青岛市某高校女职工宫颈脱落细胞感染人乳头瘤病毒型别调查
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摘要
目的调查中国石油大学(华东)青岛校区女职工群体宫颈脱落上皮细胞中人乳头瘤病毒(HPV)感染状况及病毒不同基因亚型的分布状况,为本校制定女职工两癌筛查及防治策略提供科学依据,也为青岛地区高校女职工群体HPV感染状况研究提供数据支持。方法收集2016年在校医院体检的女职工自愿进行宫颈脱落上皮细胞HPV检测的结果,然后进行统计分析。结果 1 520名进行HPV检测的女职工总体感染率为12.37%,其中高危型HPV(HR-HPV)与低危型HPV(LR-HPV)构成比分别为68.09%、31.91%;该群体感染HR-HPV主要亚型为52亚型、58亚型、39亚型,感染LR-HPV主要亚型为42亚型、53亚型、6亚型;单一HPV病毒亚型感染占75.53%,多重感染占24.47%,多重感染的多发基因亚型与人群感染HPV主要基因亚型不完全相同;不同年龄段的职工HPV感染率不同,多重感染率也不同,按年龄段均呈不对称的"U"型分布。结论本调查人群感染率略高于其他地区高校群体,人群HPV感染主要基因亚型也不同,校医院对不同年龄段的职工应制定有针对性的指导、检测、治疗和随访策略,降低本人群的HPV感染率和宫颈癌的发生率。
Objective To investigate the infectious conditions of human papillomavirus(HPV) and the distribution of its different gene subtypes in cervical exfoliated epithelial cells of female workers in the Qingdao campus of China University of Petroleum(Hua Dong), so as to provide the evidence for the development of"two-cancer"screening and prevention strategies, and the data support for the study of HPV infection in female college workers in Qingdao area.Methods The HPV detection results of cervical exfoliated epithelial cells of school female workers who took part in the physical examinations were collected and statistically analyzed in 2016. Results Among the 1 520 female workers, the overall HPV infection rate was 12.37%, including high-risk HPV(HR-HPV, 68.09%) and low risk HPV(LR-HPV, 31.91%). The main subtypes of HR-HPV infection group included 52-subtype, 58-subtype, and 39-subtype; the main subtypes of LR-HPV infection group included 42-subtype, 53-sub type, and 6-subtype. The single subtype infection accounted for75.53% and the multiple infections accounted for 24.47%. The multiple subtypes and multiple infection population HPV genotypes were not exactly the same. The workers of different ages had different HPV infection rates and different multiple infection rates, and both presented asymmetric "U" type distributions.Conclusion The HPV infection rate of the surveyed population is slightly higher than that of other groups in the surveyed area, and the main subtypes of HPV are also different. Therefore, the targeted strategies of guidance, detection, treatment and follow-up need to be formulated according to the characteristics of the different age groups, so as to reduce the HPV infection rate and cervical cancer incidence.
Objective To investigate the infectious conditions of human papillomavirus(HPV) and the distribution of its different gene subtypes in cervical exfoliated epithelial cells of female workers in the Qingdao campus of China University of Petroleum(Hua Dong), so as to provide the evidence for the development of"two-cancer"screening and prevention strategies, and the data support for the study of HPV infection in female college workers in Qingdao area.Methods The HPV detection results of cervical exfoliated epithelial cells of school female workers who took part in the physical examinations were collected and statistically analyzed in 2016. Results Among the 1 520 female workers, the overall HPV infection rate was 12.37%, including high-risk HPV(HR-HPV, 68.09%) and low risk HPV(LR-HPV, 31.91%). The main subtypes of HR-HPV infection group included 52-subtype, 58-subtype, and 39-subtype; the main subtypes of LR-HPV infection group included 42-subtype, 53-sub type, and 6-subtype. The single subtype infection accounted for75.53% and the multiple infections accounted for 24.47%. The multiple subtypes and multiple infection population HPV genotypes were not exactly the same. The workers of different ages had different HPV infection rates and different multiple infection rates, and both presented asymmetric "U" type distributions.Conclusion The HPV infection rate of the surveyed population is slightly higher than that of other groups in the surveyed area, and the main subtypes of HPV are also different. Therefore, the targeted strategies of guidance, detection, treatment and follow-up need to be formulated according to the characteristics of the different age groups, so as to reduce the HPV infection rate and cervical cancer incidence.
引文
[1]陈慧平.HPV-DNA亚型检测联合液基细胞学对宫颈癌筛查的临床价值[J].海南南医学院学报,2012,18(6):764-766.
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[3]王琳,韩莉莉,玛依努尔·尼牙孜,等.人乳头瘤病毒E6、E7蛋白在维吾尔族及汉族宫颈癌发展中的表达及意义[J].中国医药导报,2015,12(21):75-78.
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[6]陈明华,印永祥,张玉娟,等.11231例女性宫颈HPV基因分型的回顾分析[J].中国妇幼保健,2014,29(34):5570-5573.
[7]Kwan TT,Chan KK,Yip AM,et al.Acceptability of human papillomavirus vaccination among Chinese women:concerns and implications[J].BJOG,2009,116(4):501-510.
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[9]Bernard HU,C,alleja-Macias IE,Dunn ST.Genome variation of human papillomavirus types:phylogenetic and medical implications[J].Int J Cancer,2006,118(5):1071-1076.
[10]Szostek S,Klimek M,Zawilinska B,et al.Genotypespecific human papillomavirus detection in cervical smears[J].Acta Biochim Pol,2008,55(4):687-692.
[11]崔惠景,王蕴慧,文英,等.某高校女职工宫颈上皮细胞人乳头瘤状病毒基因型别分布调查分析[J].中国卫生检验杂志,2016,26,(7):1040-1042.
[12]樊静,于丹军,李淑英.秦皇岛女性人乳头瘤病毒型别分布特征分析[J].中国疗养医学,2016,25(6):667-670.
[13]Cogliano V,Baan R,Straif K,et al.Carcinogenicity of human papillomaviruses[J].Lancet Oncol,2005,6(4):204.
[14]陈霞,杨静秀,吴晓燕.HPV不同亚型在中重度宫颈上皮内瘤样变与宫颈癌中的分布及临床意义[J].中国妇幼保健,2014,29(21):3402-3404.
[15]卢娉霞,邹红,祝先进,等.1603例女性宫颈脱落细胞HPV-DNA检测结果分析[J].福建医科大学学报,2012,46(2):144-145.
[16]杨海丽,林力锋,孙冰纯.人乳头瘤病毒感染的年龄分布特点探讨[J].河北医药,2015,37(2):601-603.
[17]张青,杨真,袁小林,等.大连地区2755例不同年龄组HPV亚型感染状况分析[J].现代预防医学,2014,41(2):345-348.
[18]陶萍萍,张国荣,卞美璐,等.女性生殖道21种亚型人乳头瘤状病毒感染与性行为、孕产史、文化程度等因素相关性分析[J].中国妇产科临床杂志,2008,9(1):20-23.
[19]张淑英,马磊,韩凤英,等.HPV多重感染与新疆维吾尔族妇女宫颈癌病变的关系研究[J].新疆医科大学报,2008,31(3):313-315.
[20]杨琳,李霓,郭兰伟,等.2010年黑龙江省大庆市妇女人乳头状瘤病毒感染状况及其危险因素调查[J].中华预防医学杂志,2013,47,(2):118-123.
[2]Hoory T,Monie A,Gravitt P,et al.Molecular epidemionlogy of humanpa pillomabirus[J].J Formos Med Assoc,2008,107(3):198-217.
[3]王琳,韩莉莉,玛依努尔·尼牙孜,等.人乳头瘤病毒E6、E7蛋白在维吾尔族及汉族宫颈癌发展中的表达及意义[J].中国医药导报,2015,12(21):75-78.
[4]Pierce Campbell CM,Menezes LJ,Paskett ED,et al.Prevention of invasive cervical in the United States:past,present,and future[J].Cancer Epidemiol Biomarkers Prev,2012,21(9):1402-1408.
[5]吴韶清,廖灿,黄以宁,等.542例妇女人乳头瘤病毒多重感染检测结果分析[J].实用医学杂志,2010,26(22):4100-4102.
[6]陈明华,印永祥,张玉娟,等.11231例女性宫颈HPV基因分型的回顾分析[J].中国妇幼保健,2014,29(34):5570-5573.
[7]Kwan TT,Chan KK,Yip AM,et al.Acceptability of human papillomavirus vaccination among Chinese women:concerns and implications[J].BJOG,2009,116(4):501-510.
[8]de Villiers EM,Fauquet C,Broker TR,et al.Classification of papillomaviruses[J].Virollgy,2004,324(1):17-27.
[9]Bernard HU,C,alleja-Macias IE,Dunn ST.Genome variation of human papillomavirus types:phylogenetic and medical implications[J].Int J Cancer,2006,118(5):1071-1076.
[10]Szostek S,Klimek M,Zawilinska B,et al.Genotypespecific human papillomavirus detection in cervical smears[J].Acta Biochim Pol,2008,55(4):687-692.
[11]崔惠景,王蕴慧,文英,等.某高校女职工宫颈上皮细胞人乳头瘤状病毒基因型别分布调查分析[J].中国卫生检验杂志,2016,26,(7):1040-1042.
[12]樊静,于丹军,李淑英.秦皇岛女性人乳头瘤病毒型别分布特征分析[J].中国疗养医学,2016,25(6):667-670.
[13]Cogliano V,Baan R,Straif K,et al.Carcinogenicity of human papillomaviruses[J].Lancet Oncol,2005,6(4):204.
[14]陈霞,杨静秀,吴晓燕.HPV不同亚型在中重度宫颈上皮内瘤样变与宫颈癌中的分布及临床意义[J].中国妇幼保健,2014,29(21):3402-3404.
[15]卢娉霞,邹红,祝先进,等.1603例女性宫颈脱落细胞HPV-DNA检测结果分析[J].福建医科大学学报,2012,46(2):144-145.
[16]杨海丽,林力锋,孙冰纯.人乳头瘤病毒感染的年龄分布特点探讨[J].河北医药,2015,37(2):601-603.
[17]张青,杨真,袁小林,等.大连地区2755例不同年龄组HPV亚型感染状况分析[J].现代预防医学,2014,41(2):345-348.
[18]陶萍萍,张国荣,卞美璐,等.女性生殖道21种亚型人乳头瘤状病毒感染与性行为、孕产史、文化程度等因素相关性分析[J].中国妇产科临床杂志,2008,9(1):20-23.
[19]张淑英,马磊,韩凤英,等.HPV多重感染与新疆维吾尔族妇女宫颈癌病变的关系研究[J].新疆医科大学报,2008,31(3):313-315.
[20]杨琳,李霓,郭兰伟,等.2010年黑龙江省大庆市妇女人乳头状瘤病毒感染状况及其危险因素调查[J].中华预防医学杂志,2013,47,(2):118-123.