乌鲁木齐市哈萨克族人群高尿酸血症与代谢性疾病的研究
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摘要
目的了解乌鲁木齐市哈萨克族人群中高尿酸血症组与代谢性疾病的患病情况及其相关性,为高尿酸血症与代谢性疾病的防治提供依据。方法采用病例对照研究的方法,共调查本地区哈萨克族1 035名,其中病例组194例,对照组841例,对两组人群进行问卷调查及一般生化指标的检测。采用SPSS 17.0进行统计学分析。结果哈萨克族人群中男性高尿酸血症组血尿酸平均值为(487.76±73.08)μmol/L,女性高尿酸血症组血尿酸平均值为(436.40±75.30)μmol/L,与对照组相比,哈萨克族人群中病例组BMI、BUN、CREA和腰臀比均高于对照组;男性病例组中收缩压、舒张压、血糖和HDL均高于对照组,差异均有统计学意义(P<0.05)。在代谢性疾病的相关指标比较中,高尿酸血症组的高甘油三酯高于对照组,差异有统计学意义(P<0.01)。结论乌鲁木齐市哈萨克族人群中代谢性疾病中的高甘油三酯是发生高尿酸血症的危险因素,高尿酸血症与代谢性疾病存在一定的相关性。应该重视养成良好健康的饮食和生活习惯,重视尿酸水平,预防心脑血管疾病的发生,提高生活质量,促进健康。
[Objective]To investigate the prevalence of hyperuricemia and metabolic diseases in Kazak people in Urumqi,analyze their relationship,and provide the basis for prevention and treatment of hyperuricemia and metabolic diseases. [Methods] By case-control study,1 035 Kazak people in the area were investigated,including 194 people in case group and 841 people in control group. The questionnaire survey and general biochemical indexes detection were performed in two groups. The results were statistically analyzed by SPSS 17.0. [Results] In Kazak people,the average value of blood uric acid in male hyperuricemia group was(487.76±73.08) μmol/L,and that in female hyperuricemia group was(436.40±75.30) μmol/L. The levels of BMI,BUN,CREA and waist-hip ratio in case group were higher than those in control group,the levels of systolic blood pressure,diastolic blood pressure,blood glucose and HDL in males of case group were higher than those in control group,and the differences were statistically significant(P<0.05). For the related indexes of metabolic diseases,the level of triglyceride in case group was higher than that in control group,and the difference was statistically significant(P<0.01). [Conclusion] Among metabolic diseases,high-triglycerides is the risk factors for hyperuricemia in the Kazak population of Urumqi,and hyperuricemia is associated with metabolic diseases. It is necessary to pay attention to develop a healthy diet habits and lifestyle,and focus on the uric acid level,to prevent the occurrence of cardiovascular and cerebrovascular diseases,improve quality of life and promote health.
[Objective]To investigate the prevalence of hyperuricemia and metabolic diseases in Kazak people in Urumqi,analyze their relationship,and provide the basis for prevention and treatment of hyperuricemia and metabolic diseases. [Methods] By case-control study,1 035 Kazak people in the area were investigated,including 194 people in case group and 841 people in control group. The questionnaire survey and general biochemical indexes detection were performed in two groups. The results were statistically analyzed by SPSS 17.0. [Results] In Kazak people,the average value of blood uric acid in male hyperuricemia group was(487.76±73.08) μmol/L,and that in female hyperuricemia group was(436.40±75.30) μmol/L. The levels of BMI,BUN,CREA and waist-hip ratio in case group were higher than those in control group,the levels of systolic blood pressure,diastolic blood pressure,blood glucose and HDL in males of case group were higher than those in control group,and the differences were statistically significant(P<0.05). For the related indexes of metabolic diseases,the level of triglyceride in case group was higher than that in control group,and the difference was statistically significant(P<0.01). [Conclusion] Among metabolic diseases,high-triglycerides is the risk factors for hyperuricemia in the Kazak population of Urumqi,and hyperuricemia is associated with metabolic diseases. It is necessary to pay attention to develop a healthy diet habits and lifestyle,and focus on the uric acid level,to prevent the occurrence of cardiovascular and cerebrovascular diseases,improve quality of life and promote health.
引文
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[11]谢君杰,易汛.高尿酸血症与其它代谢性疾病的相关关系分析[J].重庆医学,2012,41(1):67-68.
[12]常颂桔,黄伟.高尿酸血症与高血压及糖尿病相关性研究进展[J].中国医疗前沿,2012,7(23):11-13.
[13]魏芳.男性高尿酸血症与心血管危险因素的相关性[J].临床医药文献电子杂志,2015(1):40-41.
[14]曹立娟,林海燕,周洁,等.山东内陆地区高尿酸血症的流行现状及影响因素分析[J].军事医学,2014(11):897-900.
[15]朱梦,王红梅,刘健.乌市体检人群高尿酸血症患病率及其肾脏损害相关分析[J].中国中西医结合肾病杂志,2014,15(2):125-128.
[16]杨思进,马依彤,刘芬,等.新疆哈萨克族原发性高血压患者高尿酸血症患病率及相关危险因素分析[J].中华高血压杂志,2010,18(9):832-836.
[2]何清.高尿酸血症和通风的病因与流行病学[J].中国临床医生,2009,37(1):11-13.
[3]汪金兰.686名健康体检人群高尿酸血症患病率及危险因素分析[J].中国乡村医药杂志,2013,20(2):54-55.
[4]CONEN D,WIETLISBACH V,BOVET P,et al.Prevalence of hyperuricemia and relation of serum uric acid with cardiovaseular risk factors in a developing country[J].BMC Public Health,2004,4(1):9-11.
[5]HAKODA M.Recent Trends in Hyperuricemia and Gout in Japan[J].JMAJ,2012,55(4):319-323.
[6]LIN CS,LEE WL,HUNG YJ,et al.Prevalence of hyperuricemia and its association with antihypertensive treatment in hypertensive patients in Taiwan[J].Int J Cardiol,2012,156(1):41-46.
[7]绉贵勉,黄江燕,车文体,等.广西城市社区居民高尿酸血症流行病学调查及其与慢性肾脏病的关系[J].中华内分泌代谢杂志,2011,27(7):561-564.
[8]卢光娅.高尿酸血症与代谢综合征的相互影响及研究进展[J].重庆医学,2011,40(15):1542-1543.
[9]雷光星,刘汉芳,白莉芬.高尿酸血症与高三酰甘油血症的相关性[J].检验医学,2010,25(4):340.
[10]海燕,马臻,董砚虑.痛风和高尿酸血症的危险因素[J].国外医学内科学分册,2003,30(5):211-213.
[11]谢君杰,易汛.高尿酸血症与其它代谢性疾病的相关关系分析[J].重庆医学,2012,41(1):67-68.
[12]常颂桔,黄伟.高尿酸血症与高血压及糖尿病相关性研究进展[J].中国医疗前沿,2012,7(23):11-13.
[13]魏芳.男性高尿酸血症与心血管危险因素的相关性[J].临床医药文献电子杂志,2015(1):40-41.
[14]曹立娟,林海燕,周洁,等.山东内陆地区高尿酸血症的流行现状及影响因素分析[J].军事医学,2014(11):897-900.
[15]朱梦,王红梅,刘健.乌市体检人群高尿酸血症患病率及其肾脏损害相关分析[J].中国中西医结合肾病杂志,2014,15(2):125-128.
[16]杨思进,马依彤,刘芬,等.新疆哈萨克族原发性高血压患者高尿酸血症患病率及相关危险因素分析[J].中华高血压杂志,2010,18(9):832-836.