强的松联合低分子肝素治疗小儿肾病综合征的疗效及安全性观察
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摘要
目的探讨强的松联合低分子肝素治疗小儿肾病综合征的疗效及安全性。方法选取2014年1月至2018年8月我院收治的82例肾病综合征患儿,随机分为两组各41例。观察组以强的松联合低分子肝素治疗,对照组以低分子肝素治疗,比较两组患儿的临床疗效、不良反应及治疗前后的肾功能指标。结果观察组的总有效率显著高于对照组(P <0.05)。治疗前,两组患儿的肾功能指标比较无统计学差异(P>0.05);治疗后,观察组的肾功能指标优于对照组(P <0.05)。两组的不良反应发生率比较无统计学差异(P>0.05)。结论强的松联合低分子肝素治疗小儿肾病综合征可显著提高临床疗效,改善肾功能,值得推广。
Objective To explore the curative effect and safety of prednisone combined with low molecular weight heparin in the treatment of children with nephrotic syndrome. Methods 82 cases of children with nephrotic syndrome admitted to our hospital from January2014 to August 2018 were selected and randomly divided into two groups, with 41 cases in each group. The observation group was treated with prednisone combined with low molecular weight heparin, and the control group was treated with low molecular weight heparin. The clinical efficacy, adverse reactions and renal function indicators before and after treatment of the two groups were compared. Results The total effective rate of the observation group was significantly higher than that of the control group(P <0.05). Before treatment, no statistical difference was found in the renal function indicators between the two groups(P >0.05). After treatment, the renal function indicators of the observation group were better than those of the control group(P <0.05). No statistical difference was found in the incidence of adverse reactions between the two groups(P >0.05). Conclusions Prednisone combined with low molecular weight heparin in the treatment of children with nephrotic syndrome can significantly improve the clinical efficacy, improve the renal function, which is worthy of promotion.
Objective To explore the curative effect and safety of prednisone combined with low molecular weight heparin in the treatment of children with nephrotic syndrome. Methods 82 cases of children with nephrotic syndrome admitted to our hospital from January2014 to August 2018 were selected and randomly divided into two groups, with 41 cases in each group. The observation group was treated with prednisone combined with low molecular weight heparin, and the control group was treated with low molecular weight heparin. The clinical efficacy, adverse reactions and renal function indicators before and after treatment of the two groups were compared. Results The total effective rate of the observation group was significantly higher than that of the control group(P <0.05). Before treatment, no statistical difference was found in the renal function indicators between the two groups(P >0.05). After treatment, the renal function indicators of the observation group were better than those of the control group(P <0.05). No statistical difference was found in the incidence of adverse reactions between the two groups(P >0.05). Conclusions Prednisone combined with low molecular weight heparin in the treatment of children with nephrotic syndrome can significantly improve the clinical efficacy, improve the renal function, which is worthy of promotion.
引文
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[5]田建梅,刘晓伟.低分子肝素联合泼尼松治疗小儿肾病综合征的效果、相关临床指标及预后分析[J].中国医药导报, 2017, 14(24):147-150.
[2]梅长林. POD-肾病综合征[M].北京:科学出版社, 2016:713-717.
[3]孙宏伟,刘云霞,刘胜阳.低分子肝素治疗对肾病综合征患者凝血指标、生化指标及临床疗效的影响[J].实用临床医药杂志, 2017,21(3):32-34, 41.
[4]张婵.低分子肝素联合强的松治疗小儿肾病综合征的疗效及对肾功能的影响[J].齐齐哈尔医学院学报, 2017, 38(14):201-202.
[5]田建梅,刘晓伟.低分子肝素联合泼尼松治疗小儿肾病综合征的效果、相关临床指标及预后分析[J].中国医药导报, 2017, 14(24):147-150.