaterials,2008,29(7):937-943.
[15]Bruchez M,Moronne M,Gin P,et al.Semiconductor nanocrystals asfluorescent biological labels[J].Science,1998,281(5385):2013-2016.
[16]Chan W C W,Nie S.Quantum dot bioconjugates for ultrasensitivenonisotopic detection[J].Science,1998,281(5385):2016-2018.
[17]Yezhelyev M V,Al-Hajj A,Morris C,et al.In situ molecular profilingof breast cancer biomarkers with multicolor quantum dots[J].Advanced Materials,2007,19(20):3146-3151.
[18]Metz S,Bonaterra G,Rudelius M,et al.Capacity of human monocytesto phagocytose approved iron oxide MR contrast agents in vitro[J].EurRadiol,2004,14(10):1851-1858.
[19]Shapiro E M,Skrtic S,Koretsky A P.Sizing it up:Cellular MRI usingmicron-sized iron oxide particles[J].Magnetic Resonance inMedicine,2005,53(2):329-338.
[20]Mei Q,Jiang C,Guan G,et al.Fluorescent graphene oxide logic gatesfor discrimination of iron(3+)and iron(2+)in living cells by imaging[J].Chemical Communications,2012,48(60):7468-7470.
[21]Sun X,Liu Z,Welsher K,et al.Nano-graphene oxide for cellularimaging and drug delivery[J].Nano Research,2008,1(3):203-212.
[22]He H,Xie C,Ren J.Nonbleaching fluorescence of gold nanoparticlesand its applications in cancer cell imaging[J].Analytical Chemistry,2008,80(15):5951-5957.
[23]Wang H,Huff T B,Zweifel D A,et al.In vitro and in vivo two-photonluminescence imaging of single gold nanorods[J].Proceedings of theNational Academy of Sciences of the United States of America,2005,102(44):15752-15756.
[24]Liu C L,Ho M L,Chen Y C,et al.Thiol-functionalized goldnanodots:Two-photon absorption property and imaging in vitro[J].The Journal of Physical Chemistry C,2009,113(50):21082-21089.
[25]Wang C,Li J,Amatore C,et al.Gold nanoclusters and graphenenanocomposites for drug delivery and imaging of cancer cells[J].Angewandte Chemie International Edition,2011,50(49):11644-11648.
[26]Wang J,Zhang G,Li Q,et al.In vivo self-bio-imaging of tumorsthrough in situ biosynthesized fluorescent gold nanoclusters[J].Scientific Reports,2013,1157(3):1-7.
[27]Choi S,Yu J,Patel S A,et al.Tailoring silver nanodots forintracellular staining[J].Photochemical&Photobiological Sciences,2011,10(1):109-115.
[28]Yu J,Patel S A,Dickson R M.In vitro and intracellular production ofpeptide-encapsulated fluorescent silver nanoclusters[J].AngewandteChemie,2007,119(12):2074-2076.
[29]Gao S,Chen D,Li Q,et al.Near-infrared fluorescence imaging ofcancer cells and tumors through specific biosynthesis of silvernanoclusters[J].Scientific Reports,2014,1038(4):1-6.
[30]Lee H,Lee K,Kim I K,et al.Fluorescent gold nanoprobe sensitive tointracellular reactive oxygen species[J].Advanced FunctionalMaterials,2009,19(12):1884-1890.
[31]Seferos D S,Giljohann D A,Hill H D,et al.Nano-flares:Probes fortransfection and m RNA detection in living cells[J].Journal of theAmerican Chemical Society,2007,129(50):15477-15479.
[32]Park H,Lee S,Chen L,et al.SERS imaging of HER2-overexpressedMCF7 cells using antibody-conjugated gold nanorods[J].PhysicalChemistry Chemical Physics,2009,11(34):7444-7449.
[33]Chon H,Lee S,Yoon S Y,et al.Simultaneous immunoassay for thedetection of two lung cancer markers using functionalized SERSnanoprobes[J].Chemical Communications,2011,47(46):12515-12517.
[34]Wang Z,Zong S,Yang J,et al.Dual-mode probe based onmesoporous silica coated gold nanorods for targeting cancer cells[J].Biosensors and Bioelectronics,2011,26(6):2883-2889.
[35]von Maltzahn G,Centrone A,Park J H,et al.SERS-coded goldnanorods as a multifunctional platform for densely multiplexed near-infrared imaging and photothermal heating[J].Advanced Materials,2009,21(31):3175-3180.
[36]Willets K A,Van Duyne R P.Localized surface plasmon resonancespectroscopy and sensing[J].Annual Review of Physical Chemistry,2007,58(1):267-297.
[37]Homola J.Surface plasmon resonance sensors for detection of chemicaland biological species[J].Chemical Reviews,2008,108(2):462-493.
[38]Mayer K M,Hafner J H.Localized surface plasmon resonance sensors[J].Chemical Reviews,2011,111(6):3828-3857.
[39]Burda C,Chen X,Narayanan R,et al.Chemistry and properties ofnanocrystals of different shapes[J].Chemical Reviews,2005,105(4):1025-1102.
[40]Lee K J,Browning L M,Nallathamby P D,et al.In vivo quantitativestudy of sized-dependent transport and toxicity of single silvernanoparticles using zebrafish embryos[J].Chemical Research inToxicology,2012,25(5):1029-1046.
[41]Lee K J,Nallathamby P D,Browning L M,et al.In vivo imaging oftransport and biocompatibility of single silver nanoparticles in earlydevelopment of zebrafish embryos[J].ACS Nano,2007,1(2):133-143.
[42]Nallathamby P D,Lee K J,Xu X H.Design of stable and uniformsingle nanoparticle photonics for in vivo dynamics imaging ofnanoenvironments of zebrafish embryonic fluids[J].ACS Nano,2008,2(7):1371-1380.
[43]Xu X H,Brownlow W J,Kyriacou S V,et al.Real-time probing ofmembrane transport in living microbial cells using single nanoparticleoptics and living cell imaging[J].Biochemistry,2004,43(32):10400-10413.
[44]Xu X H,Chen J,Jeffers R B,et al.Direct Measurement of sizes anddynamics of single living membrane transporters using nanooptics[J].Nano Letters,2002,2(3):175-182.
[45]Huang X,El-Sayed I H,Qian W,et al.Cancer cell imaging andphotothermal therapy in the near-infrared region by using goldnanorods[J].Journal of the American Chemical Society,2006,128(6):2115-2120.
[46]Nan X,Sims P A,Xie X S.Organelle tracking in a living cell withmicrosecond time resolution and nanometer spatial precision[J].Chem Phys Chem,2008,9(5):707-712.
[47]Jun Y W,Sheikholeslami S,Hostetter D R,et al.Continuous imagingof plasmon rulers in live cells reveals early-stage caspase-3activation at the single-molecule level[J].Proceedings of the NationalAcademy of Sciences,2009,106(42):17735-17740.
[48]Lee C W,Chen M J,Cheng J Y,et al.Morphological studies of livingcells using gold nanoparticles and dark-field optical section microscopy[J].Journal of Biomedical Optics,2009,14(3):034016-1-6.
[49]Wang S H,Lee C W,Chiou A,et al.Size-dependent endocytosis ofgold nanoparticles studied by three-dimensional mapping of plasmonicscattering images[J].Journal of Nanobiotechnology,2010,8:33.