乌司他丁联合血塞通注射液治疗老年急性胰腺炎的临床研究
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摘要
目的探讨乌司他丁联合血塞通注射液治疗老年急性胰腺炎的临床疗效。方法 150例老年急性胰腺炎患者,按随机数字表法分为两组各75例,对照组采用乌司他丁治疗,观察组采用乌司他丁联合血塞通注射液治疗,比较两组治疗效果及安全性。结果治疗后,两组肿瘤坏死因子α、C反应蛋白、可溶性细胞黏附因子1、二胺氧化酶、D乳酸、白介素6降低,白蛋白、前白蛋白升高(P<0.05)。观察组肿瘤坏死因子α、C反应蛋白、可溶性细胞黏附因子1、二胺氧化酶、D乳酸、白介素6低于对照组,白蛋白、前白蛋白、治疗总有效率高于对照组,临床病症好转时间、血淀粉酶恢复正常时间、首次排便时间、饮食开放时间、C反应蛋白恢复正常时间、住院时间均少于对照组(P<0.05)。两组不良反应比较,差异无统计学意义(P>0.05)。结论乌司他丁联合血塞通注射液治疗老年急性胰腺炎的疗效显著且安全性高。
Objective To investigate clinical effect of ulinastatin combined with xuesaitong injection in the treatment of elderly patients with acute pancreatitis.Methods One hundred and fifty elderly patients with acute pancreatitis were divided into observation or control groups by using random number table method,75 in each group.The control group was treated with ulinastatin while the observation group was treated with ulinastatin combined with xuesaitong injection.Treatment effect and safety were compared between the two groups.Results After treatment,the levels of TNFα,CRP,s ICAM-1,DAO,D lactic acid and IL-6 were decreased while the levels of albumin and prealbumin were increased in the two groups( P < 0. 05).The levels of TNFα,CRP,s ICAM-1,DAO,D lactic acid and IL-6 in the observation group were lower than those in the control group.The levels of albumin,prealbumin and total effective rate in the observation group were higher than those in the control group.The clinical symptoms improvement time,blood amylase returned to normal time,the first defecation time,diet opening time,CRP returned to normal time and hospitalization time in the observation group were shorter than those in the control group( P < 0. 05). There were no statistically significant differences in adverse reactions between the two groups( P > 0. 05).Conclusion Ulinastatin combined with xuesaitong injection has significant effect and high safety in the treatment of elderly patients with acute pancreatitis.
Objective To investigate clinical effect of ulinastatin combined with xuesaitong injection in the treatment of elderly patients with acute pancreatitis.Methods One hundred and fifty elderly patients with acute pancreatitis were divided into observation or control groups by using random number table method,75 in each group.The control group was treated with ulinastatin while the observation group was treated with ulinastatin combined with xuesaitong injection.Treatment effect and safety were compared between the two groups.Results After treatment,the levels of TNFα,CRP,s ICAM-1,DAO,D lactic acid and IL-6 were decreased while the levels of albumin and prealbumin were increased in the two groups( P < 0. 05).The levels of TNFα,CRP,s ICAM-1,DAO,D lactic acid and IL-6 in the observation group were lower than those in the control group.The levels of albumin,prealbumin and total effective rate in the observation group were higher than those in the control group.The clinical symptoms improvement time,blood amylase returned to normal time,the first defecation time,diet opening time,CRP returned to normal time and hospitalization time in the observation group were shorter than those in the control group( P < 0. 05). There were no statistically significant differences in adverse reactions between the two groups( P > 0. 05).Conclusion Ulinastatin combined with xuesaitong injection has significant effect and high safety in the treatment of elderly patients with acute pancreatitis.
引文
[1]朱一凡,栾富娟,唐文,等.急性胰腺炎床边指数对急性胰腺炎严重程度及预后判断价值的多中心研究[J].中华消化杂志,2014,34(9):629-630.
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[10]骆晓攀,方俊标,陈龙,等.APACHEⅡ、MODS、SOFA和LODS评分系统对重症急性胰腺炎预后评估的比较[J].医学研究杂志,2012,41(7):104-108.
[11]王学军,曾宪涛,田钰,等.国内奥曲肽与乌司他丁联用治疗急性胰腺炎效果的Meta分析[J].中国循证医学杂志,2011,11(11):1302-1312.
[12]窦文琴.乌司他丁、低分子肝素联合治疗急性胰腺炎的疗效观察[J].实用临床医药杂志,2012,16(21):102-104.
[13]陈武农,彭鹏.乌司他丁联合奥曲肽治疗重症急性胰腺炎的临床效果分析[J].当代医学,2011,17(10):148-149.
[14]雷亿群,张建平,俞春钊,等.乌司他丁对急性胰腺炎患者炎性因子的影响[J].中国生化药物杂志,2012,33(6):900-901.
[15]刘志恒,董文志,莫小华,等.三七总皂甙对大鼠急性胰腺炎腺泡细胞钙超载的调节[J].昆明医科大学学报,2014,35(11):17-20.
[16]曹秀娟,杜培洁.血塞通注射液配合西药治疗糖尿病酮症酸中毒合并急性胰腺炎疗效分析[J].陕西中医,2015,36(8):948-950.
[2]杨立新,杜丽川,刘欣,等.四种评分标准对高脂血症性急性胰腺炎病情和预后的评估作用[J].中华内科杂志,2016,55(9):695-699.
[3]李素清,马小彬,滑立伟,等.BISAP评分对急性胰腺炎严重程度及预后评估的临床价值[J].中国老年学杂志,2013,33(19):4873-4874.
[4]陈丽芬,陆国民,周群燕,等.BISAP评分对急性胰腺炎严重程度及预后评估的临床价值[J].中华胰腺病杂志,2012,12(4):219-222.
[5]关博林,张玉升.中西医结合治疗ICU重症急性胰腺炎临床疗效观察[J].中国临床医生,2013,41(1):50-51.
[6]于志强,刘增伟.探讨中西医结合治疗重症急性胰腺炎临床疗效观察[J].中外医疗,2016,35(14):169-170.
[7]中华医学会外科学分会胰腺外科学组.重症急性胰腺炎诊治指南[J].中华外科杂志,2007,45(11):727-729.
[8]范月娟,周磊,冒鹏飞,等.乌司他丁联合血塞通注射液治疗老年急性胰腺炎的疗效及对血清IL-2、TNF-α及s ICAM-1水平的影响[J].中国老年学杂志,2017,37(9):2227-2229.
[9]陈世洪,黎忠于,韦继政,等.SIRS评分和APACHEⅡ评分对急性胰腺炎患者预后评估及其临床价值[J].广西医学,2011,33(1):32-34.
[10]骆晓攀,方俊标,陈龙,等.APACHEⅡ、MODS、SOFA和LODS评分系统对重症急性胰腺炎预后评估的比较[J].医学研究杂志,2012,41(7):104-108.
[11]王学军,曾宪涛,田钰,等.国内奥曲肽与乌司他丁联用治疗急性胰腺炎效果的Meta分析[J].中国循证医学杂志,2011,11(11):1302-1312.
[12]窦文琴.乌司他丁、低分子肝素联合治疗急性胰腺炎的疗效观察[J].实用临床医药杂志,2012,16(21):102-104.
[13]陈武农,彭鹏.乌司他丁联合奥曲肽治疗重症急性胰腺炎的临床效果分析[J].当代医学,2011,17(10):148-149.
[14]雷亿群,张建平,俞春钊,等.乌司他丁对急性胰腺炎患者炎性因子的影响[J].中国生化药物杂志,2012,33(6):900-901.
[15]刘志恒,董文志,莫小华,等.三七总皂甙对大鼠急性胰腺炎腺泡细胞钙超载的调节[J].昆明医科大学学报,2014,35(11):17-20.
[16]曹秀娟,杜培洁.血塞通注射液配合西药治疗糖尿病酮症酸中毒合并急性胰腺炎疗效分析[J].陕西中医,2015,36(8):948-950.