红细胞生成素水平与风湿免疫系统疾病的研究
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摘要
目的:探究分析红细胞生成素(EPO)水平和风湿免疫系统疾病两者之间的关系,以便更加深入地了解风湿免疫系统疾病患者对于红细胞生成素的反应。方法:选自我院2008~2012年收治的风湿免疫系统疾病患者共50例,设为A组,同期缺铁性贫血(IDA)患者共50例,设为B组,并与我院同期体检结果显示为正常的健康人共50例,设为C组。对比三组人血常规、乳酸脱氢酶、肝肾功能以及网织红细胞计数等各项指标。结果:A组患者的血清EPO水平,相对于B组患者要低很多,两者具有显著差异性(P<0.05)。结论:风湿免疫系统疾病因为红细胞生成素有所降低,导致出现合并贫血症状疾病,对于此类患者应用红细胞生成素治疗方法有较为突出的临床治疗效果。
Objective:To explore the analysis of erythropoietin(EPO) level and rheumatoid disease,the relationship between the immune system,in order to more in-depth understanding of erythropoietin in patients with rheumatoid immune system disease.Methods:To choose self institute of rheumatism admitted in 2008~2012,A total of 50 patients with diseases of the immune system,as A group,in the same period,A total of 50 patients with iron deficiency anemia(IDA),set to group B,and over the same period of our hospital check-up result shows that for A total of 50 cases of normal healthy people and set as group C. Compared three groups of blood routine,lactate dehydrogenase,hepatorenal function and reticulocyte count and other indicators.Results:The serum EPO level in patients of group A,compared with group B patients were much lower,which has significant difference(P<0.05).Conclusion:Rheumatoid immune system disease because of erythropoietin is reduced,cause disease in the merger of anemia symptoms,erythropoietin treatment for such patients have a more prominent clinical curative effect.
Objective:To explore the analysis of erythropoietin(EPO) level and rheumatoid disease,the relationship between the immune system,in order to more in-depth understanding of erythropoietin in patients with rheumatoid immune system disease.Methods:To choose self institute of rheumatism admitted in 2008~2012,A total of 50 patients with diseases of the immune system,as A group,in the same period,A total of 50 patients with iron deficiency anemia(IDA),set to group B,and over the same period of our hospital check-up result shows that for A total of 50 cases of normal healthy people and set as group C. Compared three groups of blood routine,lactate dehydrogenase,hepatorenal function and reticulocyte count and other indicators.Results:The serum EPO level in patients of group A,compared with group B patients were much lower,which has significant difference(P<0.05).Conclusion:Rheumatoid immune system disease because of erythropoietin is reduced,cause disease in the merger of anemia symptoms,erythropoietin treatment for such patients have a more prominent clinical curative effect.
引文
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3 张璐,李霞,孙凌云.白细胞介素-27与自身免疫病的研究进展[J].中华风湿病学杂志,2013,17(10):703~706
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10 张红侠.促红细胞生成素与肺心病患者红细胞免疫水平的相关性研究[J].河北医科大学学报,2013;34(6):727~728
11 王一浩,付蓉,刘惠,等.免疫相关性全血细胞减少症患者自身抗体IgG对红细胞生成素受体封闭的作用[J].中华血液学杂志,2011;32(11):794~795
2 宋扬,冷青,张壮.红细胞生成素治疗多发性骨髓瘤贫血的临床观察[J].医学信息(中旬刊),2010;5(6):1528~1529
3 张璐,李霞,孙凌云.白细胞介素-27与自身免疫病的研究进展[J].中华风湿病学杂志,2013,17(10):703~706
4 余丽君.类风湿关节炎伴慢性疾病性贫血患者血清白介素1和促红细胞生成素水平及其意义[J].中国全科医学,2012;15(20):2265~2267
5 肖倩,黄旭峰.尿毒症合并贫血患者输注悬浮红细胞和红细胞生成素疗效对比研究[J].检验医学与临床,2009;6(13):1035~1036
6 蒲梦君,周京国,青玉凤,等.α地中海贫血合并类风湿关节炎一例[J].中华临床医师杂志(电子版),2013;12:5683~5684
7 杨巍,蔡彦,梅育嘉,等.促红细胞生成素治疗急性心肌梗死的研究进展[J].临床合理用药杂志,2011;4(12):128~131
8 郭炯辉,洪英,王儒柏,等.促红细胞生成素治疗老年肾性贫血的疗效[J].中国老年学杂志,2012;32(15):3329~3330
9 金尚福,林蔚素,曾斌华,等.重组人促红细胞生成素对维持性血液透析患者营养状态、红细胞免疫和凝血功能的影响[J].中国基层医药,2013;20(14):2209~2211
10 张红侠.促红细胞生成素与肺心病患者红细胞免疫水平的相关性研究[J].河北医科大学学报,2013;34(6):727~728
11 王一浩,付蓉,刘惠,等.免疫相关性全血细胞减少症患者自身抗体IgG对红细胞生成素受体封闭的作用[J].中华血液学杂志,2011;32(11):794~795