单宁酸的生物学特征及在医学和口腔医学领域的应用价值
|
摘要
背景:单宁酸在生物学和药理方面具有极强的活性,现已被应用于工业、医疗等领域。国内外对单宁酸的研究方兴未艾,单宁酸被认为是一种极具研究价值的材料。目的:分析单宁酸的生物活性及化学特性,综述其在工业、医学、口腔医学等领域的应用及展望。方法:应用计算机检索PubMed数据库、万方数据库、中国知网数据库、维普数据库中有关单宁酸的文献,中文检索词为"单宁酸,化学性质;单宁酸,生物活性;单宁酸,抗氧化性;单宁酸,工业;单宁酸,医学;单宁酸,口腔医学;单宁酸,牙本质;单宁酸,龋病;单宁酸,粘接强度"等,英文检索词为"tannic acid and chemical property,tannic acid and biological activity,tannin and antioxidant activity,tannin and industry,tannin and medicine,tannin and dentistry,tannin and dentin,tannin and tooth decay,tannin and bond strength"等。结果与结论:单宁酸为一种复杂的高分子多元酚类化合物,具有较强的功能性与生物学活性,因此被广泛应用于工业中。在医学领域,单宁酸不仅具有抑菌、抗病毒、抗炎、抗氧化等作用,并具有降血糖、降压、降脂等生理活性,而且对癌症与肿瘤有一定的抑制作用。在口腔领域,单宁酸可抑制致龋细菌的生长及牙齿菌斑生物膜的形成、保护牙周膜、预防牙釉质的表层脱矿及促进牙釉质的再矿化。基于单宁酸已知的生物学特点,其在心血管疾病、龋病的防治、麻醉等方面具有巨大科学研究价值。
BACKGROUND: Tannic acid has strong activity in biology and pharmacology, which has been used in industry, medical treatment and etc. Research focusing on tannic acid is in the ascendant, and tannic acid has beenconsidered as a promising material with high research value. OBJECTIVE: To analyze the biological activity and chemical characteristics of tannic acid, and to review its application and prospect in industry, medicine and dentistry. METHODS: We searched the articles about tannic acid in PubMed database, WanFang database, CNKI database and VIP database with the key words of "tannic acid and chemical property, tannic acid and biological activity, tannin and antioxidant activity, tannin and industry, tannin and medicine, tannin and dentistry, tannin and dentin, tannin and tooth decay, tannin and bond strength" in English and Chinese, respectively. RESULTS AND CONCLUSION: As a complex polymer polyphenol, tannic acid has strong functional and biological activity and has been widely used in industry. In medicine, tannic acid not only has bacteriostatic, antiviral, anti-inflammatory, anti-oxidation effects and physiological activities, such as, lowering blood sugar, blood pressure, lipid and so on, but is also able to inhibit the growth of cancer and tumor. In dentistry, tannic acid can inhibit the growth of cariogenic bacteria and the formation of dental plaque biofilm, protect periodontal membrane, prevent the surface demineralization of enamel and promote the re-mineralization of the enamel. As the known biological characteristics of tannic acid, it still has a huge scientific research value in the prevention and treatment of cardiovascular disease and caries as well as in anesthesia.
BACKGROUND: Tannic acid has strong activity in biology and pharmacology, which has been used in industry, medical treatment and etc. Research focusing on tannic acid is in the ascendant, and tannic acid has beenconsidered as a promising material with high research value. OBJECTIVE: To analyze the biological activity and chemical characteristics of tannic acid, and to review its application and prospect in industry, medicine and dentistry. METHODS: We searched the articles about tannic acid in PubMed database, WanFang database, CNKI database and VIP database with the key words of "tannic acid and chemical property, tannic acid and biological activity, tannin and antioxidant activity, tannin and industry, tannin and medicine, tannin and dentistry, tannin and dentin, tannin and tooth decay, tannin and bond strength" in English and Chinese, respectively. RESULTS AND CONCLUSION: As a complex polymer polyphenol, tannic acid has strong functional and biological activity and has been widely used in industry. In medicine, tannic acid not only has bacteriostatic, antiviral, anti-inflammatory, anti-oxidation effects and physiological activities, such as, lowering blood sugar, blood pressure, lipid and so on, but is also able to inhibit the growth of cancer and tumor. In dentistry, tannic acid can inhibit the growth of cariogenic bacteria and the formation of dental plaque biofilm, protect periodontal membrane, prevent the surface demineralization of enamel and promote the re-mineralization of the enamel. As the known biological characteristics of tannic acid, it still has a huge scientific research value in the prevention and treatment of cardiovascular disease and caries as well as in anesthesia.
引文
[1]石闪闪,何国庆.单宁酸及其应用研究进展[J].食品工业科技,2012,33(4):410-413.
[2]马志红,陆忠兵,石碧.单宁酸的化学性质及应用[J].天然产物研究与开发,2003,15(1):87-91.
[3]Marrassini C,Peralta I,Anesini C.Comparative study of the polyphenol content-related anti-inflammatory and antioxidant activities of two Urera aurantiaca specimens from different geographical areas.Chin Med.2018;13:22.
[4]张高娜,李金敏,徐海燕,等.单宁酸在畜牧生产业中的应用[J].广东饲料,2017,26(6):39-40.
[5]El Anany AM.Nutritional composition,antinutritional factors,bioactive compounds and antioxidant activity of guava seeds(Psidium Myrtaceae)as affected by roasting processes.J Food Sci Technol.2015;52(4):2175-2183.
[6]Basu T,Panja S,Shendge AK,et al.A natural antioxidant,tannic acid mitigates iron-overload induced hepatotoxicity in Swiss albino mice through ROS regulation.Environ Toxicol.2018;33(5):603-618.
[7]Díaz Carrasco JM,Redondo EA,Pin Viso ND,et al.Tannins and Bacitracin Differentially Modulate Gut Microbiota of Broiler Chickens.Biomed Res Int.2018;2018:1879168.
[8]Ogawa S,Yazaki Y.Tannins from Acacia mearnsii De Wild.Bark:Tannin Determination and Biological Activities.Molecules.2018;23(4).doi:10.3390/molecules23040837.
[9]Savelyev N,Baykuzina P,Dokudovskaya S,et al.Comprehensive analysis of telomerase inhibition by gallotannin.Oncotarget.2018;9(27):18712-18719.
[10]Majed F,Rashid S,Khan AQ,et al.Tannic acid mitigates the DMBA/croton oil-induced skin cancer progression in mice.Mol Cell Biochem.2015;399(1-2):217-28.
[11]Prada AL,Amado JRR,Keita H,et al.Cassia grandis fruit extract reduces the blood glucose level in alloxan-induced diabetic rats.Biomed Pharmacother.2018;103:421-428.
[12]Ployon S,Morzel M,Belloir C,et al.Mechanisms of astringency:Structural alteration of the oral mucosal pellicle by dietary tannins and protective effect of bPRPs.Food Chem.2018;253:79-87.
[13]Aguiar Galv?o WR,Braz Filho R,Canuto KM,et al.Gastroprotective and anti-inflammatory activities integrated to chemical composition of Myracrodruon urundeuva Allem?oa conservationist proposal for the species.J Ethnopharmacol.2018;222:177-189.
[14]Awaad AA,Alkanhal HF,El-Meligy RM,et al.Anti-ulcerative colitis activity of Calotropis procera Linn.Saudi Pharm J.2018;26(1):75-78.
[15]Hidaka M,Kosaka K,Tsushima S,et al.Food polyphenols targeting peptidyl prolyl cis/trans isomerase Pin1.Biochem Biophys Res Commun.2018;499(3):681-687.
[16]Gambuti A,Picariello L,Rinaldi A,et al.Evolution of Sangiovese Wines With Varied Tannin and Anthocyanin Ratios During Oxidative Aging.Front Chem.2018;6:63.
[17]Hanlin LR,Hrmova M,Harbertson FJ,et al.Review:condensed tannin and grape cell wall interactions and their impact on tannin extractability into wine.Aust J Grape Wine Res.2010;16(1):173-188.
[18]李蕊蕊,赵新节,孙玉.葡萄和葡萄酒中单宁的研究进展[J].食品与发酵工业,2016,42(4):260-265.
[19]Laguna L,Sarkar A,Bryant MG,et al.Exploring mouthfeel in model wines:Sensory-to-instrumental approaches.Food Res Int.2017;102:478-486.
[20]Wang Y,Li J,Li B.Nature-Inspired One-Step Green Procedure for Enhancing the Antibacterial and Antioxidant Behavior of a Chitin Film:Controlled Inerfacial Assembly of Tannic Acid onto a Chitin Film.J Agric Food Chem.2016;64(28):5736-5741.
[21]Kilic E,Novoselova MV,Lim SH,et al.Formulation for Oral Delivery of Lactoferrin Based on Bovine Serum Albumin and Tannic Acid Multilayer Microcapsules.Sci Rep.2017;7:44159.
[22]张文斌,曹逸群,张萌萌,等.单宁的理化性质及其应用研究[J].西部皮革,2014,36(14):24-29.
[23]Hertel S,P?tschke S,Basche S,et al.Effect of Tannic Acid on the Protective Properties of the in situ Formed Pellicle.Caries Res.2017;51(1):34-45.
[24]Natarajan V,Krithica N,Madhan B,et al.Preparation and properties of tannic acid cross-linked collagen scaffold and its application in wound healing.J Biomed Mater Res B Appl Biomater.2013;101(4):560-567.
[25]Szymańska E,Or?owski P,Winnicka K,et al.Multifunctional Tannic Acid/Silver Nanoparticle-Based Mucoadhesive Hydrogel for Improved Local Treatment of HSV Infection:In Vitro and In Vivo Studies.Int J Mol Sci.2018;19(2).pii:E387.doi:10.3390/ijms19020387.
[26]Albright V,Xu M,Palanisamy A,et al.Micelle-Coated,Hierarchically Structured Nanofibers with Dual-Release Capability for Accelerated Wound Healing and Infection Control.Adv Healthc Mater.2018;7(11):e1800132.
[27]成晓敏,王海芳,刘桂桃,等.单宁酸在冷却水中的阻垢性能研究[J].工业水处理,2012,32(3):65-67.
[28]Kostyuk VA,Potapovich AI,Strigunova EN,et al.Experimental evidence that flavonoid metal complexes may act as mimics of superoxide dismutase.Arch Biochem Biophys.2004;428(2):204-208.
[29]唐孝明,张淑云,叶皓华,等.单宁酸及金属离子后处理对真丝织物性能影响[J].针织工业,2012,40(10):31-35.
[30]赵厚宽,王鹏,谢星鹏,等.脲醛树脂合成过程中游离甲醛的抑制[J].生物质化学工程,2017,51(1):20-26
[31]聂方园,马晓丰.单宁酸的生物活性研究进展[J].化学与生物工程,2015,32(1):16-18,22.
[32]Martos GG,Mamani A,Filippone MP,et al.Ellagitannin HeTobtained from strawberry leaves is oxidized by bacterial membranes and inhibits the respiratory chain.FEBS Open Bio.2018;8(2):211-218.
[33]Reveron I,Rodriguez H,Campos G,et al.Tannic acid-dependent modulation of selected Lactobacillus plantarum traits linked to gastrointestinal survival.PloS One.2013;8:e66473.
[34]Ogawa S,Yazaki Y.Tannins from Acacia mearnsii De Wild.Bark:Tannin Determination and Biological Activities.Molecules(Basel,Switzerland).2018;23.
[35]Kamei H,Koide T,Hashimoto Y,et al.Tumor cell growth suppression by tannic acid.Cancer Biother Radiopharm.1999;14(2):135-138.
[36]Savelyev N,Baykuzina P,Dokudovskaya S,et al.Comprehensive analysis of telomerase inhibition by gallotannin.Oncotarget.2018;9:18712-18719.
[37]Nagesh PKB,Hatami E,Chowdhury P,et al.Tannic Acid Induces Endoplasmic Reticulum Stress-Mediated Apoptosis in Prostate Cancer.Cancers(Basel).2018;10(3).
[38]Jordan LG,Booth BW.HER2(+)breast cancer cells undergo apoptosis upon exposure to tannic acid released from remodeled cross-linked collagen type I.J Biomed Mater Res A.2018;106:26-32.
[39]Darvin P,Joung YH,Kang DY,et al.Tannic acid inhibits EGFR/STAT1/3 and enhances p38/STAT1 signalling axis in breast cancer cells.J Cell Mol Med.2017;21:720-734.
[40]Zhang J,Cui L,Han X,et al.Protective effects of tannic acid on acute doxorubicin-induced cardiotoxicity:Involvement of suppression in oxidative stress,inflammation,and apoptosis.Biomed Pharmacother.2017;93:1253-1260.
[41]Tikoo K,Sane MS,Gupta C.Tannic acid ameliorates doxorubicin-induced cardiotoxicity and potentiates its anti-cancer activity:potential role of tannins in cancer chemotherapy.Toxicol Appl Pharmacol.2011;251:191-200.
[42]Yesudas R,Gumaste U,Snyder R,et al.Tannic acid down-regulates the angiotensin type 1 receptor through a MAPK-dependent mechanism.Mol Endocrinol.2012;26:458-470.
[43]Fan H,Wu D,Tian W,et al.Inhibitory effects of tannic acid on fatty acid synthase and 3T3-L1 preadipocyte.Biochim Biophys Acta.2013;1831:1260-1266.
[44]Shindo H,Takahagi S,Mihara S,et al.Efficacy of sweat-antigen-inactivating skin care products on itching of patients with atopic dermatitis.Arerugi.2011;60:33-42.
[45]Phiwchai I,Yuensook W,Sawaengsiriphon N,et al.Tannic acid(TA):A molecular tool for chelating and imaging labile iron.Eur J Pharm Sci.2018;114:64-73.
[46]Larranaga A,Isa ILM,Patil V,et al.Antioxidant functionalized polymer capsules to prevent oxidative stress.Acta Biomater.2018;67:21-31.
[47]Pattarayan D,Sivanantham A,Krishnaswami V,et al.Tannic acid attenuates TGF-beta1-induced epithelial-to-mesenchymal transition by effectively intervening TGF-beta signaling in lung epithelial cells.J Cell Physiol.2018;233:2513-2525.
[48]李红,李继遥,朱昞,等.五倍子对牙菌斑生物膜细菌生长代谢的研究[J].中国中药杂志,2005,30(21):1685-1688.
[49]谢倩,李继遥,左渝陵,等.天然药物五倍子提取物对致龋菌生长的影响[J].华西口腔医学杂志,2005,23(1):82-84.
[50]张良,唐荣银,倪龙兴.五倍子水提取物对牙龈卟啉菌膜泡抑制牙周膜成纤维细胞生物活性的影响[J].牙体牙髓牙周病学杂志,2007,17(12):695-697.
[51]张苏娜,唐荣银,胡坤,等.五倍子水提取物去除根管内玷污层的扫描电镜观察[J].牙体牙髓牙周病学杂志,2007,17(11):638-641.
[52]冯雅君,王鑫,李文静,等.五倍子水煎剂对粪肠球菌的抑制作用[J].河北医药,2012,34(6):830-832.
[53]张苏娜,唐荣银,胡坤.五倍子水提取物对根管显微硬度的影响[J].实用口腔医学杂志,2010,26(2):275-276.
[54]Lin Z,Kumar A,SenBanerjee S,et al.Kruppel-like factor 2(KLF2)regulates endothelial thrombotic function.Circ Res.2005;96(5):48-57.
[55]SenBanerjee S,Lin Z,Atkins GB,et al.KLF2 Is a novel transcriptional regulator of endothelial proinflammatory activation.J Exp Med.2004;199:1305-1315.
[56]Xu Y,Liu P,Xu S,et al.Tannic acid as a plant-derived polyphenol exerts vasoprotection via enhancing KLF2expression in endothelial cells.Sci Rep.2017;7(1):6686.
[57]Epasinghe DJ,Yiu CK,Burrow MF,et al.Effect of flavonoids on the mechanical properties of demineralised dentine.JDent.2014;42(9):1178-1184.
[58]BenSaad LA,Kim KH,Quah CC,et al.Anti-inflammatory potential of ellagic acid,gallic acid and punicalagin A&Bisolated from Punica granatum.BMC Complement Altern Med.2017;17(1):47.
[59]Ajaikumar KB,Asheef M,Babu BH,et al.The inhibition of gastric mucosal injury by Punicagranatum L.(pomegranate)methanolic extract.J Ethnopharmacol.2005;96(1-2):171-176.
[60]Reddy MK,Gupta SK,Jacob MR,Khan SI,Ferreira D.Antioxidant,antimalarial and antimicrobial activities of tannin-rich fractions,ellagitannins and phenolic acids from Punica granatum L.Planta Med.2007;73(5):461-467.
[61]Gil MI,Tomás-Barberán FA,Hess-Pierce B,et al.Antioxidant activity of pomegranate juice and its relationship with phenolic composition and processing.J Agric Food Chem.2000;48(10):4581-4589.
[62]Brown BS,Yu SP.Modulation and genetic identification of the M channel.Prog Biophys Mol Biol.2000;73(2-4):135-166.
[63]Zhang X,Zhang H,Zhou N,et al.Tannic acid modulates excitability of sensory neurons and nociceptive behavior and the Ionic mechanism.Eur J Pharmacol.2015;764:633-642.
[2]马志红,陆忠兵,石碧.单宁酸的化学性质及应用[J].天然产物研究与开发,2003,15(1):87-91.
[3]Marrassini C,Peralta I,Anesini C.Comparative study of the polyphenol content-related anti-inflammatory and antioxidant activities of two Urera aurantiaca specimens from different geographical areas.Chin Med.2018;13:22.
[4]张高娜,李金敏,徐海燕,等.单宁酸在畜牧生产业中的应用[J].广东饲料,2017,26(6):39-40.
[5]El Anany AM.Nutritional composition,antinutritional factors,bioactive compounds and antioxidant activity of guava seeds(Psidium Myrtaceae)as affected by roasting processes.J Food Sci Technol.2015;52(4):2175-2183.
[6]Basu T,Panja S,Shendge AK,et al.A natural antioxidant,tannic acid mitigates iron-overload induced hepatotoxicity in Swiss albino mice through ROS regulation.Environ Toxicol.2018;33(5):603-618.
[7]Díaz Carrasco JM,Redondo EA,Pin Viso ND,et al.Tannins and Bacitracin Differentially Modulate Gut Microbiota of Broiler Chickens.Biomed Res Int.2018;2018:1879168.
[8]Ogawa S,Yazaki Y.Tannins from Acacia mearnsii De Wild.Bark:Tannin Determination and Biological Activities.Molecules.2018;23(4).doi:10.3390/molecules23040837.
[9]Savelyev N,Baykuzina P,Dokudovskaya S,et al.Comprehensive analysis of telomerase inhibition by gallotannin.Oncotarget.2018;9(27):18712-18719.
[10]Majed F,Rashid S,Khan AQ,et al.Tannic acid mitigates the DMBA/croton oil-induced skin cancer progression in mice.Mol Cell Biochem.2015;399(1-2):217-28.
[11]Prada AL,Amado JRR,Keita H,et al.Cassia grandis fruit extract reduces the blood glucose level in alloxan-induced diabetic rats.Biomed Pharmacother.2018;103:421-428.
[12]Ployon S,Morzel M,Belloir C,et al.Mechanisms of astringency:Structural alteration of the oral mucosal pellicle by dietary tannins and protective effect of bPRPs.Food Chem.2018;253:79-87.
[13]Aguiar Galv?o WR,Braz Filho R,Canuto KM,et al.Gastroprotective and anti-inflammatory activities integrated to chemical composition of Myracrodruon urundeuva Allem?oa conservationist proposal for the species.J Ethnopharmacol.2018;222:177-189.
[14]Awaad AA,Alkanhal HF,El-Meligy RM,et al.Anti-ulcerative colitis activity of Calotropis procera Linn.Saudi Pharm J.2018;26(1):75-78.
[15]Hidaka M,Kosaka K,Tsushima S,et al.Food polyphenols targeting peptidyl prolyl cis/trans isomerase Pin1.Biochem Biophys Res Commun.2018;499(3):681-687.
[16]Gambuti A,Picariello L,Rinaldi A,et al.Evolution of Sangiovese Wines With Varied Tannin and Anthocyanin Ratios During Oxidative Aging.Front Chem.2018;6:63.
[17]Hanlin LR,Hrmova M,Harbertson FJ,et al.Review:condensed tannin and grape cell wall interactions and their impact on tannin extractability into wine.Aust J Grape Wine Res.2010;16(1):173-188.
[18]李蕊蕊,赵新节,孙玉.葡萄和葡萄酒中单宁的研究进展[J].食品与发酵工业,2016,42(4):260-265.
[19]Laguna L,Sarkar A,Bryant MG,et al.Exploring mouthfeel in model wines:Sensory-to-instrumental approaches.Food Res Int.2017;102:478-486.
[20]Wang Y,Li J,Li B.Nature-Inspired One-Step Green Procedure for Enhancing the Antibacterial and Antioxidant Behavior of a Chitin Film:Controlled Inerfacial Assembly of Tannic Acid onto a Chitin Film.J Agric Food Chem.2016;64(28):5736-5741.
[21]Kilic E,Novoselova MV,Lim SH,et al.Formulation for Oral Delivery of Lactoferrin Based on Bovine Serum Albumin and Tannic Acid Multilayer Microcapsules.Sci Rep.2017;7:44159.
[22]张文斌,曹逸群,张萌萌,等.单宁的理化性质及其应用研究[J].西部皮革,2014,36(14):24-29.
[23]Hertel S,P?tschke S,Basche S,et al.Effect of Tannic Acid on the Protective Properties of the in situ Formed Pellicle.Caries Res.2017;51(1):34-45.
[24]Natarajan V,Krithica N,Madhan B,et al.Preparation and properties of tannic acid cross-linked collagen scaffold and its application in wound healing.J Biomed Mater Res B Appl Biomater.2013;101(4):560-567.
[25]Szymańska E,Or?owski P,Winnicka K,et al.Multifunctional Tannic Acid/Silver Nanoparticle-Based Mucoadhesive Hydrogel for Improved Local Treatment of HSV Infection:In Vitro and In Vivo Studies.Int J Mol Sci.2018;19(2).pii:E387.doi:10.3390/ijms19020387.
[26]Albright V,Xu M,Palanisamy A,et al.Micelle-Coated,Hierarchically Structured Nanofibers with Dual-Release Capability for Accelerated Wound Healing and Infection Control.Adv Healthc Mater.2018;7(11):e1800132.
[27]成晓敏,王海芳,刘桂桃,等.单宁酸在冷却水中的阻垢性能研究[J].工业水处理,2012,32(3):65-67.
[28]Kostyuk VA,Potapovich AI,Strigunova EN,et al.Experimental evidence that flavonoid metal complexes may act as mimics of superoxide dismutase.Arch Biochem Biophys.2004;428(2):204-208.
[29]唐孝明,张淑云,叶皓华,等.单宁酸及金属离子后处理对真丝织物性能影响[J].针织工业,2012,40(10):31-35.
[30]赵厚宽,王鹏,谢星鹏,等.脲醛树脂合成过程中游离甲醛的抑制[J].生物质化学工程,2017,51(1):20-26
[31]聂方园,马晓丰.单宁酸的生物活性研究进展[J].化学与生物工程,2015,32(1):16-18,22.
[32]Martos GG,Mamani A,Filippone MP,et al.Ellagitannin HeTobtained from strawberry leaves is oxidized by bacterial membranes and inhibits the respiratory chain.FEBS Open Bio.2018;8(2):211-218.
[33]Reveron I,Rodriguez H,Campos G,et al.Tannic acid-dependent modulation of selected Lactobacillus plantarum traits linked to gastrointestinal survival.PloS One.2013;8:e66473.
[34]Ogawa S,Yazaki Y.Tannins from Acacia mearnsii De Wild.Bark:Tannin Determination and Biological Activities.Molecules(Basel,Switzerland).2018;23.
[35]Kamei H,Koide T,Hashimoto Y,et al.Tumor cell growth suppression by tannic acid.Cancer Biother Radiopharm.1999;14(2):135-138.
[36]Savelyev N,Baykuzina P,Dokudovskaya S,et al.Comprehensive analysis of telomerase inhibition by gallotannin.Oncotarget.2018;9:18712-18719.
[37]Nagesh PKB,Hatami E,Chowdhury P,et al.Tannic Acid Induces Endoplasmic Reticulum Stress-Mediated Apoptosis in Prostate Cancer.Cancers(Basel).2018;10(3).
[38]Jordan LG,Booth BW.HER2(+)breast cancer cells undergo apoptosis upon exposure to tannic acid released from remodeled cross-linked collagen type I.J Biomed Mater Res A.2018;106:26-32.
[39]Darvin P,Joung YH,Kang DY,et al.Tannic acid inhibits EGFR/STAT1/3 and enhances p38/STAT1 signalling axis in breast cancer cells.J Cell Mol Med.2017;21:720-734.
[40]Zhang J,Cui L,Han X,et al.Protective effects of tannic acid on acute doxorubicin-induced cardiotoxicity:Involvement of suppression in oxidative stress,inflammation,and apoptosis.Biomed Pharmacother.2017;93:1253-1260.
[41]Tikoo K,Sane MS,Gupta C.Tannic acid ameliorates doxorubicin-induced cardiotoxicity and potentiates its anti-cancer activity:potential role of tannins in cancer chemotherapy.Toxicol Appl Pharmacol.2011;251:191-200.
[42]Yesudas R,Gumaste U,Snyder R,et al.Tannic acid down-regulates the angiotensin type 1 receptor through a MAPK-dependent mechanism.Mol Endocrinol.2012;26:458-470.
[43]Fan H,Wu D,Tian W,et al.Inhibitory effects of tannic acid on fatty acid synthase and 3T3-L1 preadipocyte.Biochim Biophys Acta.2013;1831:1260-1266.
[44]Shindo H,Takahagi S,Mihara S,et al.Efficacy of sweat-antigen-inactivating skin care products on itching of patients with atopic dermatitis.Arerugi.2011;60:33-42.
[45]Phiwchai I,Yuensook W,Sawaengsiriphon N,et al.Tannic acid(TA):A molecular tool for chelating and imaging labile iron.Eur J Pharm Sci.2018;114:64-73.
[46]Larranaga A,Isa ILM,Patil V,et al.Antioxidant functionalized polymer capsules to prevent oxidative stress.Acta Biomater.2018;67:21-31.
[47]Pattarayan D,Sivanantham A,Krishnaswami V,et al.Tannic acid attenuates TGF-beta1-induced epithelial-to-mesenchymal transition by effectively intervening TGF-beta signaling in lung epithelial cells.J Cell Physiol.2018;233:2513-2525.
[48]李红,李继遥,朱昞,等.五倍子对牙菌斑生物膜细菌生长代谢的研究[J].中国中药杂志,2005,30(21):1685-1688.
[49]谢倩,李继遥,左渝陵,等.天然药物五倍子提取物对致龋菌生长的影响[J].华西口腔医学杂志,2005,23(1):82-84.
[50]张良,唐荣银,倪龙兴.五倍子水提取物对牙龈卟啉菌膜泡抑制牙周膜成纤维细胞生物活性的影响[J].牙体牙髓牙周病学杂志,2007,17(12):695-697.
[51]张苏娜,唐荣银,胡坤,等.五倍子水提取物去除根管内玷污层的扫描电镜观察[J].牙体牙髓牙周病学杂志,2007,17(11):638-641.
[52]冯雅君,王鑫,李文静,等.五倍子水煎剂对粪肠球菌的抑制作用[J].河北医药,2012,34(6):830-832.
[53]张苏娜,唐荣银,胡坤.五倍子水提取物对根管显微硬度的影响[J].实用口腔医学杂志,2010,26(2):275-276.
[54]Lin Z,Kumar A,SenBanerjee S,et al.Kruppel-like factor 2(KLF2)regulates endothelial thrombotic function.Circ Res.2005;96(5):48-57.
[55]SenBanerjee S,Lin Z,Atkins GB,et al.KLF2 Is a novel transcriptional regulator of endothelial proinflammatory activation.J Exp Med.2004;199:1305-1315.
[56]Xu Y,Liu P,Xu S,et al.Tannic acid as a plant-derived polyphenol exerts vasoprotection via enhancing KLF2expression in endothelial cells.Sci Rep.2017;7(1):6686.
[57]Epasinghe DJ,Yiu CK,Burrow MF,et al.Effect of flavonoids on the mechanical properties of demineralised dentine.JDent.2014;42(9):1178-1184.
[58]BenSaad LA,Kim KH,Quah CC,et al.Anti-inflammatory potential of ellagic acid,gallic acid and punicalagin A&Bisolated from Punica granatum.BMC Complement Altern Med.2017;17(1):47.
[59]Ajaikumar KB,Asheef M,Babu BH,et al.The inhibition of gastric mucosal injury by Punicagranatum L.(pomegranate)methanolic extract.J Ethnopharmacol.2005;96(1-2):171-176.
[60]Reddy MK,Gupta SK,Jacob MR,Khan SI,Ferreira D.Antioxidant,antimalarial and antimicrobial activities of tannin-rich fractions,ellagitannins and phenolic acids from Punica granatum L.Planta Med.2007;73(5):461-467.
[61]Gil MI,Tomás-Barberán FA,Hess-Pierce B,et al.Antioxidant activity of pomegranate juice and its relationship with phenolic composition and processing.J Agric Food Chem.2000;48(10):4581-4589.
[62]Brown BS,Yu SP.Modulation and genetic identification of the M channel.Prog Biophys Mol Biol.2000;73(2-4):135-166.
[63]Zhang X,Zhang H,Zhou N,et al.Tannic acid modulates excitability of sensory neurons and nociceptive behavior and the Ionic mechanism.Eur J Pharmacol.2015;764:633-642.