大黄利胆联合甘草酸二铵治疗非酒精性脂肪性肝炎疗效观察
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摘要
目的研究大黄利胆片和甘草酸二铵胶囊对非酒精性脂肪性肝炎的影响。方法将2014年1月—2017年12月入住本院的90例非酒精性脂肪性肝炎患者随机分为对照组和实验组两组,每组各45例。对照组使用甘草酸二铵(150 mg,一日三次)。实验组采用甘草酸二铵(150 mg,3次/天)与大黄利胆(0.7 g,3次/天)合用。治疗60天观察疗效。比较两组治疗前后的临床疗效及谷丙转氨酶(ALT)、谷草转氨酶(AST)、白蛋白(ALB)、总胆红素(TBIL)、直接胆红素(DBIL)、尿酸、白细胞(WBC)、红细胞(RBC)、清基质金属蛋白酶组织抑制因子1(TIMP-1)、肿瘤坏死因子(TNF-α)等指标及药物不良反应等。结果对照组与实验组比较,临床总有效率分别为(33,73.33%) vs(43,95.56%),差异有统计学意义(P<0.05)。ALT、AST、TBIL、DBIL、ALB、尿酸、WBC、RBC、TNF-α以及TIMP-1均明显优于治疗前(P<0.05)。实验组与对照组比较,差异有统计学意义(P<0.05)。两组无明显临床不适及血常规及肝肾功能损害。结论大黄利胆和甘草酸二铵治疗非酒精性脂肪性肝炎安全有效,临床值得推广。
Objective To study the effects of rhubarb lidan tablets and diammonium glycyrrhizinate capsules on non-alcoholic steatohepatitis( NASH). Methods 90 cases of patients suffered with NASH and admitted to our hospital during January 2014 and December 2017 were randomly divided into control group and experimental group,45 cases in each group. The control group received 150 mg of diammonium glycyrrhizinate three times a day.The experimental group used diammonium glycyrrhizinate( 150 mg,three times a day) combined with rhubarb lidan tablets( 0. 7 g,three times a day). The therapeutic effect was observed after 60 days of treatment. The clinical effects of the two groups were compared before and after the treatment,including ALT,AST,ALB,total bilirubin( TBIL),direct bilirubin( DBIL),uric acid,leukocyte( WBC),red blood cell( RBC),matrix metalloproteinase inhibitor 1( TIMP-1),tumor necrosis factor( TNF-α) and other drug malfunction and so on.Results The total clinical effective rate in control group was( 33,73. 33%) lower than that of experimental group( 43,95.56%),P< 0.05. ALT,AST,TBIL,DBIL,ALB,uric acid,WBC,RBC,TNF-αand TIMP-1 were significantly better than those before treatment( P<0.05). The difference between the treatment group and the control group was statistically significant( P< 0.05). There were no significant clinical discomforts and hemocytology and liver and kidney dysfunction in the two groups. Conclusions Rhubarb lidan tablets combined with diammonium glycyrrhizinate is safe and effective in the treatment of NASH,is worthy of clinical promoting.
Objective To study the effects of rhubarb lidan tablets and diammonium glycyrrhizinate capsules on non-alcoholic steatohepatitis( NASH). Methods 90 cases of patients suffered with NASH and admitted to our hospital during January 2014 and December 2017 were randomly divided into control group and experimental group,45 cases in each group. The control group received 150 mg of diammonium glycyrrhizinate three times a day.The experimental group used diammonium glycyrrhizinate( 150 mg,three times a day) combined with rhubarb lidan tablets( 0. 7 g,three times a day). The therapeutic effect was observed after 60 days of treatment. The clinical effects of the two groups were compared before and after the treatment,including ALT,AST,ALB,total bilirubin( TBIL),direct bilirubin( DBIL),uric acid,leukocyte( WBC),red blood cell( RBC),matrix metalloproteinase inhibitor 1( TIMP-1),tumor necrosis factor( TNF-α) and other drug malfunction and so on.Results The total clinical effective rate in control group was( 33,73. 33%) lower than that of experimental group( 43,95.56%),P< 0.05. ALT,AST,TBIL,DBIL,ALB,uric acid,WBC,RBC,TNF-αand TIMP-1 were significantly better than those before treatment( P<0.05). The difference between the treatment group and the control group was statistically significant( P< 0.05). There were no significant clinical discomforts and hemocytology and liver and kidney dysfunction in the two groups. Conclusions Rhubarb lidan tablets combined with diammonium glycyrrhizinate is safe and effective in the treatment of NASH,is worthy of clinical promoting.
引文
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