激素性股骨头缺血性坏死发病机制中的细胞自噬
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摘要
背景:临床研究表明骨细胞自噬参与了激素性股骨头坏死的病理过程,并与细胞凋亡关系密切。目的:通过对细胞自噬与细胞凋亡及骨细胞的相互作用关系,总结细胞自噬在激素性股骨头缺血坏死发病机制中的研究进展。方法:由第一作者应用计算机检索应用计算机检索PubMed数据库,embase数据库,CNKI数据库中从1996年10月到2016年10月出版的文献,检索词分别为"steroid;necrosis of the femoral head;cell apoptosis;cell autophagy;osteocyte"和"糖皮质激素;股骨头坏死;骨细胞;细胞凋亡;细胞自噬"。选择激素性股骨头坏死与细胞自噬的文章,排除重复及较陈旧的文献及Meta分析。结果与结论:哺乳动物雷帕霉素靶蛋白、Beclin-1、微管相关蛋白1轻链3及骨形成蛋白、叉头框蛋白和转录基因家族和转录因子4等与细胞自噬关系密切;细胞自噬与骨细胞的相互作用与激素剂量密切相关,低剂量激素作用下,细胞自噬表现为保护作用,而随着剂量的增多,出现了大量细胞凋亡现象,同时也出现骨量减少,骨易碎性增加的现象,而细胞自噬与骨量维持、细胞凋亡的具体关系现在仍存在争论,需要进一步通过合理的实验设计去研究。
BACKGROUND: Autophagy of osteocytes has been found to be implicated in the pathogenesis of steroid-induced necrosis of the femoral head and closely related to apoptosis. OBJECTIVE: To summarize the research progress of autophagy in the pathogenesis of steroid-induced necrosis of the femoral head by studying the interaction between cell autophagy and cell apoptosis as well as osteocytes. METHODS: A computer-based online retrieval of PubMed, Embase and CNKI databases was performed for relevant literatures published from October 1996 to October 2016 with the keywords of "steroid, necrosis of the femoral head, cell apoptosis, cell autophagy, osteocyte" in Chinese and English, respectively. The articles concerning steroid-induced necrosis of femoral head and cell autophagy were collected, and the redundant and old researches or Meta analysis were removed. RESULTS AND CONCLUSION: Mammalian target of rapamycin, Beclin-1, microtubule-associated protein 1 light chain 3, bone morphogenetic proteins, fork box protein and transcription gene family and transcription factor 4 are closely related to autophagy. The interaction between autophagy and osteocytes is correlated with steroid dose: the autophagy shows protective factor under the low dose corticosteroids; however, with the increase of the dosage, a large number of apoptotic cells, and the phenomenon of bone loss can been observed. Furthermore, the relationship of cell autophagy with apoptosis and bone mass maintenance is still controversial, which needs to be explored in depth via a series of rational experiments.
BACKGROUND: Autophagy of osteocytes has been found to be implicated in the pathogenesis of steroid-induced necrosis of the femoral head and closely related to apoptosis. OBJECTIVE: To summarize the research progress of autophagy in the pathogenesis of steroid-induced necrosis of the femoral head by studying the interaction between cell autophagy and cell apoptosis as well as osteocytes. METHODS: A computer-based online retrieval of PubMed, Embase and CNKI databases was performed for relevant literatures published from October 1996 to October 2016 with the keywords of "steroid, necrosis of the femoral head, cell apoptosis, cell autophagy, osteocyte" in Chinese and English, respectively. The articles concerning steroid-induced necrosis of femoral head and cell autophagy were collected, and the redundant and old researches or Meta analysis were removed. RESULTS AND CONCLUSION: Mammalian target of rapamycin, Beclin-1, microtubule-associated protein 1 light chain 3, bone morphogenetic proteins, fork box protein and transcription gene family and transcription factor 4 are closely related to autophagy. The interaction between autophagy and osteocytes is correlated with steroid dose: the autophagy shows protective factor under the low dose corticosteroids; however, with the increase of the dosage, a large number of apoptotic cells, and the phenomenon of bone loss can been observed. Furthermore, the relationship of cell autophagy with apoptosis and bone mass maintenance is still controversial, which needs to be explored in depth via a series of rational experiments.
引文
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