无阀压电泵驱动的集成式微混合器
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摘要
设计了一种无阀压电泵驱动的集成式微混合器,其中无阀压电泵采用三棱柱阻变高度流道式结构。利用等效电路模型研究了无阀泵的流动特性,并应用Fluent软件对无阀泵及Y型微流道进行了系统仿真分析,确定了无阀泵和Y型微流道的结构参数,并优选出了系统控制参数。在实验室内制作了微混合器样机,并进行了脉动和混合效果实验,结果表明:当入口流量为0.7 mL/min、脉动频率为100Hz时,流道内脉动效果明显,由此验证了该微混合器具备良好的工作性能。此项研究可为无阀压电泵在微流控领域的应用提供借鉴。
An integrated micro-mixer driven by a valveless piezoelectric pump was designed.The valveless piezoelectric pump has triangular prismatic obstacles and variable channel heights at inlet and outlet.Based on the equivalent circuit model,the flow characteristics of the valveless pump were studied,and system simulations of the pump and the Y-type micro-channel were performed by the software Fluent. The corresponding structural parameters and control parameters of the pump and Y-type micro-channel were optimized and determined.A prototype of micro-mixer was built,and experiments on the pulsating and mixing effects were carried out in laboratory.Test results show that when the frequency is 100 Hz and the output flow rate is about0.7 mL/min,the pulsation effect is obvious in the flow channel,which verifies the good working performance of the micro-mixer.This study may provide a reference for further application of valveless piezoelectric pump in microfluidics.
An integrated micro-mixer driven by a valveless piezoelectric pump was designed.The valveless piezoelectric pump has triangular prismatic obstacles and variable channel heights at inlet and outlet.Based on the equivalent circuit model,the flow characteristics of the valveless pump were studied,and system simulations of the pump and the Y-type micro-channel were performed by the software Fluent. The corresponding structural parameters and control parameters of the pump and Y-type micro-channel were optimized and determined.A prototype of micro-mixer was built,and experiments on the pulsating and mixing effects were carried out in laboratory.Test results show that when the frequency is 100 Hz and the output flow rate is about0.7 mL/min,the pulsation effect is obvious in the flow channel,which verifies the good working performance of the micro-mixer.This study may provide a reference for further application of valveless piezoelectric pump in microfluidics.
引文
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[18]NAKATA A,TANAKA S,SUGANO K,et al.Electrical equivalent circuit model of microfluidic system containing piezoelectric valveless micropump and viscoelastic PDMS microchannnel[C]∥Proceedings of International Conference on Miniaturized Systems for Chemistry and Life Sciences.Washington,DC,USA:Chemical and Biological Microsystems Society,2008:23-24.
[2]WU M H,HUANG S B,LEE G B.Microfluidic cell culture systems for drug research[J].Lab on a Chip,2010,10(8):939-956.
[3]CHEN X,LI T.Research progress of the passive microfluidic mixers[J].Micronanoelectronic Technology,2013,50(11):710-714.
[4]PAPADOPOULOS V E,KEFALA I N,KAPROU G,et al.A passive micromixer for enzymatic digestion of DNA[J].Microelectronic Engineering,2014,124:42-46.
[5]SADABADI H,PACKIRISAMY M,WUTHRICH R.High performance cascaded PDMS micromixer based on split-and-recombination flows for lab-ona-chip applications[J].RSC Advances,2013,3(20):7296-7305.
[6]LIU K,YANG Q,CHEN F,et al.Design and analysis of the cross-linked dual helical micromixer for rapid mixing at low Reynolds numbers[J].Microfluidics&Nanofluidics,2015,19(1):169-180.
[7]SHILTON R J,YEO L Y,FRIEND J R.Quantification of surface acoustic wave induced chaotic mixingflows in microfluidic wells[J].Sensors&Actuators:B Chemical,2011,160(1):1565-1572.
[8]CHOI E,KWON K,LEE S J,et al.Non-equilibrium electrokinetic micromixer with 3D nano-channel networks[J].Lab on a Chip,2015,15(8):1794-1798.
[9]KAMALI R,SHEKOOHI S A,BINESH A.Effects of magnetic particles entrance arrangements on mixing efficiency of a magnetic bead micromixer[J].NanoMicro Letters,2014,6(1):30-37.
[10]LIM C Y,LAM Y C,YANG C.Mixing enhancement in microfluidic channel with a constriction under periodic electro-osmotic flow[J].Biomicrofluidics,2010,4(1):014101.
[11]LEE S J,KIM D.Millisecond-order rapid micromixing with non-equilibrium electrokinetic phenomena[J].Microfluidics&Nanofluidics,2012,12(6):897-906.
[12]SALMANZADEH A,SHAFIEE H,DAVALOS R V,et al.Microfluidic mixing using contactless dielectrophoresis[J].Electrophoresis,2011,32(18):2569-2578.
[13]许忠斌,杨世鹏,刘国林,等.微泵的研究现状与进展[J].液压与气动,2013(6):7-12.XU Zhongbin,YANG Shipeng,LIU Guolin,et al.Development of micropump research[J].Chinese Hydraulics&Pneumatics,2013(6):7-12.
[14]REVATHI S,PADMANABHAN R.Study of the effect on flow rate for planar type polymer-based diaphragm piezoelectric actuated valveless micropump for insulin delivery[J].Advances in Materials&Processing Technologies,2016(1):1-13.
[15]刘国君,杨旭豪,刘建芳,等.压电驱动脉动混合可控合成金纳米粒子[J].稀有金属材料与工程,2016(6):1625-1630.LIU Guojun,YANG Xuhao,LIU Jianfang,et al.Controlled synthesis of gold nanoparticles using pulsed mixing based on piezoelectric actuation[J].Rare Metal Materials and Engineering,2016(6):1625-1630.
[16]张建辉,曹炳鑫,陈道根,等.半球缺阻流体无阀压电泵的实验验证[J].光学精密工程,2014,22(1):76-84.ZHANG Jianhui,CAO Bingxing,CHEN Daogen,et al.Experimental verification on valve-less piezoelectric pump with hemisphere-segment bluff-body[J].Optics and Precision Engineering,2014,22(1):76-84.
[17]ZHANG J H,XIA Q X,YI H,et al.Theory and experimental verification of valveless piezoelectric pump with rotatable unsymmetrical slopes[J].Science China Technological Sciences,2011,54(11):3070-3077.
[18]NAKATA A,TANAKA S,SUGANO K,et al.Electrical equivalent circuit model of microfluidic system containing piezoelectric valveless micropump and viscoelastic PDMS microchannnel[C]∥Proceedings of International Conference on Miniaturized Systems for Chemistry and Life Sciences.Washington,DC,USA:Chemical and Biological Microsystems Society,2008:23-24.