老年性湿热型骨关节炎患者超氧化物歧化酶活性的变化及关联规则研究
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摘要
目的研究老年性湿热型骨关节炎患者血清中超氧化物歧化酶(SOD)活性的变化及与免疫炎症等指标的关系。方法整理安徽省中医院风湿免疫科2012年6月至2017年6月骨关节炎(OA)住院患者的病历资料,观察血清SOD活性变化,并与年龄、病程及免疫、炎症,代谢等实验室指标进行相关性分析及logistic回归分析。结果 (1) 1904例湿热证骨关节炎患者,中青年组1115例,老年组789例,老年组SOD下降者有484例,占61. 3%;中青年组SOD下降者有312例,占27. 9%。(2)老年组SOD与红细胞沉降率(ESR)、超敏C反应蛋白(hs-CRP)、三酰甘油(TG)、载脂蛋白-B(Apo-B)、补体C4呈负相关,与免疫球蛋白G(IgG)呈正相关(P <0. 05)。(3) ESR、hs-CRP、IgG、高密度脂蛋白胆固醇(HDL-C)是老年组SOD的危险因素。(4)老年组SOD与ESR、hs-CRP、IgG、免疫球蛋白M(IgM)的关联度高于中青年组。结论老年OA患者血清SOD下降可能参与了OA的发病。
Objective To study the changes of serum superoxide dismutase activity in elderly patients with damp-heat syndrome of osteoarthritis and the relationship with immune inflammation and other indicators. Methods The clinical data of hospitalized patients with osteoarthritis were collected. Syndrome differentiation of traditional Chinese medicine belongs to syndrome dampness-heat blocking collateral. We have analyzed the changes of superoxide dismutase,and correlation with age,disease duration and immunological inflammation and other laboratory indicators. The relationship between SOD and immune inflammation was analyzed by SPSS Clementine 12. 0 software Aprior module. Results( 1) In 1904 patients with damp-heat syndrome,there were 1155 cases of middle-aged and young patients group and 789 cases of elderly patients group. There were 484 cases( 61. 3%) in the elderly patients group and 312 cases( 27. 9%) in the middle-aged and young patients group.( 2) The chi-square test showed that the descending rate of SOD in the elderly group was higher than that in the middle-aged group( P < 0. 01). The rising rates of ESR,hs-CRP,IgG and IgM in the elderly group were higher than those in the middle( P < 0. 05 or P < 0. 01).( 3) Correlation analysis showed that there was a negative correlation between SOD and ESR,hs-CRP,TG,Apo-B,Complement C4,and IgG was positively correlated( P < 0. 05).( 4) Logistic regression analysis showed that ESR,hs-CRP,IGG and HDL-C were the risk factors of SOD in elderly group.( 5) The association rules showed that the correlation between SOD and ESR,hsCRP,IgG and IgM in elderly group was higher than that in middle-aged and young group. Conclusion Decreased expression of serum SOD in elderly patients with OA may be involved in the pathogenesis.
Objective To study the changes of serum superoxide dismutase activity in elderly patients with damp-heat syndrome of osteoarthritis and the relationship with immune inflammation and other indicators. Methods The clinical data of hospitalized patients with osteoarthritis were collected. Syndrome differentiation of traditional Chinese medicine belongs to syndrome dampness-heat blocking collateral. We have analyzed the changes of superoxide dismutase,and correlation with age,disease duration and immunological inflammation and other laboratory indicators. The relationship between SOD and immune inflammation was analyzed by SPSS Clementine 12. 0 software Aprior module. Results( 1) In 1904 patients with damp-heat syndrome,there were 1155 cases of middle-aged and young patients group and 789 cases of elderly patients group. There were 484 cases( 61. 3%) in the elderly patients group and 312 cases( 27. 9%) in the middle-aged and young patients group.( 2) The chi-square test showed that the descending rate of SOD in the elderly group was higher than that in the middle-aged group( P < 0. 01). The rising rates of ESR,hs-CRP,IgG and IgM in the elderly group were higher than those in the middle( P < 0. 05 or P < 0. 01).( 3) Correlation analysis showed that there was a negative correlation between SOD and ESR,hs-CRP,TG,Apo-B,Complement C4,and IgG was positively correlated( P < 0. 05).( 4) Logistic regression analysis showed that ESR,hs-CRP,IGG and HDL-C were the risk factors of SOD in elderly group.( 5) The association rules showed that the correlation between SOD and ESR,hsCRP,IgG and IgM in elderly group was higher than that in middle-aged and young group. Conclusion Decreased expression of serum SOD in elderly patients with OA may be involved in the pathogenesis.
引文
[1]周巧,刘健.骨关节炎中氧化应激相关信号转导通路的研究[J].中医药临床杂志,2016,28(8):1051-1054.
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[7]孙玥,刘健,王芳,等.探讨新风胶囊改善佐剂型关节炎大鼠心功能机制及其与氧化应激的关系[J].环球中医药,2013,6(S2):26-27.
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[9]阮丽萍,刘健,万磊,等.骨关节炎患者免疫球蛋白的变化及其相关因素分析[J].中国临床保健杂志,2014,17(2):119.
[10]阮丽萍,刘健,万磊,等.免疫球蛋白亚型在膝骨关节炎患者血清中的变化及相关性分析[J].风湿病与关节炎,2015,4(7):11.
[11]孟陆亮,杨少军,白洲霞,等.慈菇消脂丸对脂肪肝大鼠脂代谢和超氧化物歧化酶的影响[J].中医药学报,2009,37(5):30-32.
[12]辛续丽,杨桂花,胡梅,等.高脂血症人群血清超氧化物歧化酶的变化趋势[J].标记免疫分析与临床,2013,20(4):225-228.
[13]周巧,刘健,忻凌,等. 673例骨关节炎患者超氧化物歧化酶的变化及关联规则挖掘研究[J].世界中西医结合杂志,2017,12(7):958-961.
[2] HE X,ANDERSSON G,LINDGREN U,et al. Resveratrolprevents RANKL-induced osteoclast differentiation of mu-rine ostepclast progenitor RAW 264. 7 cells through inhi-bition of ROS production[J]. Biochem Biophys Res Com-mun,2010,401(3):356-362.
[3]中华医学会风湿病专业委员会.骨关节炎诊疗指南[J].中华风湿病学杂志,2003,7(11):702-704.
[4]国家中医药管理局医政司. 22个专业95个病种中医诊疗方案[M].北京:中国中医药出版社,2011:131.
[5]谈冰,刘健,章平衡,等.新风胶囊对骨关节炎血瘀状态的影响[J].中国中西医结合杂志,2016,36(12):1449-1455.
[6]程园园,刘健,冯云霞,等.超氧化物歧化酶在膝骨关节炎患者血清中的变化及相关因素分析[J].中国临床保健杂志,2012,15(5):475-478.
[7]孙玥,刘健,王芳,等.探讨新风胶囊改善佐剂型关节炎大鼠心功能机制及其与氧化应激的关系[J].环球中医药,2013,6(S2):26-27.
[8]刘丹,陈庆平,周亚妮,等.补体系统对类风湿关节炎的免疫调节作用[J].中华风湿病学杂志,2014,18(3):204-206.
[9]阮丽萍,刘健,万磊,等.骨关节炎患者免疫球蛋白的变化及其相关因素分析[J].中国临床保健杂志,2014,17(2):119.
[10]阮丽萍,刘健,万磊,等.免疫球蛋白亚型在膝骨关节炎患者血清中的变化及相关性分析[J].风湿病与关节炎,2015,4(7):11.
[11]孟陆亮,杨少军,白洲霞,等.慈菇消脂丸对脂肪肝大鼠脂代谢和超氧化物歧化酶的影响[J].中医药学报,2009,37(5):30-32.
[12]辛续丽,杨桂花,胡梅,等.高脂血症人群血清超氧化物歧化酶的变化趋势[J].标记免疫分析与临床,2013,20(4):225-228.
[13]周巧,刘健,忻凌,等. 673例骨关节炎患者超氧化物歧化酶的变化及关联规则挖掘研究[J].世界中西医结合杂志,2017,12(7):958-961.