HIV感染人群骨代谢标志物水平变化
|
摘要
目的:通过分析HIV感染者骨代谢标志物水平,探讨艾滋病病毒对骨代谢的影响及可能机制。方法:用化学发光法检测150例HIV感染人群和165例健康对照者骨钙素(BGP)、β-异构C-端肽(β-CTX)、Ⅰ型胶原氨基端肽原(PⅠNP)、甲状旁腺素(PTH)等骨代谢标志物结果并进行分析。结果:无论是男性或是女性HIV感染人群,BGP、PⅠNP、β-CTX均显著高于对照组人群(P<0. 01),而PTH显著低于对照组人群(P<0. 01)。结论:HIV感染人群骨代谢标志物水平存在明显不同,表现为骨吸收增加。
Objective: To explore the influence of HIV on bone metabolism by analyzing the biomarkers levels of bone metabolism in patients with HIV.Methods: The level of bone glutamyl protein(BGP),procollagen type Ⅰ N-terminal propeptide(PⅠNP), beta-isomerized C-telopeptide(β-CTX) and para-thyroid hormone(PTH) were detected and analyzed by chemiluminescent immunoassay in 150 pa-tients with HIV and 165 healthy controls.Results: The levels of BGP, PⅠNP and β-CTX were sig-nificantly higher than those of control group in men and female patients with HIV, but the levels of PTH were significantly lower(P<0. 01).Conclusion: The levels of biomarkers of bone metabolism were significantly different between healthy subjects and patients with bone resorption increased after HIV infection.
Objective: To explore the influence of HIV on bone metabolism by analyzing the biomarkers levels of bone metabolism in patients with HIV.Methods: The level of bone glutamyl protein(BGP),procollagen type Ⅰ N-terminal propeptide(PⅠNP), beta-isomerized C-telopeptide(β-CTX) and para-thyroid hormone(PTH) were detected and analyzed by chemiluminescent immunoassay in 150 pa-tients with HIV and 165 healthy controls.Results: The levels of BGP, PⅠNP and β-CTX were sig-nificantly higher than those of control group in men and female patients with HIV, but the levels of PTH were significantly lower(P<0. 01).Conclusion: The levels of biomarkers of bone metabolism were significantly different between healthy subjects and patients with bone resorption increased after HIV infection.
引文
[1]何美庆,柯亭羽.艾滋病与骨质疏松相关性的研究进展[J].中国医药科学,2016,6(8):34-37.He MQ, Ke TY. Research of the correlation between osteoporosis and AIDS[J]. China Medicine and Pharma-cy, 2016,6(8):34-37.
[2]张丽侠,谢静,李太生.人类免疫缺陷病毒-1感染者骨质疏松的发病机制[J].中华传染病杂志,2013,31(7):438-441.Zhang LX, Xie J, Li TS. Nosogenesis of osteoporosis patients with HIV-1[J]. Chinese Journal of Infectious Diseases,2013,31(7):438-441.
[3]陈宗锋,张强. HIV-1包膜糖蛋白gp120对骨代谢影响及其机制的研究进展[J].中华实验和临床感染病杂志:电子版,2015,9(5):621-624.Chen ZF, Zhang Q. The impression and mechanism of human immunodeficiency virus envelope glycoprotein gp120 on bone metabolism[J]. Chin J Exp Clin Infect Dis(Electronic Edition), 2015,9(5):621-624.
[4]王炬峰,许利军,黄莺,等.高效抗逆转录病毒治疗对人类免疫缺陷病毒感染者骨代谢的影响[J].浙江大学学报:医学版,2016,46(3):228-235.Wang JF, Xu LJ, Huang Y, et al. Impact of long-term highly active antiretroviral therapy on bone metabolism in AIDS patients[J]. Journal of Zhejiang University:Medical Sciences,2016,46(3):228-235.
[5] Grund B, Peng G, Gibert CL, et al. Continuous antiret-roviral therapy decreases bone mineral density[J].AIDS,2009,23(12):1 519-1 529.
[6]周兴雯,徐蕾,赵皓森,等.男性HIV感染患者性激素代谢、T淋巴细胞亚群的变化及性功能障碍发生情况分析[J].中国性科学,2018,27(7):24-26.Zhou XW, Xu L, Zhao HS, et al. Changes of sex hor-mones metabolism and T lymphocyte subsets and the in-cidence of sexual dysfunction in male patients with HIV infection[J]. Chinese J of Human Sexuality, 2018, 27(7):24-26.
[7] Gibellini D, De Crignis E, Ponti C, et al. HIV-1 trig-gers apoptosis in primary osteoblasts and HOBIT cells through TNF-αactivation[J]. J Med Virol,2008,80(9):1 507-1 514.
[8]中华医学会骨质疏松和骨矿盐疾病分会.原发性骨质疏松症诊治指南[J].中华骨质疏松和骨矿盐疾病杂志,2017,10(5):413-444.Chinese Medical Association Osteoporosis and Bone Mineral Salt Diseases Branch. Guidelines for diagnosis and treatment of primary osteoporosis[J]. Chin J Osteo-porosis and Bone Miner Res, 2017,10(5):413-444.
[9] Güerri-Fernandez R,Vestergaard P,Carbonell C, et al.HIV infection is strongly associated with hip fracture risk, independently of age, gender, and comorbidities:a population-based cohort study[J]. J Bone Miner Res,2013,28(6):1 259-1 263.
[10] Margaret LG, Jason PF, John SP, et al. Bone-density testing interval and transition to osteoporosis in older women[J]. N Engl J Med, 2012,366(3):225-233.
[2]张丽侠,谢静,李太生.人类免疫缺陷病毒-1感染者骨质疏松的发病机制[J].中华传染病杂志,2013,31(7):438-441.Zhang LX, Xie J, Li TS. Nosogenesis of osteoporosis patients with HIV-1[J]. Chinese Journal of Infectious Diseases,2013,31(7):438-441.
[3]陈宗锋,张强. HIV-1包膜糖蛋白gp120对骨代谢影响及其机制的研究进展[J].中华实验和临床感染病杂志:电子版,2015,9(5):621-624.Chen ZF, Zhang Q. The impression and mechanism of human immunodeficiency virus envelope glycoprotein gp120 on bone metabolism[J]. Chin J Exp Clin Infect Dis(Electronic Edition), 2015,9(5):621-624.
[4]王炬峰,许利军,黄莺,等.高效抗逆转录病毒治疗对人类免疫缺陷病毒感染者骨代谢的影响[J].浙江大学学报:医学版,2016,46(3):228-235.Wang JF, Xu LJ, Huang Y, et al. Impact of long-term highly active antiretroviral therapy on bone metabolism in AIDS patients[J]. Journal of Zhejiang University:Medical Sciences,2016,46(3):228-235.
[5] Grund B, Peng G, Gibert CL, et al. Continuous antiret-roviral therapy decreases bone mineral density[J].AIDS,2009,23(12):1 519-1 529.
[6]周兴雯,徐蕾,赵皓森,等.男性HIV感染患者性激素代谢、T淋巴细胞亚群的变化及性功能障碍发生情况分析[J].中国性科学,2018,27(7):24-26.Zhou XW, Xu L, Zhao HS, et al. Changes of sex hor-mones metabolism and T lymphocyte subsets and the in-cidence of sexual dysfunction in male patients with HIV infection[J]. Chinese J of Human Sexuality, 2018, 27(7):24-26.
[7] Gibellini D, De Crignis E, Ponti C, et al. HIV-1 trig-gers apoptosis in primary osteoblasts and HOBIT cells through TNF-αactivation[J]. J Med Virol,2008,80(9):1 507-1 514.
[8]中华医学会骨质疏松和骨矿盐疾病分会.原发性骨质疏松症诊治指南[J].中华骨质疏松和骨矿盐疾病杂志,2017,10(5):413-444.Chinese Medical Association Osteoporosis and Bone Mineral Salt Diseases Branch. Guidelines for diagnosis and treatment of primary osteoporosis[J]. Chin J Osteo-porosis and Bone Miner Res, 2017,10(5):413-444.
[9] Güerri-Fernandez R,Vestergaard P,Carbonell C, et al.HIV infection is strongly associated with hip fracture risk, independently of age, gender, and comorbidities:a population-based cohort study[J]. J Bone Miner Res,2013,28(6):1 259-1 263.
[10] Margaret LG, Jason PF, John SP, et al. Bone-density testing interval and transition to osteoporosis in older women[J]. N Engl J Med, 2012,366(3):225-233.