野黄芩苷治疗青光眼研究进展
|
摘要
野黄芩苷又名灯盏花乙素,是中药灯盏细辛中的主要活性物质,属黄酮类化合物,可以降低血管阻力,改善血液循环,增加循环血流量及抗血小板凝集,具有保护心脑血管、保护视神经、抗炎、抗肿瘤等多种作用,临床上已经用于治疗肾、肝功能受损,青光眼以及心脑血管等疾病。青光眼是世界第一大致盲眼病,其痊愈率低,复发率高,难以治疗,严重危害人们视觉健康。野黄芩苷可通过促进视网膜神经节细胞轴突生长,保护视神经生物活性,改善视乳头血液的微循环来治疗青光眼。本文就野黄芩苷治疗青光眼的研究进展进行综述。
引文
[1]孙兴怀.21世纪挑战青光眼[J].上海医学,2001,24(12):709-710.
[2]石慧.青光眼神经节细胞退行性病变相关研究[D].武汉:华中科技大学,2013.
[3]吴典伟.野黄芩苷对洋刀豆脲酶的抑制作用及其机理研究[D].广州:广州中医药大学,2014.
[4]杨丽.两种提取方法对黄芩籽种壳提取物中野黄芩苷含量的比较研究[J].农产品加工,2015(21):45-46.
[5]颜承,徐冠玲,谢梦,等.野黄芩苷和野黄芩素制备研究进展[J].中成药,2015,37(8):1785-1790.
[6]朱邦胜,孙洪胜,蔡明.黄芩茎叶中野黄芩苷的提取工艺研究[J].中医药临床杂志,2015,27(5);732-735.
[7]史高峰,祝娟娟,张兴潜,等.黄芩茎叶中总黄酮提取工艺优化[J].食品科学,2012,33(20):109-112.
[8]GRECO A,RIZZO M I,DE VIRGILIO A,et al.Emerging concepts in glaucoma and review of the literature[J].Am JMed,2016,129(9):1000.
[9]STAHNKE T,SIEWERT S,WALTHER E,et al.Adopting oculopressure tonometry as a transient in vivo rabbit glaucoma model[J].Cur Dir Biomed Eng,2015,1(1):127-130.
[10]BUTT N H,AYUB M H,ALI M H.Challenges in the management of glaucoma in developing countries[J].Taiwan J Ophthalmol,2016,6(3):119-122.
[11]DANFORD I D,VERKUIL L D,CHOI D J,et al.Characterizing the“POAGome”:a bioinformatics-driven approach to primary open-angle glaucoma[J].Prog Retin Eye Res,2017,58:89-114.
[12]MCMONNIES C W.Glaucoma history and risk factors[J].J Optom,2017,10(2):71-78.
[13]杨迪亚,王宁利.重视原发性开角型青光眼的整合眼科学研究[J].中华眼科医学杂志(电子版),2016,6(1):1-6.
[14]SIAUDVYTYTE L,JANULEVICIENE I,RAGAUSKAS A,et al.Update in intracranial pressure evaluation methods and translaminar pressure gradient role in glaucoma[J].Acta Ophthalmol,2015,93(1):9-15.
[15]JIA Y L,WEI E,WANG X G,et al.Optical coherence tomography angiography of optic disc perfusion in glaucoma[J].Ophthalmology,2014,121(7):1322-1332.
[16]KIM M J,KIM M J,KIM H S,et al.Risk factors for openangle glaucoma with normal baseline intraocular pressure in a young population:the Korea National Health and Nutrition Examination Survey[J].Clin Exp Ophthalmol,2014,42(9):825-832.
[17]DAI Z X,YU X B,HONG J X,et al.Development of a novel Cs A-PLGA drug delivery system based on a glaucoma drainage device for the prevention of postoperative fibrosis[J].Mater Sci Eng C Mater Biol Appl,2016,66:206-214.
[18]RAO P V,PATTABIRAMAN P P,KOPCZYNSKI C.Role of the Rho GTPase/Rho kinase signaling pathway in pathogenesis and treatment of glaucoma:bench to bedside research[J].Exp Eye Res,2017,158:23-32.
[19]梁未雯.灯盏细辛注射液对脑缺血再灌注模型大鼠的PK-PD相关性研究[D].成都:成都中医药大学,2016.
[20]张艺,盛艳梅,孟宪丽,等.灯盏花中单体成分对体外培养大鼠视网膜神经细胞的影响[J].中国中药杂志,2005,30(12):907-909.
[21]谷冬梅,张东蕾,卢山,等.中药对青光眼视神经及视网膜神经节细胞保护作用机制研究简况[J].实用中医内科杂志,2016,30(3):95-97.
[22]杨建华,付敏.灯盏细辛提取物对高眼压大鼠视网膜神经节细胞的保护作用[J].中国中医眼科杂志,2013,23(2):96-99.
[23]刘小红.压力对体外培养RGCs的影响及灯盏细辛对压力诱导RGCs损伤的保护作用[D].成都:成都中医药大学,2015.
[24]张静,杨文宇,张艺,等.灯盏细辛化学成分及视神经保护活性成分的研究[J].中国药学杂志,2006,41(22):1695-1697.
[25]杨君红,俞颂平,吴道雷.灯盏花素对青光眼滤过术后中晚期原发性开角型患者视功能的影响[J].中国药师,2015,18(12):2082-2084.
[26]张艺,盛艳梅,孟宪丽,等.中药钙拮抗作用与视神经保护的相关性研究[J].世界科学技术-中医药现代化,2005,7(4):23-27.
[27]郑晓娟.野黄芩苷抗缺血性脑损伤作用及机制研究[D].上海:上海医药工业研究院,2006.
[28]普元柱.灯盏细辛提取物酚类成分分析及血清药物化学初步研究[D].成都:成都中医药大学,2011.
[29]李华.灯盏细辛对青光眼视神经保护作用的临床研究[J].中医临床研究,2013,5(24):33-34.
[30]刘东敬,鲍捷,陈晓明,等.灯盏细辛对眼压已控制青光眼视网膜微循环的影响[J].国际眼科杂志,2006,6(1):107-109.
[2]石慧.青光眼神经节细胞退行性病变相关研究[D].武汉:华中科技大学,2013.
[3]吴典伟.野黄芩苷对洋刀豆脲酶的抑制作用及其机理研究[D].广州:广州中医药大学,2014.
[4]杨丽.两种提取方法对黄芩籽种壳提取物中野黄芩苷含量的比较研究[J].农产品加工,2015(21):45-46.
[5]颜承,徐冠玲,谢梦,等.野黄芩苷和野黄芩素制备研究进展[J].中成药,2015,37(8):1785-1790.
[6]朱邦胜,孙洪胜,蔡明.黄芩茎叶中野黄芩苷的提取工艺研究[J].中医药临床杂志,2015,27(5);732-735.
[7]史高峰,祝娟娟,张兴潜,等.黄芩茎叶中总黄酮提取工艺优化[J].食品科学,2012,33(20):109-112.
[8]GRECO A,RIZZO M I,DE VIRGILIO A,et al.Emerging concepts in glaucoma and review of the literature[J].Am JMed,2016,129(9):1000.
[9]STAHNKE T,SIEWERT S,WALTHER E,et al.Adopting oculopressure tonometry as a transient in vivo rabbit glaucoma model[J].Cur Dir Biomed Eng,2015,1(1):127-130.
[10]BUTT N H,AYUB M H,ALI M H.Challenges in the management of glaucoma in developing countries[J].Taiwan J Ophthalmol,2016,6(3):119-122.
[11]DANFORD I D,VERKUIL L D,CHOI D J,et al.Characterizing the“POAGome”:a bioinformatics-driven approach to primary open-angle glaucoma[J].Prog Retin Eye Res,2017,58:89-114.
[12]MCMONNIES C W.Glaucoma history and risk factors[J].J Optom,2017,10(2):71-78.
[13]杨迪亚,王宁利.重视原发性开角型青光眼的整合眼科学研究[J].中华眼科医学杂志(电子版),2016,6(1):1-6.
[14]SIAUDVYTYTE L,JANULEVICIENE I,RAGAUSKAS A,et al.Update in intracranial pressure evaluation methods and translaminar pressure gradient role in glaucoma[J].Acta Ophthalmol,2015,93(1):9-15.
[15]JIA Y L,WEI E,WANG X G,et al.Optical coherence tomography angiography of optic disc perfusion in glaucoma[J].Ophthalmology,2014,121(7):1322-1332.
[16]KIM M J,KIM M J,KIM H S,et al.Risk factors for openangle glaucoma with normal baseline intraocular pressure in a young population:the Korea National Health and Nutrition Examination Survey[J].Clin Exp Ophthalmol,2014,42(9):825-832.
[17]DAI Z X,YU X B,HONG J X,et al.Development of a novel Cs A-PLGA drug delivery system based on a glaucoma drainage device for the prevention of postoperative fibrosis[J].Mater Sci Eng C Mater Biol Appl,2016,66:206-214.
[18]RAO P V,PATTABIRAMAN P P,KOPCZYNSKI C.Role of the Rho GTPase/Rho kinase signaling pathway in pathogenesis and treatment of glaucoma:bench to bedside research[J].Exp Eye Res,2017,158:23-32.
[19]梁未雯.灯盏细辛注射液对脑缺血再灌注模型大鼠的PK-PD相关性研究[D].成都:成都中医药大学,2016.
[20]张艺,盛艳梅,孟宪丽,等.灯盏花中单体成分对体外培养大鼠视网膜神经细胞的影响[J].中国中药杂志,2005,30(12):907-909.
[21]谷冬梅,张东蕾,卢山,等.中药对青光眼视神经及视网膜神经节细胞保护作用机制研究简况[J].实用中医内科杂志,2016,30(3):95-97.
[22]杨建华,付敏.灯盏细辛提取物对高眼压大鼠视网膜神经节细胞的保护作用[J].中国中医眼科杂志,2013,23(2):96-99.
[23]刘小红.压力对体外培养RGCs的影响及灯盏细辛对压力诱导RGCs损伤的保护作用[D].成都:成都中医药大学,2015.
[24]张静,杨文宇,张艺,等.灯盏细辛化学成分及视神经保护活性成分的研究[J].中国药学杂志,2006,41(22):1695-1697.
[25]杨君红,俞颂平,吴道雷.灯盏花素对青光眼滤过术后中晚期原发性开角型患者视功能的影响[J].中国药师,2015,18(12):2082-2084.
[26]张艺,盛艳梅,孟宪丽,等.中药钙拮抗作用与视神经保护的相关性研究[J].世界科学技术-中医药现代化,2005,7(4):23-27.
[27]郑晓娟.野黄芩苷抗缺血性脑损伤作用及机制研究[D].上海:上海医药工业研究院,2006.
[28]普元柱.灯盏细辛提取物酚类成分分析及血清药物化学初步研究[D].成都:成都中医药大学,2011.
[29]李华.灯盏细辛对青光眼视神经保护作用的临床研究[J].中医临床研究,2013,5(24):33-34.
[30]刘东敬,鲍捷,陈晓明,等.灯盏细辛对眼压已控制青光眼视网膜微循环的影响[J].国际眼科杂志,2006,6(1):107-109.