血清癌胚抗原水平与原发性肝癌预后的关系分析
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摘要
目的探讨机体血清癌胚抗原(CEA)水平与原发性肝癌患者预后的相关性。方法选取2016年1月至2017年5月我院收治的107例原发性肝癌患者(研究组),另选取同期前来我院体检的107例健康人群作为对照组,两组受试者均接受血清CEA检测。研究组本次入院治疗后需予以1年有效随访。分析研究组治疗前、对照组血清CEA检测结果,研究组预后良好(无瘤生存)、预后不良原发性肝癌患者血清CEA检测结果。结果研究组治疗前血清CEA水平显著高于对照组(P<0.05);研究组预后良好者治疗前血清CEA水平显著低于预后不良者(P<0.05)。结论应用血清CEA检测值对诊断原发性肝癌、评估患者治疗预后均具有重要价值,有利于临床医生准确掌握患者病情、制定针对性的治疗方案,对保障其疗效及生命安全均具有积极意义。
Objective To investigate the relationship between serum carcinoembryonic antigen(CEA) level and prognosis in patients with primary liver cancer.Methods One hundred and seven patients with primary hepatocellular carcinoma(the study group) were selected from January 2016 to May2017,and 107 healthy people who came to our hospital for medical examination in the same period were selected as the control group,and both groups were tested for serum CEA.The primary liver cancer patients in the study group were followed up for one year after admission.The results of CEA test before and after treatment in the study group were compared.The prognosis of the study group(no tumor survival) and the prognosis of primary liver cancer patients with serum CEA results.Results The serum CEA level of patients with primary liver cancer in the study group was significantly higher than that of the control group(P<0.05).The serum CEA level in patients with good prognosis in the study group was significantly higher than that in patients with poor prognosis(P<0.05).Conclusions The application of serum CEA detection value is of great value in diagnosing primary liver cancer and evaluating the prognosis of patients.It is beneficial for clinicians to accurately grasp the patient's condition and formulate targeted treatment plans,which is of positive significance for ensuring its efficacy and life safety.
Objective To investigate the relationship between serum carcinoembryonic antigen(CEA) level and prognosis in patients with primary liver cancer.Methods One hundred and seven patients with primary hepatocellular carcinoma(the study group) were selected from January 2016 to May2017,and 107 healthy people who came to our hospital for medical examination in the same period were selected as the control group,and both groups were tested for serum CEA.The primary liver cancer patients in the study group were followed up for one year after admission.The results of CEA test before and after treatment in the study group were compared.The prognosis of the study group(no tumor survival) and the prognosis of primary liver cancer patients with serum CEA results.Results The serum CEA level of patients with primary liver cancer in the study group was significantly higher than that of the control group(P<0.05).The serum CEA level in patients with good prognosis in the study group was significantly higher than that in patients with poor prognosis(P<0.05).Conclusions The application of serum CEA detection value is of great value in diagnosing primary liver cancer and evaluating the prognosis of patients.It is beneficial for clinicians to accurately grasp the patient's condition and formulate targeted treatment plans,which is of positive significance for ensuring its efficacy and life safety.
引文
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[2]Li R,Yaa F,Liu L,et a1.Cytokine-induced killer cell therapy for the treatment of primary hepatocellular carcinoma subsequent to liver transplantation:a case report[J].Oneology Letters,2016,11(3):1885-1889.DOI:10.3892/ol.2016.4109.
[3]Sun B,Zhang S,Zbang D,el al.Vasculogenic mimicry is associated with high tumor grade,invasion and metastasis,and short survival in patientswith hepatocellular carcinoma[J].Oncol Rep,2006,16(4):693-698.
[4]王丹霞,全文婕,史晓欣,等.肝癌早期诊断标志物及其检测方法的研究进展[J].肿瘤药学,2016,6(1):15-20.DOI:10.3969/j.issn.2095-1264.2016.01.04.
[5]刘凌云,何沙,卢永刚.联合检测血清AFU、AFP、β2-MG、CA199及CEA对原发性肝癌诊断的临床意义[J].海南医学,2013,24(13):1948-1950.DOI:10.3969/j.issn.1003-6350.2013.13.0806.
[6]聂荣慧,刘元元.肿瘤标志物AFP、CA125、CA199和CEA检测在肝炎、肝硬化患者诊断和治疗中的应用[J].吉林大学学报(医学版),2012,38(1):119-122.
[7]赵睿,王启之.肝癌诊断的肿瘤标志物研究进展[J].国际消化病杂志,2013,33(1):29-31.DOI:10.3969/j.issn.1673-534X.2013.01.009.