中药诱导血管性休眠防治肿瘤的研究进展
|
摘要
肿瘤休眠是恶性肿瘤的生物学特征之一,也是肿瘤难以根治、复发转移的主要原因。在无法根除肿瘤细胞的情况下,可通过诱导肿瘤细胞休眠减缓生长、防止肿瘤复发或通过靶向存活机制、耐药机制诱导残留休眠细胞死亡。血管性休眠作为肿瘤休眠的一种类型,通过抑制内皮细胞增殖和血管生成,调节促血管生成因子和抗血管生成因子间的平衡,可以使肿瘤细胞退出生长周期,维持休眠状态,能显著抑制肿瘤的复发和转移。中医"久病入络"理论与西医肿瘤血管生成理念相似,通过中医药抑制促血管生成因子可诱导肿瘤血管性休眠,从而防止肿瘤复发。本研究对中医药诱导血管性休眠的相关机制进行综述,以期为中医药对肿瘤的精准治疗提供理论依据。
引文
[1]Harper KL,Sosa MS,Entenberg D,et al.Corrigendum:Mechanism of early dissemination and metastasis in Her2+mammary cancer[J].Nature,2018,553(7688):366.
[2]Fluegen G,Avivar-Valderas A,Wang Y,et al.Phenotypic heterogeneity of disseminated tumour cells is preset by primary tumour hypoxic microenvironments[J].Nature Cell Biology,2017,19(2):120-132.
[3]Kazerounian S,Lawler J.Integration of pro-and anti-angiogenic signals byendothelial cells[J].J Cell Commun Signal,2018,12(1):171-179.
[4]Hadfield G.The Dormant Cancer Cell[J].British Medical Journal,1954,2(4898):1225-1225.
[5]Goss PE,Chambers AF.Doestumour dormancy offer atherap eutictarget[J].Nature reviews cancer,2010,10(12):871-877.
[6]Aguirre-Ghiso,Julio A.Models,mechanisms and clinical evidence for cancer dormancy[J].Nature Reviews Cancer,2007,7(11):834-846.
[7]Natale G,Bocci G.Does metronomic chemotherapy induce tumor angiogenic dormancy?A review of available preclinical and clinical data[J].Cancer letters,2018(432):28-37.
[8]孟琳,王丹丹,唐琪,等.肿瘤休眠及其相关机制研究进展[J].吉林大学学报(医学版),2016,42(5):1030-1033.
[9]Dalai SK,Khoruzhenko S,Drake CG,et al.Resolution of infection promotes a state of dormancy and long survival of CD4 memory T cells[J].Immunologyand cell biology,2011,89(8):870.
[10]Pascual G,Domínguez D,Benitah S A.The contributions of cancer cell metabolism to metastasis[J].Disease models&mechanisms,2018,11(8):dmm032920.
[11]Folkman J.Tumorangiogenesis:apossible control point in tumor growth[J].Annals ofinternal medicine,1975,82(1):96-100.
[12]Carmeliet P.Mechanisms of angiogenesis and arteriogenesis[J].Nature medicine,2000,6(4):389.
[13]Hidalgo M,Martinez-Garcia M,Le Tourneau C,et al.First-in-human phase i study of single-agent vanucizumab,a first-in-class bispecific anti-angiopoietin-2/anti-vegf-a antibody,in adult patients with advanced solid tumors[J].Clinical Cancer Research,2018,24(7):1536-1545.
[14]Senger DR,Perruzzi CA,Feder J,et al.Ahighlyconserved vascular permeability factor secreted by a variety of human and rodent tumor cell lines[J].Cancer research,1986,46(11):5629-5632.
[15]Ferrara N,Henzel WJ.Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells[J].Biochemical and biophysical research communications,1989,161(2):851-858.
[16]Leung DW,Cachianes G,Kuang WJ,et al.Vascular endothelial growth factor is a secreted angiogenic mitogen[J].Science,1989,246(4935):1306-1309.
[17]Lee S,KimH J,Oh SC,et al.Genipin inhibits the invasion and migration of colon cancer cells by the suppression of HIF-1αaccumulation and VEGF expression[J].Food and Chemical Toxicology,2018,116:70-76.
[18]Kim BR,Jeong YA,Na YJ,et al.Genipin suppresses colorectal cancer cells by inhibiting the Sonic Hedgehog pathway[J].Oncotarget,2017,8(60):101952.
[19]Sun S,Gong F,Liu P,et al.Metformin combined with quercetin synergistically repressed prostate cancer cells via inhibition of VEGF/PI3K/Akt signaling pathway[J].Gene,2018(664):50-57.
[20]Lee Y W,Hwang Y E,Lee J Y,et al.VEGF si RNA Delivery by a Cancer-Specific Cell-Penetrating Peptide[J].Journal of microbiology and biotechnology,2018,28(3):367.
[21]Zhou Y,Yu F,Zhang F,et al.Cyclam-Modified PEI for Combined VEGF si RNA Silencing and CXCR4 Inhibition To Treat Metastatic Breast Cancer[J].Biomacromolecules,2018,19(2):392-401.
[22]韦堂军,程银.略论传统中医的肿瘤辨治观[J].世界科学技术-中医药现代化,2015,17(4):891-896.
[23]Yihong C,Fan L,Nurshat K,et al.15,16-Dihydrotanshinone I inhibits hemangiomas through inducing pro-apoptotic and anti-angiogenic mechanisms in vitro and invivo[J].FrontiersinPharmacology,2018(9):25.
[24]Wang T,Chen W,Wu J.H2-P,a honokiol derivative,exerts anti-angiogenesis effects via c-MYC signaling pathway in glioblastoma[J].Journal ofCellular Biochemistry,2018,119(4):3142-3148.
[25]Zhang X,Cao M,Pu L,et al.A novel flavonoid isolated from Sophora flavescens exhibited anti-angiogenesis activity,decreased VEGF expression and caused G0/G1 cell cycle arrest in vitro[J].Pharmazie,2013,68(5):369-375.
[26]Lu D,Xia Y,Tong B,et al.In vitro Anti-angiogenesis effects and active constituents ofthe saponin fraction fromgleditsia sinensis[J].Integrative Cancer Therapies,2014,13(5):446-457.
[27]Wang T,Liu J,Xiao XQ.Cantharidin inhibits angiogenesis by suppressingVEGF-induced JAK1/STAT3,ERKand AKTsignalingpathways[J].Archives ofPharmacal Research,2015,38(2):282-289.
[28]Li M,Yu X,Li W,et al.Deguelin suppresses angiogenesis in human hepatocellular carcinoma by targeting HGF-c-Met pathway[J].Oncotarget,2018,9(1):152-166.
[29]Pan Z,ZhuangJ,Ji C,et al.Curcumin inhibits hepatocellular carcinoma growth by targeting VEGF expression[J].Oncology Letters,2018,15(4):4821-4826.
[30]宋红,包素珍,郑小伟,等.血管内皮细胞生长因子在Lewis肺癌组织中表达的意义及十全大补汤对其干预作用[J].中华中医药杂志,2008,23(8):684-687.
[31]郜明,张伟伟,吴家明,等.十全大补汤对体外血管生成的影响[J].南京中医药大学学报,2008,24(2):101-103.
[2]Fluegen G,Avivar-Valderas A,Wang Y,et al.Phenotypic heterogeneity of disseminated tumour cells is preset by primary tumour hypoxic microenvironments[J].Nature Cell Biology,2017,19(2):120-132.
[3]Kazerounian S,Lawler J.Integration of pro-and anti-angiogenic signals byendothelial cells[J].J Cell Commun Signal,2018,12(1):171-179.
[4]Hadfield G.The Dormant Cancer Cell[J].British Medical Journal,1954,2(4898):1225-1225.
[5]Goss PE,Chambers AF.Doestumour dormancy offer atherap eutictarget[J].Nature reviews cancer,2010,10(12):871-877.
[6]Aguirre-Ghiso,Julio A.Models,mechanisms and clinical evidence for cancer dormancy[J].Nature Reviews Cancer,2007,7(11):834-846.
[7]Natale G,Bocci G.Does metronomic chemotherapy induce tumor angiogenic dormancy?A review of available preclinical and clinical data[J].Cancer letters,2018(432):28-37.
[8]孟琳,王丹丹,唐琪,等.肿瘤休眠及其相关机制研究进展[J].吉林大学学报(医学版),2016,42(5):1030-1033.
[9]Dalai SK,Khoruzhenko S,Drake CG,et al.Resolution of infection promotes a state of dormancy and long survival of CD4 memory T cells[J].Immunologyand cell biology,2011,89(8):870.
[10]Pascual G,Domínguez D,Benitah S A.The contributions of cancer cell metabolism to metastasis[J].Disease models&mechanisms,2018,11(8):dmm032920.
[11]Folkman J.Tumorangiogenesis:apossible control point in tumor growth[J].Annals ofinternal medicine,1975,82(1):96-100.
[12]Carmeliet P.Mechanisms of angiogenesis and arteriogenesis[J].Nature medicine,2000,6(4):389.
[13]Hidalgo M,Martinez-Garcia M,Le Tourneau C,et al.First-in-human phase i study of single-agent vanucizumab,a first-in-class bispecific anti-angiopoietin-2/anti-vegf-a antibody,in adult patients with advanced solid tumors[J].Clinical Cancer Research,2018,24(7):1536-1545.
[14]Senger DR,Perruzzi CA,Feder J,et al.Ahighlyconserved vascular permeability factor secreted by a variety of human and rodent tumor cell lines[J].Cancer research,1986,46(11):5629-5632.
[15]Ferrara N,Henzel WJ.Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells[J].Biochemical and biophysical research communications,1989,161(2):851-858.
[16]Leung DW,Cachianes G,Kuang WJ,et al.Vascular endothelial growth factor is a secreted angiogenic mitogen[J].Science,1989,246(4935):1306-1309.
[17]Lee S,KimH J,Oh SC,et al.Genipin inhibits the invasion and migration of colon cancer cells by the suppression of HIF-1αaccumulation and VEGF expression[J].Food and Chemical Toxicology,2018,116:70-76.
[18]Kim BR,Jeong YA,Na YJ,et al.Genipin suppresses colorectal cancer cells by inhibiting the Sonic Hedgehog pathway[J].Oncotarget,2017,8(60):101952.
[19]Sun S,Gong F,Liu P,et al.Metformin combined with quercetin synergistically repressed prostate cancer cells via inhibition of VEGF/PI3K/Akt signaling pathway[J].Gene,2018(664):50-57.
[20]Lee Y W,Hwang Y E,Lee J Y,et al.VEGF si RNA Delivery by a Cancer-Specific Cell-Penetrating Peptide[J].Journal of microbiology and biotechnology,2018,28(3):367.
[21]Zhou Y,Yu F,Zhang F,et al.Cyclam-Modified PEI for Combined VEGF si RNA Silencing and CXCR4 Inhibition To Treat Metastatic Breast Cancer[J].Biomacromolecules,2018,19(2):392-401.
[22]韦堂军,程银.略论传统中医的肿瘤辨治观[J].世界科学技术-中医药现代化,2015,17(4):891-896.
[23]Yihong C,Fan L,Nurshat K,et al.15,16-Dihydrotanshinone I inhibits hemangiomas through inducing pro-apoptotic and anti-angiogenic mechanisms in vitro and invivo[J].FrontiersinPharmacology,2018(9):25.
[24]Wang T,Chen W,Wu J.H2-P,a honokiol derivative,exerts anti-angiogenesis effects via c-MYC signaling pathway in glioblastoma[J].Journal ofCellular Biochemistry,2018,119(4):3142-3148.
[25]Zhang X,Cao M,Pu L,et al.A novel flavonoid isolated from Sophora flavescens exhibited anti-angiogenesis activity,decreased VEGF expression and caused G0/G1 cell cycle arrest in vitro[J].Pharmazie,2013,68(5):369-375.
[26]Lu D,Xia Y,Tong B,et al.In vitro Anti-angiogenesis effects and active constituents ofthe saponin fraction fromgleditsia sinensis[J].Integrative Cancer Therapies,2014,13(5):446-457.
[27]Wang T,Liu J,Xiao XQ.Cantharidin inhibits angiogenesis by suppressingVEGF-induced JAK1/STAT3,ERKand AKTsignalingpathways[J].Archives ofPharmacal Research,2015,38(2):282-289.
[28]Li M,Yu X,Li W,et al.Deguelin suppresses angiogenesis in human hepatocellular carcinoma by targeting HGF-c-Met pathway[J].Oncotarget,2018,9(1):152-166.
[29]Pan Z,ZhuangJ,Ji C,et al.Curcumin inhibits hepatocellular carcinoma growth by targeting VEGF expression[J].Oncology Letters,2018,15(4):4821-4826.
[30]宋红,包素珍,郑小伟,等.血管内皮细胞生长因子在Lewis肺癌组织中表达的意义及十全大补汤对其干预作用[J].中华中医药杂志,2008,23(8):684-687.
[31]郜明,张伟伟,吴家明,等.十全大补汤对体外血管生成的影响[J].南京中医药大学学报,2008,24(2):101-103.