α-葡萄糖苷酶抑制剂的药理作用及研究进展
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摘要
糖尿病已成为严重危害人类生命健康的重大疾病之一。α-葡萄糖苷酶抑制剂在治疗糖尿病的应用上取得了良好的治疗效果。本研究主要对α-葡萄糖苷酶抑制剂的药理作用及研究现状进行综述,旨在为今后新型α-葡萄糖苷酶抑制剂的研发提供参考。
It is well-known that diabetes has become the major diseases to human beings.It is lucky that α-glucosidase inhibitors have good therapeutic effects in the treatment of diabetes.Therefore,the paper tries to present the research advances of α-glucosidase inhibitors and pharmacological effects.The purpose is to provide some references for the future development of new α-glucosidase inhibitors.
It is well-known that diabetes has become the major diseases to human beings.It is lucky that α-glucosidase inhibitors have good therapeutic effects in the treatment of diabetes.Therefore,the paper tries to present the research advances of α-glucosidase inhibitors and pharmacological effects.The purpose is to provide some references for the future development of new α-glucosidase inhibitors.
引文
[1]张劼,李兴.终末糖基化产物在糖尿病微血管病变中的作用[J].医学综述,2007,14(24).
[2]张文婷.α-葡萄糖苷酶抑制剂的研究进展[J].福建医药杂志,2009,31(2).
[3]王翼,张旭.α-葡萄糖苷酶抑制剂的研究进展[J].海峡药学,2009,21(9).
[4]郭风霞,曾阳,徐萌.α-葡萄糖苷酶抑制剂的药理研究进展[J].青海师范大学学报,2011,1(18).
[5]王谦,张璐,边晓丽,等.α-葡萄糖苷酶抑制剂及构效关系的研究进展[J].中国新药杂志,2014,23(2).
[6]廉武星,林毓清.α-葡萄糖苷酶抑制剂及其临床应用研究进展[J].实用医药杂志,2014,31(6).
[7]何素婷,许激扬,陈代杰.具有α-葡萄糖苷酶抑制作用的抗糖尿病药物[J].工业微生物,2003,33(1).
[8]王欣荣,孙敏,何璧梅,等.α-葡萄糖苷酶抑制剂HW110产生菌的研究[J].生物技术,2005,115(2).
[9]郎国竣,杨贇,高菊芳.微生物源α-葡萄糖苷酶抑制剂506157的分离纯化及结构鉴定[J].化学与生物工程,2007,10(24).
[10]Lee S S,Lin H C,Chen C K.Acylated flavonol monorhamnosides,!-glucosidase inhibitors,fromMachilus philippinensis[J].Phytochemist ry,2008,69(12).
[11]Gao H,Huang Y,Gao B,et al.Chebulagic acid is a potentα-glucosidase inhibitor[J].Biosci Biotechnol Biochem,2008,72(2).
[12]卢大胜,冯偲慜,雍克岚,等.用固定化酶筛选模型从天然药物中筛选α-葡萄糖苷酶抑制剂[J].中国新药杂志,2005,14(12).
[13]Nie W,Luo J G,Wang X B,et al.Synthesis of newα-glucosidase inhibitors based on oleanolic acid incorporating cinnamic amides[J].Chem Pharm Bull,2011,59(8).
[14]Raju B C,Tiwari A K,Kumar J A,et al.α-Glucosidase inhibitory antihyperglycemic activity of substitutedchromenone derivatives[J].Bioorg Med Chem,2010,18(1).
[15]Noguchi-Yachide T,Aoyama A,Makishima M,et al.Liver X receptor antagonists with a phthalimide skeleton derived from thalidomide-related glucosidase inhibitors[J].Bioorg Med Chem Lett,2007,17(14).
[2]张文婷.α-葡萄糖苷酶抑制剂的研究进展[J].福建医药杂志,2009,31(2).
[3]王翼,张旭.α-葡萄糖苷酶抑制剂的研究进展[J].海峡药学,2009,21(9).
[4]郭风霞,曾阳,徐萌.α-葡萄糖苷酶抑制剂的药理研究进展[J].青海师范大学学报,2011,1(18).
[5]王谦,张璐,边晓丽,等.α-葡萄糖苷酶抑制剂及构效关系的研究进展[J].中国新药杂志,2014,23(2).
[6]廉武星,林毓清.α-葡萄糖苷酶抑制剂及其临床应用研究进展[J].实用医药杂志,2014,31(6).
[7]何素婷,许激扬,陈代杰.具有α-葡萄糖苷酶抑制作用的抗糖尿病药物[J].工业微生物,2003,33(1).
[8]王欣荣,孙敏,何璧梅,等.α-葡萄糖苷酶抑制剂HW110产生菌的研究[J].生物技术,2005,115(2).
[9]郎国竣,杨贇,高菊芳.微生物源α-葡萄糖苷酶抑制剂506157的分离纯化及结构鉴定[J].化学与生物工程,2007,10(24).
[10]Lee S S,Lin H C,Chen C K.Acylated flavonol monorhamnosides,!-glucosidase inhibitors,fromMachilus philippinensis[J].Phytochemist ry,2008,69(12).
[11]Gao H,Huang Y,Gao B,et al.Chebulagic acid is a potentα-glucosidase inhibitor[J].Biosci Biotechnol Biochem,2008,72(2).
[12]卢大胜,冯偲慜,雍克岚,等.用固定化酶筛选模型从天然药物中筛选α-葡萄糖苷酶抑制剂[J].中国新药杂志,2005,14(12).
[13]Nie W,Luo J G,Wang X B,et al.Synthesis of newα-glucosidase inhibitors based on oleanolic acid incorporating cinnamic amides[J].Chem Pharm Bull,2011,59(8).
[14]Raju B C,Tiwari A K,Kumar J A,et al.α-Glucosidase inhibitory antihyperglycemic activity of substitutedchromenone derivatives[J].Bioorg Med Chem,2010,18(1).
[15]Noguchi-Yachide T,Aoyama A,Makishima M,et al.Liver X receptor antagonists with a phthalimide skeleton derived from thalidomide-related glucosidase inhibitors[J].Bioorg Med Chem Lett,2007,17(14).