精神专科医院大肠埃希菌感染分布情况及耐药性分析
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摘要
目的分析住院患者大肠埃希菌感染分布及耐药情况,为临床合理用药提供依据。方法选择2016年1月至2018年1月该院发生大肠埃希菌感染的住院患者108例。采用法国梅里埃ATB半自动细菌分析仪进行细菌鉴定和药敏试验,统计大肠埃希菌的感染部位及耐药情况,并对结果进行分析。结果 108例大肠埃希菌感染患者中来自泌尿道43株(39.8%)、呼吸道40株(37.0%)、分泌物19株(19.5%)、血液4株(3.7%)、引流液2株(1.8%)。大肠埃希菌对氨苄西林和头孢呋辛的耐药率分别为98.86%和72.72%,对碳青霉烯类药物亚胺培南的耐药率较低仅为0.1%。108株大肠埃希菌中产超广谱β-内酰胺酶(ESBLs)的菌株为20株,占18.51%。结论该院住院患者大肠埃希菌感染主要分布在泌尿道和呼吸道。多重耐药ESBLs菌株时有检出,碳青霉烯类药物依然是最有效的抗菌治疗药物。
Objective To study the drug resistance and distribution of Escherichia coli infections in the psychiatric patients in order to provide guidance for reasonable use of antibiotics.Methods A total of 108 psychiatric patients who were hospitalized from Jan 2016 to Jan 2018 with Escherichia coli infection were enrolled in this research.Infection site and distribution of Escherichia coli were calculated,besides the drug susceptibility testing was detected by ATB-identification system of BioMerieux,France.Results A total of 108 psychiatric patients with Escherichia coli infections.43 strains were distributed in the urinary tract(39.8%),40 strains were distributed in the respiratory tract(37.0%),19 strains were distributed in the secreta(19.5%),4 strains were distributed in the blood(3.7%),2 strains were distributed in the other parts(1.8%).The drug resistance rate of Escherichia coli for ampicillin and cefuroxime the was 98.86% and 72.72%,while the drug resistance rate of Escherichia coli for carbapenem imipenem the was 0.1%.20 strains of 108 strains Escherichia coli were extended-spectrumβ-lactamase(ESBLs)account for 18.51%.Conclusion The dominant distribution of psychiatric patients with Escherichia coli infection were urinary tract and respiratory tract.The ESBLs were sensitivity to carbapenem.Finally,drug resistance and distribution of Escherichia coli in clinical should be tested tightly so as to reasonably use antibiotics.
Objective To study the drug resistance and distribution of Escherichia coli infections in the psychiatric patients in order to provide guidance for reasonable use of antibiotics.Methods A total of 108 psychiatric patients who were hospitalized from Jan 2016 to Jan 2018 with Escherichia coli infection were enrolled in this research.Infection site and distribution of Escherichia coli were calculated,besides the drug susceptibility testing was detected by ATB-identification system of BioMerieux,France.Results A total of 108 psychiatric patients with Escherichia coli infections.43 strains were distributed in the urinary tract(39.8%),40 strains were distributed in the respiratory tract(37.0%),19 strains were distributed in the secreta(19.5%),4 strains were distributed in the blood(3.7%),2 strains were distributed in the other parts(1.8%).The drug resistance rate of Escherichia coli for ampicillin and cefuroxime the was 98.86% and 72.72%,while the drug resistance rate of Escherichia coli for carbapenem imipenem the was 0.1%.20 strains of 108 strains Escherichia coli were extended-spectrumβ-lactamase(ESBLs)account for 18.51%.Conclusion The dominant distribution of psychiatric patients with Escherichia coli infection were urinary tract and respiratory tract.The ESBLs were sensitivity to carbapenem.Finally,drug resistance and distribution of Escherichia coli in clinical should be tested tightly so as to reasonably use antibiotics.
引文
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[4]汪璐,曲远青.大肠埃希菌和肺炎克雷伯菌的临床分布及耐药监测[J].中国实验诊断学,2017,21(11):1893-1896.
[5]张文利,刘军,张坚,等.维吾尔族与汉族新生儿感染产超广谱β-内酰胺酶与头孢菌素酶病原菌的耐药性及基因型分析[J].中华预防医学杂志,2011,45(3):217-224.
[6]李海英,王金波,王华,等.近3年分离大肠埃希菌耐药性的分析[J].中国抗生素杂志,2018,43(5):620-623.
[7]SINGH S K,MISHRA M,SAHOO M,et al.Antibiotic resistance determinants and clonal relationships among multidrug-resistant isolates of Klebsiella pneumoniae[J].Microb Pathog,2017(110):31-36.