痛风的分子机制与中药治疗研究进展
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摘要
痛风是由于长期嘌呤代谢紊乱引起的,痛风的发病率逐年增加,且发病年龄出现低龄化趋势。近年来研究人员从分子及细胞水平对痛风的机制进行了大量研究,并从抑制尿酸生成、促进尿酸排泄和抑制炎症因子等方面阐述痛风治疗途径。通过国内外文献研究,综述了痛风产生的分子机制以及单味中药、复方和活性化合物对其的治疗作用,并提出建议与展望。
Gout is caused by long-term purine metabolic disorders.With the incidence of gout increasing year by year,the onset age trends to be younger and younger.In recent years,a lot of research has been conducted from the molecular and cellular levels to elucidate the mechanism of gout;and the anti-gout effect was described from inhibiting uric acid production,promoting uric acid excretion and inhibition of inflammatory factors,and many other aspects.This paper reviews the molecular mechanism of gout occurrence and the therapeutic effects of monotherapy,compound and active compounds using traditional Chinese medicine,and offered proposals and prospects.
Gout is caused by long-term purine metabolic disorders.With the incidence of gout increasing year by year,the onset age trends to be younger and younger.In recent years,a lot of research has been conducted from the molecular and cellular levels to elucidate the mechanism of gout;and the anti-gout effect was described from inhibiting uric acid production,promoting uric acid excretion and inhibition of inflammatory factors,and many other aspects.This paper reviews the molecular mechanism of gout occurrence and the therapeutic effects of monotherapy,compound and active compounds using traditional Chinese medicine,and offered proposals and prospects.
引文
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[13]SAKIYAMA M,MATSUO H,SHIMIZU S,et al.The effects of URAT1/SLC22A12 nonfunctional variants,R90H and W258X,on serum uric acid levels and gout/hyperuricemia progression[J].Scientific Reports,2016,6:20148.
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[16]朱立然,陈光亮.尿酸转运蛋白研究进展[J].2012,17(11):1289-1294.
[17]谢华,陈敏,易青,等.表没食子儿茶素没食子酸酯对高尿酸血症大鼠血管内皮炎症因子的作用[J].中国动脉硬化杂志,2017,25(1):13-18.
[18]罗来敏,陈钦开,杨小娟.降尿酸治疗对痛风高尿酸血症患者IL-1β和NALP3水平的影响[J].南昌大学学报(医学版),2016,56(1):63-66.
[19]王茉琳,李晓光,王建杰,等.NLRP3炎性体在原发性高尿酸血症患者中的表达[J].中国老年学杂志,2017,37(2):346-347.
[20]曾金祥,许兵兵,李敏,等.藏药短管兔耳草醇提物降低急性高尿酸血症小鼠血尿酸水平及机制研究[J].中国新药杂志,2015,24(21):2489-2493.
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[22]戴芸,杨林,朱莉萍.白芍总苷降尿酸实验研究[J].化学工程师,2016,(3):68-70.
[23]程虹毓,朱继孝.银杏叶提取物降尿酸及对黄嘌呤氧化酶抑制作用研究[J].中医药通报,2013,12(2):61-63.
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[25]陈璇,任泽明,童晔玲,等.蜂胶配伍姜黄抗高尿酸血症实验研究[J].新中医,2016,48(2):233-235.
[26]江凌圳,童晔玲,戴关海,等.蜂胶泽苓软胶囊抗小鼠高尿酸作用的实验研究[J].中国中医药科技,2013,20(2):127-128.
[27]彭健波,聂海英,李锦辉,等.复方肿节风颗粒及其单方对高尿酸血症小鼠的影响[J].湖北农业科学,2015,54(11):2683-2685.
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