国际药理学专家谈医药科技创新及对学术交流的思考
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摘要
该文对国内外8位药理学专业专家进行了深入访谈,探讨:①学术交流对于科技创新(如药理学理论与技术创新、新药研发等)和人才培养的作用;②整合与利用国际专家和专业资源、促进我国科技创新、人才培养以及提升我国在国际组织的影响力和话语权等方面的建议。通过访谈,总结先前国际交流成功的经验及存在的问题,给出今后发展的建议,为进一步提升中国药理学会的国际学术交流水平,进一步为发挥国际学术交流在国家科技创新体系中的作用提供参考。
To investigate ① the role of international communication on scientific and technological innovation issues such as new drug research and development,pharmacological theory and technological innovation,education,personnel training; ② comments of the patterns to enhance communications with international experts and to use professional resources,thus to promote domestic scientific and technological innovation,to enhance personal training,and to strengthen the international influence of the society,eight pharmacologists from either China or abroad were interviewed. The successful experiences and existing problems were summarized from the interviews. The suggestions of future development were proposed to improve the level of international scientific communication of Chinese Pharmacological Society,and thus provide further reference for displaying functions of international scientific communication on the national system of scientific and technological innovation.
To investigate ① the role of international communication on scientific and technological innovation issues such as new drug research and development,pharmacological theory and technological innovation,education,personnel training; ② comments of the patterns to enhance communications with international experts and to use professional resources,thus to promote domestic scientific and technological innovation,to enhance personal training,and to strengthen the international influence of the society,eight pharmacologists from either China or abroad were interviewed. The successful experiences and existing problems were summarized from the interviews. The suggestions of future development were proposed to improve the level of international scientific communication of Chinese Pharmacological Society,and thus provide further reference for displaying functions of international scientific communication on the national system of scientific and technological innovation.
引文
[1] 郭巧生,王长林.我国药用植物栽培历史概况与展望[J].中国中药杂志,2015,40(17):3391-3394.
[2] HAMEDI A,ZARSHENAS M M,SOHRABPOUR M,et al.Herbal medicinal oils in traditional Persian medicine[J].Pharm Biol,2013,51(9):1208-1218.
[3] RUPANI R,CHAVEZ A.Medicinal plants with traditional use:Ethnobotany in the Indian subcontinent[J].Clin Dermatol,2018,36(3):306-309.
[4] DESBOROUGH M J R,KEELING D M.The aspirin story-from willow to wonder drug[J].Br J Haematol,2017,177(5):674-683.
[5] KHAN M O,DEIMLING M J,PHILIP A.Medicinal chemistry and the pharmacy curriculum[J].Am J Pharm Educ,2011,75(8):161.
[6] Nobel Media AB 2019.The Nobel Prize in Physiology or Medicine 2018[A/OL].(2018-10-01)[2019-03-14].https://www.nobelprize.org/prizes/medicine/2018/summary/.
[7] MILLAN M J,GOODWIN G M,MEYER-lINDENBERG A,et al.Learning from the past and looking to the future:Emerging perspectives for improving the treatment of psychiatric disorders[J].Eur Neuropsychopharmacol,2015,25(5):599-656.
[8] PANKEVICH D E,ALTEVOGT B M,DUNLOP J,et al.Improving and accelerating drug development for nervous system disorders[J].Neuron,2014,84(3):546-553.
[9] ESCH E W,BAHINSKI A,HUH D.Organs-on-chips at the frontiers of drug discovery[J].Nat Rev Drug Discov,2015,14(4):248-260.
[10] BORENSTEIN J T.Organs-on-chips:how microsystems technology can transform the drug development process[J].IEE Pulse,2016,7(2):22-26.
[11] TAKAHASH T.Organoids for drug discovery and persona-lized medicine[J].Ann Rev Pharmacol Toxicol,2019,59:447-462.
[12] ROSSI G,MANFRIN A,LUTOLF M P.Progress and potential in organoid research [J].Nat Rev Genetics,2018,19(11):671-687.
[13] CHEN K G,MALLON B S,PARK K,et al.Pluripotent stem cell platforms for drug discovery[J].Trends Mol Med,2018,24(9):805-820.
[14] ZHANG L,TAN J,HAN D,et al.From machine learning to deep learning:progress in machine intelligence for rational drug discovery[J].Drug Discov Today,2017,22(11):1680-1685.
[15] CAMACHO D M,COLLINS K M,POWERS R K,et al.Next-generation machine learning for biological networks[J].Cell,2018,173(7):1581-1592.
[16] Nobel Media AB 2019.Charles K.Kao-Facts[A/OL].(2009-12-08)[2019-03-14].https://www.nobelprize.org/prizes/physics/2009/kao/facts/.
[17] Nobel Media AB 2019.Daniel C.Tsui-Facts[A/OL].(1998-12-08)[2019-03-14].https://www.nobelprize.org/prizes/physics/1998/tsui/facts/.
[18] Nobel Media AB 2019.Chen Ning Yang-Facts[A/OL].(1957-12-11)[2019-03-14].https://www.nobelprize.org/prizes/physics/1957/yang/facts/.
[19] Nobel Media AB 2019.Tsung-Dao Lee-Facts[A/OL].(1957-12-11)[2019-03-14].https://www.nobelprize.org/prizes/physics/1957/lee/facts/.
[20] Nobel Media AB 2019.Enrico Fermi-Facts[A/OL].(1938-12-12)[2019-03-14].https://www.nobelprize.org/prizes/physics/1938/fermi/facts/.
[21] 刘干中.中国药理学会成立30周年祝词[J].中国药理学与毒理学杂志,2015,29(5):678.
[22] FACCENDA E,MAXWELL S,SZAREK J L.The IUPHAR pharmacology education project[J].Clin Pharmacol Ther,2019,105(1):45-48.
[23] BARRETT J E,MCGONIGLE P,CLARK J E.Graduate education in pharmacology:addressing the need for specialized training for pharmaceutical and biotechnology careers[J].Pharmacol Res,2016,113(Pt A):327-331.
[2] HAMEDI A,ZARSHENAS M M,SOHRABPOUR M,et al.Herbal medicinal oils in traditional Persian medicine[J].Pharm Biol,2013,51(9):1208-1218.
[3] RUPANI R,CHAVEZ A.Medicinal plants with traditional use:Ethnobotany in the Indian subcontinent[J].Clin Dermatol,2018,36(3):306-309.
[4] DESBOROUGH M J R,KEELING D M.The aspirin story-from willow to wonder drug[J].Br J Haematol,2017,177(5):674-683.
[5] KHAN M O,DEIMLING M J,PHILIP A.Medicinal chemistry and the pharmacy curriculum[J].Am J Pharm Educ,2011,75(8):161.
[6] Nobel Media AB 2019.The Nobel Prize in Physiology or Medicine 2018[A/OL].(2018-10-01)[2019-03-14].https://www.nobelprize.org/prizes/medicine/2018/summary/.
[7] MILLAN M J,GOODWIN G M,MEYER-lINDENBERG A,et al.Learning from the past and looking to the future:Emerging perspectives for improving the treatment of psychiatric disorders[J].Eur Neuropsychopharmacol,2015,25(5):599-656.
[8] PANKEVICH D E,ALTEVOGT B M,DUNLOP J,et al.Improving and accelerating drug development for nervous system disorders[J].Neuron,2014,84(3):546-553.
[9] ESCH E W,BAHINSKI A,HUH D.Organs-on-chips at the frontiers of drug discovery[J].Nat Rev Drug Discov,2015,14(4):248-260.
[10] BORENSTEIN J T.Organs-on-chips:how microsystems technology can transform the drug development process[J].IEE Pulse,2016,7(2):22-26.
[11] TAKAHASH T.Organoids for drug discovery and persona-lized medicine[J].Ann Rev Pharmacol Toxicol,2019,59:447-462.
[12] ROSSI G,MANFRIN A,LUTOLF M P.Progress and potential in organoid research [J].Nat Rev Genetics,2018,19(11):671-687.
[13] CHEN K G,MALLON B S,PARK K,et al.Pluripotent stem cell platforms for drug discovery[J].Trends Mol Med,2018,24(9):805-820.
[14] ZHANG L,TAN J,HAN D,et al.From machine learning to deep learning:progress in machine intelligence for rational drug discovery[J].Drug Discov Today,2017,22(11):1680-1685.
[15] CAMACHO D M,COLLINS K M,POWERS R K,et al.Next-generation machine learning for biological networks[J].Cell,2018,173(7):1581-1592.
[16] Nobel Media AB 2019.Charles K.Kao-Facts[A/OL].(2009-12-08)[2019-03-14].https://www.nobelprize.org/prizes/physics/2009/kao/facts/.
[17] Nobel Media AB 2019.Daniel C.Tsui-Facts[A/OL].(1998-12-08)[2019-03-14].https://www.nobelprize.org/prizes/physics/1998/tsui/facts/.
[18] Nobel Media AB 2019.Chen Ning Yang-Facts[A/OL].(1957-12-11)[2019-03-14].https://www.nobelprize.org/prizes/physics/1957/yang/facts/.
[19] Nobel Media AB 2019.Tsung-Dao Lee-Facts[A/OL].(1957-12-11)[2019-03-14].https://www.nobelprize.org/prizes/physics/1957/lee/facts/.
[20] Nobel Media AB 2019.Enrico Fermi-Facts[A/OL].(1938-12-12)[2019-03-14].https://www.nobelprize.org/prizes/physics/1938/fermi/facts/.
[21] 刘干中.中国药理学会成立30周年祝词[J].中国药理学与毒理学杂志,2015,29(5):678.
[22] FACCENDA E,MAXWELL S,SZAREK J L.The IUPHAR pharmacology education project[J].Clin Pharmacol Ther,2019,105(1):45-48.
[23] BARRETT J E,MCGONIGLE P,CLARK J E.Graduate education in pharmacology:addressing the need for specialized training for pharmaceutical and biotechnology careers[J].Pharmacol Res,2016,113(Pt A):327-331.