Fas及其配体FasL等与凋亡相关的基因参与葡萄膜炎发病机制的研究进展
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摘要
葡萄膜炎是一种种类繁多、病因复杂的疾病,可由感染、外伤、遗传、自身免疫反应等因素引发。其中,以自身免疫反应最为常见。对免疫学发展机制的深入研究是目前葡萄膜炎的主要研究方向。其中,细胞因子在葡萄膜炎发病过程中的作用及其与疾病活动之间的关系正受到越来越多的关注,并逐渐形成了一个免疫应答体系。而近期的研究发现,Fas及其配体Fas L等相关基因在葡萄膜炎的发生发展中起到了一定的作用,这可能是葡萄膜炎反复发作的原因。
Uveitis is a disease with wide variety and complex etiology,caused by infection,trauma,genetic,autoimmune reaction and other factors. Among them,autoimmune reaction is the most common factor. A deep study on the development of immunology mechanism is the main research direction of uveitis.The role of cytokines in the pathogenesis of uveitis and the relationship between the activity of disease and cytokines receive more and more attention and gradually form a system of immune response. Recent studies have found that relevant genes of Fas and Fas L have played a certain role in the pathogenesis of uveitis,which may be the cause of recurrent uveitis.
Uveitis is a disease with wide variety and complex etiology,caused by infection,trauma,genetic,autoimmune reaction and other factors. Among them,autoimmune reaction is the most common factor. A deep study on the development of immunology mechanism is the main research direction of uveitis.The role of cytokines in the pathogenesis of uveitis and the relationship between the activity of disease and cytokines receive more and more attention and gradually form a system of immune response. Recent studies have found that relevant genes of Fas and Fas L have played a certain role in the pathogenesis of uveitis,which may be the cause of recurrent uveitis.
引文
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[3]Scheepers MA,Rogers G,Corcoran C.The value of routine polymerase chain reaction analysis of intraocular fluid specimens in the diagnosis of infectious posterior uveitis[J].Sci World J,2013,22:545-149.
[4]刘雪霞.葡萄膜炎的病因及治疗进展[J/CD].中华眼科医学杂志:电子版,2014,4:39-42.
[5]曲晓妮,盛梅.葡萄膜炎的中西医病理机制及其治疗研究近况[J].四川中医,2009,27:47-49.
[6]杨培增,李绍珍.葡萄膜炎[M].北京:人民卫生出版社,1998:63-96.
[7]Ke Y,Sum D,Shao H.Anti-CD3 antibody ameliorates experimental autoimmune uveitis by inducing both IL-10 and TGF-βdependent regulatory T cells[J].Clin Immunol,2011,138:311-320.
[8]滕达,毕宏生,崔彦.葡萄膜炎相关细胞因子的研究进展[J].中国实用眼科杂志,2013,31:11-14.
[9]温鑫.CD4-T细胞与非感染性葡萄膜炎[J].眼科研究,2010,28:560-564.
[10]李剑冰,徐国兴.葡萄膜炎及其模型中相关细胞因子的研究进展[J].国际眼科杂志,2015,15:1172-1175.
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[13]Yew DT,Liu WK.Fas and activated caspase 8 innormal,Alzheimer and multiple infarct brains[J].Neuro sci Lett,2004,367:113-117.
[14]Cheng J,Liu C.Pur.fication and character ization of the Fas-l and that induces apoptosis[J].Science,1994,263:1759-1761.
[15]Ju SR,Rothstein A.Fas(CO95)/Fas L interactions required for programmed cell death after T cell activation[J].Nature,1995,373:444-446.
[16]Takahashi TM.Human Fas ligand:gene structure,chromosomal location and species specificity[J].Int Immunol,1994,6:1567-1574.
[17]陈津,张如松.细胞凋亡机制概述[J].2011,4:886-888.
[18]邱淑敏,刘美玲,汉丽梅.中药诱导肿瘤细胞凋亡机制研究进展[J].动物医学进展,2015,36:83-86.
[19]赵瑞杰.Caspase家族与细胞凋亡的关系[J].中国畜牧杂志,2010,46:73-78.
[20]Kmi HS.Retinal ganglion cell death is delayed by activation of retinal l intrinsic cell survival program[J].Bra in Res,2005,1057:17-28.
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[22]Morad SA.Ceramide-orchestrated signalling in cancer cells[J].Nat Rev Cancer,2013,13:51-65.
[23]Yonug MM,Wang HG.Sphingolipids:regulators of crosstalk between apoptosis and autophagy[J].J Lipid Res,2013,54:5-19.
[24]毕会娥.神经酰胺--内质网应激--AMPK在视网膜色素上皮细胞凋亡中的作用及机制研究[D].南京医科大学,2014.
[25]Chen CL,Chang WT,Teng CF.Ceramide induces p38 MAPK and JNK activation through a mechanism involving a thioredoxin interacting protein mediated pathway[J].Blood,2008,111:4365-4373.
[26]Alderson MR,Maraskovsky E.Fas transduces activation signals in normal human T lymphocytes[J].J Exp Med,1993,178:2231-2235.
[27]黎明.Fas-Fas L系统在细胞凋亡、免疫反应及肿瘤发生发展中的作用[J].昆明医学院学报,2002,1:95-99.
[28]Niederkorn JY.See no evil,hear no evil,do no evil:the lessons of immune privilege[J].Nat Immunol,2006,7:354-359.
[29]桑威.Fas/Fas L系统参与的几种生物学效应[J].国际免疫学杂志,2006,29:389-392.
[30]Bellgrau D,Selawry H.A role for CD95 ligand in preventing graft rejection[J].Nature,1995,337:630.
[31]余奇.实验性自身免疫性葡萄膜炎模型的研究进展[J].上海交通大学学报(医学版),2013,33:1411-1414.
[32]熊柯.免疫赦免机制的研究[J].器官移植,2012,3:53-57.
[33]Von Toerne C,Kaufmann U.Effector T cells driving monophasic vs.relapsing/remitting experimental autoimmune uveitis show unique pathway signatures[J].Mol Immunol,2010,48:272-280.
[34]刘爱旗,夏璐.CCK-8法与MTT法检测兔成纤维细胞活性的比较研究[J].中国医学创新,2013,10:12-13.
[35]Wang JA,Fan YQ.All ograftic bone marrow derived mesenchymal stem cells transplanted into heart infarcted model of rabbit to renovate infarcted heart[J].Zhejiang Univ Sci,2004,5:1279-1285.
[36]Pak HN,Kim DT.Mesenchymal stem cell injection induces cardiac nerve sprouting and increased tenascin expression in a swinemodel ofmyocardial infarction[J].J Cardiovasc Electrophysiol,2003,14:841-848.
[37]Connell J,Bennett MW.Fas resistance and counter attack in the tumor-immune conflict[J].Ann N Y Acad Sci,2000,910:178.
[38]杨培增,周红颜.实验性自身免疫性葡萄膜炎组织切片研究[J].中华眼底病杂志,2000,16:35-40.
[39]周贵生,任欢,危国军,等.实验自身免疫性葡萄膜视网膜炎中Bcl-2、Fas L的表达[J].哈尔滨医科大学学报,2008,42:31-33.
[40]Jiang G,Wang Y,Yun J,et al.HMGB1 release triggered by the interaction of live retinal cells and uveitogenic T cells is Fas/Fas L activation-dependent[J].J Neuroinflammation,2015,12:179.
[41]Matta B,Jha P,Bora PS,et al.Antigen-specific tolerance inhibits autoimmune uveitis in pre-sensitized animals by deletion and CD4+CD25+T-regulatory cells[J].Immunol Cell Biol,2010,88:187-96.
[42]顾秀丽,李晓芳.Fas,Fas-L,Bcl-2基因家族凋亡相关基因在葡萄膜炎发病机制中的作用研究进展[J].内蒙古医学院学报,2006,28:235-239.
[43]陈玲.Fas/Fas L系统及其在葡萄膜炎中的意义[J].眼科研究,2001,19:560-562.
[44]陈玲,周红颜,钟晖.Behcet病患者外周血淋巴细Fas,Fas L,mRNA的表达及意义[J].中国实用眼科杂志,2002,20:18-20.
[45]籍莉,孔庆瑜,林健贤,等.Fas/Fas L抗原在葡萄膜炎患者外周T淋巴细胞上的表达[J].眼视光学杂志,2001,3:210-212.
[46]王培.补肾明目口服液联合糖皮质激素体外对慢性葡萄膜炎患者外周血淋巴细胞凋亡率及Fas和Fas L表达的影响[J].医药卫生科技辑(S1),2011,73:18-22.
[2]刘家琦,李凤鸣.实用眼科学[M].北京:人民卫生出版社,2010:142.
[3]Scheepers MA,Rogers G,Corcoran C.The value of routine polymerase chain reaction analysis of intraocular fluid specimens in the diagnosis of infectious posterior uveitis[J].Sci World J,2013,22:545-149.
[4]刘雪霞.葡萄膜炎的病因及治疗进展[J/CD].中华眼科医学杂志:电子版,2014,4:39-42.
[5]曲晓妮,盛梅.葡萄膜炎的中西医病理机制及其治疗研究近况[J].四川中医,2009,27:47-49.
[6]杨培增,李绍珍.葡萄膜炎[M].北京:人民卫生出版社,1998:63-96.
[7]Ke Y,Sum D,Shao H.Anti-CD3 antibody ameliorates experimental autoimmune uveitis by inducing both IL-10 and TGF-βdependent regulatory T cells[J].Clin Immunol,2011,138:311-320.
[8]滕达,毕宏生,崔彦.葡萄膜炎相关细胞因子的研究进展[J].中国实用眼科杂志,2013,31:11-14.
[9]温鑫.CD4-T细胞与非感染性葡萄膜炎[J].眼科研究,2010,28:560-564.
[10]李剑冰,徐国兴.葡萄膜炎及其模型中相关细胞因子的研究进展[J].国际眼科杂志,2015,15:1172-1175.
[11]陈暐.自身免疫性葡萄膜炎与Th1、Th17相关细胞因子的研究进展[J].中华实验眼科杂志,2014,32:943-949.
[12]Luger D,Silver PB,Tang J,et al.Either a Th17 or a Th1effector response can drive autoimmunity:conditions of disease induction affect dominant effector category[J].J Exp Med,2008,205:799-810.
[13]Yew DT,Liu WK.Fas and activated caspase 8 innormal,Alzheimer and multiple infarct brains[J].Neuro sci Lett,2004,367:113-117.
[14]Cheng J,Liu C.Pur.fication and character ization of the Fas-l and that induces apoptosis[J].Science,1994,263:1759-1761.
[15]Ju SR,Rothstein A.Fas(CO95)/Fas L interactions required for programmed cell death after T cell activation[J].Nature,1995,373:444-446.
[16]Takahashi TM.Human Fas ligand:gene structure,chromosomal location and species specificity[J].Int Immunol,1994,6:1567-1574.
[17]陈津,张如松.细胞凋亡机制概述[J].2011,4:886-888.
[18]邱淑敏,刘美玲,汉丽梅.中药诱导肿瘤细胞凋亡机制研究进展[J].动物医学进展,2015,36:83-86.
[19]赵瑞杰.Caspase家族与细胞凋亡的关系[J].中国畜牧杂志,2010,46:73-78.
[20]Kmi HS.Retinal ganglion cell death is delayed by activation of retinal l intrinsic cell survival program[J].Bra in Res,2005,1057:17-28.
[21]Thorburn J,Rao A,Thomas LR,et al.Thorburn A.Selective inactivation of a Fas-associated death domain protein(FADD)-dependent apoptosis and autophagy pathway in immortal epithelial cells[J].Mol Biol Cell,2005,16:1189-1199.
[22]Morad SA.Ceramide-orchestrated signalling in cancer cells[J].Nat Rev Cancer,2013,13:51-65.
[23]Yonug MM,Wang HG.Sphingolipids:regulators of crosstalk between apoptosis and autophagy[J].J Lipid Res,2013,54:5-19.
[24]毕会娥.神经酰胺--内质网应激--AMPK在视网膜色素上皮细胞凋亡中的作用及机制研究[D].南京医科大学,2014.
[25]Chen CL,Chang WT,Teng CF.Ceramide induces p38 MAPK and JNK activation through a mechanism involving a thioredoxin interacting protein mediated pathway[J].Blood,2008,111:4365-4373.
[26]Alderson MR,Maraskovsky E.Fas transduces activation signals in normal human T lymphocytes[J].J Exp Med,1993,178:2231-2235.
[27]黎明.Fas-Fas L系统在细胞凋亡、免疫反应及肿瘤发生发展中的作用[J].昆明医学院学报,2002,1:95-99.
[28]Niederkorn JY.See no evil,hear no evil,do no evil:the lessons of immune privilege[J].Nat Immunol,2006,7:354-359.
[29]桑威.Fas/Fas L系统参与的几种生物学效应[J].国际免疫学杂志,2006,29:389-392.
[30]Bellgrau D,Selawry H.A role for CD95 ligand in preventing graft rejection[J].Nature,1995,337:630.
[31]余奇.实验性自身免疫性葡萄膜炎模型的研究进展[J].上海交通大学学报(医学版),2013,33:1411-1414.
[32]熊柯.免疫赦免机制的研究[J].器官移植,2012,3:53-57.
[33]Von Toerne C,Kaufmann U.Effector T cells driving monophasic vs.relapsing/remitting experimental autoimmune uveitis show unique pathway signatures[J].Mol Immunol,2010,48:272-280.
[34]刘爱旗,夏璐.CCK-8法与MTT法检测兔成纤维细胞活性的比较研究[J].中国医学创新,2013,10:12-13.
[35]Wang JA,Fan YQ.All ograftic bone marrow derived mesenchymal stem cells transplanted into heart infarcted model of rabbit to renovate infarcted heart[J].Zhejiang Univ Sci,2004,5:1279-1285.
[36]Pak HN,Kim DT.Mesenchymal stem cell injection induces cardiac nerve sprouting and increased tenascin expression in a swinemodel ofmyocardial infarction[J].J Cardiovasc Electrophysiol,2003,14:841-848.
[37]Connell J,Bennett MW.Fas resistance and counter attack in the tumor-immune conflict[J].Ann N Y Acad Sci,2000,910:178.
[38]杨培增,周红颜.实验性自身免疫性葡萄膜炎组织切片研究[J].中华眼底病杂志,2000,16:35-40.
[39]周贵生,任欢,危国军,等.实验自身免疫性葡萄膜视网膜炎中Bcl-2、Fas L的表达[J].哈尔滨医科大学学报,2008,42:31-33.
[40]Jiang G,Wang Y,Yun J,et al.HMGB1 release triggered by the interaction of live retinal cells and uveitogenic T cells is Fas/Fas L activation-dependent[J].J Neuroinflammation,2015,12:179.
[41]Matta B,Jha P,Bora PS,et al.Antigen-specific tolerance inhibits autoimmune uveitis in pre-sensitized animals by deletion and CD4+CD25+T-regulatory cells[J].Immunol Cell Biol,2010,88:187-96.
[42]顾秀丽,李晓芳.Fas,Fas-L,Bcl-2基因家族凋亡相关基因在葡萄膜炎发病机制中的作用研究进展[J].内蒙古医学院学报,2006,28:235-239.
[43]陈玲.Fas/Fas L系统及其在葡萄膜炎中的意义[J].眼科研究,2001,19:560-562.
[44]陈玲,周红颜,钟晖.Behcet病患者外周血淋巴细Fas,Fas L,mRNA的表达及意义[J].中国实用眼科杂志,2002,20:18-20.
[45]籍莉,孔庆瑜,林健贤,等.Fas/Fas L抗原在葡萄膜炎患者外周T淋巴细胞上的表达[J].眼视光学杂志,2001,3:210-212.
[46]王培.补肾明目口服液联合糖皮质激素体外对慢性葡萄膜炎患者外周血淋巴细胞凋亡率及Fas和Fas L表达的影响[J].医药卫生科技辑(S1),2011,73:18-22.