芫花提取物在疾病治疗中的研究进展
摘要
<正>芫花作为一种瑞香科植物,最早记录可以追溯到《神农本草》中,主要分布在长江流域及华北地区[1]。在中国中医上千年的处方历史中,芫花经常用来治疗水肿、哮喘、咳嗽和癌症等疾病[2,3]。类风湿关节炎的药理研究表明芫花提取物通过抗氧化、抗炎和血液流变学调节机制显著降低了大鼠关节炎程度[4,5]。瑞香芫花的化学成分有香豆素类、黄酮
引文
[1]孙文婷,蔡由生,杨升平.芫花根的化学成分[J].中国实验方剂学杂志,2016,22(23):49-54.
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[10]张志强,李石飞,张立伟,等.黄芫花化学成分及其抗乙肝病毒作用[J].中草药,2017,48(7):1292-1297.
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[26]苗培培,赵园园,苗青,等.羟基芫花素对UGTs及UGT1A1活性抑制作用种属差异的体外研究[J].中国中药杂志,2016,41(3):504-508.
[27]李振岚,张桥,楼坚伟,等.十枣汤研究进展[J].中国实验方剂学杂志,2018,24(17):221-226.
[28]张保献,原思通,张静修,等.芫花的现代研究概况[J].中国中医药信息杂志,1995,2(10):21-24.
[29]许云,阮秦莉,纪蕾蕾,等.芫花素对模式生物秀丽隐杆线虫的毒性作用[J].中国药理学与毒理学杂志,2017,31(5):414-421.
[30]Han BS,Kim KS,Kim YJ,et al.Daphnane diterpenes from daphne genkwa activate nurr1 and have a neuroprotective effect in an animal model of parkinson′s disease[J].J Nat Prod,2016,79(6):1604-1609.
[2]Ben-Haim S,Seabold JE,Hawes DR,et al.Leukocyte scintigraphy in the diagnosis of mycotic aneurysm[J].J Nucl Med,1992,33(8):1486-1493.
[3]Liu J,Zhai WM,Yang YX,et al.GABA and 5-HT systems are implicated in the anxiolytic-like effect of spinosin in mice[J].Pharmacol Biochem Behav,2015,128:41-49.
[4]Chen ZT.A new species of neoperla(Plecoptera:Perlidae)from Zhejiang Province of China[J].Zootaxa,2016,4093(4):589-594.
[5]Zhang CF,Zhang SL,He X,et al.Antioxidant effects of Genkwa flos flavonoids on Freunds adjuvant-induced rheumatoid arthritis in rats[J].J Ethnopharmacol,2014,153(3):793-800.
[6]Jiang CP,He X,Yang XL,et al.Anti-rheumatoid arthritic activity of flavonoids from Daphne genkwa[J].Phytomedicine,2014,21(6):830-837.
[7]Uyangaa E,Choi JY,Ryu HW,et al.Anti-herpes activity of vinegar-processed daphne genkwa flos via enhancement of natural killer cell activity[J].Immune Netw,2015,15(2):91-99.
[8]李玲芝,宋少江,高品一.芫花的化学成分及药理作用研究进展[J].沈阳药科大学学报,2007,24(9):587-592.
[9]夏素霞,李玲芝,李菲菲,等.芫花花蕾中的两个新二萜[J].化学学报,2011,69(20):2518-2522.
[10]张志强,李石飞,张立伟,等.黄芫花化学成分及其抗乙肝病毒作用[J].中草药,2017,48(7):1292-1297.
[11]徐贝贝,张朋,刘明华,等.芫花枝条化学成分的研究[J].烟台大学学报(自然科学与工程版),2010,23(2):111-115.
[12]尹宁宁.芫花条化学成分的研究[D].广州:中山中医药大学,2001.
[13]徐光,李天景,阮征,等.芫花枝条木脂素化学成分研究[J].中国现代中药,2014,16(6):447-450.
[14]和蕾,史琪荣,柳润辉,等.芫花条中香豆素类成分研究[J].药学实践杂志,2008,26(6):441-443.
[15]郭洁茹.两种荛花属药用植物化学成分和生物活性研究[D].武汉:华中科技大学,2012.
[16]Li F,Sun Q,Hong L,et al.Daphnane-type diterpenes with inhibitory activities against human cancer cell lines from Daphne genkwa[J].Bioorg Med Chem Lett,2013,23(9):2500-2504.
[17]Kang JI,Hong JY,Lee HJ,et al.Anti-tumor activity of yuanhuacine by regulating AMPK/mTOR signaling pathway and actin cytoskeleton organization in non-small cell lung cancer cells[J].PLoS One,2015,10(12):e0144368.
[18]Hong JY,Chung HJ,Lee HJ,et al.Growth inhibition of human lung cancer cells via down-regulation of epidermal growth factor receptor signaling by yuanhuadine,a daphnane diterpene from Daphne genkwa[J].J Nat Prod,2011,74(10):2102-2108.
[19]Zheng W,Gao X,Gu Q,et al.Antitumor activity of daphnodorins from Daphne genkwa roots[J].Int Immunopharmacol,2007,7(2):128-134.
[20]Han BS,Minh NV,Choi HY,et al.Daphnane and phorbol diterpenes,anti-neuroinflammatory compounds with NURR1acti-vation from the roots and stems of daphne genkwa[J].Biol Pharm Bull,2017,40(12):2205-2211.
[21]Wang L,Lan XY,Ji J,et al.Anti-inflammatory and anti-angiogenic activities in vitro of eight diterpenes from Daphne genkwa based on hierarchical cluster and principal component analysis[J].J Nat Med,2018,72(3):675-685.
[22]涂苑青,黄丰,朱苗苗,等.瑞香素对脂多糖诱导的小鼠小胶质细胞炎症反应的保护作用[J].时珍国医国药,2013,24(5):1169-1172.
[23]张立,喻文进,刘慧琼,等.西瑞香素抗炎抑菌作用的初步实验研究[J].中医药导报,2012,18(6):72-73.
[24]郑维发,王莉,石枫,等.盐藻水提物对小鼠细胞免疫功能的影响(英)[J].中成药,2004,26(12):53-58.
[25]潘琳琳,史仁杰.芫花根水提物镇痛机制的研究[J].东南大学学报(医学版),2018,37(1):27-30.
[26]苗培培,赵园园,苗青,等.羟基芫花素对UGTs及UGT1A1活性抑制作用种属差异的体外研究[J].中国中药杂志,2016,41(3):504-508.
[27]李振岚,张桥,楼坚伟,等.十枣汤研究进展[J].中国实验方剂学杂志,2018,24(17):221-226.
[28]张保献,原思通,张静修,等.芫花的现代研究概况[J].中国中医药信息杂志,1995,2(10):21-24.
[29]许云,阮秦莉,纪蕾蕾,等.芫花素对模式生物秀丽隐杆线虫的毒性作用[J].中国药理学与毒理学杂志,2017,31(5):414-421.
[30]Han BS,Kim KS,Kim YJ,et al.Daphnane diterpenes from daphne genkwa activate nurr1 and have a neuroprotective effect in an animal model of parkinson′s disease[J].J Nat Prod,2016,79(6):1604-1609.