脂肪干细胞在宫腔粘连中的应用进展及前景
摘要
临床上各种因素如宫腔介入手术后,子宫内膜感染,盆腔放疗等造成子宫内膜破坏的病例数越来越多,随之常常出现宫腔不同程度的粘连,针对三级预防而言,如何治疗宫腔粘连,解决患者妊娠需求问题是临床科研人员着重关注的问题。近年转化医学发展迅猛,胚胎干细胞、骨髓干细胞等干细胞都有成功移植到宫腔粘连动物模型体内并改善其子宫内膜粘连。但其中脂肪干细胞具有取材方便,创伤小,来源丰富,规避伦理问题等优点受到广泛关注。结合二者,将脂肪干细胞诱导转化为子宫内膜细胞修复子宫内膜成为治疗宫腔粘连的新思路。
引文
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[31]BANSAL V,DE D,AN J,et al.Chemical induced conversion of mouse fibroblasts and human adipose-derived stem cells into skeletal muscle-like cells[J].Biomaterials,2019,193:30-46.
[32]FARONI A,KILIC M A,REID A J.Maintenance of a Schwann-Like phenotype in differentiated Adipose-Derived stem cells requires the synergistic action of multiple growth factors[J].Stem Cells Int,2017.2017:1479137.
[33]RESCH A,WOLF S,MANN A,et al.Co-Culturing human adipose derived stem cells and schwann cells on spider Silk-Anew approach as prerequisite for enhanced nerve regeneration[J].Int J Mol Sci,2018,20(1).
[34]YANG L,WANG Z F,WU H,et al.MiR-142-5p improves neural differentiation and proliferation of Adipose-Derived stem cells[J].Cell Physiol Biochem,2018,50(6):2097-2107.
[35]孔德胜.脂肪间充质干细胞治疗大鼠宫腔粘连的疗效评价及机制探讨,2017,河北医科大学.
[36]WANG Y,ZHOU S,YANG R,et al.Bioengineered bladder patches constructed from multilayered adipose-derived stem cell sheets for bladder regeneration[J].Acta Biomater,2018,85:131-141.
[37]SUN H,LU J,LI B,et al.Partial regeneration of uterine horns in rats through adipose-derived stem cell sheets[J].Biol Reprod,2018,99(5):1057-1069.
[2]SALAZAR C A,ISAACSON K,MORRIS S.A comprehensive review of Asherman's syndrome:Causes,symptoms and treatment options[J].Current opinion in obstetrics&gynecology,2017,29(4):249-256.
[3]LI X,WU L,ZHOU Y,et al.New crosslinked hyaluronan gel for the prevention of intrauterine adhesions after dilation and curettage in patients with delayed miscarriage:A prospective,multicenter,randomized,controlled trial[J].J Minim Invasive Gynecol,2019,26(1):94-99.
[4]李杨杨,张佳佳,何荣霞.子宫内膜再生与干细胞移植治疗宫腔粘连研究进展[J].医学研究生学报,2018(4):425-429.
[5]CAO Y,SUN H,ZHU H,et al.Allogeneic cell therapy using umbilical cord MSCs on collagen scaffolds for patients with recurrent uterine adhesion:A phase I clinical trial[J].Stem Cell Res Ther,2018,9(1):192.
[6]JU B,PAN C,GU Y,et al.Application of bone Marrow-Derived mesenchymal stem cells in the treatment of intrauterine adhesions in rats[J].Cell Physiol Biochem,2016,39(4):1553-1560.
[7]CABANILLAS S,CERVELL I,ARBONA C,et al.Autologous cell therapy with CD133+bone marrow-derived stem cells for refractory Asherman's syndrome and endometrial atrophy:A pilot cohort study[J].Hum Reprod(Oxford,England),2016,31(5):1087-1896.
[8]DEANS R,ABBOTT J.Review of intrauterine adhesions[J].JMinim Invasive Gynecol,2010,17(5):555-569.
[9]YOU L,HUANG H P.Risk factors of intrauterine adhesion after hysteroscopic resection of endometrial polyps[J].Zhongguo Yi Xue Ke Xue Yuan Xue Bao,2017,39(6):812-816.
[10]LEMMERS M,THURKOW A L,HEYMANS M W,et al.Systematic review and meta-analysis of intrauterine adhesions after miscarriage:Prevalence,risk factors and long-term reproductive outcome[J].Hum Reprod Update,2014,20(2):262-278.
[11]HOOKER A B,DE LEEUW R A,VAN DE VEN P M,et al.Reproductive performance after the application of hyaluronic acid gel after dilation and curettage in women who have experienced at least one previous curettage:Long-term results of a multicenter prospective randomized trial[J].Fertil Steril,2018,110(7):1231-1238.
[12]HAI N,DING X.Intrauterine adhesion after transvaginal ultrasound-guided radiofrequency myolysis[J].J Obstet Gynaecol Res,2015,41(11):1851-1854.
[13]CHI Y,HE P,LEI L,et al.Transdermal estrogen gel and oral aspirin combination therapy improves fertility prognosis via the promotion of endometrial receptivity in moderate to severe intrauterine adhesion[J].Mol Med Rep,2018,17(5):6337-6344.
[14]CAI Y,WU F,YU Y,et al.Porous scaffolds from droplet microfluidics for prevention of intrauterine adhesion[J].Acta Biomater,2019,84:222-230.
[15]KHAN Z,GOLDBERG J M.Hysteroscopic management of asherman's syndrome[J].J Minim Invasive Gynecol,2018,25(2):218-228.
[16]ZHENG F,ZHU B,LIU Y,et al.Meta-analysis of the use of amniotic membrane to prevent recurrence of intrauterine adhesion after hysteroscopic adhesiolysis[J].Int J Gynaecol Obstet,2018,143(2):145-149.
[17]MANTAS D,TSILIMIGRAS D I,MORIS D,et al.Comparison of the viability and yield of Adipose-Derived stem cells(ASCs)from different donor areas[J].In vivo,2017,31(6):1229-1234.
[18]BACAKOVA L,ZARUBOVA J,TRAVNICKOVA M,et al.Stem cells:Their source,potency and use in regenerative therapies with focus on adipose-derived stem cells-a review[J].Biotechnol.Adv,2018,36(4):1111-1126.
[19]ZN M,A L,MM A,et al.Ultrasound-assisted liposuction provides a source for functional adipose-derived stromal cells.[J].Cytotherapy,2017,19(12):1491-1500.
[20]GURTOWSKA N,OLKOWSKA J,KAZMIERSKI L,et al.Adipose-Derived stem cells as a tool in Cell-Based therapies[J].Archivum immunologiae et therapiae experimentalis,2016,64(6):443-454.
[21]HASEGAWA S,IGARASHI T,YAMADA T,et al.Enhancement of individual differences in proliferation and differentiation potentials of aged human adipose-derived stem cells[J].Regen Ther,2017,6:29-40.
[22]ROXBURGH J,METCALFE A D,MARTIN Y H.The effect of medium selection on adipose-derived stem cell expansion and differentiation:Implications for application in regenerative medicine[J].Cytotechnology,2016,68(4):957-967.
[23]CHOI J W,SHIN S,LEE C Y,et al.Rapid induction of osteogenic markers in mesenchymal stem cells by Adipose-Derived stromal vascular fraction cells[J].Cell Physiol Biochem,2017,44(1):53-65.
[24]GOLA J,SIKORA B,HYBIAK J,et al.Impact of antibiotics on the proliferation and differentiation of human Adipose-Derived mesenchymal stem cells[J].Int J Mol Sci,2017,18(12):2522.
[25]LIU L,MOU S,ZHAO H,et al.Investigation of platelet-rich plasma in increasing proliferation and migration of endometrial mesenchymal stem cells and improving pregnancy outcome of patients with thin endometrium[J].J Cell Biochem,2018(ahead of print).
[26]TAN Q W,CHEN Y J,ZHANG Y,et al.The effects of Platelet-Rich plasma and Adipose-Derived stem cells on neovascularization and fat graft survival[J].Aesthetic Plast Surg,2018,42(1):1-8.
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[28]WU R,RUAN J,SUN Y,et al.Long non-coding RNA HIF1A-AS2 facilitates adipose-derived stem cells(ASCs)osteogenic differentiation through miR-665/IL6 axis via PI3K/Akt signaling pathway[J].Stem Cell Res Ther,2018,9(1):348.
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[30]ZABONICK J,GETTLER B,WILLIAMS S K.Vasculogenic and angiogenic potential of adipose stromal vascular fraction cell populations in vitro[J].In Vitro Cell Dev Biol Anim,2018.54(1):32-40.
[31]BANSAL V,DE D,AN J,et al.Chemical induced conversion of mouse fibroblasts and human adipose-derived stem cells into skeletal muscle-like cells[J].Biomaterials,2019,193:30-46.
[32]FARONI A,KILIC M A,REID A J.Maintenance of a Schwann-Like phenotype in differentiated Adipose-Derived stem cells requires the synergistic action of multiple growth factors[J].Stem Cells Int,2017.2017:1479137.
[33]RESCH A,WOLF S,MANN A,et al.Co-Culturing human adipose derived stem cells and schwann cells on spider Silk-Anew approach as prerequisite for enhanced nerve regeneration[J].Int J Mol Sci,2018,20(1).
[34]YANG L,WANG Z F,WU H,et al.MiR-142-5p improves neural differentiation and proliferation of Adipose-Derived stem cells[J].Cell Physiol Biochem,2018,50(6):2097-2107.
[35]孔德胜.脂肪间充质干细胞治疗大鼠宫腔粘连的疗效评价及机制探讨,2017,河北医科大学.
[36]WANG Y,ZHOU S,YANG R,et al.Bioengineered bladder patches constructed from multilayered adipose-derived stem cell sheets for bladder regeneration[J].Acta Biomater,2018,85:131-141.
[37]SUN H,LU J,LI B,et al.Partial regeneration of uterine horns in rats through adipose-derived stem cell sheets[J].Biol Reprod,2018,99(5):1057-1069.