摘要
首先,在氢氧化钾的催化作用下,分别将葡萄糖、麦芽糖与甲基丙烯酸缩水甘油酯反应,得到甲基丙烯酰化的葡萄糖(G-GM)和麦芽糖(M-GM)两种水溶性单体。采用傅里叶变换红外光谱(FT-IR)仪、核磁共振波谱(~1HNMR)仪确定其结构。然后以G-GM/M-GM的水溶液为连续相,二氧化碳为分散相,二丙烯酸聚乙二醇酯(M_W:1 000)为交联剂,制备水包二氧化碳型高内相乳液(内相体积分数大于74.05%),研究了表面活性剂的用量对乳液稳定性的影响。最后以过硫酸钾/四甲基乙二胺为引发剂,引发连续相中的单体聚合,得到大孔材料。实验结果显示,所得高内相乳液具有较好的稳定性,最高能稳定存在48 h以上。扫描电镜(SEM)分析表明,所得大孔材料的孔径分布与所用表面活性剂的浓度存在关系,其平均孔径分布在10~25μm之间,且存在大量的开孔结构,该材料有望在组织工程领域得到应用。
Glucose/maltose-based monomers(G-GM/M-GM) were synthesized by the reaction of glucose/maltose with glycidyl methacrylate using potassium hydrate as the catalyst. FT-IR,~1H NMR analysis confirmed the corresponding structures. Then the CO_2-in-water high internal emulsions(HIPE, the internal phase fraction is more than 74.05%) were prepared by using G-GM/M-GM solution as the continuous phase, liquid CO_2 as the dispersion phase, PVA-1788 as the surfactant. The results indicated that the HIPEs had sufficient stability, and could keep stable for more than 48 h. After the continuous phase was polymerized by ammonium peroxydisulfate/N,N,N′,N′-tetramethylethylenediamine as the redox initiator system, the G-GM/M-GM-based macroporous materials were obtained. SEM analysis indicated that G-GM/M-GM-based materials had rich cell structure with open-cell morphology, and the average pore sizes were distributed in 10—25 μm. These structures endowed these mate-rials with the potentiality to be used in tissue engineering applications.
引文
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