针刺结合中药周期疗法对IVF-ET失败患者不良子宫内膜容受性、胚胎种植率及妊娠率的影响
|
摘要
目的:研究针刺和中药周期疗法联合应用对体外受精-胚胎移植(IVF-ET)失败患者不良子宫内膜容受性、胚胎种植率和妊娠率的影响。方法:选取2016年5月—2017年5月佛山市妇幼保健院收治的行IVF-ET失败2次的患者100例,随机平均分成实验组和对照组。对照组自然等待3个月后继续常规IVF-ET治疗;实验组采用针刺联合中药周期疗法治疗3个月后再行常规IVF-ET治疗。对比分析两组患者的妊娠率、胚胎种植率、A型子宫内膜比例和子宫内膜血流指标。结果:实验组患者妊娠率、胚胎种植率和A型子宫内膜比例显著高于对照组(P <0. 05),差异具有统计学意义;实验组患者子宫内膜血流指标显著低于对照组(P <0. 05),差异具有统计学意义。结论:针刺结合中药周期疗法能显著改善IVF-ET失败患者子宫内膜容受性,增加患者再次IVF-ET的胚胎种植率和妊娠率。
Objective: To study the effect of acupuncture combined with TCM cycle therapy on adverse endometrial receptivity,embryo implantation rate and pregnancy rate in patients with IVF-ET failure. Methods: 100 patients with two failures of IVF-ET from May 2016 to May 2017 were randomly divided into the study group and the control group. The control group was given IVF-ET treatment after three months natural wait for pregnacy; the study group was treated with acupuncture combined with TCM cycle therapy for three months before routine IVF-ET. The pregnancy rate,embryo implantation rate,ratio of type A endometrium and endometrial blood flow were compared between the two groups. Results: The pregnancy rate,embryo implantation rate,and type A endometrium were significantly higher in the study group than those in the control group( P <0. 05). The index of endometrial blood flow was significantly lower in the study group than that in the control group( P < 0. 05). Conclusion: Acupuncture combined with TCM cycle therapy can significantly improve the endometrial receptivity of the patients after IVF-ET failure,and it can increase the rate of embryo implantation and pregnancy of IVF-ET.
Objective: To study the effect of acupuncture combined with TCM cycle therapy on adverse endometrial receptivity,embryo implantation rate and pregnancy rate in patients with IVF-ET failure. Methods: 100 patients with two failures of IVF-ET from May 2016 to May 2017 were randomly divided into the study group and the control group. The control group was given IVF-ET treatment after three months natural wait for pregnacy; the study group was treated with acupuncture combined with TCM cycle therapy for three months before routine IVF-ET. The pregnancy rate,embryo implantation rate,ratio of type A endometrium and endometrial blood flow were compared between the two groups. Results: The pregnancy rate,embryo implantation rate,and type A endometrium were significantly higher in the study group than those in the control group( P <0. 05). The index of endometrial blood flow was significantly lower in the study group than that in the control group( P < 0. 05). Conclusion: Acupuncture combined with TCM cycle therapy can significantly improve the endometrial receptivity of the patients after IVF-ET failure,and it can increase the rate of embryo implantation and pregnancy of IVF-ET.
引文
[1]陆柳如,吴克明.中医药在体外受精-胚胎移植技术中的研究现状[J].中国中药杂志,2015,40(16):3142-3146.
[2]席军花. IVF-ET失败不孕妇女心理压力及生活质量[J].实用妇科内分泌杂志(电子版),2017,4(15):89-90.
[3]徐金龙.分期针灸疗法对IVF-ET反复移植失败患者子宫内膜厚度的临床观察[C]//中国针灸学会. 2017世界针灸学术大会暨2017中国针灸学会年会论文集,2017:2.
[4]尤昭玲,袁家麟.中医妇科学[M].北京:中国中医药出版社,2005:135-136.
[5]王玢,孔娜,刘景瑜,等.超长方案体外受精胚胎移植失败后重复促排卵妊娠结果分析[J].中华男科学杂志,2017,23(12):1099-1102.
[6]徐小芳.补肾益气和血法中药对IVF-ET妇女子宫内膜和子宫血流的影响[D].武汉:湖北中医药大学,2017.
[7]王学乾,梁路,黄德清,等.针灸应用于体外受精—胚胎移植(IVF-ET)的临床研究进展[J].世界最新医学信息文摘,2017,17(9):29-31.
[8]丁唤飞,田莉.冻融胚胎移植周期子宫内膜厚度与妊娠结局的关系[J].中华妇产科杂志,2018,53(11):742-748.
[9]张少娣,路锦,耿嘉瑄,等.子宫内膜及内膜下血流参数对冷冻胚胎移植周期妊娠结局的影响[J].中华超声影像学杂志,2014,23(9):794-797.
[10]周莉,王茵萍.针灸序贯疗法成功助孕反复IVF-ET失败13次病案1例[J].中国中医基础医学杂志,2016,22(11):1528-1529.
[11]陈秀芳,何秀容,廖湘萍.中药周期疗法助孕IVF-ET术胚胎着床或早期妊娠失败45例临床体会[J].中国民族民间医药,2016,25(15):107-108.
[12]谷向向.补肾法、疏肝法对IVF-ET胚胎着床反复失败患者子宫内膜容受性的影响机制及其比较[D].石家庄:河北医科大学,2016.
[13]牛聪.中药内服外治法联合运用对体外受精-胚胎移植成功率的影响[J].中医药临床杂志,2016,28(1):58-60.
[14]高志云,刘莹,高修安,等.二至增膜汤对IVF-ET失败患者不良子宫内膜血流的影响[J].中医学报,2015,30(10):1480-1481.
[15]王珍.补肾疏肝调冲法对IVF-ET着床失败者进周前内膜及其血供影响的研究[D].成都:成都中医药大学,2014.
[16]钟燕梅.中医药多途径介入IVF-ET失败患者的助孕疗效评价[D].成都:成都中医药大学,2014.
[17]陈芊,郝翠芳.针灸对IVF-ET反复种植失败患者子宫内膜血流及胞饮突表达的影响[J].生殖与避孕,2015,35(3):159-165.
[18]徐金龙,杨增荣,钱婧,等.分期针灸对IVF-ET反复移植失败患者子宫内膜厚度的影响[J].上海针灸杂志,2018,37(2):200-204.
[19]宋俏蔚,陈嫣,孙亦婷,等.补肾活血调周法改善反复体外受精-胚胎移植失败患者卵巢储备功能的机理研究[J].中华中医药学刊,2014,32(2):375-377.
[2]席军花. IVF-ET失败不孕妇女心理压力及生活质量[J].实用妇科内分泌杂志(电子版),2017,4(15):89-90.
[3]徐金龙.分期针灸疗法对IVF-ET反复移植失败患者子宫内膜厚度的临床观察[C]//中国针灸学会. 2017世界针灸学术大会暨2017中国针灸学会年会论文集,2017:2.
[4]尤昭玲,袁家麟.中医妇科学[M].北京:中国中医药出版社,2005:135-136.
[5]王玢,孔娜,刘景瑜,等.超长方案体外受精胚胎移植失败后重复促排卵妊娠结果分析[J].中华男科学杂志,2017,23(12):1099-1102.
[6]徐小芳.补肾益气和血法中药对IVF-ET妇女子宫内膜和子宫血流的影响[D].武汉:湖北中医药大学,2017.
[7]王学乾,梁路,黄德清,等.针灸应用于体外受精—胚胎移植(IVF-ET)的临床研究进展[J].世界最新医学信息文摘,2017,17(9):29-31.
[8]丁唤飞,田莉.冻融胚胎移植周期子宫内膜厚度与妊娠结局的关系[J].中华妇产科杂志,2018,53(11):742-748.
[9]张少娣,路锦,耿嘉瑄,等.子宫内膜及内膜下血流参数对冷冻胚胎移植周期妊娠结局的影响[J].中华超声影像学杂志,2014,23(9):794-797.
[10]周莉,王茵萍.针灸序贯疗法成功助孕反复IVF-ET失败13次病案1例[J].中国中医基础医学杂志,2016,22(11):1528-1529.
[11]陈秀芳,何秀容,廖湘萍.中药周期疗法助孕IVF-ET术胚胎着床或早期妊娠失败45例临床体会[J].中国民族民间医药,2016,25(15):107-108.
[12]谷向向.补肾法、疏肝法对IVF-ET胚胎着床反复失败患者子宫内膜容受性的影响机制及其比较[D].石家庄:河北医科大学,2016.
[13]牛聪.中药内服外治法联合运用对体外受精-胚胎移植成功率的影响[J].中医药临床杂志,2016,28(1):58-60.
[14]高志云,刘莹,高修安,等.二至增膜汤对IVF-ET失败患者不良子宫内膜血流的影响[J].中医学报,2015,30(10):1480-1481.
[15]王珍.补肾疏肝调冲法对IVF-ET着床失败者进周前内膜及其血供影响的研究[D].成都:成都中医药大学,2014.
[16]钟燕梅.中医药多途径介入IVF-ET失败患者的助孕疗效评价[D].成都:成都中医药大学,2014.
[17]陈芊,郝翠芳.针灸对IVF-ET反复种植失败患者子宫内膜血流及胞饮突表达的影响[J].生殖与避孕,2015,35(3):159-165.
[18]徐金龙,杨增荣,钱婧,等.分期针灸对IVF-ET反复移植失败患者子宫内膜厚度的影响[J].上海针灸杂志,2018,37(2):200-204.
[19]宋俏蔚,陈嫣,孙亦婷,等.补肾活血调周法改善反复体外受精-胚胎移植失败患者卵巢储备功能的机理研究[J].中华中医药学刊,2014,32(2):375-377.