儿童肥胖的危害研究进展
摘要
儿童肥胖是遗传、环境、饮食等各种因素相互作用导致的慢性代谢性疾病,我国肥胖儿童呈逐年增加趋势,且肥胖对儿童身体及心理造成的危害日益受到重视,基于此,本研究就肥胖对儿童呼吸系统、心血管系统、内分泌系统及生长发育等产生的危害进行综述,以期为儿童肥胖的防治提供参考。
引文
[1]王向军,杨漾,吴艳强,等.上海市7-18岁学生1985至2014年的超重和肥胖流行趋势[J].中国循证儿科杂志,2017,12(2):126-130.
[2]王烁,董彦会,王政和,等.1985-2014年中国7-18岁学生超重与肥胖流行趋势[J].中华预防医学杂志,2017,51(4):300-305.
[3]MA Y N,CHEN T,WANG D,et al.Prevalence of overweight and obesity among preschool children from six cities of northeast China[J].Arch Med Res,2011,42(7):633-640.
[4]杨丽丽,席波.济南市城区6-17岁儿童青少年超重和肥胖流行现状[J].中国儿童保健杂志,2017,25(11):1108-1112.
[5]李珊珊,王海俊,马军.儿童肥胖的流行趋势[J].中国生育健康杂志,2008,19(3):173-175.
[6]王文媛,傅平,汪之顼.儿童肥胖的流行趋势及影响因素研究进展[J].中国妇幼健康研究,2008,19(6):591-594.
[7]Q MUSAIGER A,AI-MANNAI,AI-MARZOG Q.Overweight and obesity among children(10-13 years)in Bahrain:a comparison between two international standards[J].Pak J Med Sci,2014,30(3):497-500.
[8]WANG G,DIETZ W H.Economic burden of obesity in youths aged6 to 17 years,1979-1999[J].Pediatrics,2002,109(6):1195.
[9]吴旭龙,赵雯,李晶晶,等.北京市学龄前儿童单纯性肥胖影响因素研究[J].中国儿童保健杂志,2015,23(4):340-343.
[10]中国肥胖问题工作组,季成叶.中国学龄儿童青少年超重、肥胖筛查体重指数值分类标准[J].中华流行病学杂志,2004,25(2):10-15.
[11]DA ROSA G J,SCHIVINSKI C I.Assessment of respiratory muscle strength in children according to the classification of body mass index[J].Rev Paul Pediatr,2014,32(2):250-255.
[12]GOZAL D,KHEIRANDISH-GOZAL L.Childhood obesity and sleep:relatives,partners,or both?a critical perspective on the evidence[J].Ann N Y Acad Sci,2012,1264(1):135-141.
[13]SINGANAYAGAM A,CHALMERS J D.Obesity is associated with improved survival in community-acquired pneumonia[J].Eur Respir J,2013,42(1):180-187.
[14]GRUCHAA-NIEDOSZYTKO M,MAGORZEWICZ S,NIEDOSZYTKO M,et al.The influence of obesity on inflammation and clinical symptoms in asthma[J].Adv Med Sci,2013,58(1):15-21.
[15]BRUSKE I,FLEXEDER C,HEINRICH J.Body mass index and the incidence of asthma in children[J].Curr Opin Allergy Clin Immunol,2014,14(2):155-160.
[16]HASELKORN T,FISH J E,CHIPPS B E,et al.Effect of weight change on asthma-related health outcomes in patients with severe or difficult-to-treat asthma[J].Respir Med,2009,103(2):274-283.
[17]RAZI E,RAZI A,MOOSAVI G A.Influence of body mass indexes on response to treatment in acute asthma[J].Acta Med Iran,2014,52(3):192-196.
[18]王婧,潘家华.肥胖对哮喘儿童治疗效果及肺功能的影响[J].中国当代儿科杂志,2016,18(1):55-60.
[19]陈海燕,陈梦莹,彭璐婷,等.肥胖儿童血清25羟维生素D水平及其临床意义[J].中国儿童保健杂志,2013,21(3):247-250.
[20]BREHM J M,CELEDN J C,SOTO-QUIROS M E,et al.Serum vitamin D levels and markers of severity of childhood asthma in Costa Rica[J].Am J Respir Crit Care Med,2009,179(9):765-771.
[21]LEI Y,YANG H,ZHEN L.Obesity is a risk factor for allergic rhinitis in children of Wuhan(China)[J].Asia Pac Allergy,2016,6(2):101-104.
[22]刘革伟,吕涛,张晓萍,等.鞍山城区肥胖患儿与上呼吸道感染的相关性调查分析[J].中华医院感染学杂志,2014,24(4):1001-1003.
[23]侯冬青,赵小元,段佳丽,等.不同肥胖程度儿童罹患心血管代谢异常风险的横断面调查[J].中国循证儿科杂志,2014,9(2):101-106.
[24]JUONALA M,MAGNUSSEN C G,BERENSON G S,等.儿童期肥胖、成年期肥胖和心血管风险因子[J].中华高血压杂志,2012,20(1):84-85.
[25]CHINALI M,DE SIMONE G,ROMAN M J,et al.Impact of obesity on cardiac geometry and function in a population of adolescents:the strong heart study[J].J Am Coll Cardiol,2006,47(11):2267-2273.
[26]HAJI S A,ULUSOY R E,PATEL D A,et al.Predictors of left ventricular dilatation in young adults(from the Bogalusa Heart Study)[J].Am J Cardiol,2006,98(9):1234-1237.
[27]于佳,倪唤春,罗心平.脂质代谢相关基因多态性与动脉粥样硬化[J].国际心血管病杂志,2014,41(3):173-175.
[28]胡楠,刘艳,李素芬,等.不同体质指数儿童青少年瘦素、脂联素、FGF-21与胰岛素抵抗的相关性分析[J].天津医科大学学报,2017,23(5):419-422.
[29]FRAYN K N,KARPE F,FIEIDING B A,et al.Integrative physiology of human adipose tissue[J].Int J Obes Relat Metab Disord,2003,27(8):875-888.
[30]张丽琴,李亚蕊.单纯性肥胖儿童内分泌激素变化研究[J].2012,30(11):146-148.
[31]MOORE S I,HUFFNAGLE G B,CHEN G H,et al.Leptin modulates neutrophil phagocytosis of klebsiella pneumoniae[J].Infect Immun,2003,71(7):4182-4185.
[32]STOJANOVIC'S,ILIC'M D,ILIC'S,et al.The significance of adiponectin as a biomarker in metabolic syndrome and/or coronary artery disease[J].Vojnosanit Pregl,2015,72(9):779-784.
[33]SOOD A,QUALLS C,SCHUYLER M,et al.Low serum adiponectin predicts future risk for asthma in women[J].Am J Respir Crit Care Med,2012,186(1):41-47.
[34]GIANOTTI T F,SOOKOIAN S,DIEUZEIDE G,et al.A decreased mitochondrial DNA content is related to insulin resistance in adolescents[J].Obesity(Silver Spring),2008,16(7):1591-1595.
[35]JURASCHEK S P,KOVELL L C,MILLER E R,et al.Dose-response association of uncontrolled blood pressure and cardiovascular disease risk factors with hyperuricemia and gout[J].PLo S One,2013,8(2):1-8.
[36]BORATYNSKA M,KARBOWSKA A,KLINGER M.The effect of hyperuricemia on endothelial biomarkers and renal function in kidney allograft recipients[J].Transplant Proc,2010,42(10):4074-4077.
[37]王慧,郭丽丽,梁虹,等.血清生长激素水平与儿童单纯性肥胖伴身高略矮的关系[J].现代生物医学进展,2015,15(7):1304-1305.
[38]SUN Y,TAO F,SU P Y.National estimates of pubertal milestones among urban and rural Chinese boys[J].Ann Hum Biol,2012,39(6):461-467.
[39]尤箫萌,单川,沈秀华.儿童肥胖与性早熟的研究进展[J].上海交通大学学报(医学版),2012,32(7):949-951.
[40]COLLABORATIVE GROUP ON HORMONAL FACTORS IN BREAST CANCER.Menarche,menopause,and breast cancer risk:individual participant meta-analysis,including 118 964 women with breast cancer from 117 epidemiological studies[J].Lancet Oncol,2012,13(11):1141-1151.
[41]GOLUB M S,COLLMAN G W,FOSTER P M,et al.Public health implications of altered puberty timing[J].Pediatrics,2008,121(Suppl 3):S218-S230.
[42]祝素萍,杜青,陈妙,等.单纯性肥胖合并脂代谢紊乱儿童免疫功能分析[J].中国乡村医药,2012,19(18):39-40.
[43]叶超群,康玉华,杨俊卿.肥胖、耐力运动对单纯性肥胖少年儿童免疫功能的影响[J].中国运动医学杂志,2000,19(1):45-48.
[44]杨怡,陈洁,杨萱,等.超重、肥胖学龄儿童心理健康状况调查[J].中国健康心理学杂志,2015,23(10):1586-1589.
[45]张俊格,陈丽雯.单纯性肥胖儿童行为心理干预指导效果评价[J].河北医药,2011,33(16):2550-2551.
[46]黄平,洪恬.肥胖儿童与普通儿童自尊与攻击性的比较研究[J].中国健康心理学杂志,2012,20(1):80-82.
[47]MADOWITZ J,KNATZ S,MAGINOT T,et al.Teasing,depression and unhealthy weight control behaviour in obese children[J].Pediatr Obes,2012,7(6):446-452.
[48]马冬静.体育运动与超重、肥胖儿童执行功能的研究进展[J].当代体育科技,2015,5(8):7-8.
[49]DAVIS C L,COOPER S.Fitness,fatness,cognition,behavior,and academic achievement among overweight children:do cross-sectional associations correspond to exercise trial outcomes[J].Prev Med,2011,52(Suppl 1),S65-S69.
[50]阳秀英,李新影.青少年超重、肥胖与抑郁和行为问题的关系[J].中国心理卫生杂志,2016,30(7):519-526.
[2]王烁,董彦会,王政和,等.1985-2014年中国7-18岁学生超重与肥胖流行趋势[J].中华预防医学杂志,2017,51(4):300-305.
[3]MA Y N,CHEN T,WANG D,et al.Prevalence of overweight and obesity among preschool children from six cities of northeast China[J].Arch Med Res,2011,42(7):633-640.
[4]杨丽丽,席波.济南市城区6-17岁儿童青少年超重和肥胖流行现状[J].中国儿童保健杂志,2017,25(11):1108-1112.
[5]李珊珊,王海俊,马军.儿童肥胖的流行趋势[J].中国生育健康杂志,2008,19(3):173-175.
[6]王文媛,傅平,汪之顼.儿童肥胖的流行趋势及影响因素研究进展[J].中国妇幼健康研究,2008,19(6):591-594.
[7]Q MUSAIGER A,AI-MANNAI,AI-MARZOG Q.Overweight and obesity among children(10-13 years)in Bahrain:a comparison between two international standards[J].Pak J Med Sci,2014,30(3):497-500.
[8]WANG G,DIETZ W H.Economic burden of obesity in youths aged6 to 17 years,1979-1999[J].Pediatrics,2002,109(6):1195.
[9]吴旭龙,赵雯,李晶晶,等.北京市学龄前儿童单纯性肥胖影响因素研究[J].中国儿童保健杂志,2015,23(4):340-343.
[10]中国肥胖问题工作组,季成叶.中国学龄儿童青少年超重、肥胖筛查体重指数值分类标准[J].中华流行病学杂志,2004,25(2):10-15.
[11]DA ROSA G J,SCHIVINSKI C I.Assessment of respiratory muscle strength in children according to the classification of body mass index[J].Rev Paul Pediatr,2014,32(2):250-255.
[12]GOZAL D,KHEIRANDISH-GOZAL L.Childhood obesity and sleep:relatives,partners,or both?a critical perspective on the evidence[J].Ann N Y Acad Sci,2012,1264(1):135-141.
[13]SINGANAYAGAM A,CHALMERS J D.Obesity is associated with improved survival in community-acquired pneumonia[J].Eur Respir J,2013,42(1):180-187.
[14]GRUCHAA-NIEDOSZYTKO M,MAGORZEWICZ S,NIEDOSZYTKO M,et al.The influence of obesity on inflammation and clinical symptoms in asthma[J].Adv Med Sci,2013,58(1):15-21.
[15]BRUSKE I,FLEXEDER C,HEINRICH J.Body mass index and the incidence of asthma in children[J].Curr Opin Allergy Clin Immunol,2014,14(2):155-160.
[16]HASELKORN T,FISH J E,CHIPPS B E,et al.Effect of weight change on asthma-related health outcomes in patients with severe or difficult-to-treat asthma[J].Respir Med,2009,103(2):274-283.
[17]RAZI E,RAZI A,MOOSAVI G A.Influence of body mass indexes on response to treatment in acute asthma[J].Acta Med Iran,2014,52(3):192-196.
[18]王婧,潘家华.肥胖对哮喘儿童治疗效果及肺功能的影响[J].中国当代儿科杂志,2016,18(1):55-60.
[19]陈海燕,陈梦莹,彭璐婷,等.肥胖儿童血清25羟维生素D水平及其临床意义[J].中国儿童保健杂志,2013,21(3):247-250.
[20]BREHM J M,CELEDN J C,SOTO-QUIROS M E,et al.Serum vitamin D levels and markers of severity of childhood asthma in Costa Rica[J].Am J Respir Crit Care Med,2009,179(9):765-771.
[21]LEI Y,YANG H,ZHEN L.Obesity is a risk factor for allergic rhinitis in children of Wuhan(China)[J].Asia Pac Allergy,2016,6(2):101-104.
[22]刘革伟,吕涛,张晓萍,等.鞍山城区肥胖患儿与上呼吸道感染的相关性调查分析[J].中华医院感染学杂志,2014,24(4):1001-1003.
[23]侯冬青,赵小元,段佳丽,等.不同肥胖程度儿童罹患心血管代谢异常风险的横断面调查[J].中国循证儿科杂志,2014,9(2):101-106.
[24]JUONALA M,MAGNUSSEN C G,BERENSON G S,等.儿童期肥胖、成年期肥胖和心血管风险因子[J].中华高血压杂志,2012,20(1):84-85.
[25]CHINALI M,DE SIMONE G,ROMAN M J,et al.Impact of obesity on cardiac geometry and function in a population of adolescents:the strong heart study[J].J Am Coll Cardiol,2006,47(11):2267-2273.
[26]HAJI S A,ULUSOY R E,PATEL D A,et al.Predictors of left ventricular dilatation in young adults(from the Bogalusa Heart Study)[J].Am J Cardiol,2006,98(9):1234-1237.
[27]于佳,倪唤春,罗心平.脂质代谢相关基因多态性与动脉粥样硬化[J].国际心血管病杂志,2014,41(3):173-175.
[28]胡楠,刘艳,李素芬,等.不同体质指数儿童青少年瘦素、脂联素、FGF-21与胰岛素抵抗的相关性分析[J].天津医科大学学报,2017,23(5):419-422.
[29]FRAYN K N,KARPE F,FIEIDING B A,et al.Integrative physiology of human adipose tissue[J].Int J Obes Relat Metab Disord,2003,27(8):875-888.
[30]张丽琴,李亚蕊.单纯性肥胖儿童内分泌激素变化研究[J].2012,30(11):146-148.
[31]MOORE S I,HUFFNAGLE G B,CHEN G H,et al.Leptin modulates neutrophil phagocytosis of klebsiella pneumoniae[J].Infect Immun,2003,71(7):4182-4185.
[32]STOJANOVIC'S,ILIC'M D,ILIC'S,et al.The significance of adiponectin as a biomarker in metabolic syndrome and/or coronary artery disease[J].Vojnosanit Pregl,2015,72(9):779-784.
[33]SOOD A,QUALLS C,SCHUYLER M,et al.Low serum adiponectin predicts future risk for asthma in women[J].Am J Respir Crit Care Med,2012,186(1):41-47.
[34]GIANOTTI T F,SOOKOIAN S,DIEUZEIDE G,et al.A decreased mitochondrial DNA content is related to insulin resistance in adolescents[J].Obesity(Silver Spring),2008,16(7):1591-1595.
[35]JURASCHEK S P,KOVELL L C,MILLER E R,et al.Dose-response association of uncontrolled blood pressure and cardiovascular disease risk factors with hyperuricemia and gout[J].PLo S One,2013,8(2):1-8.
[36]BORATYNSKA M,KARBOWSKA A,KLINGER M.The effect of hyperuricemia on endothelial biomarkers and renal function in kidney allograft recipients[J].Transplant Proc,2010,42(10):4074-4077.
[37]王慧,郭丽丽,梁虹,等.血清生长激素水平与儿童单纯性肥胖伴身高略矮的关系[J].现代生物医学进展,2015,15(7):1304-1305.
[38]SUN Y,TAO F,SU P Y.National estimates of pubertal milestones among urban and rural Chinese boys[J].Ann Hum Biol,2012,39(6):461-467.
[39]尤箫萌,单川,沈秀华.儿童肥胖与性早熟的研究进展[J].上海交通大学学报(医学版),2012,32(7):949-951.
[40]COLLABORATIVE GROUP ON HORMONAL FACTORS IN BREAST CANCER.Menarche,menopause,and breast cancer risk:individual participant meta-analysis,including 118 964 women with breast cancer from 117 epidemiological studies[J].Lancet Oncol,2012,13(11):1141-1151.
[41]GOLUB M S,COLLMAN G W,FOSTER P M,et al.Public health implications of altered puberty timing[J].Pediatrics,2008,121(Suppl 3):S218-S230.
[42]祝素萍,杜青,陈妙,等.单纯性肥胖合并脂代谢紊乱儿童免疫功能分析[J].中国乡村医药,2012,19(18):39-40.
[43]叶超群,康玉华,杨俊卿.肥胖、耐力运动对单纯性肥胖少年儿童免疫功能的影响[J].中国运动医学杂志,2000,19(1):45-48.
[44]杨怡,陈洁,杨萱,等.超重、肥胖学龄儿童心理健康状况调查[J].中国健康心理学杂志,2015,23(10):1586-1589.
[45]张俊格,陈丽雯.单纯性肥胖儿童行为心理干预指导效果评价[J].河北医药,2011,33(16):2550-2551.
[46]黄平,洪恬.肥胖儿童与普通儿童自尊与攻击性的比较研究[J].中国健康心理学杂志,2012,20(1):80-82.
[47]MADOWITZ J,KNATZ S,MAGINOT T,et al.Teasing,depression and unhealthy weight control behaviour in obese children[J].Pediatr Obes,2012,7(6):446-452.
[48]马冬静.体育运动与超重、肥胖儿童执行功能的研究进展[J].当代体育科技,2015,5(8):7-8.
[49]DAVIS C L,COOPER S.Fitness,fatness,cognition,behavior,and academic achievement among overweight children:do cross-sectional associations correspond to exercise trial outcomes[J].Prev Med,2011,52(Suppl 1),S65-S69.
[50]阳秀英,李新影.青少年超重、肥胖与抑郁和行为问题的关系[J].中国心理卫生杂志,2016,30(7):519-526.