痰热清注射液治疗支气管哮喘急性发作期对患者血清炎性因子水平的影响
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摘要
目的探讨痰热清注射液治疗支气管哮喘急性发作期对患者血清炎性因子水平的影响。方法选取我院收治的150例支气管哮喘急性发作期患者为研究对象,按照治疗方式的不同将其分为对照组(75例,常规西药治疗)与观察组(75例,常规西药+痰热清注射液治疗)。对比两组患者的临床疗效、治疗前、后肺功能、血清炎性因子水平及ACT评分。结果观察组的治疗总有效率明显高于对照组(P<0.05)。治疗后,两组的FEV1、FVC、PEF、FEV1%、PEF%及FEV1/FVC较治疗前均明显升高,且观察组明显高于对照组(P<0.05)。治疗后,两组的IL-6、IL-18及TNF-α水平均显著降低,且观察组低于对照组(P<0.05)。治疗后,两组的ACT各项评分较治疗前均明显升高,且观察组高于对照组(P<0.05)。结论痰热清注射液治疗支气管哮喘急性发作期的效果显著,可以提高患者的肺功能,改善患者的血清炎性因子水平及ACT评分,值得临床推广与应用。
Objective To investigate the effect of Tanreqing injection on levels of serum inflammatory factors in patients with acute episode of bronchial asthma. Methods A total of 150 patients with acute episode of bronchial asthma treated in our hospital were selected as research objects and divided into control group(75 cases, routine western medicine treatment)and observation group(75 cases, routine western medicine and Tanreqing injection treatment) according to different treatment methods. The clinical efficacy, pulmonary function, levels of serum inflammatory factors and ACT scores before and after treatment of the two groups were compared. Results The total effective rate of treatment in the observation group was significantly higher than that in the control group(P<0.05). After treatment, the FEV1, FVC, PEF, FEV1%, PEF% and FEV1/FVC in the two groups were significantly higher than those before treatment, and those of the observation group were significantly higher than the control group(P <0.05). After treatment, the levels of IL-6, IL-18 and TNF-α in the two groups significantly decreased, and those of the observation group were lower than the control group(P <0.05). After treatment, the ACT scores of the two groups were significantly higher than those before treatment, and those of the observation group were higher than the control group(P<0.05). Conclusion Tanreqing injection is effective in treating acute episode of bronchial asthma. It can improve the pulmonary function, levels of serum inflammatory factors and ACT score of patients, which is worthy of clinical promotion and application.
Objective To investigate the effect of Tanreqing injection on levels of serum inflammatory factors in patients with acute episode of bronchial asthma. Methods A total of 150 patients with acute episode of bronchial asthma treated in our hospital were selected as research objects and divided into control group(75 cases, routine western medicine treatment)and observation group(75 cases, routine western medicine and Tanreqing injection treatment) according to different treatment methods. The clinical efficacy, pulmonary function, levels of serum inflammatory factors and ACT scores before and after treatment of the two groups were compared. Results The total effective rate of treatment in the observation group was significantly higher than that in the control group(P<0.05). After treatment, the FEV1, FVC, PEF, FEV1%, PEF% and FEV1/FVC in the two groups were significantly higher than those before treatment, and those of the observation group were significantly higher than the control group(P <0.05). After treatment, the levels of IL-6, IL-18 and TNF-α in the two groups significantly decreased, and those of the observation group were lower than the control group(P <0.05). After treatment, the ACT scores of the two groups were significantly higher than those before treatment, and those of the observation group were higher than the control group(P<0.05). Conclusion Tanreqing injection is effective in treating acute episode of bronchial asthma. It can improve the pulmonary function, levels of serum inflammatory factors and ACT score of patients, which is worthy of clinical promotion and application.
引文
[1]李振,徐叶光,林文博.痰热清注射液对支气管哮喘急性发作期伴肺部感染患者的临床疗效观察[J].中国社区医师,2015,32(24):86-87.
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[3]熊晏,李劲风,柏冲飞,等.痰热清注射液治疗慢性呼吸系统疾病急性发作临床研究进展[J].中药与临床,2016,7(6):56-58.
[4]林江涛,祝墡珠,王家骥,等.中国支气管哮喘防治指南(基层版)[J].中国实用内科杂志,2013,33(8):615-622
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[7]国家中医药管理局.中医病证诊断疗效标准[S].南京:南京大学出版社,1994:5.
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[9]赵宁波,王东兴,杜学航.痰热清注射液治疗呼吸系统疾病临床应用新进展[J].中国中医急症,2018,27(4):740-742.
[10]苏楠,林江涛,刘国梁,等.我国8省市支气管哮喘患者控制水平的流行病学调查[J].中华内科杂志,2014,53(8):601-606.
[11]王华启.孟鲁司特对哮喘急性发作期患者外周血炎症因子的影响[J].广东医学,2013,34(1):124-125.
[12]曹宗黎.化痰降气汤治疗支气管哮喘的临床观察[J].湖北中医杂志,2016,38(5):37-38.
[13]罗海红,徐燕.痰热清注射液联合布地奈德雾化吸入对支气管哮喘急性发作患者气道嗜酸性炎性反应及肺功能的影响[J].中国基层医药,2014,21(11):1700-1702.
[14]王增玲,吴航.丹参注射液联合痰热清注射液治疗小儿支气管哮喘发作期54例[J].中国继续医学教育,2014,6(8):177-178.
[2]林志雄,王开梅.痰热清联合吸入用布地奈德对小儿支气管哮喘的治疗作用及对气道反应性和hs-CRP、降钙素原的影响[J].中药材,2017,40(7):1735-1737.
[3]熊晏,李劲风,柏冲飞,等.痰热清注射液治疗慢性呼吸系统疾病急性发作临床研究进展[J].中药与临床,2016,7(6):56-58.
[4]林江涛,祝墡珠,王家骥,等.中国支气管哮喘防治指南(基层版)[J].中国实用内科杂志,2013,33(8):615-622
[5]郑筱萸.中药新药临床研究指导原则[M].北京:中国医药科技出版社,2002:532-533.
[6]陈丽丽.穴位经皮给药联合痰热清对支气管哮喘急性发作期患者肺功能及血清ESR、CRP、IL-5水平的影响[J].现代中西医结合杂志,2016,25(20):2213-2215.
[7]国家中医药管理局.中医病证诊断疗效标准[S].南京:南京大学出版社,1994:5.
[8]徐敏洁,宋丽萍.布地奈德治疗中重度支气管哮喘急性发作患儿的效果及对肺功能的影响[J].中国医院药学杂志,2014,34(7):565-568.
[9]赵宁波,王东兴,杜学航.痰热清注射液治疗呼吸系统疾病临床应用新进展[J].中国中医急症,2018,27(4):740-742.
[10]苏楠,林江涛,刘国梁,等.我国8省市支气管哮喘患者控制水平的流行病学调查[J].中华内科杂志,2014,53(8):601-606.
[11]王华启.孟鲁司特对哮喘急性发作期患者外周血炎症因子的影响[J].广东医学,2013,34(1):124-125.
[12]曹宗黎.化痰降气汤治疗支气管哮喘的临床观察[J].湖北中医杂志,2016,38(5):37-38.
[13]罗海红,徐燕.痰热清注射液联合布地奈德雾化吸入对支气管哮喘急性发作患者气道嗜酸性炎性反应及肺功能的影响[J].中国基层医药,2014,21(11):1700-1702.
[14]王增玲,吴航.丹参注射液联合痰热清注射液治疗小儿支气管哮喘发作期54例[J].中国继续医学教育,2014,6(8):177-178.