转录因子FoxO1在糖尿病中的作用研究
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摘要
在糖尿病的进程中,常伴随有多种蛋白质的表达水平及功能的改变。叉头框蛋白1(FOXO1)蛋白是人体内重要的转录因子,可以调节机体中多种基因的表达,包括与糖脂代谢、胰岛素抵抗、胰岛β细胞增殖分化和凋亡、线粒体功能以及细胞自噬密切相关的基因。近年来,随着技术的不断进步,越来越多的实验结果表明,FoxO1可以通过上述不同的途径参与糖尿病的形成及其相关肝脏、血管、神经、心脏并发症的发展。研究FoxO1在糖尿病及其并发症中的作用,有助于为寻找糖尿病及其并发症的治疗靶点提供新思路。
引文
1 郑舒静,陈诺琦.胰岛β细胞转录因子FoxO1的研究进展.医学综述,2011,17:47~49.
2 Su D,Coudriet GM,Hyun Kim D,et al.FoxO1 links insulin resistance to proinflammatory cytokine IL-1βproduction in macrophages.Diabetes,2009,58:2624~2633.
3 Tsuchiya K,Tanaka J,Shuiqing Y,et al.FoxOs integrate pleiotropic actions of insulin in vascular endothelium to protect mice from atherosclerosis.Cell Metab,2012,15:372 ~381.
4 Siqueira MF,Li J,Chehab L,et al.Impaired wound healing in mouse models of diabetes is mediated by TNF-αdysregulation and associated with enhanced activation of forkhead box O1(FOXO1).Diabetologia,2010,58:378 ~388.
5 Zhao Y,Yang J,Liao W,et al.Cytosolic FoxO1 is essential for the induction of autophagy and tumor suppressor activity.Nat Cell Biol,2010,12:665~683.
6 Han J,Pan XY,Xu Y,et al.Curcumin induced autophagy to protect vascular endothelial cell survival from oxidative stress damage.Autophagy,2012,8:1~15.
7 Cheng Z,Tseng Y,White MF.Insulin signaling meets mitochondria in metabolism.Trends Endocrinol Metab,2010,21 :589~598.
8 Cheng Z,Guo S,Copps K,et al.FoxO1 integrates insulin signaling with mitochondrial function in the liver.Nat Med,2009,15:1307~1311.
9 Li T,Ma H,Park YJ,et al.Forkhead box transcription factor O1 inhibits cholesterol 7α-hydroxylase in human hepatocytes and in high fat diet-fed mice.Biochim Biophys Acta,2009,1791:991~996.
10 Tanaka J,Qiang L,Banks AS,et al.Foxo1 links hyperglycemia to LDL oxidation and endothelial nitric oxide synthase dysfunction in vascular endothelial cells.Diabetes,2009,58:2344~2354.
11 Tie L,An Y,Han J,et al.Genistein accelerates refractory wound healing by suppressing superoxide and FoxO1/iNOS pathway in type 1 diabetes.J Nutr Biochem,2013,24:88 ~96.
12 冯世栋,孙璐,路晓艳等.FoxO1变化对糖尿病小鼠心肌缺血/再灌注损伤的影响.心脏杂志,2012,24:303 ~307.
13 Battiprolu PK,Hojayev B,Jiang N,et al.Metabolic stress-induced activation of FoxO1 triggers diabetic cardiomyopathy in mice.J Clin Invest,2012,122:1109~1118.
14 Nagashima T,Shigematsu N,Maruki R,et al.Discovery of novel forkheadbox O1 inhibitors for treating type 2 diabetes:improvement of fasting glycemia in diabetic db/db mice.Mol Pharmacol,2010,78:961~970.
15 Tanaka H,Nagashima T,Shimaya A,et al.Effects of the novel Foxo1 inhibitor AS1708727 on plasma glucose and triglyceride levels in diabetic db/db mice.Eur J Pharmacol,2010,645:185~191.
2 Su D,Coudriet GM,Hyun Kim D,et al.FoxO1 links insulin resistance to proinflammatory cytokine IL-1βproduction in macrophages.Diabetes,2009,58:2624~2633.
3 Tsuchiya K,Tanaka J,Shuiqing Y,et al.FoxOs integrate pleiotropic actions of insulin in vascular endothelium to protect mice from atherosclerosis.Cell Metab,2012,15:372 ~381.
4 Siqueira MF,Li J,Chehab L,et al.Impaired wound healing in mouse models of diabetes is mediated by TNF-αdysregulation and associated with enhanced activation of forkhead box O1(FOXO1).Diabetologia,2010,58:378 ~388.
5 Zhao Y,Yang J,Liao W,et al.Cytosolic FoxO1 is essential for the induction of autophagy and tumor suppressor activity.Nat Cell Biol,2010,12:665~683.
6 Han J,Pan XY,Xu Y,et al.Curcumin induced autophagy to protect vascular endothelial cell survival from oxidative stress damage.Autophagy,2012,8:1~15.
7 Cheng Z,Tseng Y,White MF.Insulin signaling meets mitochondria in metabolism.Trends Endocrinol Metab,2010,21 :589~598.
8 Cheng Z,Guo S,Copps K,et al.FoxO1 integrates insulin signaling with mitochondrial function in the liver.Nat Med,2009,15:1307~1311.
9 Li T,Ma H,Park YJ,et al.Forkhead box transcription factor O1 inhibits cholesterol 7α-hydroxylase in human hepatocytes and in high fat diet-fed mice.Biochim Biophys Acta,2009,1791:991~996.
10 Tanaka J,Qiang L,Banks AS,et al.Foxo1 links hyperglycemia to LDL oxidation and endothelial nitric oxide synthase dysfunction in vascular endothelial cells.Diabetes,2009,58:2344~2354.
11 Tie L,An Y,Han J,et al.Genistein accelerates refractory wound healing by suppressing superoxide and FoxO1/iNOS pathway in type 1 diabetes.J Nutr Biochem,2013,24:88 ~96.
12 冯世栋,孙璐,路晓艳等.FoxO1变化对糖尿病小鼠心肌缺血/再灌注损伤的影响.心脏杂志,2012,24:303 ~307.
13 Battiprolu PK,Hojayev B,Jiang N,et al.Metabolic stress-induced activation of FoxO1 triggers diabetic cardiomyopathy in mice.J Clin Invest,2012,122:1109~1118.
14 Nagashima T,Shigematsu N,Maruki R,et al.Discovery of novel forkheadbox O1 inhibitors for treating type 2 diabetes:improvement of fasting glycemia in diabetic db/db mice.Mol Pharmacol,2010,78:961~970.
15 Tanaka H,Nagashima T,Shimaya A,et al.Effects of the novel Foxo1 inhibitor AS1708727 on plasma glucose and triglyceride levels in diabetic db/db mice.Eur J Pharmacol,2010,645:185~191.