雌二醇分子印迹聚合物的制备与应用研究进展
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摘要
雌二醇环境内分泌干扰物的滥用及残留对生物体和环境危害较大,其含量低且易受复杂基质干扰而难以检测。通过分子印迹技术(MIT)制备的分子印迹聚合物(MIPs)以其高选择性、高稳定性、容易制备等优势,在基质复杂、含量低、危害大的目标物分析检测中备受青睐,雌二醇分子印迹聚合物(E_2-MIPs)已有较多报道。综述了2014～2018年以来,E_2-MIPs的自由基聚合、溶胶-凝胶聚合和表面印迹聚合方法制备及E_2-MIPs在样品前处理、传感器、膜分离等方面的应用,并对E_2-MIPs的制备和应用前景进行了展望。
The abuse and residues of estradiol environmental endocrine disruptors are very harmful to the organism and the environment,and estradiol is difficult to be detected owing to the low content and the complicated matrices interferences. Molecularly imprinted polymers( MIPs) prepared by molecular imprinting technology have versatile advantages of the high selectivity, high stability and easy preparation. Consequently,MIPs have gained popularity in the analysis of hazardous targets at low levels in complicated matrices. Among MIPs,a number of studies based on E_2-MIPs have been reported. Herein,related preparation methods and applications of E_2-MIPs are reviewed since 2014-2018,focusing on free radical polymerization,sol-gel polymerization and the new surface imprinting methods for E_2-MIPs,and their applications in sample pretreatment,sensor and membrane separation.Finally,the challenges and perspectives of E_2-MIPs are proposed.
The abuse and residues of estradiol environmental endocrine disruptors are very harmful to the organism and the environment,and estradiol is difficult to be detected owing to the low content and the complicated matrices interferences. Molecularly imprinted polymers( MIPs) prepared by molecular imprinting technology have versatile advantages of the high selectivity, high stability and easy preparation. Consequently,MIPs have gained popularity in the analysis of hazardous targets at low levels in complicated matrices. Among MIPs,a number of studies based on E_2-MIPs have been reported. Herein,related preparation methods and applications of E_2-MIPs are reviewed since 2014-2018,focusing on free radical polymerization,sol-gel polymerization and the new surface imprinting methods for E_2-MIPs,and their applications in sample pretreatment,sensor and membrane separation.Finally,the challenges and perspectives of E_2-MIPs are proposed.
引文
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