天然右旋龙脑精制工艺研究
|
摘要
以石油醚溶剂进行天然龙脑的精制,研究固液比、溶解温度、结晶温度对精制效果的影响。结果表明,较优的工艺条件是:固液质量比1∶1,溶解温度70℃,结晶温度5℃,产品收率可达70. 90%,天然龙脑含量98. 03%。各因素对龙脑精制得率影响顺序是:固液质量比>溶解温度>结晶温度。
The nature borneol was purification by petroleum ether as the solvent. The influence of the solid-liquid ratio,dissolution temperature and crystallization temperature on the purification effect were investigated. The result showed that the optimized conditions were: the solid-liquid ratio was 1 ∶ 1,the dissolution temperature was 70 ℃,the crystallization temperature was 5 ℃,the yield of the purification was70. 90%,the nature borneol content of the product was 98. 03%. The influence order factor on the yield of purification was solid-liquid ratio > dissolution temperature > crystallization temperature.
The nature borneol was purification by petroleum ether as the solvent. The influence of the solid-liquid ratio,dissolution temperature and crystallization temperature on the purification effect were investigated. The result showed that the optimized conditions were: the solid-liquid ratio was 1 ∶ 1,the dissolution temperature was 70 ℃,the crystallization temperature was 5 ℃,the yield of the purification was70. 90%,the nature borneol content of the product was 98. 03%. The influence order factor on the yield of purification was solid-liquid ratio > dissolution temperature > crystallization temperature.
引文
[1]刘宝全,钟美玲,李柏龙,等.龙脑樟枝叶的组成特点研究[J].大连民族学院学报,2017,19(1):28-31.
[2]梁忠云,李桂珍,陈海燕,等.龙脑樟叶脱脑油成分分析[J].香料香精化妆品,2016(1):1-4.
[3]杨国英,张洪,陈震.樟脑电合成龙脑[J].应用化工,2008,37(1):37-40.
[4]郭珊珊,余玲,陈巧玲,等.冰片药效学研究进展[J].中国现代中药,2008,10(6):6-9.
[5]张宇思,王成章,周昊,等.不同产地龙脑樟叶挥发油成分的GC-MS分析[J].中国实验方剂学杂志,2014,20(10):57-61.
[6]陈红梅,孙凌峰.江西吉安龙脑樟资源开发与利用前景[J].林业科学,2006,42(3):94-98.
[7]崔琳.天然冰片的精制工艺优化研究[D].长沙:中南林业科技大学,2015.
[8]宋永芳,罗嘉梁.高纯度天然右旋龙脑的制备研究[J].林产化学与工业,2003,23(3):11-14.
[9]陈楚阳.从龙脑樟提取天然冰片的工艺研究[D].武汉:武汉工程大学,2017.
[2]梁忠云,李桂珍,陈海燕,等.龙脑樟叶脱脑油成分分析[J].香料香精化妆品,2016(1):1-4.
[3]杨国英,张洪,陈震.樟脑电合成龙脑[J].应用化工,2008,37(1):37-40.
[4]郭珊珊,余玲,陈巧玲,等.冰片药效学研究进展[J].中国现代中药,2008,10(6):6-9.
[5]张宇思,王成章,周昊,等.不同产地龙脑樟叶挥发油成分的GC-MS分析[J].中国实验方剂学杂志,2014,20(10):57-61.
[6]陈红梅,孙凌峰.江西吉安龙脑樟资源开发与利用前景[J].林业科学,2006,42(3):94-98.
[7]崔琳.天然冰片的精制工艺优化研究[D].长沙:中南林业科技大学,2015.
[8]宋永芳,罗嘉梁.高纯度天然右旋龙脑的制备研究[J].林产化学与工业,2003,23(3):11-14.
[9]陈楚阳.从龙脑樟提取天然冰片的工艺研究[D].武汉:武汉工程大学,2017.