免疫固定电泳对多发性骨髓瘤的诊断价值
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摘要
目的探讨免疫固定电泳(IFE)在多发性骨髓瘤(MM)诊断中的价值。方法采用法国Sebia公司生产的Hydarsys 2琼脂糖凝胶电泳仪,对临床上有检测需求的患者血清进行IFE,并回顾性分析其相关实验室检查资料。结果 155例患者的血清IFE检测结果中,67例阳性,其中经临床诊断证实的MM 51例。IFE对MM诊断的灵敏度和特异度分别为69.9%、80.5%。51例IFE阳性的MM患者中,以免疫球蛋白(Ig)Gκ型和λ型为主,分别占19.61%、27.45%,但其余各型均有分布。51例IFE阳性MM患者病例资料回顾性分析结果显示,由于原发疾病被贫血、骨痛等首发症状掩盖,患者常会就诊于其他科室。结论 IFE对MM的准确诊断、疗效监测、预后判断具有重要的临床意义。
Objective To evaluate the value of immunofixation electrophoresis(IFE)in the diagnosis of multiple myeloma(MM).Methods The Sebia Hydrasys 2 agarose electrophoresis apparatus made byFrance was adopted to perform IFE on the serum samples in the patients with the clinical IFE detection demand.The related laboratory detection data of these patients were retrospectively analyzed.Results Among 155 cases of IFE detection results,67 cases were positive,in which 51 cases of MM were verified by clinical diagnosis.The sensitivity and specificity of IFE for diagnosing MM were 69.9% and 80.5% respectively.In 51 cases of MM,IgG kappa type and IgG lambda type were predominant,accounting for 19.61% and 27.45%,respectively,but the other types had distribution.The retrospective analysis results of the medical record data in 51 cases of MM and positive IFE showed that the patients often visited to other departments because the primary disease was covered with the initial symptoms such as anemia,bone pain.Conclusion IFE has important clinical significance for accurately diagnosing MM,monitoring the curative effect and judging prognosis.
Objective To evaluate the value of immunofixation electrophoresis(IFE)in the diagnosis of multiple myeloma(MM).Methods The Sebia Hydrasys 2 agarose electrophoresis apparatus made byFrance was adopted to perform IFE on the serum samples in the patients with the clinical IFE detection demand.The related laboratory detection data of these patients were retrospectively analyzed.Results Among 155 cases of IFE detection results,67 cases were positive,in which 51 cases of MM were verified by clinical diagnosis.The sensitivity and specificity of IFE for diagnosing MM were 69.9% and 80.5% respectively.In 51 cases of MM,IgG kappa type and IgG lambda type were predominant,accounting for 19.61% and 27.45%,respectively,but the other types had distribution.The retrospective analysis results of the medical record data in 51 cases of MM and positive IFE showed that the patients often visited to other departments because the primary disease was covered with the initial symptoms such as anemia,bone pain.Conclusion IFE has important clinical significance for accurately diagnosing MM,monitoring the curative effect and judging prognosis.
引文
[1]田永芳,贾海英,田洪燕.47例多发性骨髓瘤综合分析[J].临床血液学杂志:输血与检验版,2010,23(4):473-474,478.
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[4]张之南.血液病诊断及疗效标准[M].2版.北京:科学出版社,1998:373-380.
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[6]International Myeloma Working Group.Criteria for the classification of monoclonal gammopathies,multiple myeloma and related disorders:a report of the International Myeloma Working Group[J].Br J Haematol,2003,121(5):749-757.
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[8]卢娉霞,陈莺,张敬喜.免疫固定电泳在多发性骨髓瘤免疫分型中的应用[J].实验与检验医学,2009,27(3):267-268.
[9]乔永红,保方,陈莲英,等.免疫固定电泳技术在多发性骨髓瘤31例中的诊断价值[J].交通医学,2011,24(5):477-478.
[10]刘玉梅,黄琳淋,赵有利,等.296例血清免疫固定电泳检测结果分析[J].微循环学杂志,2012,22(2):45-46.
[2]张之南,沈悌.血液病诊断及疗效标准[M].3版.北京:科学出版社,2007:32-234.
[3]罗琳,罗军,赖颖晖,等.33例多发性骨髓瘤患者血清免疫学特征[J].临床血液学杂志,2006,19(1):39-40.
[4]张之南.血液病诊断及疗效标准[M].2版.北京:科学出版社,1998:373-380.
[5]张磊,高秀登,刘树业.免疫固定电泳在多发性骨髓瘤中的诊断价值[J].中国实验诊断学,2011,15(3):517-519.
[6]International Myeloma Working Group.Criteria for the classification of monoclonal gammopathies,multiple myeloma and related disorders:a report of the International Myeloma Working Group[J].Br J Haematol,2003,121(5):749-757.
[7]孟秀琴,艾工文.18例多发性骨髓瘤临床分析[J].临床血液学杂志,2005,18(1):40-41.
[8]卢娉霞,陈莺,张敬喜.免疫固定电泳在多发性骨髓瘤免疫分型中的应用[J].实验与检验医学,2009,27(3):267-268.
[9]乔永红,保方,陈莲英,等.免疫固定电泳技术在多发性骨髓瘤31例中的诊断价值[J].交通医学,2011,24(5):477-478.
[10]刘玉梅,黄琳淋,赵有利,等.296例血清免疫固定电泳检测结果分析[J].微循环学杂志,2012,22(2):45-46.