摘要
近年来,由于在视神经脊髓炎(NMO)中发现了特异性抗体-抗水通道蛋白抗体,学者开始重视对NMO的研究。随着研究的不断深入,人们对NMO发病机制的了解也日益增多,目前认为,NMO的发病是基因、免疫机制、环境等多种影响因素共同作用的结果,其中免疫系统在NMO的发生、发展中具有重要作用。免疫系统是一个复杂的大网络,各部分之间的相互协调是维持机体正常稳态的关键,任何一个环节的破坏均可能会引起免疫平衡的打破。该文从抗体、补体、免疫细胞的角度就NMO的免疫学发病机制研究进展作一综述。
Recently,researchers have begun to pay attention to the study of neuromyelitis optica(NMO)due to the discovery of the specific antibody-anti-aquaporin antibodies.With the deepening of research,understanding of the pathogenesis of NMO is increasing.It is believed that the pathogenesis of NMO is the consequence of the combined effect of genes,immune mechanisms and environment.Among them,the immune system is the most impotant role.The immune system is a large complex network,The coordination of which is the key to maintaining the homeostasis of body.And the destruction of any link might break the balance of immune system.In the present review,we will summarize the research progress of immunological pathogenesis of NMO from the perspective of antibody,complement and immune cells.
引文
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