益肾活血中药内服外用联合人工周期治疗卵巢功能减退临床观察
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摘要
目的:观察益肾活血中药内服外用联合人工周期治疗卵巢功能减退的临床疗效。方法:选取符合入选标准的70例卵巢功能减退患者,按照治疗方法分为治疗组和对照组,各组35例。对照组给予戊酸雌二醇联合黄体酮胶囊行人工周期治疗,治疗组在对照组人工周期治疗的基础上予以补肾活血中药治疗。观察比较两组的临床疗效。结果:治疗组总有效率为85.71%,显著高于对照组的60.00%(P﹤0.05);治疗组治疗后的窦卵泡数显著多于对照组(P﹤0.05);两组治疗后的卵泡刺激素(FSH)均较治疗前显著下降(P﹤0.05),两组治疗后的雌二醇(E2)值较治疗前显著升高(P﹤0.05);治疗组治疗后的FSH、LH值均显著低于对照组(P﹤0.05),治疗组治疗后的E2值均显著高于对照组(P﹤0.05)。结论:益肾活血中药内服外用联合人工周期治疗卵巢功能减退患者疗效显著优于单纯人工周期治疗。
Objective:To observe the clinical effect of orally and externally used traditional Chinese drugs for reinforcing kidney and promoting blood circulation combined with artificial cycles on ovarian function failure. Methods:70 cases of selected patients with ovarian function failure,who met the inclusion criteria,were randomly divided into treatment group and control group,35 cases in each group.The control group was treated with estradiol valerate and progesterone capsules which were used for artificial cycles,while the treatment group was treated with traditional Chinese drugs for reinforcing kidney and promoting blood circulation on the basis of control group.After treatment for 3 consecutive menstrual cycles,the clinical effects of two groups were evaluated.Results:The total effective rate of treatment group was 85.71%,which was significantly higher than 60.00% of control group(P<0.05). After treatment:antral follicle number of treatment group was significantly more than that of control group(P<0.05);follicle stimulating hormone(FSH)of both groups was significantly lower than before treatment(P<0.05);the values of estradiol(E2)of both groups were significantly higher than before treatment(P<0.05);the values of FSH and LH of treatment group were significantly lower than those of control group(P<0.05);and the value of estradiol(E2)of treatment group was significantly higher than that of control group(P<0.05). Conclusion:The clinical effect of orally and externally used traditional Chinese drugs for reinforcing kidney and promoting blood circulation combined with artificial cycles on ovarian function failure is significantly better than that of simple artificial cycles.
Objective:To observe the clinical effect of orally and externally used traditional Chinese drugs for reinforcing kidney and promoting blood circulation combined with artificial cycles on ovarian function failure. Methods:70 cases of selected patients with ovarian function failure,who met the inclusion criteria,were randomly divided into treatment group and control group,35 cases in each group.The control group was treated with estradiol valerate and progesterone capsules which were used for artificial cycles,while the treatment group was treated with traditional Chinese drugs for reinforcing kidney and promoting blood circulation on the basis of control group.After treatment for 3 consecutive menstrual cycles,the clinical effects of two groups were evaluated.Results:The total effective rate of treatment group was 85.71%,which was significantly higher than 60.00% of control group(P<0.05). After treatment:antral follicle number of treatment group was significantly more than that of control group(P<0.05);follicle stimulating hormone(FSH)of both groups was significantly lower than before treatment(P<0.05);the values of estradiol(E2)of both groups were significantly higher than before treatment(P<0.05);the values of FSH and LH of treatment group were significantly lower than those of control group(P<0.05);and the value of estradiol(E2)of treatment group was significantly higher than that of control group(P<0.05). Conclusion:The clinical effect of orally and externally used traditional Chinese drugs for reinforcing kidney and promoting blood circulation combined with artificial cycles on ovarian function failure is significantly better than that of simple artificial cycles.
引文
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[10]张玲,赵凡桂,王文君,等.卵巢储备功能低下的不孕患者中西医结合疗效探讨[J].中国妇幼保健院,2014,26(29):4 293-4 295.
[2]中华医学会临床诊疗指南(妇产科分册)[S].北京:人民卫生出版社,2007:118.
[3]杨冬梓.妇科内分泌疾病检查项目选择及应用[M].北京:人民卫生出版社,2012:74-76.
[4]张玉珍.中医妇科学[M].第2版.北京:中国中医药出版社,2007:79-95.
[5]中华人民共和国卫生部.中药新药临床研究指导原则[S].北京:中国医药科技出版社,2002:240-241.
[6]王颖,杨贵忠,王丽萍,等.卵巢动脉血流与卵巢储备功能关系的研究[J].中国妇幼健康研究,2008,19(5):429-431.
[7]张雯婷.补肾疏肝活血调周法治疗卵巢功能减退的临床观察[J].中国中医药现代远程教育,2016,14(18):76-78.
[8]王玉东.补肾活血促卵泡发育的临床研究[J].山东中医药大学学报,2002,26(31):209.
[9]周笑梅,陈颖异.补肾活血中药治疗卵巢储备功能低下的机理概述[J].中国中医药科技,2014,21(3):345-346.
[10]张玲,赵凡桂,王文君,等.卵巢储备功能低下的不孕患者中西医结合疗效探讨[J].中国妇幼保健院,2014,26(29):4 293-4 295.