摘要
目的:观察加味阳和汤治疗脊柱结核的临床疗效。方法:选取2015年4月至2018年4月在本院治疗的脊柱结核患者60例,按照随机数字表法分为治疗组和常规组,每组30例。常规组给予常规抗结核西药治疗,治疗组在常规组治疗的基础上给予加味阳和汤加减治疗。观察两组患者治疗前后疼痛视觉模拟量表评分(visual analogue scale,VAS)变化情况,采用酶联免疫吸附试验测定两组患者白细胞介素-1β(interleukin-1β,IL-1β)、白细胞介素-17(interleukin-17,IL-17)及肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)水平进行测定。结果:治疗组有效率93. 33%,常规组有效率70. 00%,治疗组有效率高于常规组,差异有统计学意义(P <0. 05);治疗组治疗后疼痛VAS评分明显低于常规组,差异有统计学意义(P <0. 05);治疗组治疗后IL-1β、IL-17及TNF-α水平均低于常规组,差异有统计学意义(P <0. 05);治疗组治疗后基质金属蛋白酶-1(matrix metalloproteinase-1,MMP-1)、基质金属蛋白酶-9(matrix metalloproteinase-9,MMP-9)及单核细胞趋化因子-1(monocyte chemokine-1,MCP-1)水平均低于常规组,差异有统计学意义(P <0. 05)。结论:加味阳和汤联合常规西药抗结核药物治疗脊柱结核能够提高疗效,有助于改善患者疼痛症状,降低炎症因子水平,安全性较高,减少手术治疗概率。
Objective: To observe the clinical curative effect of Supplemented Harmonious Yang Decoction on spinal tuberculosis.Methods: Sixty patients with spinal tuberculosis treated in our hospital from April 2015 to April 2018 were divided into the treatment group and the routine group according to random number table method,with 30 cases in each group. The routine group was treated with conventional anti-tuberculosis Western medicine,while the treatment group was treated with Supplemented Harmonious Yang Decoction on the basis of the routine treatment. The changes of pain visual analogue scale( VAS) before and after the treatment were observed. The levels of interleukin-1β( IL-1β),interleukin-17( IL-17) and tumor necrosis factor-α( TNF-α) were measured by enzyme-linked immunosorbent assay( ELISA). Results: The effective rate was 93. 33% in the treatment group and70. 00% in the routine group,the treatment group was higher than the routine group and the difference was statistically significant( P < 0. 05). The VAS score of pain in the treatment group was significantly lower than that in the conventional group,and the difference was statistically significant( P < 0. 05). The levels of IL-1β,IL-17 and TNF-α in the treatment group were lower than those in the conventional group,and all the differences were statistically significant( P < 0. 05). The levels of matrix metalloproteinase-1,matrix metalloproteinase-9 and monocyte chemokine-1 in the treatment group after the treatment were significantly lower than those in the conventional group and all the differences were statistically significant( P < 0. 05). Conclusion: Supplemented Harmonious Yang Decoction combined with conventional Western medicine in the treatment of spinal tuberculosis can improve the curative effect,help to improve the pain symptoms of patients,reduce the level of inflammatory factors with high safety,and reduce the probability of surgical treatment.
引文
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