不同功能残气量对可吸入颗粒物在人体肺腺泡区沉积影响的实验研究
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摘要
研究可吸入颗粒物在肺腺泡内的沉积规律对于明确肺气肿等常见呼吸系统疾病的诱因和发展,以及优化临床治疗和预防方案具有重要意义。本文建立了能够模拟终末细支气管和肺腺泡颗粒物沉积的体外实验模型,在不同功能残气量模式下研究了不同粒径的可吸入颗粒物在肺腺泡内的沉积率。结果表明,颗粒物直径是影响颗粒物在肺腺泡沉积的重要因素,1μm左右的颗粒物沉积率最高。功能残气量增大,颗粒物沉积率显著降低。本文研究结果为肺气肿和尘肺等疾病的靶向吸入治疗提供了数据支撑和优化途径,建立的模型也为研究可吸入颗粒物在肺腺泡内的沉积规律提供了一种可行的体外实验模型。
Research on the deposition of inhalable particles in the alveoli of the lungs is important to the causes,development for common respiratory diseases such as emphysema, and even the optimization of clinical treatment and prevention programs of them. In this paper, an in vitro experimental model was established to simulate the deposition of terminal bronchioles and pulmonary acinus particles. The deposition rate of inhalable particles with different particle sizes in the pulmonary acinus was studied under different functional residual capacity. The results showed that the particle diameter was an important factor affecting the deposition of particles in the lung alveoli. Particles with 1 μm diameter had the highest deposition rate. With the functional residual capacity increasing, particulate deposition rate significantly reduced. The results of this study may provide data support and optimization strategy for target inhalation therapy of respiratory diseases such as emphysema and pneumoconiosis. The established model may also provide a feasible in vitro experimental model for studying the deposition of inhalable particles in the pulmonary alveoli.
Research on the deposition of inhalable particles in the alveoli of the lungs is important to the causes,development for common respiratory diseases such as emphysema, and even the optimization of clinical treatment and prevention programs of them. In this paper, an in vitro experimental model was established to simulate the deposition of terminal bronchioles and pulmonary acinus particles. The deposition rate of inhalable particles with different particle sizes in the pulmonary acinus was studied under different functional residual capacity. The results showed that the particle diameter was an important factor affecting the deposition of particles in the lung alveoli. Particles with 1 μm diameter had the highest deposition rate. With the functional residual capacity increasing, particulate deposition rate significantly reduced. The results of this study may provide data support and optimization strategy for target inhalation therapy of respiratory diseases such as emphysema and pneumoconiosis. The established model may also provide a feasible in vitro experimental model for studying the deposition of inhalable particles in the pulmonary alveoli.
引文
1Fernández Tena A,Casan Clarà P. Deposition of inhaled particlesin the lungs. Arch Bronconeumol,2012,48(7): 240-246.
2Tsuda A,Henry F S,Butler J P. Chaotic mixing of alveolated ductflow in rhythmically expanding pulmonary acinus. J Appl Physiol,1995,79(3): 1055-1063.
3Darquenne C,Harrington L,Prisk G K. Alveolar duct expansiongreatly enhances aerosol deposition: a three-dimensionalcomputational fluid dynamics study. Philos Trans A Math PhysEng Sci,2009,367(1896): 2333-2346.
4Sznitman J,Heimsch T,Wildhaber J H,et al. Respiratory flowphenomena and gravitational deposition in a three-dimensionalspace-filling model of the pulmonary acinar tree. J Biomech Eng,2009,131(3): 031010.
5Ma Baoshun,Darquenne C. Aerosol deposition characteristics indistal acinar airways under cyclic breathing conditions. J ApplPhysiol,2011,110(5): 1271-1282.
6李振振. 肺腺泡内颗粒物的沉积及阻塞影响的数值模拟研究. 西安: 西安建筑科技大学,2016.
7Oakes J M,Day S,Weinstein S J,et al. Flow field analysis inexpanding healthy and emphysematous alveolar models usingparticle image velocimetry. J Biomech Eng,2010,132(2): 021008.
8Berg E J,Weisman J L,Oldham M J,et al. Flow field analysis in acompliant acinus replica model using particle image velocimetry(PIV). J Biomech,2010,43(6): 1039-1047.
9Fishler R,Mulligan M K,Sznitman J. Acinus-on-a-chip: amicrofluidic platform for pulmonary acinar flows. J Biomech,2013,46(16): 2817-2823.
10International Commissionon Radiological Protection (ICRP).Human respiratory tract model for radiological protection. ICRPPublication 66. Annals of ICRP,1994,24(1-3).
11Haefeli-Bleuer B,Weibel E R. Morphometry of the humanpulmonary acinus. Anat Rec,1988,220(4): 401-414.
12?ywczyk ?,Moskal A. Modeling of the influence of tissuemechanical properties on the process of aerosol particlesdeposition in a model of human alveolus. J Drug Deliv Sci Tec,2012,22(2): 153-159.
13Sznitman J. Respiratory flows in the pulmonary acinus and insightson the control of alveolar flows// International Conference onSensors and Control Techniques (ICSC2000). Wuhan:International Society for Optics and Photonics,2008: 496-499.
14王兴华,周鸣镝,成红娟. 湿空气热物性参数的计算//中国建筑学会建筑热能动力分会全国区域能源专业委员会年会. 牡丹江: 中国建筑学会建筑热能动力分会,2013.
15丁玉龙,苍大强,杨天钧. 稀相气固两相垂直管流内的固相浓度和粘度. 北京科技大学学报,1994,16(1): 20-25.
16Chhabra S,Prasad A K. Flow and particle dispersion in apulmonary alveolus--part Ⅰ: velocity measurements andconvective particle transport. J Biomech Eng,2010,132(5): 051009.
17黄俊. 可吸入颗粒在肺泡中沉积的数值模拟. 杭州: 浙江大学,2016.
18郭西龙. 颗粒物在人体肺部沉积规律及影响因素研究. 长沙: 中南大学,2013.
19符乃方,董志超,李羡筠,等. 职业性尘肺病治疗方法研究进展.职业与健康,2016,32(24): 3452-3456.
2Tsuda A,Henry F S,Butler J P. Chaotic mixing of alveolated ductflow in rhythmically expanding pulmonary acinus. J Appl Physiol,1995,79(3): 1055-1063.
3Darquenne C,Harrington L,Prisk G K. Alveolar duct expansiongreatly enhances aerosol deposition: a three-dimensionalcomputational fluid dynamics study. Philos Trans A Math PhysEng Sci,2009,367(1896): 2333-2346.
4Sznitman J,Heimsch T,Wildhaber J H,et al. Respiratory flowphenomena and gravitational deposition in a three-dimensionalspace-filling model of the pulmonary acinar tree. J Biomech Eng,2009,131(3): 031010.
5Ma Baoshun,Darquenne C. Aerosol deposition characteristics indistal acinar airways under cyclic breathing conditions. J ApplPhysiol,2011,110(5): 1271-1282.
6李振振. 肺腺泡内颗粒物的沉积及阻塞影响的数值模拟研究. 西安: 西安建筑科技大学,2016.
7Oakes J M,Day S,Weinstein S J,et al. Flow field analysis inexpanding healthy and emphysematous alveolar models usingparticle image velocimetry. J Biomech Eng,2010,132(2): 021008.
8Berg E J,Weisman J L,Oldham M J,et al. Flow field analysis in acompliant acinus replica model using particle image velocimetry(PIV). J Biomech,2010,43(6): 1039-1047.
9Fishler R,Mulligan M K,Sznitman J. Acinus-on-a-chip: amicrofluidic platform for pulmonary acinar flows. J Biomech,2013,46(16): 2817-2823.
10International Commissionon Radiological Protection (ICRP).Human respiratory tract model for radiological protection. ICRPPublication 66. Annals of ICRP,1994,24(1-3).
11Haefeli-Bleuer B,Weibel E R. Morphometry of the humanpulmonary acinus. Anat Rec,1988,220(4): 401-414.
12?ywczyk ?,Moskal A. Modeling of the influence of tissuemechanical properties on the process of aerosol particlesdeposition in a model of human alveolus. J Drug Deliv Sci Tec,2012,22(2): 153-159.
13Sznitman J. Respiratory flows in the pulmonary acinus and insightson the control of alveolar flows// International Conference onSensors and Control Techniques (ICSC2000). Wuhan:International Society for Optics and Photonics,2008: 496-499.
14王兴华,周鸣镝,成红娟. 湿空气热物性参数的计算//中国建筑学会建筑热能动力分会全国区域能源专业委员会年会. 牡丹江: 中国建筑学会建筑热能动力分会,2013.
15丁玉龙,苍大强,杨天钧. 稀相气固两相垂直管流内的固相浓度和粘度. 北京科技大学学报,1994,16(1): 20-25.
16Chhabra S,Prasad A K. Flow and particle dispersion in apulmonary alveolus--part Ⅰ: velocity measurements andconvective particle transport. J Biomech Eng,2010,132(5): 051009.
17黄俊. 可吸入颗粒在肺泡中沉积的数值模拟. 杭州: 浙江大学,2016.
18郭西龙. 颗粒物在人体肺部沉积规律及影响因素研究. 长沙: 中南大学,2013.
19符乃方,董志超,李羡筠,等. 职业性尘肺病治疗方法研究进展.职业与健康,2016,32(24): 3452-3456.